MAPK Pathway

No Pathway Network information available for MAPK Pathway

Pathways in the MAPK Pathway SuperPath

#	Name	Source	Genes
1	MAPK Pathway	Tocris	ARAF BRAF EGFR ERBB2 ERBB3 ERBB4 FOS GSK3A GSK3B HSP90AA1 HSP90AA2P HSP90AB1 HSP90B1 IL13 IL1A IL1B IL1R1 IL1R2 IL2 IL2RA IL5 IL5RA ITGA11 ITGA4 ITGAV ITGB1 JUN MAP2K1 MAP2K2 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PRKCA PRKCB PRKCG PTK2 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 SRC STAT1 STAT3 TP53 (see all 63) (see less)
2	Toll-like Receptor Pathway	Tocris	AKT1 AKT2 AKT3 CASP8 CHUK IKBKB IKBKG IL13 IL1A IL1B IL1R1 IL1R2 IL2 IL2RA IL5 IL5RA JUN MAP2K1 MAP2K2 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 NFKB1 NFKB2 NFKBIA PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RELA TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 (see all 58) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
2	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
3	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
4	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
5	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	2
6	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	2
7	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	2
8	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	2
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
10	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
11	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
12	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
13	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
14	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
15	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
16	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
17	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
18	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
19	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
20	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
21	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
22	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
23	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
24	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
25	IL13	Interleukin 13	Protein Coding	2
26	IL1A	Interleukin 1 Alpha	Protein Coding	2
27	IL1B	Interleukin 1 Beta	Protein Coding	2
28	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	2
29	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	2
30	IL2	Interleukin 2	Protein Coding	2
31	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	2
32	IL5	Interleukin 5	Protein Coding	2
33	IL5RA	Interleukin 5 Receptor Subunit Alpha	Protein Coding	2
34	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
35	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
36	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
37	TP53	Tumor Protein P53	Protein Coding	1
38	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
39	PRKCA	Protein Kinase C Alpha	Protein Coding	1
40	PRKCB	Protein Kinase C Beta	Protein Coding	1
41	PRKCG	Protein Kinase C Gamma	Protein Coding	1
42	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
43	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	1
44	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	1
45	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	1
46	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
47	ITGA11	Integrin Subunit Alpha 11	Protein Coding	1
48	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
49	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
50	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
51	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
52	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
53	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
54	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	1
55	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
56	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
57	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
58	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
59	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
60	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
61	HSP90AA2P	Heat Shock Protein 90 Alpha Family Class A Member 2, Pseudogene	Pseudogene	1
62	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	1
63	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
64	TLR1	Toll Like Receptor 1	Protein Coding	1
65	TLR2	Toll Like Receptor 2	Protein Coding	1
66	TLR3	Toll Like Receptor 3	Protein Coding	1
67	TLR4	Toll Like Receptor 4	Protein Coding	1
68	TLR5	Toll Like Receptor 5	Protein Coding	1
69	TLR6	Toll Like Receptor 6	Protein Coding	1
70	TLR7	Toll Like Receptor 7	Protein Coding	1
71	TLR8	Toll Like Receptor 8	Protein Coding	1
72	TLR9	Toll Like Receptor 9	Protein Coding	1
73	TLR10	Toll Like Receptor 10	Protein Coding	1
74	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
75	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
76	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
77	CASP8	Caspase 8	Protein Coding	1
78	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
79	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	1
80	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
81	MAPK15	Mitogen-Activated Protein Kinase 15	Protein Coding	1
82	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
83	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
84	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
85	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
86	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
87	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
88	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1

