MAP Kinase Signaling

No Pathway Network information available for MAP Kinase Signaling

Pathways in the MAP Kinase Signaling SuperPath

#	Name	Source	Genes
1	MAP Kinase Signaling	Cell Signaling Technology	AJUBA ARAF ATF2 BAD BATF BRAF CAD CDC42 DUSP1 DUSP10 DUSP16 DUSP3 DUSP4 DUSP6 ELK1 FOS FOSB FOSL1 FOSL2 FOXO3 FYN GNAQ GSTP1 HCK HRAS HSF1 HSPB1 JUN JUNB JUND KRAS KSR1 LAMTOR4 LCK LGALS1 LYN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K11 MAP3K2 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAP3K9 MAP4K2 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MCRIP1 MEF2A MEF2C MRAS NELFCD NF1 NIBAN2 NRAS PEA15 PEBP1 PPM1A PPP2CA PPP2R1A PPP2R2A PTPN11 RAC1 RAC2 RAC3 RAF1 RANBP3 RASD1 RASGRP3 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RRAS SFN SHOC2 SOS1 SPAG9 SPRY1 SPRY2 SRC SRF STK33 TAB1 TAB2 TAB3 VRK3 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 113) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
2	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
3	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
4	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
5	SFN	Stratifin	Protein Coding	1
6	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
7	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
8	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
9	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
10	ATF2	Activating Transcription Factor 2	Protein Coding	1
11	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
12	BATF	Basic Leucine Zipper ATF-Like Transcription Factor	Protein Coding	1
13	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
14	CAD	Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase	Protein Coding	1
15	CDC42	Cell Division Cycle 42	Protein Coding	1
16	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
17	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
18	DUSP10	Dual Specificity Phosphatase 10	Protein Coding	1
19	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	1
20	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	1
21	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	1
22	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
23	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
24	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
25	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
26	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
27	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
28	NIBAN2	Niban Apoptosis Regulator 2	Protein Coding	1
29	MCRIP1	MAPK Regulated Corepressor Interacting Protein 1	Protein Coding	1
30	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
31	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
32	FOXO3	Forkhead Box O3	Protein Coding	1
33	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
34	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
35	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
36	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
37	LGALS1	Galectin 1	Protein Coding	1
38	MAP4K2	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2	Protein Coding	1
39	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
40	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
41	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	1
42	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
43	HSF1	Heat Shock Transcription Factor 1	Protein Coding	1
44	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
45	SPAG9	Sperm Associated Antigen 9	Protein Coding	1
46	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
47	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
48	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
49	AJUBA	Ajuba LIM Protein	Protein Coding	1
50	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
51	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
52	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
53	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
54	KSR1	Kinase Suppressor Of Ras 1	Protein Coding	1
55	LAMTOR4	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4	Protein Coding	1
56	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
57	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
58	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
59	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
60	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	1
61	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
62	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
63	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
64	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
65	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
66	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
67	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
68	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
69	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
70	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
71	MAP3K9	Mitogen-Activated Protein Kinase Kinase Kinase 9	Protein Coding	1
72	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
73	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
74	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
75	RPS6KA4	Ribosomal Protein S6 Kinase A4	Protein Coding	1
76	NELFCD	Negative Elongation Factor Complex Member C/D	Protein Coding	1
77	NF1	Neurofibromin 1	Protein Coding	1
78	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
79	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
80	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
81	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
82	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
83	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
84	PEA15	Proliferation And Apoptosis Adaptor Protein 15	Protein Coding	1
85	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
86	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
87	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
88	PPM1A	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A	Protein Coding	1
89	RAC1	Rac Family Small GTPase 1	Protein Coding	1
90	RAC2	Rac Family Small GTPase 2	Protein Coding	1
91	RAC3	Rac Family Small GTPase 3	Protein Coding	1
92	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
93	RANBP3	RAN Binding Protein 3	Protein Coding	1
94	RASD1	Ras Related Dexamethasone Induced 1	Protein Coding	1
95	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	1
96	PEBP1	Phosphatidylethanolamine Binding Protein 1	Protein Coding	1
97	RRAS	RAS Related	Protein Coding	1
98	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
99	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
100	SHOC2	SHOC2 Leucine Rich Repeat Scaffold Protein	Protein Coding	1
101	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
102	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
103	SPRY1	Sprouty RTK Signaling Antagonist 1	Protein Coding	1
104	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
105	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
106	SRF	Serum Response Factor	Protein Coding	1
107	STK33	Serine/Threonine Kinase 33	Protein Coding	1
108	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
109	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	1
110	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	1
111	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
112	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	1
113	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	1

