MAPK-Erk Pathway

Pathway network for the MAPK-Erk Pathway SuperPath

Sources:

Sino Biological

Pathways in the MAPK-Erk Pathway SuperPath

#	Name	Source	Genes
1	MAPK-Erk Pathway	Sino Biological	ADAM12 ATF1 ATF4 BAD BCL2L11 BLK BRAF BUB1 CCT2 CDC25A CDC25C CDKN1B CEBPB CIB1 CREB1 CREB3 CREB3L1 CREB3L2 CREB3L4 CREBZF CRK DAPK1 DAPK2 DAPK3 DUSP6 EDIL3 EEF2K EIF4B EIF5 ELK1 EMB EPHA1 EPHA2 EPHA3 EPHA4 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 ESR1 ESR2 ETS1 ETV1 FBLN5 FERMT2 FGF1 FOS FRS2 FURIN FYN GSK3B H3C1 HMGN1 HRAS ICAM4 IGF2BP2 IMP3 IMP4 IMPA1 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB1BP1 ITGB2 ITGB3 ITGB3BP ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 KRAS KSR2 LAMTOR1 LAMTOR2 LAMTOR3 LCK LYN MAP2K1 MAP2K2 MAP3K8 MAPK1 MAPK3 MARK3 METTL1 MITF MKNK1 MXD1 NFKB1 NFKBIA NFKBIB NR4A1 NRAS PAK1 PAX6 PEA15 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G4A PLD1 PPARA PPARG PPARGC1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKACA PRKACB PRKAG1 PRKAG2 PRKAG3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ PTK2 PXN RACK1 RAF1 RAP1A RAP1B RASSF5 RPS6 RPS6KA1 RPS6KA5 RPTOR RSPRY1 SHC1 SHC4 SHCBP1 SPRED1 SRC STAT1 STAT3 STK11 TAL1 YBX1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 171) (see less)
2	Actin Dynamics Signaling Pathway	Sino Biological	ADAM12 ARHGEF16 ARHGEF3 ARHGEF39 ARHGEF7 ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 ARPC5L BLK CALM1 CALM2 CALM3 CALML3 CALML5 CAPZA1 CAPZA2 CAPZB CDC42 CFL1 CFL2 CIB1 CRK CTTN EDIL3 EIF5 EMB EPHA1 EPHA2 EPHA3 EPHA4 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FBLN5 FERMT2 FGF1 FSCN1 FSCN3 FURIN FYN FZD1 FZD10 FZD2 FZD4 FZD5 FZD9 GNAI3 GSN HRAS HSP90AA1 HSP90AB1 HSP90B1 ICAM4 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB1BP1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 KRAS LCK LIMK2 LYN MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP3K2 MAP3K3 MLC1 MYLK3 NRAS PAK1 PFN1 PFN2 PFN4 PIK3CA PIK3CB PIK3R1 PIK3R2 PKD1L2 PPP1R12A PPP3CA PPP3R1 PRKACA PRKACB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ PTK2 PXN RAC1 RAC2 RAC3 RBL2 RHOA ROCK2 SRC TMOD1 TMOD2 TMOD3 TMOD4 VASP VAV1 WASF1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 149) (see less)
3	G Protein-coupled Receptors Signaling Pathway	Sino Biological	ARRB1 ARRB2 BRAF CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2G CAMK4 CAMKK1 CAMKV CDC25A CDC25C DNM2 DUSP6 EPHA1 EPHA2 EPHA3 EPHA4 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FGF1 GNA11 GNAI1 GNAI3 GRK3 HRAS IGF2BP2 IMP3 IMP4 IMPA1 ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB1BP1 ITGB2 ITGB3 ITGB3BP ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 KRAS KSR2 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MAPK6 MAPK7 MARK3 NRAS PEA15 PIK3CA PIK3CB PIK3R1 PIK3R2 PLA2G4A PRKACA PRKACB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCZ PTK2 RACK1 RAF1 RAP1A RAP1B RASGRF1 RGS1 RGS11 RGS13 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS3 RGS4 RGS5 RGS6 RGS7 RGS7BP RGS8 RGS9 RPS6KA1 SLA SRC SYN1 SYN3 TH (see all 125) (see less)

