MAPK signaling pathway

No Pathway Network information available for MAPK signaling pathway

Pathways in the MAPK signaling pathway SuperPath

#	Name	Source	Genes
1	MAPK signaling pathway	WikiPathways	AKT1 AKT2 AKT3 ARAF ARRB1 ARRB2 ATF2 ATF4 BDNF BRAF CACNA1A CACNA1B CACNA1C-IT2 CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CASP3 CD14 CDC25B CDC42 CHUK CRK CRKL DAXX DDIT3 DUSP1 DUSP10 DUSP16 DUSP2 DUSP3 DUSP4 DUSP6 DUSP7 DUSP8 DUSP9 ECSIT EGF EGFR ELK1 ELK4 FAS FASLG FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF16 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLNA FLNB FLNC FOS GADD45A GNA12 GNG12 GRB2 HRAS HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 HSPB1 IKBKB IKBKG IL1A IL1B IL1R1 IL1R2 JUN JUND KRAS LAMTOR3 LRRK2 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K1 MAP3K11 MAP3K12 MAP3K13 MAP3K14 MAP3K2 MAP3K20 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK7 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MAX MEF2C MKNK1 MKNK2 MRAS MYC NF1 NFATC1 NFATC3 NFKB1 NFKB2 NGF NLK NR4A1 NRAS NTF3 NTF4 NTRK1 NTRK2 PAK1 PAK2 PDGFA PDGFB PDGFRB PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PPM1A PPM1B PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PPP5C PRKACA PRKACB PRKACG PRKCA PRKCD PRKCG PTPN5 PTPN7 PTPRR RAC1 RAC2 RAC3 RAF1 RAP1A RAP1B RAPGEF2 RASA1 RASA2 RASGRF1 RASGRF2 RASGRP1 RASGRP2 RASGRP3 RASGRP4 RELA RELB RPS6KA3 RPS6KA4 RPS6KA5 RRAS RRAS2 SOS1 SOS2 SRF STK3 STK4 STMN1 TAB1 TAB2 TAOK1 TAOK2 TAOK3 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TNF TNFRSF1A TP53 TRAF2 TRAF6 (see all 244) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
2	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
3	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
4	PLA2G4D	Phospholipase A2 Group IVD	Protein Coding	1
5	PLA2G4F	Phospholipase A2 Group IVF	Protein Coding	1
6	PLA2G4E	Phospholipase A2 Group IVE	Protein Coding	1
7	PLA2G4B	Phospholipase A2 Group IVB	Protein Coding	1
8	CDC42	Cell Division Cycle 42	Protein Coding	1
9	FGF19	Fibroblast Growth Factor 19	Protein Coding	1
10	CDC25B	Cell Division Cycle 25B	Protein Coding	1
11	RAPGEF2	Rap Guanine Nucleotide Exchange Factor 2	Protein Coding	1
12	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	1
13	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	1
14	CACNA2D4	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 4	Protein Coding	1
15	CD14	CD14 Molecule	Protein Coding	1
16	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	1
17	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
18	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	1
19	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	1
20	FGF16	Fibroblast Growth Factor 16	Protein Coding	1
21	FGF17	Fibroblast Growth Factor 17	Protein Coding	1
22	FGF18	Fibroblast Growth Factor 18	Protein Coding	1
23	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
24	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
25	PTPN5	Protein Tyrosine Phosphatase Non-Receptor Type 5	Protein Coding	1
26	CASP3	Caspase 3	Protein Coding	1
27	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	1
28	FGF23	Fibroblast Growth Factor 23	Protein Coding	1
29	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
30	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	1
31	CACNB4	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4	Protein Coding	1
32	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	1
33	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	1
34	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	1
35	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	1
36	CACNA1F	Calcium Voltage-Gated Channel Subunit Alpha1 F	Protein Coding	1
37	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	1
38	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	1
39	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
40	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
41	TP53	Tumor Protein P53	Protein Coding	1
42	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
43	TNF	Tumor Necrosis Factor	Protein Coding	1
44	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
45	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
46	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
47	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
48	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
49	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
50	STK4	Serine/Threonine Kinase 4	Protein Coding	1
51	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
52	SRF	Serum Response Factor	Protein Coding	1
53	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
54	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
55	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
56	RRAS	RAS Related	Protein Coding	1
57	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
58	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
59	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
60	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	1
61	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
62	RASA2	RAS P21 Protein Activator 2	Protein Coding	1
63	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
64	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
65	RAC3	Rac Family Small GTPase 3	Protein Coding	1
66	RAC2	Rac Family Small GTPase 2	Protein Coding	1
67	RAC1	Rac Family Small GTPase 1	Protein Coding	1
68	TAOK1	TAO Kinase 1	Protein Coding	1
69	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
70	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
71	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
72	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
73	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
74	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
75	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
