MAPK Signaling: Oxidative Stress

No Pathway Network information available for MAPK Signaling: Oxidative Stress

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with MAPK Signaling: Oxidative Stress SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Cardiofaciocutaneous syndrome 1EnrichmentBRAF, KRAS, MAP2K1, MAP2K28.96
2Cardiofaciocutaneous syndromeEnrichmentBRAF, KRAS, MAP2K1, MAP2K28.96
3Noonan syndrome 1EnrichmentBRAF, KRAS, MAP2K1, MAP2K2, MRAS, RAF18.52
4RasopathyEnrichmentBRAF, KRAS, MAP2K1, MAP2K2, MRAS, RAF18.17
5Noonan syndrome and noonan-related syndromeEnrichmentBRAF, KRAS, MAP2K1, MAP2K2, RAF17.77
6Gallbladder cancerEnrichmentBRAF, KRAS, TP535.18
7Pilomyxoid astrocytomaEnrichmentBRAF, KRAS, RAF15.18
8Lung non-small cell carcinomaEnrichmentBRAF, KRAS, MAP2K14.52
9Lung cancer susceptibility 3EnrichmentBRAF, KRAS, TP534.18
10Langerhans cell histiocytosisEnrichmentBRAF, MAP2K14.00
11Colorectal cancerEnrichmentBAX, BRAF, NFE2L2, SRC, TP533.82
12Diffuse large b-cell lymphomaEnrichmentBRAF, FOXO1, TP533.76
13Thyroid cancer, nonmedullary, 1EnrichmentBRAF, TP533.70
14Lung sarcomatoid carcinomaEnrichmentKRAS, TP533.70
15Noonan syndrome with multiple lentiginesEnrichmentBRAF, RAF13.70
16Rhabdomyosarcoma 2EnrichmentFOXO1, TP533.48
17Histiocytoid hemangiomaEnrichmentFOS, FOSB3.48
18Breast adenocarcinomaEnrichmentKRAS, TP533.31
19Capillary malformation-arteriovenous malformation 1EnrichmentKRAS, MAP2K13.16
20Noonan syndrome 3EnrichmentKRAS, RAF13.16
21Lung cancerEnrichmentBRAF, KRAS, NFE2L23.08
22Melanocytic nevus syndrome, congenitalEnrichmentBRAF, RAF13.04
23Lymphoma, non-hodgkin, familialEnrichmentBRAF, TP533.04
24Breast cancerEnrichmentJUN, KRAS, SHC1, TP533.02
25Primary hyperaldosteronismEnrichmentBRAF, TP532.93
26Specific learning disabilityEnrichmentMAPK1, YWHAG2.75
27Lip and oral cavity carcinomaEnrichmentBRAF, TP532.67
28Autosomal dominant non-syndromic intellectual disabilityEnrichmentCAMK2A, PPP3CA, YWHAZ2.51
29Myeloma, multipleEnrichmentBRAF, KRAS, TP532.37
30Arteriovenous malformations of the brainEnrichmentBRAF, KRAS2.27
31Granulomatous disease, chronic, autosomal recessive, 4EnrichmentCYBA2.23
32Oculoectodermal syndromeEnrichmentKRAS2.23
33Pallister-killian syndromeEnrichmentARAF2.23
34Intellectual developmental disorder, x-linked 99EnrichmentUSP9X2.23
35Noonan syndrome 5EnrichmentRAF12.23
36Melorheostosis, isolatedEnrichmentMAP2K12.23
37Noonan syndrome 7EnrichmentBRAF2.23
38Leopard syndrome 3EnrichmentBRAF2.23
39Cardiomyopathy, dilated, 1nnEnrichmentRAF12.23
40Cardiofaciocutaneous syndrome 3EnrichmentMAP2K12.23
41Autoimmune lymphoproliferative syndrome, type iiiEnrichmentPRKCD2.23
42Noonan syndrome 11EnrichmentMRAS2.23
43Noonan syndrome 13EnrichmentMAPK12.23
44Combined oxidative phosphorylation deficiency 29EnrichmentTXN22.23
45Intellectual developmental disorder, autosomal recessive 63EnrichmentCAMK2A2.23
46Developmental and epileptic encephalopathy 91EnrichmentPPP3CA2.23
47Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual developmentEnrichmentPPP3CA2.23
48Bone marrow failure syndrome 5EnrichmentTP532.23
49Immune dysregulation, autoimmunity, and autoinflammationEnrichmentPLCG12.23
50Immunodeficiency, developmental delay, and hypohomocysteinemiaEnrichmentNFE2L22.23
51Papilloma of choroid plexusEnrichmentTP532.23
52Basal cell carcinoma 7EnrichmentTP532.23
53Intellectual developmental disorder, x-linked 99, syndromic, female-restrictedEnrichmentUSP9X2.23
54Anaplastic thyroid carcinomaEnrichmentTP532.23
55Cardiofaciocutaneous syndrome 2EnrichmentKRAS2.23
56LymphangiomaEnrichmentBRAF2.23
57Thrombocytopenia 4EnrichmentCYCS2.23
58Phace associationEnrichmentBRAF2.23