Gene overlap in member pathways for MAPK-Erk Pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EPHA1	EPH Receptor A1	Protein Coding	3
2	EPHA2	EPH Receptor A2	Protein Coding	3
3	EPHA3	EPH Receptor A3	Protein Coding	3
4	EPHA4	EPH Receptor A4	Protein Coding	3
5	EPHA6	EPH Receptor A6	Protein Coding	3
6	EPHA7	EPH Receptor A7	Protein Coding	3
7	EPHA8	EPH Receptor A8	Protein Coding	3
8	EPHB1	EPH Receptor B1	Protein Coding	3
9	EPHB2	EPH Receptor B2	Protein Coding	3
10	EPHB3	EPH Receptor B3	Protein Coding	3
11	EPHB4	EPH Receptor B4	Protein Coding	3
12	EPHB6	EPH Receptor B6	Protein Coding	3
13	FGF1	Fibroblast Growth Factor 1	Protein Coding	3
14	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	3
15	ITGA1	Integrin Subunit Alpha 1	Protein Coding	3
16	ITGA10	Integrin Subunit Alpha 10	Protein Coding	3
17	ITGA11	Integrin Subunit Alpha 11	Protein Coding	3
18	ITGA2	Integrin Subunit Alpha 2	Protein Coding	3
19	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	3
20	ITGA3	Integrin Subunit Alpha 3	Protein Coding	3
21	ITGA4	Integrin Subunit Alpha 4	Protein Coding	3
22	ITGB1	Integrin Subunit Beta 1	Protein Coding	3
23	ITGA5	Integrin Subunit Alpha 5	Protein Coding	3
24	ITGA6	Integrin Subunit Alpha 6	Protein Coding	3
25	ITGA7	Integrin Subunit Alpha 7	Protein Coding	3
26	ITGA8	Integrin Subunit Alpha 8	Protein Coding	3
27	ITGA9	Integrin Subunit Alpha 9	Protein Coding	3
28	ITGAD	Integrin Subunit Alpha D	Protein Coding	3
29	ITGAE	Integrin Subunit Alpha E	Protein Coding	3
30	ITGAL	Integrin Subunit Alpha L	Protein Coding	3
31	ITGAM	Integrin Subunit Alpha M	Protein Coding	3
32	ITGB2	Integrin Subunit Beta 2	Protein Coding	3
33	ITGAV	Integrin Subunit Alpha V	Protein Coding	3
34	ITGAX	Integrin Subunit Alpha X	Protein Coding	3
35	ITGB1BP1	Integrin Subunit Beta 1 Binding Protein 1	Protein Coding	3
36	ITGB3	Integrin Subunit Beta 3	Protein Coding	3
37	ITGB4	Integrin Subunit Beta 4	Protein Coding	3
38	ITGB5	Integrin Subunit Beta 5	Protein Coding	3
39	ITGB6	Integrin Subunit Beta 6	Protein Coding	3
40	ITGB7	Integrin Subunit Beta 7	Protein Coding	3
41	ITGB8	Integrin Subunit Beta 8	Protein Coding	3
42	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	3
43	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	3
44	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	3
45	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	3
46	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
47	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
48	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
49	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
50	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	3
51	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	3
52	PRKCA	Protein Kinase C Alpha	Protein Coding	3
53	PRKCB	Protein Kinase C Beta	Protein Coding	3
54	PRKCD	Protein Kinase C Delta	Protein Coding	3
55	PRKCE	Protein Kinase C Epsilon	Protein Coding	3
56	PRKCG	Protein Kinase C Gamma	Protein Coding	3
57	PRKCH	Protein Kinase C Eta	Protein Coding	3
58	PRKCI	Protein Kinase C Iota	Protein Coding	3
59	PRKCZ	Protein Kinase C Zeta	Protein Coding	3
60	PTK2	Protein Tyrosine Kinase 2	Protein Coding	3
61	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
62	ADAM12	ADAM Metallopeptidase Domain 12	Protein Coding	2
63	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
64	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
65	CDC25A	Cell Division Cycle 25A	Protein Coding	2
66	CDC25C	Cell Division Cycle 25C	Protein Coding	2
67	CIB1	Calcium And Integrin Binding 1	Protein Coding	2
68	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
69	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	2
70	EDIL3	EGF Like And Discoidin Domains 3	Protein Coding	2
71	EIF5	Eukaryotic Translation Initiation Factor 5	Protein Coding	2
72	EMB	Embigin	Protein Coding	2
73	FBLN5	Fibulin 5	Protein Coding	2
74	FERMT2	FERM Domain Containing Kindlin 2	Protein Coding	2
75	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	2
76	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
77	ICAM4	Intercellular Adhesion Molecule 4 (Landsteiner-Wiener Blood Group)	Protein Coding	2
78	IGF2BP2	Insulin Like Growth Factor 2 MRNA Binding Protein 2	Protein Coding	2
79	IMP3	IMP U3 Small Nucleolar Ribonucleoprotein 3	Protein Coding	2
80	IMP4	IMP U3 Small Nucleolar Ribonucleoprotein 4	Protein Coding	2
81	IMPA1	Inositol Monophosphatase 1	Protein Coding	2
82	ITGB3BP	Integrin Subunit Beta 3 Binding Protein	Protein Coding	2
83	KSR2	Kinase Suppressor Of Ras 2	Protein Coding	2
84	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
85	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
86	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
87	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
88	MARK3	Microtubule Affinity Regulating Kinase 3	Protein Coding	2
89	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
90	PEA15	Proliferation And Apoptosis Adaptor Protein 15	Protein Coding	2
91	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	2
92	PXN	Paxillin	Protein Coding	2
93	RACK1	Receptor For Activated C Kinase 1	Protein Coding	2
94	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	2
95	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	2
96	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	2
97	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	2
98	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	2
99	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	2
100	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	2
101	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	2
102	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	2
103	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	2
104	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	2
105	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
106	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
107	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
108	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	2
109	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
110	ATF1	Activating Transcription Factor 1	Protein Coding	1
111	ATF4	Activating Transcription Factor 4	Protein Coding	1
112	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
113	BCL2L11	BCL2 Like 11	Protein Coding	1
114	BUB1	BUB1 Mitotic Checkpoint Serine/Threonine Kinase	Protein Coding	1
115	CCT2	Chaperonin Containing TCP1 Subunit 2	Protein Coding	1
116	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
117	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	1
118	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
119	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
120	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	1
121	CREB3L2	CAMP Responsive Element Binding Protein 3 Like 2	Protein Coding	1
122	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
123	CREBZF	CREB/ATF BZIP Transcription Factor	Protein Coding	1
124	DAPK1	Death Associated Protein Kinase 1	Protein Coding	1
125	DAPK2	Death Associated Protein Kinase 2	Protein Coding	1
126	DAPK3	Death Associated Protein Kinase 3	Protein Coding	1
127	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	1
128	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	1
129	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
130	ESR1	Estrogen Receptor 1	Protein Coding	1
131	ESR2	Estrogen Receptor 2	Protein Coding	1
132	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
133	ETV1	ETS Variant Transcription Factor 1	Protein Coding	1
134	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
135	FRS2	Fibroblast Growth Factor Receptor Substrate 2	Protein Coding	1
136	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
137	H3C1	H3 Clustered Histone 1	Protein Coding	1
138	HMGN1	High Mobility Group Nucleosome Binding Domain 1	Protein Coding	1