76	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
77	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
78	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
79	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
80	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
81	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
82	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
83	PRKCG	Protein Kinase C Gamma	Protein Coding	1
84	PRKCD	Protein Kinase C Delta	Protein Coding	1
85	CACNA2D3	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 3	Protein Coding	1
86	PRKCA	Protein Kinase C Alpha	Protein Coding	1
87	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
88	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
89	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
90	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
91	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	1
92	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	1
93	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	1
94	PPM1B	Protein Phosphatase, Mg2+/Mn2+ Dependent 1B	Protein Coding	1
95	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
96	MAP3K20	Mitogen-Activated Protein Kinase Kinase Kinase 20	Protein Coding	1
97	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
98	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
99	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
100	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
101	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
102	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
103	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	1
104	NTF4	Neurotrophin 4	Protein Coding	1
105	NTF3	Neurotrophin 3	Protein Coding	1
106	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
107	NGF	Nerve Growth Factor	Protein Coding	1
108	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
109	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
110	NF1	Neurofibromin 1	Protein Coding	1
111	ATF4	Activating Transcription Factor 4	Protein Coding	1
112	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
113	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
114	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
115	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
116	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
117	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
118	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
119	ARRB2	Arrestin Beta 2	Protein Coding	1
120	ARRB1	Arrestin Beta 1	Protein Coding	1
121	STMN1	Stathmin 1	Protein Coding	1
122	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
123	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
124	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
125	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
126	FASLG	Fas Ligand	Protein Coding	1
127	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	1
128	IL1B	Interleukin 1 Beta	Protein Coding	1
129	IL1A	Interleukin 1 Alpha	Protein Coding	1
130	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
131	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
132	HSPB1	Heat Shock Protein Family B (Small) Member 1	Protein Coding	1
133	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
134	HSPA6	Heat Shock Protein Family A (Hsp70) Member 6	Protein Coding	1
135	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	1
136	HSPA1L	Heat Shock Protein Family A (Hsp70) Member 1 Like	Protein Coding	1
137	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	1
138	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
139	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
140	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
141	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
142	FGF21	Fibroblast Growth Factor 21	Protein Coding	1
143	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	1
144	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
145	FLNC	Filamin C	Protein Coding	1
146	FLNB	Filamin B	Protein Coding	1
147	MAPK8IP3	Mitogen-Activated Protein Kinase 8 Interacting Protein 3	Protein Coding	1
148	FLNA	Filamin A	Protein Coding	1
149	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	1
150	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
151	RRAS2	RAS Related 2	Protein Coding	1
152	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
153	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
154	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
155	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
156	FGF14	Fibroblast Growth Factor 14	Protein Coding	1
157	FGF13	Fibroblast Growth Factor 13	Protein Coding	1
158	FGF12	Fibroblast Growth Factor 12	Protein Coding	1
159	FGF10	Fibroblast Growth Factor 10	Protein Coding	1
160	FGF9	Fibroblast Growth Factor 9	Protein Coding	1
161	FGF8	Fibroblast Growth Factor 8	Protein Coding	1
162	FGF7	Fibroblast Growth Factor 7	Protein Coding	1
163	FGF6	Fibroblast Growth Factor 6	Protein Coding	1
164	FGF5	Fibroblast Growth Factor 5	Protein Coding	1
165	FGF4	Fibroblast Growth Factor 4	Protein Coding	1
166	FGF3	Fibroblast Growth Factor 3	Protein Coding	1
167	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
168	FGF1	Fibroblast Growth Factor 1	Protein Coding	1
169	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
170	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
171	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
172	EGF	Epidermal Growth Factor	Protein Coding	1
173	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
174	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	1
175	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	1
176	DUSP2	Dual Specificity Phosphatase 2	Protein Coding	1
177	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
178	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
179	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