Disorders associated with MAP Kinase Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NF1, NRAS, PTPN11, RAF1, SHOC2, SOS1	10.92
2	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, SHOC2, SOS1	10.67
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, PTPN11, RAF1, RRAS, SHOC2, SOS1	10.50
4	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, RAF1, SOS1	9.11
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.34
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.34
7	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	7.79
8	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NF1, NRAS, PTPN11, RRAS	7.56
9	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	6.51
10	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.25
11	Specific learning disability	Enrichment	MAPK1, PTPN11, RPS6KA3, YWHAG	5.84
12	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.65
13	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11, YWHAZ	5.65
14	Noonan syndrome with multiple lentigines	Enrichment	BRAF, PTPN11, RAF1	5.65
15	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	4.72
16	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	4.72
17	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.72
18	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	4.72
19	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.16
20	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.16
21	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	4.03
22	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.69
23	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2, NF1	3.39
24	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.39
25	Pilocytic astrocytoma	Enrichment	KRAS, NF1	3.39
26	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS, MAP4K4	3.31
27	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.17
28	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	2.85
29	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.85
30	Gallbladder cancer	Enrichment	BRAF, KRAS	2.85
31	Bladder cancer	Enrichment	HRAS, KRAS, NF1	2.76
32	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS, PTPN11	2.67
33	Lung cancer	Enrichment	BRAF, KRAS, MAP3K8	2.63
34	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	2.62
35	Ventricular septal defect	Enrichment	BRAF, RPS6KA3	2.62
36	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	2.53
37	Pectus excavatum	Enrichment	PTPN11, SHOC2	2.44
38	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS	2.37
39	Aortic valve disease 1	Enrichment	SOS1, TAB2	2.30
40	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.23
41	Rhabdomyosarcoma	Enrichment	HRAS, NF1	2.12
42	Metachondromatosis	Enrichment	PTPN11	2.08
43	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.08
44	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.08
45	Oculoectodermal syndrome	Enrichment	KRAS	2.08
46	Pallister-killian syndrome	Enrichment	ARAF	2.08
47	Noonan syndrome 5	Enrichment	RAF1	2.08
48	Noonan syndrome 4	Enrichment	SOS1	2.08
49	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.08
50	Melorheostosis, isolated	Enrichment	MAP2K1	2.08
51	Noonan syndrome 7	Enrichment	BRAF	2.08
52	Leopard syndrome 3	Enrichment	BRAF	2.08
53	Leopard syndrome 1	Enrichment	PTPN11	2.08
54	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.08
55	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.08
56	Melanosis, neurocutaneous	Enrichment	NRAS	2.08
57	Iga nephropathy 3	Enrichment	SPRY2	2.08
58	Noonan syndrome 6	Enrichment	NRAS	2.08
59	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.08
60	Sturge-weber syndrome	Enrichment	GNAQ	2.08
61	Noonan syndrome 11	Enrichment	MRAS	2.08
62	Noonan syndrome 13	Enrichment	MAPK1	2.08
63	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.08
64	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.08
65	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.08
66	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.08
67	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.08
68	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.08
69	Lymphangioma	Enrichment	BRAF	2.08
70	Noonan syndrome-like disorder with loose anagen hair 1	Enrichment	SHOC2	2.08
71	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.08
72	Phace association	Enrichment	BRAF	2.08
73	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	2.08
74	Melorheostosis	Enrichment	MAP2K1	2.08
75	Leopard syndrome 2	Enrichment	RAF1	2.08
76	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.08
77	Spermatogenic failure 93	Enrichment	STK33	2.08
78	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.08
79	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	2.08
80	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.08