139	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	1
140	LAMTOR2	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 2	Protein Coding	1
141	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	1
142	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
143	METTL1	Methyltransferase 1, TRNA Methylguanosine	Protein Coding	1
144	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
145	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
146	MXD1	MAX Dimerization Protein 1	Protein Coding	1
147	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
148	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
149	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
150	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
151	PAX6	Paired Box 6	Protein Coding	1
152	PLD1	Phospholipase D1	Protein Coding	1
153	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	1
154	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
155	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
156	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
157	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
158	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
159	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
160	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	1
161	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
162	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1
163	RASSF5	Ras Association Domain Family Member 5	Protein Coding	1
164	RPS6	Ribosomal Protein S6	Protein Coding	1
165	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
166	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
167	RSPRY1	Ring Finger And SPRY Domain Containing 1	Protein Coding	1
168	SHC1	SHC Adaptor Protein 1	Protein Coding	1
169	SHC4	SHC Adaptor Protein 4	Protein Coding	1
170	SHCBP1	SHC Binding And Spindle Associated 1	Protein Coding	1
171	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	1
172	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
173	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
174	STK11	Serine/Threonine Kinase 11	Protein Coding	1
175	TAL1	TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor	Protein Coding	1
176	YBX1	Y-Box Binding Protein 1	Protein Coding	1
177	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	1
178	ARHGEF3	Rho Guanine Nucleotide Exchange Factor 3	Protein Coding	1
179	ARHGEF39	Rho Guanine Nucleotide Exchange Factor 39	Protein Coding	1
180	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
181	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	1
182	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	1
183	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	1
184	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	1
185	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	1
186	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	1
187	ARPC5L	Actin Related Protein 2/3 Complex Subunit 5 Like	Protein Coding	1
188	CALM1	Calmodulin 1	Protein Coding	1
189	CALM2	Calmodulin 2	Protein Coding	1
190	CALM3	Calmodulin 3	Protein Coding	1
191	CALML3	Calmodulin Like 3	Protein Coding	1
192	CALML5	Calmodulin Like 5	Protein Coding	1
193	CAPZA1	Capping Actin Protein Of Muscle Z-Line Subunit Alpha 1	Protein Coding	1
194	CAPZA2	Capping Actin Protein Of Muscle Z-Line Subunit Alpha 2	Protein Coding	1
195	CAPZB	Capping Actin Protein Of Muscle Z-Line Subunit Beta	Protein Coding	1
196	CDC42	Cell Division Cycle 42	Protein Coding	1
197	CFL1	Cofilin 1	Protein Coding	1
198	CFL2	Cofilin 2	Protein Coding	1
199	CTTN	Cortactin	Protein Coding	1
200	FSCN1	Fascin Actin-Bundling Protein 1	Protein Coding	1
201	FSCN3	Fascin Actin-Bundling Protein 3	Protein Coding	1
202	FZD1	Frizzled Class Receptor 1	Protein Coding	1
203	FZD10	Frizzled Class Receptor 10	Protein Coding	1
204	FZD2	Frizzled Class Receptor 2	Protein Coding	1
205	FZD4	Frizzled Class Receptor 4	Protein Coding	1
206	FZD5	Frizzled Class Receptor 5	Protein Coding	1
207	FZD9	Frizzled Class Receptor 9	Protein Coding	1
208	GSN	Gelsolin	Protein Coding	1
209	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
210	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
211	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
212	LIMK2	LIM Domain Kinase 2	Protein Coding	1
213	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
214	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
215	MLC1	Modulator Of VRAC Current 1	Protein Coding	1
216	MYLK3	Myosin Light Chain Kinase 3	Protein Coding	1
217	PFN1	Profilin 1	Protein Coding	1
218	PFN2	Profilin 2	Protein Coding	1
219	PFN4	Profilin Family Member 4	Protein Coding	1
220	PKD1L2	Polycystin 1 Like 2 (Gene/Pseudogene)	Protein Coding	1
221	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
222	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
223	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
224	RAC1	Rac Family Small GTPase 1	Protein Coding	1
225	RAC2	Rac Family Small GTPase 2	Protein Coding	1
226	RAC3	Rac Family Small GTPase 3	Protein Coding	1
227	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	1
228	RHOA	Ras Homolog Family Member A	Protein Coding	1
229	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
230	TMOD1	Tropomodulin 1	Protein Coding	1
231	TMOD2	Tropomodulin 2	Protein Coding	1
232	TMOD3	Tropomodulin 3	Protein Coding	1
233	TMOD4	Tropomodulin 4	Protein Coding	1
234	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1
235	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
236	WASF1	WASP Family Member 1	Protein Coding	1
237	ARRB1	Arrestin Beta 1	Protein Coding	1
238	ARRB2	Arrestin Beta 2	Protein Coding	1
239	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
240	CAMK1D	Calcium/Calmodulin Dependent Protein Kinase ID	Protein Coding	1
241	CAMK1G	Calcium/Calmodulin Dependent Protein Kinase IG	Protein Coding	1
242	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
243	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
244	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
245	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
246	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	1
247	CAMKV	CaM Kinase Like Vesicle Associated	Protein Coding	1
248	DNM2	Dynamin 2	Protein Coding	1
249	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
250	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
251	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
252	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
253	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
254	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
255	RGS1	Regulator Of G Protein Signaling 1	Protein Coding	1
256	RGS11	Regulator Of G Protein Signaling 11	Protein Coding	1
257	RGS13	Regulator Of G Protein Signaling 13	Protein Coding	1
258	RGS14	Regulator Of G Protein Signaling 14	Protein Coding	1
259	RGS16	Regulator Of G Protein Signaling 16	Protein Coding	1
260	RGS17	Regulator Of G Protein Signaling 17	Protein Coding	1
261	RGS18	Regulator Of G Protein Signaling 18	Protein Coding	1
262	RGS19	Regulator Of G Protein Signaling 19	Protein Coding	1
263	RGS2	Regulator Of G Protein Signaling 2	Protein Coding	1
264	RGS3	Regulator Of G Protein Signaling 3	Protein Coding	1
265	RGS4	Regulator Of G Protein Signaling 4	Protein Coding	1
266	RGS5	Regulator Of G Protein Signaling 5	Protein Coding	1
267	RGS6	Regulator Of G Protein Signaling 6	Protein Coding	1
268	RGS7	Regulator Of G Protein Signaling 7	Protein Coding	1
269	RGS7BP	Regulator Of G Protein Signaling 7 Binding Protein	Protein Coding	1
270	RGS8	Regulator Of G Protein Signaling 8	Protein Coding	1
271	RGS9	Regulator Of G Protein Signaling 9	Protein Coding	1
272	SLA	Src Like Adaptor	Protein Coding	1
273	SYN1	Synapsin I	Protein Coding	1
274	SYN3	Synapsin III	Protein Coding	1
275	TH	Tyrosine Hydroxylase	Protein Coding	1