180	DAXX	Death Domain Associated Protein	Protein Coding	1
181	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
182	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
183	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
184	ATF2	Activating Transcription Factor 2	Protein Coding	1
185	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
186	LRRK2	Leucine Rich Repeat Kinase 2	Protein Coding	1
187	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
188	DUSP10	Dual Specificity Phosphatase 10	Protein Coding	1
189	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
190	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	1
191	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
192	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
193	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
194	DUSP9	Dual Specificity Phosphatase 9	Protein Coding	1
195	DUSP8	Dual Specificity Phosphatase 8	Protein Coding	1
196	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	1
197	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	1
198	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
199	RPS6KA4	Ribosomal Protein S6 Kinase A4	Protein Coding	1
200	CACNA1I	Calcium Voltage-Gated Channel Subunit Alpha1 I	Protein Coding	1
201	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	1
202	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	1
203	MAP4K3	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3	Protein Coding	1
204	RASGRP4	RAS Guanyl Releasing Protein 4	Protein Coding	1
205	MAP4K1	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1	Protein Coding	1
206	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
207	CACNA1C-IT2	CACNA1C Intronic Transcript 2	RNA Gene	1
208	CACNG1	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1	Protein Coding	1
209	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	1
210	MAP3K12	Mitogen-Activated Protein Kinase Kinase Kinase 12	Protein Coding	1
211	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	1
212	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
213	STK3	Serine/Threonine Kinase 3	Protein Coding	1
214	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
215	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
216	CACNG6	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 6	Protein Coding	1
217	CACNG7	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7	Protein Coding	1
218	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	1
219	MAP4K2	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2	Protein Coding	1
220	PTPRR	Protein Tyrosine Phosphatase Receptor Type R	Protein Coding	1
221	PTPN7	Protein Tyrosine Phosphatase Non-Receptor Type 7	Protein Coding	1
222	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
223	PPP5C	Protein Phosphatase 5 Catalytic Subunit	Protein Coding	1
224	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	1
225	PPM1A	Protein Phosphatase, Mg2+/Mn2+ Dependent 1A	Protein Coding	1
226	NLK	Nemo Like Kinase	Protein Coding	1
227	TAOK3	TAO Kinase 3	Protein Coding	1
228	ECSIT	ECSIT Signaling Integrator	Protein Coding	1
229	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
230	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
231	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
232	TAOK2	TAO Kinase 2	Protein Coding	1
233	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
234	MAP3K13	Mitogen-Activated Protein Kinase Kinase Kinase 13	Protein Coding	1
235	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
236	MKNK2	MAPK Interacting Serine/Threonine Kinase 2	Protein Coding	1
237	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	1
238	CACNG5	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5	Protein Coding	1
239	FGF22	Fibroblast Growth Factor 22	Protein Coding	1
240	FGF20	Fibroblast Growth Factor 20	Protein Coding	1
241	MAPK8IP2	Mitogen-Activated Protein Kinase 8 Interacting Protein 2	Protein Coding	1
242	FGF11	Fibroblast Growth Factor 11	Protein Coding	1
243	ELK4	ETS Transcription Factor ELK4	Protein Coding	1
244	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with MAPK signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NF1, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RASA2, RRAS, RRAS2, SOS1, SOS2	11.25
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	10.16
4	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, HRAS, KRAS, MAP2K1, NRAS	7.86
5	Pilomyxoid astrocytoma	Enrichment	BRAF, FGFR1, KRAS, NTRK2, RAF1	7.43
6	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	6.99
7	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	6.99
8	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, FGF10, KRAS, TP53	5.50
9	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS	5.47
10	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	5.47
11	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2, FGFR3	5.24
12	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	5.24
13	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	5.17
14	Bladder cancer	Enrichment	EGFR, FGFR3, HRAS, KRAS, NF1, TP53	4.97
15	Loeys-dietz syndrome	Enrichment	TGFB2, TGFB3, TGFBR1, TGFBR2	4.92
16	Lung cancer	Enrichment	BRAF, EGFR, FAS, FASLG, KRAS, MAP3K8	4.71
17	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	4.64
18	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NF1, NRAS, RRAS	4.35
19	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR, HRAS, TP53	4.35
20	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3, FLNC	4.25
21	Breast adenocarcinoma	Enrichment	AKT1, KRAS, TP53	3.96
22	Lung squamous cell carcinoma	Enrichment	EGFR, FGFR3, KRAS	3.96
23	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS, NTRK1	3.82
24	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3, TP53	3.80
25	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	3.72
26	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, RASA1	3.72