81	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.08
82	Immunodeficiency 22	Enrichment	LCK	2.08
83	Thrombocytopenia 6	Enrichment	SRC	2.08
84	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.08
85	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.08
86	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.08
87	Trigonitis	Enrichment	RAF1	2.08
88	Plexiform neurofibroma	Enrichment	NF1	2.08
89	Neurofibroma	Enrichment	NF1	2.08
90	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	2.08
91	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.08
92	Neurofibromatosis	Enrichment	NF1	2.08
93	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.08
94	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.08
95	Congenital pulmonary airway malformation	Enrichment	KRAS	2.08
96	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.08
97	Optic nerve glioma	Enrichment	NF1	2.08
98	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.08
99	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.08
100	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.08
101	Nocarh syndrome	Enrichment	CDC42	2.08
102	Syringocystadenoma papilliferum	Enrichment	BRAF	2.08
103	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.08
104	Ganglioglioma	Enrichment	BRAF	2.08
105	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.08
106	Phace syndrome	Enrichment	BRAF	2.08
107	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.08
108	Mef2c-related disorder	Enrichment	MEF2C	2.08
109	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.08
110	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.08
111	Classic hairy cell leukemia	Enrichment	BRAF	2.08
112	Verrucous hemangioma	Enrichment	MAP3K3	2.08
113	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.08
114	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.08
115	Neurocutaneous melanocytosis	Enrichment	NRAS	2.08
116	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.08
117	Malignant astrocytoma	Enrichment	PTPN11	2.08
118	Patent foramen ovale	Enrichment	PTPN11, TAB2	2.02
119	Myeloma, multiple	Enrichment	BRAF, KRAS, NF1	1.95
120	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C, NF1, PTPN11	1.89
121	Cafe-au-lait spots, multiple	Enrichment	NF1	1.78
122	Fibromatosis, gingival, 1	Enrichment	SOS1	1.78
123	Scoliosis, isolated 1	Enrichment	MAPK7	1.78
124	Costello syndrome	Enrichment	HRAS	1.78
125	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.78
126	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	1.78
127	Developmental and epileptic encephalopathy 50	Enrichment	CAD	1.78
128	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.78
129	Werner syndrome	Enrichment	PTPN11	1.78
130	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	1.78
131	Noonan syndrome-like disorder with loose anagen hair	Enrichment	SHOC2	1.78
132	Kala-azar 2	Enrichment	GSTP1	1.78
133	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.78
134	Bardet-biedl syndrome 9	Enrichment	NF1	1.78
135	Immune system disease	Enrichment	CDC42	1.78
136	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.78
137	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.78
138	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	1.78
139	Tafro syndrome	Enrichment	MAP2K2	1.78
140	Phakomatosis cesioflammea	Enrichment	GNAQ	1.78
141	Wooly hair nevus	Enrichment	HRAS	1.78
142	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	1.71
143	Pelvic organ prolapse	Enrichment	TAB2	1.61
144	Ataxia-telangiectasia	Enrichment	BRAF	1.61
145	Watson syndrome	Enrichment	NF1	1.61
146	Nuchal bleb, familial	Enrichment	SOS1	1.61
147	Neurofibromatosis, familial spinal	Enrichment	NF1	1.61
148	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	1.61
149	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.61
150	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.61
151	Anus, imperforate	Enrichment	MAP4K4	1.61
152	Tethered spinal cord syndrome	Enrichment	BRAF	1.61
153	Bacteremia 2	Enrichment	MAPKAPK3	1.61
154	Polycystic kidney disease 4	Enrichment	SHOC2	1.61
155	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.61
156	Brain cancer	Enrichment	NF1	1.61
157	Spermatocytoma	Enrichment	HRAS	1.61
158	Tricuspid valve insufficiency	Enrichment	PTPN11	1.61
159	Anastomosing haemangioma	Enrichment	GNAQ	1.61
160	Dilated cardiomyopathy	Enrichment	BRAF, RAF1, TAB2	1.54
161	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.48
162	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.48
163	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.48
164	Congenital generalized lipodystrophy	Enrichment	FOS	1.48
165	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.48
166	Embryonal rhabdomyosarcoma	Enrichment	NF1	1.48
167	Craniopharyngioma	Enrichment	BRAF	1.48