Disorders associated with MAPK-Erk Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SPRED1	10.77
2	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	9.58
3	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	8.97
4	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	8.57
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.16
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	8.16
7	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	6.63
8	Capillary malformation-arteriovenous malformation 1	Enrichment	EPHB4, KRAS, MAP2K1, PIK3CA	6.63
9	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	6.33
10	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	6.12
11	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11, PIK3CA, PIK3R1	6.12
12	Arteriovenous malformation	Enrichment	EPHB4, HRAS, MAP2K1, PIK3CA	6.08
13	Myopathy, x-linked, with excessive autophagy	Enrichment	EPHB4, HRAS, MAP2K1, PIK3CA	5.86
14	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.52
15	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA, STK11	4.95
16	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B, ITGB3	4.82
17	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	4.58
18	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1	4.58
19	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	4.58
20	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.58
21	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	4.58
22	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, PPARG	4.55
23	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.16
24	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.07
25	Colorectal cancer	Enrichment	BRAF, BUB1, NRAS, PIK3CA, PIK3R1, PPARG, SRC	3.95
26	Melanoma	Enrichment	BRAF, MITF, STK11	3.65
27	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	3.60
28	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.60
29	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3, STAT3	3.33
30	Myxofibrosarcoma	Enrichment	CREB3L1, CREB3L2	3.33
31	Melanoma of soft tissue	Enrichment	ATF1, CREB1	3.33
32	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.30
33	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.30
34	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.30
35	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS, SYN3	3.18
36	Lung cancer	Enrichment	BRAF, KRAS, MAP3K8, PIK3CA	3.18
37	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, YWHAZ	3.15
38	Capillary malformations, congenital	Enrichment	GNA11, PIK3CA	3.08
39	Congenital generalized lipodystrophy	Enrichment	FOS, PPARG	3.03
40	Melanoma, cutaneous malignant 1	Enrichment	BRAF, MITF, STK11	2.93
41	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	2.91
42	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	2.91
43	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	2.91
44	Aniridia	Enrichment	EPHA2, PAX6	2.81
45	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	2.77
46	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.77
47	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	2.76
48	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	2.63
49	Non-immune hydrops fetalis	Enrichment	EPHB4, HRAS, KRAS	2.55
50	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.54
51	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	2.54
52	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	2.44
53	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	2.37
54	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.28
55	Myeloma, multiple	Enrichment	BRAF, H3C1, KRAS, PIK3R2	2.27
56	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	2.15
57	Specific learning disability	Enrichment	MAPK1, YWHAG	2.09
58	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.09
59	Lymphatic malformation 5	Enrichment	EPHB4	2.04
60	Macrodactyly	Enrichment	PIK3CA	2.04
61	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.04
62	Oculoectodermal syndrome	Enrichment	KRAS	2.04
63	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.04
64	Noonan syndrome 5	Enrichment	RAF1	2.04
65	Melorheostosis, isolated	Enrichment	MAP2K1	2.04
66	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.04
67	Noonan syndrome 7	Enrichment	BRAF	2.04
68	Leopard syndrome 3	Enrichment	BRAF	2.04
69	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.04
70	Cowden syndrome 5	Enrichment	PIK3CA	2.04
71	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.04
72	Melanosis, neurocutaneous	Enrichment	NRAS	2.04
73	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	2.04
74	Noonan syndrome 6	Enrichment	NRAS	2.04
75	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.04
76	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.04
77	Noonan syndrome 13	Enrichment	MAPK1	2.04
78	Intellectual developmental disorder, x-linked 50	Enrichment	SYN1	2.04
79	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.04
80	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.04
81	Short syndrome	Enrichment	PIK3R1	2.04
82	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.04
83	Epilepsy, x-linked 1, with variable learning disabilities and behavior disorders	Enrichment	SYN1	2.04
84	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.04
85	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.04
86	Prolonged electroretinal response suppression 1	Enrichment	RGS9	2.04
87	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.04
88	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	2.04
89	Lymphangioma	Enrichment	BRAF	2.04
90	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.04