27	Gallbladder cancer	Enrichment	BRAF, KRAS, TP53	3.72
28	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	3.72
29	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3, TP53	3.69
30	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6, FGF17, FGF8, FGFR1	3.59
31	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR, KRAS, MAP4K4	3.49
32	Cervical cancer	Enrichment	FGFR3, TP53	3.49
33	Pulmonic stenosis	Enrichment	BRAF, SOS1	3.49
34	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	3.49
35	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	3.49
36	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	3.49
37	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	3.49
38	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.49
39	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	3.49
40	Cervix carcinoma	Enrichment	FGFR3, TP53	3.49
41	Pleomorphic rhabdomyosarcoma	Enrichment	NF1, TP53	3.49
42	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, RASA1	3.35
43	Primary hyperaldosteronism	Enrichment	BRAF, CACNA1H, TP53	3.35
44	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B, CACNA2D1, FGF12, NTRK2, PPP3CA	3.31
45	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	3.20
46	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, RASA1	3.20
47	Kallmann syndrome	Enrichment	DUSP6, FGF17, FGF8, FGFR1	3.16
48	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.02
49	Larsen syndrome	Enrichment	FGFR3, FLNB	3.02
50	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.02
51	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	3.02
52	Frontometaphyseal dysplasia	Enrichment	FLNA, MAP3K7	3.02
53	Spermatocytoma	Enrichment	FGFR3, HRAS	3.02
54	Gastric cancer	Enrichment	FGFR2, IL1B, KRAS, NF1, TP53	3.00
55	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FLNA, TGFB2, TGFB3, TGFBR1, TGFBR2	2.96
56	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS, MAP3K6	2.72
57	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	2.72
58	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	2.72
59	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2, NF1	2.72
60	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	2.72
61	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	2.72
62	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	2.72
63	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	2.72
64	Embryonal rhabdomyosarcoma	Enrichment	NF1, TP53	2.72
65	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	2.72
66	Pilocytic astrocytoma	Enrichment	KRAS, NF1	2.72
67	Ovarian cancer	Enrichment	AKT1, EGFR, KRAS, MAP3K1, NTRK1, RRAS2, TP53	2.64
68	Rhabdomyosarcoma	Enrichment	HRAS, NF1, TP53	2.57
69	Rhabdomyosarcoma 2	Enrichment	NF1, TP53	2.51
70	Holoprosencephaly	Enrichment	FGF8, FGFR1	2.51
71	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRB	2.51
72	Myeloma, multiple	Enrichment	BRAF, FGFR3, KRAS, NF1, TP53	2.49
73	Patent foramen ovale	Enrichment	FLNA, FLNC, TAB2	2.42
74	Split-hand/foot malformation 1	Enrichment	FGFR2, MAP3K20	2.34
75	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	2.34
76	Colorectal cancer	Enrichment	AKT1, BRAF, FGFR2, FGFR3, NRAS, TP53	2.32
77	Esophageal cancer	Enrichment	TGFBR2, TP53	2.20
78	Squamous cell carcinoma, head and neck	Enrichment	EGFR, TP53	2.20
79	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.20
80	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	2.20
81	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.20
82	Malaria	Enrichment	IKBKG, MAPKAPK3, TNF	2.11
83	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	2.08
84	Fanconi anemia, complementation group c	Enrichment	FLNA, TAOK1	2.08
85	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	2.08
86	Lennox-gastaut syndrome	Enrichment	CACNA1A, MAPK10	2.08
87	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	1.97
88	Adult hepatocellular carcinoma	Enrichment	EGF, TP53	1.97
89	Ventricular septal defect	Enrichment	BRAF, RPS6KA3	1.97
90	Breast cancer	Enrichment	AKT1, CACNA2D1, JUN, KRAS, TP53	1.95
91	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNA1I, CACNG2, PPP3CA, TAOK1	1.91
92	Migraine with or without aura 1	Enrichment	CACNA1A, TAB2	1.80
93	Specific learning disability	Enrichment	MAPK1, RPS6KA3	1.80
94	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	1.75
95	Hypochondroplasia	Enrichment	FGFR3	1.75
96	Boomerang dysplasia	Enrichment	FLNB	1.75
97	Proteus syndrome	Enrichment	AKT1	1.75
98	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	1.75
99	Osteoglophonic dysplasia	Enrichment	FGFR1	1.75
100	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	1.75
101	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	1.75
102	Thanatophoric dysplasia, type i	Enrichment	FGFR3	1.75
103	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	1.75
104	Trigonocephaly 1	Enrichment	FGFR1	1.75
105	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.75
106	Spinocerebellar ataxia 27a	Enrichment	FGF14	1.75
107	Coffin-lowry syndrome	Enrichment	RPS6KA3	1.75
108	Oculoectodermal syndrome	Enrichment	KRAS	1.75
109	Muenke syndrome	Enrichment	FGFR3	1.75
110	Pallister-killian syndrome	Enrichment	ARAF	1.75
111	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	1.75
112	Incontinentia pigmenti	Enrichment	IKBKG	1.75
113	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	1.75
114	Otopalatodigital syndrome, type i	Enrichment	FLNA	1.75
115	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	1.75
116	Noonan syndrome 5	Enrichment	RAF1	1.75
117	Hypomagnesemia 4, renal	Enrichment	EGF	1.75
118	Noonan syndrome 4	Enrichment	SOS1	1.75
119	Epilepsy, idiopathic generalized 9	Enrichment	CACNB4	1.75
120	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.75
121	Brugada syndrome 4	Enrichment	CACNB2	1.75
122	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	1.75
123	Melorheostosis, isolated	Enrichment	MAP2K1	1.75
124	Noonan syndrome 7	Enrichment	BRAF	1.75