59Spinocerebellar ataxia 14EnrichmentPRKCG2.23
60MelorheostosisEnrichmentMAP2K12.23
61Leopard syndrome 2EnrichmentRAF12.23
62Cardiofaciocutaneous syndrome 4EnrichmentMAP2K22.23
63Autoinflammation, antibody deficiency, and immune dysregulationEnrichmentPLCG22.23
64Ductal carcinoma in situEnrichmentTP532.23
65Familial cold autoinflammatory syndrome 3EnrichmentPLCG22.23
66Developmental and epileptic encephalopathy 56EnrichmentYWHAG2.23
67Thrombocytopenia 6EnrichmentSRC2.23
68Intellectual developmental disorder, autosomal dominant 53EnrichmentCAMK2A2.23
69TrigonitisEnrichmentRAF12.23
70Thyroid gland undifferentiated carcinomaEnrichmentTP532.23
71Intellectual developmental disorder, autosomal dominant 59EnrichmentCAMK2G2.23
72Small-cell carcinoma of the ovary of hypercalcemic typeEnrichmentTP532.23
73Female-restricted syndromic x-linked intellectual disability 99EnrichmentUSP9X2.23
74Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtypeEnrichmentTP532.23
75Congenital pulmonary airway malformationEnrichmentKRAS2.23
76Choroid plexus cancerEnrichmentTP532.23
77Syringocystadenoma papilliferumEnrichmentBRAF2.23
78Pleomorphic xanthoastrocytomaEnrichmentTP532.23
79GangliogliomaEnrichmentBRAF2.23
80Nongerminomatous germ cell tumorEnrichmentBRAF2.23
81Phace syndromeEnrichmentBRAF2.23
82Classic hairy cell leukemiaEnrichmentBRAF2.23
83Distal 17p13.3 microdeletion syndromeEnrichmentYWHAE2.23
84Pancreatic cancerEnrichmentKRAS, TP532.04
85Adrenocortical carcinoma, hereditaryEnrichmentTP531.94
86Cervical cancerEnrichmentTP531.94
87Pulmonic stenosisEnrichmentBRAF1.94
88Histiocytoma, angiomatoid fibrousEnrichmentCREB11.94
89Encephalocraniocutaneous lipomatosisEnrichmentKRAS1.94
90Ras-associated autoimmune leukoproliferative disorderEnrichmentKRAS1.94
91Lymphoma, hodgkin, classicEnrichmentTP531.94
92Spinocerebellar ataxia 48EnrichmentSTUB11.94
93Congenital fibrosarcomaEnrichmentTP531.94
94Li-fraumeni syndrome 1EnrichmentTP531.94
95SarcomaEnrichmentTP531.94
96Cervix carcinomaEnrichmentTP531.94
97Hodgkin's lymphomaEnrichmentTP531.94
98Pleomorphic rhabdomyosarcomaEnrichmentTP531.94
99Tafro syndromeEnrichmentMAP2K21.94
100Submucosal cleft palateEnrichmentUBB1.94
101Cleft hard palateEnrichmentUBB1.94
102Bladder cancerEnrichmentKRAS, TP531.91
103Differentiated thyroid carcinomaEnrichmentBRAF, KRAS1.91
104Ataxia-telangiectasiaEnrichmentBRAF1.76
105Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasiaEnrichmentCYBA1.76
106Uvula, bifidEnrichmentUBB1.76
107Osteogenic sarcomaEnrichmentTP531.76
108Cleft soft palateEnrichmentUBB1.76
109Nasopharyngeal carcinomaEnrichmentTP531.76
110Miller-dieker lissencephaly syndromeEnrichmentYWHAE1.76
111Chromosome 17p13.3, centromeric, duplication syndromeEnrichmentYWHAE1.76
112Tethered spinal cord syndromeEnrichmentBRAF1.76
113Atypical teratoid rhabdoid tumorEnrichmentTP531.76
114Anaplastic astrocytomaEnrichmentTP531.76
115Squamous cell carcinomaEnrichmentTP531.76
116T-cell acute lymphoblastic leukemiaEnrichmentBAX1.76
117AdenocarcinomaEnrichmentTP531.76
118Bone osteosarcomaEnrichmentTP531.76
119Autoimmune polyendocrine syndrome type 1EnrichmentCYBA1.76
120Melanoma of soft tissueEnrichmentCREB11.76
121Hyperpigmentation of the skinEnrichmentUSP9X1.76
122Leukemia, acute myeloidEnrichmentKRAS, TP531.65
123Schimmelpenning-feuerstein-mims syndromeEnrichmentKRAS1.64
124Diffuse gastric and lobular breast cancer syndromeEnrichmentKRAS1.64
125Small cell cancer of the lungEnrichmentTP531.64
126Neurofibromatosis-noonan syndromeEnrichmentMAP2K21.64
127Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK11.64
128Congenital generalized lipodystrophyEnrichmentFOS1.64
129Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentKRAS1.64