91	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.04
92	Phace association	Enrichment	BRAF	2.04
93	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.04
94	X-linked epilepsy with variable learning disabilities and behavior disorders	Enrichment	SYN1	2.04
95	Melorheostosis	Enrichment	MAP2K1	2.04
96	Leopard syndrome 2	Enrichment	RAF1	2.04
97	Lethal congenital contracture syndrome 5	Enrichment	DNM2	2.04
98	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.04
99	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.04
100	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.04
101	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.04
102	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.04
103	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.04
104	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.04
105	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.04
106	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.04
107	Visual impairment and progressive phthisis bulbi	Enrichment	MARK3	2.04
108	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	2.04
109	Thrombocytopenia 6	Enrichment	SRC	2.04
110	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.04
111	Intellectual developmental disorder, autosomal recessive 59	Enrichment	IMPA1	2.04
112	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.04
113	Trigonitis	Enrichment	RAF1	2.04
114	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.04
115	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.04
116	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.04
117	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	2.04
118	Hypospadias	Enrichment	PIK3CA	2.04
119	Congenital pulmonary airway malformation	Enrichment	KRAS	2.04
120	Rare venous malformation	Enrichment	PIK3CA	2.04
121	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.04
122	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.04
123	Diaphragmatic eventration	Enrichment	PIK3CA	2.04
124	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.04
125	Syringocystadenoma papilliferum	Enrichment	BRAF	2.04
126	Rare combined vascular malformation	Enrichment	PIK3CA	2.04
127	Ganglioglioma	Enrichment	BRAF	2.04
128	Cavernous lymphangioma	Enrichment	PIK3CA	2.04
129	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.04
130	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.04
131	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.04
132	Phace syndrome	Enrichment	BRAF	2.04
133	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.04
134	Classic hairy cell leukemia	Enrichment	BRAF	2.04
135	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.04
136	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.04
137	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.04
138	Macrodactyly of toe	Enrichment	PIK3CA	2.04
139	Ephb4-related lymphatic-related hydrops fetalis	Enrichment	EPHB4	2.04
140	Neurocutaneous melanocytosis	Enrichment	NRAS	2.04
141	Vein of galen aneurysmal malformation	Enrichment	EPHB4	2.04
142	Thrombocytopenia	Enrichment	ITGA2B, ITGB3, SRC	2.01
143	Blood group system, landsteiner-wiener	Enrichment	ICAM4	1.96
144	Cutis laxa, autosomal recessive, type ia	Enrichment	FBLN5	1.96
145	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.96
146	Macular degeneration, age-related, 3	Enrichment	FBLN5	1.96
147	Omodysplasia 2	Enrichment	FZD2	1.96
148	Amyloidosis, finnish type	Enrichment	GSN	1.96
149	Amyotrophic lateral sclerosis 18	Enrichment	PFN1	1.96
150	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	1.96
151	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	1.96
152	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.96
153	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	1.96
154	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.96
155	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.96
156	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	1.96
157	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.96
158	Nemaline myopathy 7	Enrichment	CFL2	1.96
159	Cutis laxa, autosomal dominant 2	Enrichment	FBLN5	1.96
160	Long qt syndrome 16	Enrichment	CALM3	1.96
161	Microphthalmia/coloboma 11	Enrichment	FZD5	1.96
162	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	1.96
163	Immunodeficiency 22	Enrichment	LCK	1.96
164	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.96
165	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.96
166	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	1.96
167	Charcot-marie-tooth disease, demyelinating, type 1h	Enrichment	FBLN5	1.96
168	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.96
169	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.96
170	Long qt syndrome 15	Enrichment	CALM2	1.96
171	Cerebral cavernous malformations 5	Enrichment	MAP3K3	1.96
172	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.96
173	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.96
174	Nocarh syndrome	Enrichment	CDC42	1.96
175	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.96
176	Verrucous hemangioma	Enrichment	MAP3K3	1.96
177	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.96
178	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	1.96
179	Hereditary sensorimotor neuropathy with hyperelastic skin	Enrichment	FBLN5	1.96
180	Immunodeficiency due to defect in mapbp-interacting protein	Enrichment	LAMTOR2	1.90
181	Legius syndrome	Enrichment	SPRED1	1.90
182	Heterochromia iridis	Enrichment	MITF	1.90
183	Tietz albinism-deafness syndrome	Enrichment	MITF	1.90
184	Cardiac valvular dysplasia 1	Enrichment	PLD1	1.90
185	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	1.90