125	Leopard syndrome 3	Enrichment	BRAF	1.75
126	Apert syndrome	Enrichment	FGFR2	1.75
127	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	1.75
128	Atelosteogenesis, type iii	Enrichment	FLNB	1.75
129	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.75
130	Atelosteogenesis, type i	Enrichment	FLNB	1.75
131	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	1.75
132	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.75
133	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	1.75
134	Melanosis, neurocutaneous	Enrichment	NRAS	1.75
135	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	1.75
136	Noonan syndrome 9	Enrichment	SOS2	1.75
137	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	1.75
138	Noonan syndrome 6	Enrichment	NRAS	1.75
139	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	1.75
140	Fetal encasement syndrome	Enrichment	CHUK	1.75
141	46,xy sex reversal 6	Enrichment	MAP3K1	1.75
142	Episodic ataxia, type 5	Enrichment	CACNB4	1.75
143	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	1.75
144	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	1.75
145	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	1.75
146	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	1.75
147	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	1.75
148	Noonan syndrome 11	Enrichment	MRAS	1.75
149	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	1.75
150	Immunodeficiency 15b	Enrichment	IKBKB	1.75
151	Developmental delay with or without intellectual impairment or behavioral abnormalities	Enrichment	TAOK1	1.75
152	Noonan syndrome 13	Enrichment	MAPK1	1.75
153	Myopathy, centronuclear, 6, with fiber-type disproportion	Enrichment	MAP3K20	1.75
154	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	1.75
155	Immunodeficiency 15a	Enrichment	IKBKB	1.75
156	Intellectual developmental disorder, x-linked 110	Enrichment	FGF13	1.75
157	Spinocerebellar ataxia 27b, late-onset	Enrichment	FGF14	1.75
158	Neurodevelopmental disorder with speech impairment and with or without seizures	Enrichment	CACNA1I	1.75
159	Knobloch syndrome 2	Enrichment	PAK2	1.75
160	Congenital myopathy 18	Enrichment	CACNA1S	1.75
161	Terminal osseous dysplasia	Enrichment	FLNA	1.75
162	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	1.75
163	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	1.75
164	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	1.75
165	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.75
166	Bone marrow failure syndrome 5	Enrichment	TP53	1.75
167	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	1.75
168	Fg syndrome 2	Enrichment	FLNA	1.75
169	Papilloma of choroid plexus	Enrichment	TP53	1.75
170	Parkinson-dementia syndrome	Enrichment	MAPT	1.75
171	Cone-rod dystrophy, x-linked, 3	Enrichment	CACNA1F	1.75
172	Basal cell carcinoma 7	Enrichment	TP53	1.75
173	Immunodeficiency 110 with lymphoproliferation	Enrichment	STK4	1.75
174	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	1.75
175	Retinal cone dystrophy 4	Enrichment	CACNA2D4	1.75
176	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.75
177	Anaplastic thyroid carcinoma	Enrichment	TP53	1.75
178	Developmental and epileptic encephalopathy 90	Enrichment	FGF13	1.75
179	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	1.75
180	Supranuclear palsy, progressive, 1	Enrichment	MAPT	1.75
181	Metacarpal 4-5 fusion	Enrichment	FGF16	1.75
182	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	1.75
183	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	1.75
184	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	1.75
185	Familial isolated trichomegaly	Enrichment	FGF5	1.75
186	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.75
187	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	1.75
188	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.75
189	Lymphangioma	Enrichment	BRAF	1.75
190	Epilepsy, childhood absence 6	Enrichment	CACNA1H	1.75
191	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	1.75
192	Camurati-engelmann disease 2	Enrichment	TGFB2	1.75
193	Progressive supranuclear palsy	Enrichment	MAPT	1.75
194	Malignant hyperthermia 5	Enrichment	CACNA1S	1.75
195	Phace association	Enrichment	BRAF	1.75
196	Charcot-marie-tooth disease, axonal, type 2f	Enrichment	HSPB1	1.75
197	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.75
198	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	1.75
199	Melorheostosis	Enrichment	MAP2K1	1.75
200	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	1.75
201	Leopard syndrome 2	Enrichment	RAF1	1.75
202	Multiple synostoses syndrome 3	Enrichment	FGF9	1.75
203	Glaucoma 1, open angle, o	Enrichment	NTF4	1.75
204	Intellectual developmental disorder, autosomal dominant 10	Enrichment	CACNG2	1.75
205	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	1.75
206	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	1.75
207	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	1.75
208	Multiple sclerosis 5	Enrichment	TNFRSF1A	1.75
209	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	1.75
210	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	1.75
211	Polydactyly-macrocephaly syndrome	Enrichment	MAX	1.75
212	Cowden syndrome 6	Enrichment	AKT1	1.75
213	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	1.75
214	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.75
215	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	1.75
216	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	1.75
217	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	1.75
218	Spinocerebellar ataxia 42	Enrichment	CACNA1G	1.75
219	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	1.75
220	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	1.75
221	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	1.75
222	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	1.75
223	Ductal carcinoma in situ	Enrichment	TP53	1.75