Disorders associated with MAPK Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, ERBB2, MAP2K1, PIK3CA	9.07
2	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, PIK3CA, TP53	6.70
3	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR, PIK3CA, TP53	6.69
4	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.53
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2	6.42
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1, MAP2K2	6.42
7	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, ERBB2, TP53	6.39
8	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1, MAP2K2, RAF1	6.26
9	Colorectal cancer	Enrichment	BRAF, ERBB2, PIK3CA, PIK3R1, SRC, TP53	5.53
10	Gallbladder cancer	Enrichment	BRAF, PIK3CA, TP53	5.48
11	Noonan syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2, RAF1	5.46
12	Rasopathy	Enrichment	BRAF, MAP2K1, MAP2K2, RAF1	5.23
13	Lung cancer	Enrichment	BRAF, EGFR, ERBB2, PIK3CA	4.86
14	Breast cancer	Enrichment	AKT1, CASP8, IL2, JUN, PIK3CA	4.78
15	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.75
16	Gastric cancer	Enrichment	ERBB2, IL1B, PIK3CA, TP53	4.34
17	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.27
18	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.27
19	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.27
20	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	4.20
21	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3, TP53	4.06
22	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.97
23	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	3.90
24	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.90
25	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	3.75
26	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.57
27	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	3.50
28	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	3.50
29	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	3.43
30	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.43
31	Squamous cell carcinoma, head and neck	Enrichment	EGFR, TP53	3.36
32	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	3.36
33	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, RAF1	3.23
34	Glioma susceptibility 1	Enrichment	ERBB2, TP53	3.23
35	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	3.23
36	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	3.20
37	Adult hepatocellular carcinoma	Enrichment	CASP8, PIK3CA	3.20
38	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.20
39	Primary hyperaldosteronism	Enrichment	BRAF, TP53	3.13
40	Ventricular septal defect	Enrichment	BRAF, RPS6KA3	3.13
41	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	3.10
42	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.10
43	Meningioma	Enrichment	AKT1, PIK3CA	2.94
44	Ovarian cancer	Enrichment	EGFR, ERBB2, PIK3CA, TP53	2.91
45	Nk-cell enteropathy	Enrichment	ERBB4, PIK3CB	2.80
46	Myeloma, multiple	Enrichment	BRAF, PIK3R2, TP53	2.65
47	Gliosarcoma	Enrichment	EGFR, TP53	2.61
48	Giant cell glioblastoma	Enrichment	EGFR, TP53	2.56
49	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR	2.46
50	Hepatocellular carcinoma	Enrichment	CASP8, PIK3CA	2.41
51	Multisystem inflammatory syndrome in children	Enrichment	TLR3, TLR6	2.41
52	Macrodactyly	Enrichment	PIK3CA	2.37
53	Proteus syndrome	Enrichment	AKT1	2.37
54	Leprosy 3	Enrichment	TLR2	2.37
55	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.37
56	Incontinentia pigmenti	Enrichment	IKBKG	2.37
57	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.37
58	Legionnaire disease	Enrichment	TLR5	2.37
59	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.37
60	Caspase 8 deficiency	Enrichment	CASP8	2.37
61	Melorheostosis, isolated	Enrichment	MAP2K1	2.37
62	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.37
63	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.37
64	Cowden syndrome 5	Enrichment	PIK3CA	2.37
65	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.37
66	Leprosy 5	Enrichment	TLR1	2.37
67	Fetal encasement syndrome	Enrichment	CHUK	2.37
68	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.37
69	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.37
70	Immunodeficiency 15b	Enrichment	IKBKB	2.37
71	Immunodeficiency 15a	Enrichment	IKBKB	2.37
72	Short syndrome	Enrichment	PIK3R1	2.37
73	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.37
74	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.37
75	Systemic lupus erythematosus 1	Enrichment	TLR5	2.37
76	X-linked immunodeficiency 74	Enrichment	TLR7	2.37
77	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.37
78	Systemic lupus erythematosus 17	Enrichment	TLR7	2.37
79	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.37
80	Allergic rhinitis	Enrichment	IL13	2.37
81	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.37
82	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.37
83	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.37
84	Melorheostosis	Enrichment	MAP2K1	2.37
85	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.37
86	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.37
87	Cowden syndrome 6	Enrichment	AKT1	2.37
88	Melioidosis	Enrichment	TLR5	2.37
89	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.37
90	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.37
91	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.37
92	Macular degeneration, age-related, 10	Enrichment	TLR4	2.37
93	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.37
94	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.37
95	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.37