186	Spondyloepimetaphyseal dysplasia, faden-alkuraya type	Enrichment	RSPRY1	1.90
187	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	1.90
188	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	1.90
189	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	1.90
190	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	1.90
191	Ovarian dysgenesis 8	Enrichment	ESR2	1.90
192	Neuroendocrine tumor	Enrichment	CDKN1B	1.90
193	Immunodeficiency 31a	Enrichment	STAT1	1.90
194	Immunodeficiency 31b	Enrichment	STAT1	1.90
195	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	1.90
196	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	1.90
197	Microcephaly 30, primary, autosomal recessive	Enrichment	BUB1	1.90
198	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	1.90
199	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	1.90
200	Primary immunodeficiency syndrome due to p14 deficiency	Enrichment	LAMTOR2	1.90
201	Intestinal polyposis syndrome	Enrichment	STK11	1.90
202	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	1.90
203	Systemic lupus erythematosus	Enrichment	BLK, ETS1, ITGAM	1.89
204	Breast cancer	Enrichment	ESR1, KRAS, PIK3CA, SHC1	1.83
205	Gastric cancer	Enrichment	KRAS, PIK3CA, STK11	1.77
206	Gliosarcoma	Enrichment	NFKBIA, PPARG	1.77
207	Hereditary breast carcinoma	Enrichment	ESR1, KRAS, PIK3CA	1.75
208	Lymphatic malformation 1	Enrichment	EPHB4	1.74
209	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.74
210	Sorsby fundus dystrophy	Enrichment	SYN3	1.74
211	Scoliosis, isolated 1	Enrichment	MAPK7	1.74
212	Costello syndrome	Enrichment	HRAS	1.74
213	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.74
214	Intracranial hypertension, idiopathic	Enrichment	EPHB4	1.74
215	Pulmonic stenosis	Enrichment	BRAF	1.74
216	Keratosis, seborrheic	Enrichment	PIK3CA	1.74
217	Segawa syndrome, autosomal recessive	Enrichment	TH	1.74
218	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.74
219	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.74
220	Noonan syndrome 8	Enrichment	PIK3CA	1.74
221	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	1.74
222	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.74
223	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.74
224	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.74
225	Fibrolamellar carcinoma	Enrichment	PRKACA	1.74
226	Bradyopsia	Enrichment	RGS9	1.74
227	Hereditary lymphedema i	Enrichment	EPHB4	1.74
228	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	1.74
229	Tafro syndrome	Enrichment	MAP2K2	1.74
230	Phakomatosis cesioflammea	Enrichment	GNA11	1.74
231	Wooly hair nevus	Enrichment	HRAS	1.74
232	Giant cell glioblastoma	Enrichment	NFKBIA, PPARG	1.72
233	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.66
234	Maturity-onset diabetes of the young, type 11	Enrichment	BLK	1.66
235	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.66
236	Otosclerosis 4	Enrichment	PKD1L2	1.66
237	Long qt syndrome 14	Enrichment	CALM1	1.66
238	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	1.66
239	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.66
240	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	1.66
241	Epidermodysplasia verruciformis 3	Enrichment	CIB1	1.66
242	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	1.66
243	Immune system disease	Enrichment	CDC42	1.66
244	Immunodeficiency 133	Enrichment	ARPC5	1.66
245	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3	1.63
246	Hydrops fetalis, nonimmune	Enrichment	EPHB4, HRAS	1.63
247	Keratitis, hereditary	Enrichment	PAX6	1.60
248	Peutz-jeghers syndrome	Enrichment	STK11	1.60
249	Foveal hypoplasia 1	Enrichment	PAX6	1.60
250	Carotid intimal medial thickness 1	Enrichment	PPARG	1.60
251	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.60
252	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.60
253	Optic nerve hypoplasia, bilateral	Enrichment	PAX6	1.60
254	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.60
255	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.60
256	Immunodeficiency 31c	Enrichment	STAT1	1.60
257	Melanoma, cutaneous malignant 8	Enrichment	MITF	1.60
258	Papillary renal cell carcinoma	Enrichment	MITF	1.60
259	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	1.60
260	Familial partial lipodystrophy	Enrichment	PPARG	1.60
261	Common variable immunodeficiency 12	Enrichment	NFKB1	1.60
262	Dystonia, dopa-responsive	Enrichment	TH	1.56
263	Ataxia-telangiectasia	Enrichment	BRAF	1.56
264	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.56
265	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.56
266	Muscular dystrophy, congenital, due to integrin alpha-7 deficiency	Enrichment	ITGA7	1.56
267	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.56
268	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.56
269	Tethered spinal cord syndrome	Enrichment	BRAF	1.56
270	Lymphatic malformation 7	Enrichment	EPHB4	1.56
271	Immunodeficiency 14	Enrichment	PIK3R1	1.56
272	Capillary malformation-arteriovenous malformation 2	Enrichment	EPHB4	1.56
273	Spermatocytoma	Enrichment	HRAS	1.56
274	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.56
275	Anastomosing haemangioma	Enrichment	GNA11	1.56
276	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	1.56
277	Keratoacanthoma	Enrichment	PIK3CA	1.56
278	Prostate cancer	Enrichment	EPHB2, PIK3CA	1.54
279	Myocardial infarction	Enrichment	ESR1, ITGB3	1.51
280	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.49
281	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.49
282	Autosomal recessive cutis laxa type i	Enrichment	FBLN5	1.49