224	Kosaki overgrowth syndrome	Enrichment	PDGFRB	1.75
225	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	1.75
226	Hartsfield syndrome	Enrichment	FGFR1	1.75
227	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	Enrichment	CACNA1G	1.75
228	Loeys-dietz syndrome 5	Enrichment	TGFB3	1.75
229	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	1.75
230	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.75
231	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	1.75
232	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	1.75
233	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	1.75
234	X-linked ehlers-danlos syndrome	Enrichment	FLNA	1.75
235	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.75
236	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	1.75
237	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	1.75
238	Immunodeficiency 53	Enrichment	RELB	1.75
239	Bartsocas-papas syndrome 2	Enrichment	CHUK	1.75
240	Epilepsy, familial adult myoclonic, 7	Enrichment	RAPGEF2	1.75
241	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	1.75
242	Developmental and epileptic encephalopathy 47	Enrichment	FGF12	1.75
243	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	1.75
244	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.75
245	Trigonitis	Enrichment	RAF1	1.75
246	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.75
247	Plexiform neurofibroma	Enrichment	NF1	1.75
248	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.75
249	Neurofibroma	Enrichment	NF1	1.75
250	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	1.75
251	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	1.75
252	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	1.75
253	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	1.75
254	Capillary hemangioma	Enrichment	AKT3	1.75
255	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.75
256	Neurofibromatosis	Enrichment	NF1	1.75
257	Immunodeficiency 112	Enrichment	MAP3K14	1.75
258	Flnb-related disorders	Enrichment	FLNB	1.75
259	5q14.3 microdeletion syndrome	Enrichment	MEF2C	1.75
260	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	1.75
261	Conn's syndrome	Enrichment	CACNA1H	1.75
262	Congenital pulmonary airway malformation	Enrichment	KRAS	1.75
263	Optic nerve glioma	Enrichment	NF1	1.75
264	Choroid plexus cancer	Enrichment	TP53	1.75
265	Immunodeficiency 64	Enrichment	RASGRP1	1.75
266	Gorham's disease	Enrichment	RASA1	1.75
267	Spinocerebellar ataxia type 27b	Enrichment	FGF14	1.75
268	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	1.75
269	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.75
270	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	1.75
271	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	1.75
272	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.75
273	Nocarh syndrome	Enrichment	CDC42	1.75
274	Sporadic hemiplegic migraine	Enrichment	CACNA1A	1.75
275	Syringocystadenoma papilliferum	Enrichment	BRAF	1.75
276	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	1.75
277	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	1.75
278	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	1.75
279	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.75
280	Ganglioglioma	Enrichment	BRAF	1.75
281	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	1.75
282	Nongerminomatous germ cell tumor	Enrichment	BRAF	1.75
283	Phace syndrome	Enrichment	BRAF	1.75
284	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	1.75
285	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.75
286	Mef2c-related disorder	Enrichment	MEF2C	1.75
287	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	1.75
288	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.75
289	Classic hairy cell leukemia	Enrichment	BRAF	1.75
290	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	1.75
291	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.75
292	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.75
293	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	1.75
294	Interstitial lung disease specific to childhood	Enrichment	FGF10	1.75
295	Neurocutaneous melanocytosis	Enrichment	NRAS	1.75
296	Nik deficiency	Enrichment	MAP3K14	1.75
297	Polyvalvular heart disease syndrome	Enrichment	TAB2	1.75
298	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.75
299	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	1.75
300	Meningioma	Enrichment	AKT1, PDGFB	1.72
301	Connective tissue disease	Enrichment	FGFR3, FLNB, TGFBR2	1.71
302	Aortic valve disease 1	Enrichment	SOS1, TAB2	1.66
303	Alzheimer's disease	Enrichment	MAPT, TNF	1.66
304	Pheochromocytoma	Enrichment	MAX, NF1	1.59
305	Cone-rod dystrophy 6	Enrichment	CACNA1F, CACNA2D4	1.59
306	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	1.59
307	Hydrocephalus	Enrichment	FGFR2, PDGFRB	1.54
308	Lynch syndrome	Enrichment	KRAS, TGFBR2	1.54
309	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	1.48
310	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	1.48
311	Leukemia, acute myeloid	Enrichment	KRAS, NRAS, TP53	1.46
312	Cafe-au-lait spots, multiple	Enrichment	NF1	1.45
313	Burkitt lymphoma	Enrichment	MYC	1.45
314	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.45
315	Fibromatosis, gingival, 1	Enrichment	SOS1	1.45
316	Otodental dysplasia	Enrichment	FGF3	1.45
317	Scoliosis, isolated 1	Enrichment	MAPK7	1.45
318	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.45
319	Camurati-engelmann disease 1	Enrichment	TGFB1	1.45
320	Costello syndrome	Enrichment	HRAS	1.45
321	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	1.45
322	Trichomegaly	Enrichment	FGF5	1.45
323	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	1.45
324	Otopalatodigital syndrome, type ii	Enrichment	FLNA	1.45
325	Melnick-needles syndrome	Enrichment	FLNA	1.45
326	Pulmonary hypoplasia, primary	Enrichment	FGF10	1.45