96	Hypospadias	Enrichment	PIK3CA	2.37
97	Capillary hemangioma	Enrichment	AKT3	2.37
98	Rare venous malformation	Enrichment	PIK3CA	2.37
99	Diaphragmatic eventration	Enrichment	PIK3CA	2.37
100	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.37
101	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.37
102	Rare combined vascular malformation	Enrichment	PIK3CA	2.37
103	Cavernous lymphangioma	Enrichment	PIK3CA	2.37
104	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.37
105	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.37
106	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.37
107	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.37
108	Macrodactyly of toe	Enrichment	PIK3CA	2.37
109	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.37
110	Erythroleukemia, familial	Enrichment	ERBB3	2.33
111	Paget disease, extramammary	Enrichment	ERBB2	2.33
112	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.33
113	Pallister-killian syndrome	Enrichment	ARAF	2.33
114	Noonan syndrome 5	Enrichment	RAF1	2.33
115	Noonan syndrome 7	Enrichment	BRAF	2.33
116	Leopard syndrome 3	Enrichment	BRAF	2.33
117	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.33
118	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.33
119	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.33
120	Bone marrow failure syndrome 5	Enrichment	TP53	2.33
121	Papilloma of choroid plexus	Enrichment	TP53	2.33
122	Basal cell carcinoma 7	Enrichment	TP53	2.33
123	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.33
124	Anaplastic thyroid carcinoma	Enrichment	TP53	2.33
125	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.33
126	Lymphangioma	Enrichment	BRAF	2.33
127	Phace association	Enrichment	BRAF	2.33
128	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.33
129	Leopard syndrome 2	Enrichment	RAF1	2.33
130	Immunodeficiency 31a	Enrichment	STAT1	2.33
131	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	2.33
132	Immunodeficiency 31b	Enrichment	STAT1	2.33
133	Ductal carcinoma in situ	Enrichment	TP53	2.33
134	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.33
135	Thrombocytopenia 6	Enrichment	SRC	2.33
136	Trigonitis	Enrichment	RAF1	2.33
137	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.33
138	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.33
139	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.33
140	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.33
141	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.33
142	Choroid plexus cancer	Enrichment	TP53	2.33
143	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.33
144	Syringocystadenoma papilliferum	Enrichment	BRAF	2.33
145	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.33
146	Ganglioglioma	Enrichment	BRAF	2.33
147	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.33
148	Phace syndrome	Enrichment	BRAF	2.33
149	Classic hairy cell leukemia	Enrichment	BRAF	2.33
150	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.33
151	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.33
152	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3	2.10
153	Prostate cancer	Enrichment	PIK3CA, TP53	2.10
154	Scoliosis, isolated 1	Enrichment	MAPK7	2.07
155	Immunodeficiency 33	Enrichment	IKBKG	2.07
156	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.07
157	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.07
158	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.07
159	Keratosis, seborrheic	Enrichment	PIK3CA	2.07
160	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.07
161	Noonan syndrome 8	Enrichment	PIK3CA	2.07
162	Spermatogenic failure 17	Enrichment	PIK3C2G	2.07
163	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.07
164	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.07
165	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.07
166	Rela fusion-positive ependymoma	Enrichment	RELA	2.07
167	Senior-loken syndrome 7	Enrichment	AKT3	2.07
168	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.07
169	Leprosy 1	Enrichment	TLR6	2.07
170	Immune system disease	Enrichment	PIK3CD	2.07
171	Bardet-biedl syndrome 16	Enrichment	AKT3	2.07
172	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.07
173	Common variable immunodeficiency 12	Enrichment	NFKB1	2.07
174	Tafro syndrome	Enrichment	MAP2K2	2.07
175	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.03
176	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.03
177	Cervical cancer	Enrichment	TP53	2.03
178	Pulmonic stenosis	Enrichment	BRAF	2.03
179	Lymphoma, hodgkin, classic	Enrichment	TP53	2.03
180	Immunodeficiency 31c	Enrichment	STAT1	2.03
181	Congenital fibrosarcoma	Enrichment	TP53	2.03
182	Li-fraumeni syndrome 1	Enrichment	TP53	2.03
183	Sarcoma	Enrichment	TP53	2.03
184	Cervix carcinoma	Enrichment	TP53	2.03
185	Hodgkin's lymphoma	Enrichment	TP53	2.03
186	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.03
187	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.89
188	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.89
189	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.89
190	Keratoacanthoma	Enrichment	PIK3CA	1.89
191	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.86
192	Ataxia-telangiectasia	Enrichment	BRAF	1.86
193	Osteogenic sarcoma	Enrichment	TP53	1.86
194	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.86
195	Tethered spinal cord syndrome	Enrichment	BRAF	1.86
196	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.86
197	Hyper ige syndrome	Enrichment	STAT3	1.86
198	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.86