283	Autosomal dominant cutis laxa	Enrichment	FBLN5	1.49
284	Megalencephalic leukoencephalopathy with subcortical cysts	Enrichment	MLC1	1.49
285	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	1.44
286	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.44
287	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.44
288	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.44
289	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.44
290	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.44
291	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.44
292	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.44
293	Retinitis pigmentosa 26	Enrichment	ITGA4	1.44
294	Achromatopsia 4	Enrichment	GNAI3	1.44
295	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.44
296	Hereditary ataxia	Enrichment	PRKCG	1.44
297	Cerebrovascular disease	Enrichment	PIK3CA	1.44
298	Craniopharyngioma	Enrichment	BRAF	1.44
299	Pilocytic astrocytoma	Enrichment	KRAS	1.44
300	Newborn respiratory distress syndrome	Enrichment	BRAF	1.44
301	Epidermolytic nevus	Enrichment	HRAS	1.44
302	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.44
303	Jacobsen syndrome	Enrichment	ETS1	1.43
304	Thyroid carcinoma, familial medullary	Enrichment	ESR2	1.43
305	Waardenburg syndrome, type 2a	Enrichment	MITF	1.43
306	Gillespie syndrome	Enrichment	PAX6	1.43
307	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.43
308	Estrogen resistance	Enrichment	ESR1	1.43
309	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.43
310	Hyper ige syndrome	Enrichment	STAT3	1.43
311	Testicular germ cell cancer	Enrichment	STK11	1.43
312	Migraine without aura	Enrichment	ESR1	1.43
313	Testicular cancer	Enrichment	STK11	1.43
314	Apc-associated polyposis conditions	Enrichment	STK11	1.43
315	Pancreatic cancer	Enrichment	KRAS, STK11	1.41
316	Severe covid-19	Enrichment	CIB1, ITGAV	1.40
317	Dystonia	Enrichment	CAMK2B, TH	1.39
318	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2	1.36
319	Retinopathy of prematurity	Enrichment	FZD4	1.36
320	Autosomal dominant robinow syndrome	Enrichment	FZD2	1.36
321	Eyelid coloboma	Enrichment	FZD5	1.36
322	Inherited epidermodysplasia verruciformis	Enrichment	CIB1	1.36
323	Lens coloboma	Enrichment	FZD5	1.36
324	Cataract 6, multiple types	Enrichment	EPHA2	1.34
325	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.34
326	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.34
327	Epidermolysis bullosa	Enrichment	ITGA6	1.34
328	Aplasia cutis congenita	Enrichment	ITGB4	1.34
329	Hemimegalencephaly	Enrichment	PIK3CA	1.34
330	Long qt syndrome	Enrichment	CALM1, CALM2	1.34
331	Aniridia 1	Enrichment	PAX6	1.31
332	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.31
333	Leptin deficiency or dysfunction	Enrichment	PPARG	1.31
334	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.31
335	Primary hyperparathyroidism	Enrichment	CDKN1B	1.31
336	Clear cell papillary renal cell carcinoma	Enrichment	MITF	1.31
337	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.28
338	Exudative vitreoretinopathy 1	Enrichment	FZD4	1.27
339	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2	1.27
340	Norrie disease	Enrichment	FZD4	1.27
341	Megalencephalic leukoencephalopathy with subcortical cysts 1	Enrichment	MLC1	1.27
342	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	1.27
343	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.27
344	Coloboma of choroid and retina	Enrichment	FZD5	1.27
345	Endometrial stromal sarcoma	Enrichment	YWHAE	1.27
346	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.27
347	Melanoma, uveal	Enrichment	GNA11	1.27
348	Myopathy, centronuclear, 1	Enrichment	DNM2	1.27
349	Cowden syndrome 1	Enrichment	PIK3CA	1.27
350	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.27
351	Wilms tumor 5	Enrichment	BRAF	1.27
352	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.27
353	Familial adenomatous polyposis 1	Enrichment	STK11	1.21
354	Histiocytoid hemangioma	Enrichment	FOS	1.21
355	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.21
356	Myelofibrosis	Enrichment	SRC	1.20
357	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.20
358	Overgrowth syndrome	Enrichment	PIK3R1	1.20
359	Coloboma of optic nerve	Enrichment	FZD5	1.19
360	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.19
361	Autosomal recessive robinow syndrome	Enrichment	FZD2	1.19
362	Kidney clear cell sarcoma	Enrichment	YWHAE	1.19
363	Typical nemaline myopathy	Enrichment	CFL2	1.19
364	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2, RAF1	1.19
365	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.15
366	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.15
367	Early-onset posterior polar cataract	Enrichment	EPHA2	1.15
368	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	PAX6	1.13
369	Testicular germ cell tumor	Enrichment	STK11	1.13
370	Waardenburg syndrome, type 4a	Enrichment	MITF	1.13
371	Anterior segment dysgenesis 5	Enrichment	PAX6	1.13
372	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.13
373	Waardenburg syndrome	Enrichment	MITF	1.13
374	Coats disease	Enrichment	FZD4	1.13
375	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B	1.11
376	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.10
377	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.10
378	Primary hyperaldosteronism	Enrichment	BRAF	1.10
379	Ventricular septal defect	Enrichment	BRAF	1.10
380	Cowden syndrome	Enrichment	PIK3CA	1.10
381	Renal agenesis, bilateral	Enrichment	ITGA8	1.10
382	Exudative vitreoretinopathy	Enrichment	FZD4	1.07