327	Night blindness, congenital stationary, type 2a	Enrichment	CACNA1F	1.45
328	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	1.45
329	Immunodeficiency 33	Enrichment	IKBKG	1.45
330	Frontometaphyseal dysplasia 1	Enrichment	FLNA	1.45
331	Parkinson disease 8, autosomal dominant	Enrichment	LRRK2	1.45
332	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	1.45
333	Macroglossia	Enrichment	TAOK1	1.45
334	Pick disease of brain	Enrichment	MAPT	1.45
335	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.45
336	Aural atresia, congenital	Enrichment	FGFR2	1.45
337	Keratosis, seborrheic	Enrichment	FGFR3	1.45
338	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	1.45
339	Neuronopathy, distal hereditary motor, autosomal dominant 3	Enrichment	HSPB1	1.45
340	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.45
341	Lymphoma, hodgkin, classic	Enrichment	TP53	1.45
342	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.45
343	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.45
344	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	1.45
345	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.45
346	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.45
347	Neurodevelopmental disorder with or without variable brain abnormalities	Enrichment	MAPK8IP3	1.45
348	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	1.45
349	Noonan syndrome 12	Enrichment	RRAS2	1.45
350	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.45
351	Neurodevelopmental disorder with developmental delay and with or without motor or speech delay	Enrichment	TAOK1	1.45
352	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	1.45
353	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.45
354	Infantile myofibromatosis	Enrichment	PDGFRB	1.45
355	Immunodeficiency 127	Enrichment	TNF	1.45
356	Rela fusion-positive ependymoma	Enrichment	RELA	1.45
357	Senior-loken syndrome 7	Enrichment	AKT3	1.45
358	Split hand-foot malformation	Enrichment	FGFR2	1.45
359	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	1.45
360	Cardiovascular system disease	Enrichment	FLNC	1.45
361	Split-foot malformation with mesoaxial polydactyly	Enrichment	MAP3K20	1.45
362	Camurati-engelmann disease	Enrichment	TGFB1	1.45
363	Congenital fibrosarcoma	Enrichment	TP53	1.45
364	Li-fraumeni syndrome 1	Enrichment	TP53	1.45
365	Sarcoma	Enrichment	TP53	1.45
366	Fibrolamellar carcinoma	Enrichment	PRKACA	1.45
367	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	1.45
368	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.45
369	Bardet-biedl syndrome 9	Enrichment	NF1	1.45
370	Immune system disease	Enrichment	CDC42	1.45
371	Hodgkin's lymphoma	Enrichment	TP53	1.45
372	Bardet-biedl syndrome 16	Enrichment	AKT3	1.45
373	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	1.45
374	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.45
375	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	1.45
376	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.45
377	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	1.45
378	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.45
379	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.45
380	Common variable immunodeficiency 12	Enrichment	NFKB1	1.45
381	Tafro syndrome	Enrichment	MAP2K2	1.45
382	Progressive bulbar palsy	Enrichment	CACNA1A	1.45
383	Oculootodental syndrome	Enrichment	FGF3	1.45
384	Wooly hair nevus	Enrichment	HRAS	1.45
385	Dandy-walker syndrome	Enrichment	BRAF, PDGFRB	1.44
386	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	1.39
387	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, TP53	1.35
388	Behcet syndrome	Enrichment	FAS, TNFRSF1A	1.35
389	Diffuse large b-cell lymphoma	Enrichment	BRAF, TP53	1.35
390	Ehlers-danlos syndrome	Enrichment	TGFB2, TGFBR2	1.35
391	Craniosynostosis	Enrichment	FGFR2, FGFR3	1.31
392	Prune belly syndrome	Enrichment	FLNA	1.28
393	Achondroplasia	Enrichment	FGFR3	1.28
394	Van der woude syndrome 1	Enrichment	CACNA1E	1.28
395	Pelvic organ prolapse	Enrichment	TAB2	1.28
396	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.28
397	Klippel-feil syndrome 1, autosomal dominant	Enrichment	LRRK2	1.28
398	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	1.28
399	Ataxia-telangiectasia	Enrichment	BRAF	1.28
400	Arterial tortuosity syndrome	Enrichment	FLNA	1.28
401	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23	1.28
402	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	1.28
403	Watson syndrome	Enrichment	NF1	1.28
404	Periventricular nodular heterotopia 1	Enrichment	FLNA	1.28
405	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.28
406	Myopathy, myofibrillar, 5	Enrichment	FLNC	1.28
407	Nuchal bleb, familial	Enrichment	SOS1	1.28
408	Osteogenic sarcoma	Enrichment	TP53	1.28
409	Spondylocarpotarsal synostosis syndrome	Enrichment	FLNB	1.28
410	Psoriatic arthritis	Enrichment	TNF	1.28
411	Nasopharyngeal carcinoma	Enrichment	TP53	1.28
412	Neurofibromatosis, familial spinal	Enrichment	NF1	1.28
413	Congenital short bowel syndrome	Enrichment	FLNA	1.28
414	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.28
415	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	1.28
416	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.28
417	Myopathy, distal, 4	Enrichment	FLNC	1.28
418	Anus, imperforate	Enrichment	MAP4K4	1.28
419	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A	1.28
420	Tethered spinal cord syndrome	Enrichment	BRAF	1.28
421	Bacteremia 2	Enrichment	MAPKAPK3	1.28
422	Wieacker-wolff syndrome	Enrichment	RASA1	1.28
423	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.28
424	Hamartoma	Enrichment	FGFR3	1.28
425	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.28
426	Testicular germ cell cancer	Enrichment	FGFR3	1.28
427	Anaplastic astrocytoma	Enrichment	TP53	1.28
428	Myxoid liposarcoma	Enrichment	DDIT3	1.28
429	Squamous cell carcinoma	Enrichment	TP53	1.28