168	Tuberculosis	Enrichment	MAPKAPK3	1.48
169	Newborn respiratory distress syndrome	Enrichment	BRAF	1.48
170	Epidermolytic nevus	Enrichment	HRAS	1.48
171	Middle aortic syndrome	Enrichment	NF1	1.48
172	Gingival fibromatosis	Enrichment	SOS1	1.48
173	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.48
174	Colorectal cancer	Enrichment	BRAF, NRAS, SRC	1.44
175	Capillary malformations, congenital	Enrichment	GNAQ	1.39
176	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.39
177	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	SHOC2	1.39
178	Rhabdomyosarcoma 2	Enrichment	NF1	1.39
179	Lymphoma	Enrichment	PTPN11	1.39
180	Endometrial stromal sarcoma	Enrichment	YWHAE	1.39
181	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.36
182	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.31
183	Melanoma, uveal	Enrichment	GNAQ	1.31
184	Wilms tumor 5	Enrichment	BRAF	1.31
185	Patent ductus arteriosus	Enrichment	PTPN11	1.31
186	Breast adenocarcinoma	Enrichment	KRAS	1.31
187	Lung squamous cell carcinoma	Enrichment	KRAS	1.31
188	Kidney clear cell sarcoma	Enrichment	YWHAE	1.31
189	Gastric cancer	Enrichment	KRAS, NF1	1.30
190	Multiple endocrine neoplasia, type i	Enrichment	MAP4K2	1.24
191	Myelofibrosis	Enrichment	SRC	1.24
192	Thrombocytopenia	Enrichment	PTPN11, SRC	1.22
193	Gastroesophageal reflux	Enrichment	RPS6KA3	1.19
194	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	1.19
195	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	SHOC2	1.19
196	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.19
197	Orthostatic intolerance	Enrichment	RPS6KA3	1.19
198	Ewing sarcoma	Enrichment	NF1	1.19
199	Lennox-gastaut syndrome	Enrichment	MAPK10	1.19
200	Neurofibromatosis, type i	Enrichment	NF1	1.14
201	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.14
202	Leukemia, acute lymphoblastic 3	Enrichment	NF1	1.14
203	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.14
204	Primary hyperaldosteronism	Enrichment	BRAF	1.14
205	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, NF1	1.11
206	Melanoma	Enrichment	BRAF	1.10
207	Microcephaly	Enrichment	MAPK1, PTPN11, YWHAG	1.08
208	Migraine with or without aura 1	Enrichment	TAB2	1.06
209	Epicanthus	Enrichment	PTPN11	1.02
210	Congenital long qt syndrome	Enrichment	PTPN11	1.02
211	Inherited cancer-predisposing syndrome	Enrichment	MAP4K2, NF1, PTPN11	1.01
212	Protein-deficiency anemia	Enrichment	NRAS	0.99
213	Osteoporosis	Enrichment	SRC	0.96
214	Pheochromocytoma	Enrichment	NF1	0.96
215	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.96
216	Wilms tumor 1	Enrichment	BRAF	0.93
217	Lynch syndrome	Enrichment	KRAS	0.93
218	Breast cancer	Enrichment	JUN, KRAS	0.89
219	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.88
220	Dandy-walker syndrome	Enrichment	BRAF	0.88
221	Heart, malformation of	Enrichment	MAPK1	0.85
222	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	0.85
223	Diffuse large b-cell lymphoma	Enrichment	BRAF	0.83
224	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	0.79
225	Skin disease	Enrichment	NF1	0.77
226	Malaria	Enrichment	MAPKAPK3	0.76
227	Kallmann syndrome	Enrichment	DUSP6	0.76
228	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.74
229	Scoliosis	Enrichment	PTPN11	0.74
230	Pancreatic cancer	Enrichment	KRAS	0.72
231	Developmental and epileptic encephalopathy 1	Enrichment	CAD	0.72
232	Strabismus	Enrichment	PTPN11	0.69
233	Long qt syndrome 1	Enrichment	PTPN11	0.65
234	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.62
235	Severe combined immunodeficiency	Enrichment	LCK	0.62
236	Left ventricular noncompaction	Enrichment	RAF1	0.60
237	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.58
238	Complex neurodevelopmental disorder	Enrichment	PPP2CA, RAC3	0.56
239	Charcot-marie-tooth disease	Enrichment	HSPB1	0.54
240	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.52
241	Hereditary breast carcinoma	Enrichment	KRAS	0.51
242	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.47
243	Hypertelorism	Enrichment	RPS6KA3	0.45
244	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.45
245	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.43
246	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	0.43
247	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.41
248	Ovarian cancer	Enrichment	KRAS	0.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAP Kinase Signaling

Pathway Network for MAP Kinase Signaling

Member Pathways for MAP Kinase Signaling

Pathways in the MAP Kinase Signaling SuperPath

Associated Genes for MAP Kinase Signaling

Associated Disorders for MAP Kinase Signaling

Disorders associated with MAP Kinase Signaling SuperPath

STRING Interaction Network for MAP Kinase Signaling

Sources for MAP Kinase Signaling