383	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.07
384	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.07
385	Waardenburg syndrome, type 1	Enrichment	MITF	1.07
386	Waardenburg syndrome, type 2e	Enrichment	MITF	1.07
387	Common variable immunodeficiency	Enrichment	NFKB1	1.07
388	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.05
389	Stroke, ischemic	Enrichment	PRKCH	1.05
390	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.05
391	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.02
392	Glioma susceptibility 1	Enrichment	H3C1	1.02
393	Ewing sarcoma	Enrichment	ETV1	1.02
394	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1	1.02
395	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.02
396	Type 2 diabetes mellitus	Enrichment	IGF2BP2, PPARG	1.01
397	Cat eye syndrome	Enrichment	FZD5	0.98
398	Meningioma	Enrichment	PIK3CA	0.98
399	Neurofibromatosis, type i	Enrichment	SPRED1	0.97
400	Neural tube defects	Enrichment	ITGB1	0.95
401	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	0.95
402	Protein-deficiency anemia	Enrichment	NRAS	0.95
403	Nk-cell enteropathy	Enrichment	PIK3CB	0.95
404	Combined immunodeficiency	Enrichment	ARPC1B	0.94
405	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	0.94
406	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	0.94
407	Peters-plus syndrome	Enrichment	PAX6	0.92
408	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	0.92
409	Multiple sclerosis	Enrichment	ITGB4	0.92
410	Osteoporosis	Enrichment	SRC	0.92
411	Cataract	Enrichment	EPHA2	0.92
412	Isolated macular dystrophy	Enrichment	ITGA4	0.92
413	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA, YWHAG	0.90
414	Wilms tumor 1	Enrichment	BRAF	0.89
415	Congenital myopathy 4a, autosomal dominant	Enrichment	ITGA7	0.89
416	Migraine with or without aura 1	Enrichment	ESR1	0.89
417	Microphthalmia/coloboma 12	Enrichment	FZD5	0.87
418	Ovarian cancer	Enrichment	CDKN1B, KRAS, PIK3CA	0.87
419	Rhabdomyosarcoma	Enrichment	HRAS	0.86
420	Hypertelorism	Enrichment	PAX6, PIK3CA	0.86
421	Hypertension, essential	Enrichment	RGS5	0.84
422	Dandy-walker syndrome	Enrichment	BRAF	0.84
423	Cataract 44	Enrichment	EPHA2	0.84
424	Polycystic liver disease	Enrichment	CDC25A	0.84
425	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	0.84
426	Acute promyelocytic leukemia	Enrichment	STAT3	0.82
427	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, MITF	0.82
428	Coloboma of macula	Enrichment	FZD5	0.82
429	Heart, malformation of	Enrichment	MAPK1	0.81
430	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	0.81
431	Early-onset nuclear cataract	Enrichment	EPHA2	0.81
432	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	0.77
433	Sudden infant death syndrome	Enrichment	CALM2	0.77
434	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	0.76
435	Anterior segment dysgenesis	Enrichment	PAX6	0.76
436	Male infertility with spermatogenesis disorder	Enrichment	SPRED1	0.76
437	Endometrial cancer	Enrichment	PIK3CA	0.75
438	Centronuclear myopathy	Enrichment	DNM2	0.75
439	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	0.74
440	Hepatocellular carcinoma	Enrichment	PIK3CA	0.73
441	Skin disease	Enrichment	ITGB4	0.73
442	Kallmann syndrome	Enrichment	DUSP6	0.72
443	Maturity-onset diabetes of the young	Enrichment	BLK	0.70
444	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.70
445	Tetralogy of fallot	Enrichment	EPHB4	0.67
446	Macs syndrome	Enrichment	PAX6	0.65
447	Inherited cancer-predisposing syndrome	Enrichment	CDKN1B, MITF, STK11	0.63
448	Microphthalmia	Enrichment	PAX6	0.61
449	Brittle bone disorder	Enrichment	CREB3L1	0.60
450	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TAL1	0.60
451	Ear malformation	Enrichment	MITF	0.58
452	Left ventricular noncompaction	Enrichment	RAF1	0.56
453	Severe combined immunodeficiency	Enrichment	LCK	0.51
454	Epilepsy	Enrichment	SYN1	0.51
455	Myopathy	Enrichment	DNM2	0.51
456	Microcephaly	Enrichment	CAMK2B, MAPK1	0.50
457	Charcot-marie-tooth disease	Enrichment	DNM2	0.50
458	Nephrotic syndrome	Enrichment	ITGA3	0.48
459	Non-syndromic genetic deafness	Enrichment	MITF	0.44
460	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.41
461	Complex neurodevelopmental disorder	Enrichment	RAC3, WASF1	0.40
462	Nonsyndromic hearing loss	Enrichment	MITF	0.38
463	Autosomal recessive non-syndromic intellectual disability	Enrichment	IMPA1	0.38
464	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.38
465	Cone-rod dystrophy 2	Enrichment	ITGA4	0.33
466	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.33
467	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PFN1	0.32
468	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MITF	0.32
469	Autism	Enrichment	CAMK2G	0.31
470	Hereditary retinal dystrophy	Enrichment	ITGA4, RGS9, SYN3	0.30
471	Fundus dystrophy	Enrichment	ITGA4, RGS9, SYN3	0.30
472	Leber plus disease	Enrichment	RGS9	0.23
473	Congenital nervous system abnormality	Enrichment	CAMK2B	0.20
474	Nervous system disease	Enrichment	CAMK2B	0.20
475	Rare genetic deafness	Enrichment	MITF	0.20
476	Autism spectrum disorder	Enrichment	MAP2K1	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAPK-Erk Pathway

Pathway Network for MAPK-Erk Pathway

Pathway network for the MAPK-Erk Pathway SuperPath

Member Pathways for MAPK-Erk Pathway

Pathways in the MAPK-Erk Pathway SuperPath

Gene overlap in member pathways for MAPK-Erk Pathway SuperPath

Associated Genes for MAPK-Erk Pathway

Associated Disorders for MAPK-Erk Pathway

Disorders associated with MAPK-Erk Pathway SuperPath

STRING Interaction Network for MAPK-Erk Pathway

Sources for MAPK-Erk Pathway