130Hereditary ataxiaEnrichmentPRKCG1.64
131Embryonal rhabdomyosarcomaEnrichmentTP531.64
132CraniopharyngiomaEnrichmentBRAF1.64
133Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemiaEnrichmentYWHAZ1.64
134Pilocytic astrocytomaEnrichmentKRAS1.64
135Newborn respiratory distress syndromeEnrichmentBRAF1.64
136Pseudomyogenic hemangioendotheliomaEnrichmentFOSB1.64
137Gastric cancerEnrichmentKRAS, TP531.59
138Hereditary breast carcinomaEnrichmentKRAS, TP531.57
139Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominantEnrichmentTRAF61.54
140LymphomaEnrichmentTP531.54
141Acute megakaryocytic leukemiaEnrichmentTP531.54
142Autosomal thrombocytopenia with normal plateletsEnrichmentCYCS1.54
143Endometrial stromal sarcomaEnrichmentYWHAE1.54
144ThrombocytopeniaEnrichmentCYCS, SRC1.50
145Li-fraumeni syndromeEnrichmentTP531.46
146Wilms tumor 5EnrichmentBRAF1.46
147Spinocerebellar ataxia, autosomal recessive 16EnrichmentSTUB11.46
148Adrenocortical carcinomaEnrichmentTP531.46
149Lung squamous cell carcinomaEnrichmentKRAS1.46
150Kidney clear cell sarcomaEnrichmentYWHAE1.46
151Esophageal cancerEnrichmentTP531.40
152Nevus, epidermalEnrichmentKRAS1.40
153Thyroid cancer, nonmedullary, 2EnrichmentBRAF1.40
154MyelofibrosisEnrichmentSRC1.40
155Squamous cell carcinoma, head and neckEnrichmentTP531.40
156Leukemia, chronic myeloidEnrichmentKRAS1.40
157Essential thrombocythemiaEnrichmentTP531.40
158Follicular thyroid carcinomaEnrichmentBRAF1.40
159B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentTP531.40
160Hereditary breast ovarian cancer syndromeEnrichmentKRAS, TP531.39
161Undetermined early-onset epileptic encephalopathyEnrichmentPPP3CA, YWHAG1.38
162Glioma susceptibility 1EnrichmentTP531.34
163Lennox-gastaut syndromeEnrichmentMAPK101.34
164Cardiomyopathy, familial hypertrophic, 4EnrichmentBRAF1.29
165Inflammatory bowel disease 1EnrichmentPRKCQ1.29
166Arteriovenous malformationEnrichmentMAP2K11.29
167Adult hepatocellular carcinomaEnrichmentTP531.29
168Chronic granulomatous diseaseEnrichmentCYBA1.29
169Ventricular septal defectEnrichmentBRAF1.29
170Leukemia, chronic lymphocyticEnrichmentTP531.25
171Myopathy, x-linked, with excessive autophagyEnrichmentMAP2K11.25
172MelanomaEnrichmentBRAF1.25
173Familial colorectal cancerEnrichmentTP531.25
174Myelodysplastic syndromeEnrichmentTP531.21
175Juvenile myelomonocytic leukemiaEnrichmentKRAS1.17
176Chromosome 1p36 deletion syndromeEnrichmentPRKCZ1.14
177OsteoporosisEnrichmentSRC1.10
178Dilated cardiomyopathyEnrichmentBRAF, RAF11.10
179Wilms tumor 1EnrichmentBRAF1.08
180Lynch syndromeEnrichmentKRAS1.08
181RhabdomyosarcomaEnrichmentTP531.05
182GliosarcomaEnrichmentTP531.05
183Melanoma, cutaneous malignant 1EnrichmentBRAF1.02
184Dandy-walker syndromeEnrichmentBRAF1.02
185Giant cell glioblastomaEnrichmentTP531.02
186Heart, malformation ofEnrichmentMAPK11.00
187HepatoblastomaEnrichmentTP530.94
188Ovarian cancerEnrichmentKRAS, TP530.93
189Hepatocellular carcinomaEnrichmentTP530.92
190Diamond-blackfan anemia 1EnrichmentTP530.90
191Cardiomyopathy, familial hypertrophic, 1EnrichmentRAF10.88
192Prostate cancerEnrichmentTP530.81
193MicrocephalyEnrichmentMAPK1, YWHAG0.79
194Non-immune hydrops fetalisEnrichmentKRAS0.78
195Familial hypertrophic cardiomyopathyEnrichmentRAF10.76
196Left ventricular noncompactionEnrichmentRAF10.73
197Non-syndromic x-linked intellectual disabilityEnrichmentUSP9X0.72
198Diamond-blackfan anemiaEnrichmentTP530.72
199Familial isolated dilated cardiomyopathyEnrichmentRAF10.57
200AutismEnrichmentCAMK2G0.46
201Autism spectrum disorderEnrichmentMAP2K10.33
202Inherited cancer-predisposing syndromeEnrichmentTP530.27

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