MAPK pathway in congenital thyroid cancer

No Pathway Network information available for MAPK pathway in congenital thyroid cancer

Pathways in the MAPK pathway in congenital thyroid cancer SuperPath

#	Name	Source	Genes
1	MAPK pathway in congenital thyroid cancer	WikiPathways	ALK BRAF GAREM2 KSR1 MAP2K1 MAP2K2 MAPK3 RAF1 SHC1 SOS1 SOS2 (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GAREM2	GRB2 Associated Regulator Of MAPK1 Subtype 2	Protein Coding	1
2	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	1
3	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
4	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
5	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
6	SHC1	SHC Adaptor Protein 1	Protein Coding	1
7	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
8	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
9	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
10	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
11	KSR1	Kinase Suppressor Of Ras 1	Protein Coding	1

Disorders associated with MAPK pathway in congenital thyroid cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2, RAF1, SOS1, SOS2	10.67
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, MAP2K1, MAP2K2, RAF1, SOS1	10.45
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, MAP2K1, MAP2K2	8.80
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, MAP2K1, MAP2K2	8.80
6	Melanocytic nevus syndrome, congenital	Enrichment	ALK, BRAF, RAF1	7.65
7	Pulmonic stenosis	Enrichment	BRAF, SOS1	6.22
8	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	5.75
9	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	5.45
10	Noonan syndrome 3	Enrichment	RAF1, SOS1	4.90
11	Pilomyxoid astrocytoma	Enrichment	BRAF, RAF1	4.90
12	Lung non-small cell carcinoma	Enrichment	BRAF, MAP2K1	4.48
13	Differentiated thyroid carcinoma	Enrichment	ALK, BRAF	3.62
14	Lung cancer	Enrichment	ALK, BRAF	3.53
15	Noonan syndrome 5	Enrichment	RAF1	3.09
16	Noonan syndrome 4	Enrichment	SOS1	3.09
17	Melorheostosis, isolated	Enrichment	MAP2K1	3.09
18	Noonan syndrome 7	Enrichment	BRAF	3.09
19	Leopard syndrome 3	Enrichment	BRAF	3.09
20	Neuroblastoma 3	Enrichment	ALK	3.09
21	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	3.09
22	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.09
23	Noonan syndrome 9	Enrichment	SOS2	3.09
24	Lymphangioma	Enrichment	BRAF	3.09
25	Phace association	Enrichment	BRAF	3.09
26	Melorheostosis	Enrichment	MAP2K1	3.09
27	Leopard syndrome 2	Enrichment	RAF1	3.09
28	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	3.09
29	Trigonitis	Enrichment	RAF1	3.09
30	Alk-positive anaplastic large cell lymphoma	Enrichment	ALK	3.09
31	Syringocystadenoma papilliferum	Enrichment	BRAF	3.09
32	Ganglioglioma	Enrichment	BRAF	3.09
33	Nongerminomatous germ cell tumor	Enrichment	BRAF	3.09
34	Phace syndrome	Enrichment	BRAF	3.09
35	Classic hairy cell leukemia	Enrichment	BRAF	3.09
36	Alk-positive large b-cell lymphoma	Enrichment	ALK	3.09
37	Fibromatosis, gingival, 1	Enrichment	SOS1	2.79
38	Tafro syndrome	Enrichment	MAP2K2	2.79
39	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	2.74
40	Ataxia-telangiectasia	Enrichment	BRAF	2.61
41	Nuchal bleb, familial	Enrichment	SOS1	2.61
42	Long-chain 3-hydroxyacyl-coa dehydrogenase deficiency	Enrichment	GAREM2	2.61
43	Mitochondrial trifunctional protein deficiency 1	Enrichment	GAREM2	2.61
44	Tethered spinal cord syndrome	Enrichment	BRAF	2.61
45	Mitochondrial trifunctional protein deficiency	Enrichment	GAREM2	2.61
46	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.49
47	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.49
48	Craniopharyngioma	Enrichment	BRAF	2.49
49	Newborn respiratory distress syndrome	Enrichment	BRAF	2.49
50	Gingival fibromatosis	Enrichment	SOS1	2.49
51	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.49
52	Wilms tumor 5	Enrichment	BRAF	2.31
53	Inflammatory myofibroblastic tumor	Enrichment	ALK	2.31
54	Lung squamous cell carcinoma	Enrichment	ALK	2.31
55	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	2.25
56	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	2.25
57	Gallbladder cancer	Enrichment	BRAF	2.25
58	Follicular thyroid carcinoma	Enrichment	BRAF	2.25
59	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	2.19
60	Neuroblastoma	Enrichment	ALK	2.19
61	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	2.14
62	Arteriovenous malformation	Enrichment	MAP2K1	2.14
63	Primary hyperaldosteronism	Enrichment	BRAF	2.14
64	Ventricular septal defect	Enrichment	BRAF	2.14
65	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	2.09
66	Melanoma	Enrichment	BRAF	2.09
67	Lip and oral cavity carcinoma	Enrichment	BRAF	2.01
68	Aortic valve disease 1	Enrichment	SOS1	1.98
69	Lung cancer susceptibility 3	Enrichment	BRAF	1.95
70	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.95
71	Wilms tumor 1	Enrichment	BRAF	1.92
72	Rhabdomyosarcoma	Enrichment	ALK	1.89
73	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.86
74	Dandy-walker syndrome	Enrichment	BRAF	1.86
75	Arteriovenous malformations of the brain	Enrichment	BRAF	1.82
76	Diffuse large b-cell lymphoma	Enrichment	BRAF	1.82
77	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.71
78	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.58
79	Left ventricular noncompaction	Enrichment	RAF1	1.55
80	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.38
81	Myeloma, multiple	Enrichment	BRAF	1.35
82	Breast cancer	Enrichment	SHC1	1.23
83	Colorectal cancer	Enrichment	BRAF	1.17
84	Ovarian cancer	Enrichment	ALK	1.10
85	Autism spectrum disorder	Enrichment	MAP2K1	1.07
86	Inherited cancer-predisposing syndrome	Enrichment	ALK	0.99

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAPK pathway in congenital thyroid cancer

Pathway Network for MAPK pathway in congenital thyroid cancer

Member Pathways for MAPK pathway in congenital thyroid cancer

Pathways in the MAPK pathway in congenital thyroid cancer SuperPath

Associated Genes for MAPK pathway in congenital thyroid cancer

Associated Disorders for MAPK pathway in congenital thyroid cancer

Disorders associated with MAPK pathway in congenital thyroid cancer SuperPath

STRING Interaction Network for MAPK pathway in congenital thyroid cancer

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