199	Anaplastic astrocytoma	Enrichment	TP53	1.86
200	Squamous cell carcinoma	Enrichment	TP53	1.86
201	Adenocarcinoma	Enrichment	TP53	1.86
202	Bone osteosarcoma	Enrichment	TP53	1.86
203	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.86
204	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	1.82
205	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.77
206	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.77
207	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.77
208	Cerebrovascular disease	Enrichment	PIK3CA	1.77
209	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.77
210	Small cell cancer of the lung	Enrichment	TP53	1.73
211	Retinitis pigmentosa 26	Enrichment	ITGA4	1.73
212	Barrett esophagus	Enrichment	ERBB2	1.73
213	Congenital generalized lipodystrophy	Enrichment	FOS	1.73
214	Lung sarcomatoid carcinoma	Enrichment	TP53	1.73
215	Hereditary ataxia	Enrichment	PRKCG	1.73
216	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.73
217	Craniopharyngioma	Enrichment	BRAF	1.73
218	Newborn respiratory distress syndrome	Enrichment	BRAF	1.73
219	Capillary malformations, congenital	Enrichment	PIK3CA	1.67
220	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.67
221	Herpes simplex virus encephalitis	Enrichment	TLR3	1.67
222	Rhabdomyosarcoma 2	Enrichment	TP53	1.64
223	Lymphoma	Enrichment	TP53	1.64
224	Histiocytoid hemangioma	Enrichment	FOS	1.64
225	Acute megakaryocytic leukemia	Enrichment	TP53	1.64
226	Hypertelorism	Enrichment	PIK3CA, RPS6KA3	1.62
227	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.60
228	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.60
229	Li-fraumeni syndrome	Enrichment	TP53	1.56
230	Wilms tumor 5	Enrichment	BRAF	1.56
231	Adrenocortical carcinoma	Enrichment	TP53	1.56
232	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.56
233	Nevus, epidermal	Enrichment	PIK3CA	1.53
234	Megacolon	Enrichment	AKT3	1.53
235	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA	1.53
236	Overgrowth syndrome	Enrichment	PIK3R1	1.53
237	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA	1.53
238	Esophageal cancer	Enrichment	TP53	1.49
239	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.49
240	Myelofibrosis	Enrichment	SRC	1.49
241	Noonan syndrome 3	Enrichment	RAF1	1.49
242	Essential thrombocythemia	Enrichment	TP53	1.49
243	Follicular thyroid carcinoma	Enrichment	BRAF	1.49
244	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.49
245	Lennox-gastaut syndrome	Enrichment	MAPK10	1.47
246	Gastroesophageal reflux	Enrichment	RPS6KA3	1.44
247	Orthostatic intolerance	Enrichment	RPS6KA3	1.44
248	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.44
249	Rheumatoid arthritis	Enrichment	TLR1	1.42
250	Coronary heart disease 5	Enrichment	IKBKG	1.42
251	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.39
252	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.38
253	Polymicrogyria	Enrichment	AKT3	1.38
254	Leukemia, chronic lymphocytic	Enrichment	TP53	1.34
255	Melanoma	Enrichment	BRAF	1.34
256	Familial colorectal cancer	Enrichment	TP53	1.34
257	Asthma	Enrichment	IL13	1.34
258	Myelodysplastic syndrome	Enrichment	TP53	1.30
259	Specific learning disability	Enrichment	RPS6KA3	1.30
260	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.27
261	Neural tube defects	Enrichment	ITGB1	1.23
262	Acute promyelocytic leukemia	Enrichment	STAT3	1.23
263	Lynch syndrome	Enrichment	PIK3CA	1.21
264	Osteoporosis	Enrichment	SRC	1.20
265	Isolated macular dystrophy	Enrichment	ITGA4	1.20
266	Wilms tumor 1	Enrichment	BRAF	1.17
267	Rhabdomyosarcoma	Enrichment	TP53	1.14
268	Human immunodeficiency virus type 1	Enrichment	TLR3	1.13
269	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.12
270	Dandy-walker syndrome	Enrichment	BRAF	1.12
271	Behcet syndrome	Enrichment	TLR4	1.11
272	Endometrial cancer	Enrichment	PIK3CA	1.06
273	Hepatoblastoma	Enrichment	TP53	1.03
274	Malaria	Enrichment	IKBKG	1.03
275	Diamond-blackfan anemia 1	Enrichment	TP53	0.99
276	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.98
277	Pancreatic cancer	Enrichment	TP53	0.96
278	Inherited cancer-predisposing syndrome	Enrichment	EGFR, TP53	0.90
279	Severe covid-19	Enrichment	ITGAV	0.90
280	Differentiated thyroid carcinoma	Enrichment	BRAF	0.90
281	Severe combined immunodeficiency	Enrichment	IKBKB	0.88
282	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.85
283	Left ventricular noncompaction	Enrichment	RAF1	0.82
284	Systemic lupus erythematosus	Enrichment	TLR7	0.81
285	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.81
286	Diamond-blackfan anemia	Enrichment	TP53	0.81
287	Type 2 diabetes mellitus	Enrichment	AKT2	0.78
288	Leukemia, acute myeloid	Enrichment	TP53	0.77
289	Thrombocytopenia	Enrichment	SRC	0.70
290	Autosomal dominant non-syndromic intellectual disability	Enrichment	ERBB4	0.68
291	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.66
292	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.65
293	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4	0.63
294	Cone-rod dystrophy 2	Enrichment	ITGA4	0.57
295	Autism spectrum disorder	Enrichment	MAP2K1	0.43
296	Hereditary retinal dystrophy	Enrichment	ITGA4	0.13
297	Fundus dystrophy	Enrichment	ITGA4	0.13

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAPK Pathway

Pathway Network for MAPK Pathway

Member Pathways for MAPK Pathway

Pathways in the MAPK Pathway SuperPath

Associated Genes for MAPK Pathway

Associated Disorders for MAPK Pathway

Disorders associated with MAPK Pathway SuperPath

STRING Interaction Network for MAPK Pathway

Sources for MAPK Pathway