430	Adenocarcinoma	Enrichment	TP53	1.28
431	Migraine without aura	Enrichment	TNF	1.28
432	Brain cancer	Enrichment	NF1	1.28
433	Bone osteosarcoma	Enrichment	TP53	1.28
434	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.28
435	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	1.28
436	Testicular cancer	Enrichment	FGFR3	1.28
437	Vogt-koyanagi-harada disease	Enrichment	FAS	1.28
438	Hereditary episodic ataxia	Enrichment	CACNA1A	1.28
439	Centronuclear myopathy	Enrichment	CACNA1S, MAP3K20	1.27
440	Hepatoblastoma	Enrichment	FGFR3, TP53	1.27
441	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX, NF1	1.27
442	Dilated cardiomyopathy	Enrichment	BRAF, FLNC, RAF1, TAB2	1.25
443	Congenital stationary night blindness	Enrichment	CACNA1F, CACNA2D4	1.20
444	Parkinson disease, late-onset	Enrichment	LRRK2, MAPT	1.16
445	Cardiomyopathy, familial hypertrophic, 1	Enrichment	FLNC, RAF1	1.16
446	Spastic ataxia	Enrichment	CACNA1G, CACNB4, FLNC	1.16
447	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	1.15
448	Small cell cancer of the lung	Enrichment	TP53	1.15
449	Spinocerebellar ataxia 6	Enrichment	CACNA1A	1.15
450	Aland island eye disease	Enrichment	CACNA1F	1.15
451	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	1.15
452	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.15
453	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.15
454	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.15
455	Cardiomyopathy, familial hypertrophic, 26	Enrichment	FLNC	1.15
456	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	1.15
457	Congenital generalized lipodystrophy	Enrichment	FOS	1.15
458	Cerebellar atrophy with seizures and variable developmental delay	Enrichment	CACNA2D2	1.15
459	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	1.15
460	Multiple synostoses syndrome	Enrichment	FGF9	1.15
461	Hereditary ataxia	Enrichment	PRKCG	1.15
462	Aortic aneurysm	Enrichment	TGFBR1	1.15
463	Craniopharyngioma	Enrichment	BRAF	1.15
464	Tuberculosis	Enrichment	MAPKAPK3	1.15
465	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.15
466	Newborn respiratory distress syndrome	Enrichment	BRAF	1.15
467	Epidermolytic nevus	Enrichment	HRAS	1.15
468	Malignant hyperthermia	Enrichment	CACNA1S	1.15
469	Episodic ataxia	Enrichment	CACNA1A	1.15
470	2p21 microdeletion syndrome	Enrichment	PPM1B	1.15
471	Knobloch syndrome	Enrichment	PAK2	1.15
472	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	1.15
473	Cerebral malaria	Enrichment	TNF	1.15
474	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.15
475	Glioma	Enrichment	FGFR2	1.15
476	Middle aortic syndrome	Enrichment	NF1	1.15
477	Gingival fibromatosis	Enrichment	SOS1	1.15
478	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.15
479	Pancreatic cancer	Enrichment	KRAS, TP53	1.13
480	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, NF1, TP53	1.12
481	Brugada syndrome	Enrichment	CACNA2D1, CACNB2	1.10
482	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.06
483	Capillary malformations, congenital	Enrichment	RASA1	1.06
484	Neuronopathy, distal hereditary motor, autosomal dominant 2	Enrichment	HSPB1	1.06
485	Episodic ataxia, type 2	Enrichment	CACNA1A	1.06
486	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.06
487	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.06
488	Knobloch syndrome 1	Enrichment	PAK2	1.06
489	Heart conduction disease	Enrichment	FLNC	1.06
490	Amblyopia	Enrichment	CACNA1F	1.06
491	Lymphoma	Enrichment	TP53	1.06
492	Cardiac arrest	Enrichment	CACNA2D1	1.06
493	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.06
494	Histiocytoid hemangioma	Enrichment	FOS	1.06
495	Vascular dementia	Enrichment	TNF	1.06
496	Acute megakaryocytic leukemia	Enrichment	TP53	1.06
497	Hemimegalencephaly	Enrichment	AKT3	1.06
498	Dementia	Enrichment	MAPT	1.06
499	Congenital short qt syndrome	Enrichment	CACNA2D1	1.06
500	Inherited cancer-predisposing syndrome	Enrichment	EGFR, MAP4K2, MAX, NF1, TP53	1.05
501	Atrial septal defect 1	Enrichment	TGFB2	0.99
502	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	0.99
503	Li-fraumeni syndrome	Enrichment	TP53	0.99
504	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S	0.99
505	Machado-joseph disease	Enrichment	LRRK2	0.99
506	Cowden syndrome 1	Enrichment	EGFR	0.99
507	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	0.99
508	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	0.99
509	Testicular germ cell tumor	Enrichment	FGFR3	0.99
510	Wilms tumor 5	Enrichment	BRAF	0.99
511	Hemangioma, capillary infantile	Enrichment	RASA1	0.99
512	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	0.99
513	Basal cell carcinoma 1	Enrichment	RASA1	0.99
514	Patent ductus arteriosus	Enrichment	FLNA	0.99
515	Adrenocortical carcinoma	Enrichment	TP53	0.99
516	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	0.99
517	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	0.99
518	46,xy disorder of sex development	Enrichment	FGFR3	0.99
519	Inherited arrhythmogenic cardiomyopathy	Enrichment	FLNC	0.99
520	Childhood absence epilepsy	Enrichment	CACNA1H	0.99
521	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	0.97
522	Familial hypertrophic cardiomyopathy	Enrichment	FLNC, RAF1	0.93
523	Severe combined immunodeficiency	Enrichment	IKBKB, STK4	0.93
524	Multiple endocrine neoplasia, type i	Enrichment	MAP4K2	0.92
525	Brugada syndrome 1	Enrichment	CACNA2D1	0.92
526	Semantic dementia	Enrichment	MAPT	0.92
527	Essential thrombocythemia	Enrichment	TP53	0.92
528	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	0.92
529	Megacolon	Enrichment	AKT3	0.92
530	Myofibrillar myopathy	Enrichment	FLNC	0.92
531	Hypophosphatemic rickets	Enrichment	FGF23	0.92
532	Familial isolated restrictive cardiomyopathy	Enrichment	FLNC	0.92
533	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	0.92
534	Eye disease	Enrichment	CACNA1F, CACNA2D4	0.88
535	Glioma susceptibility 1	Enrichment	TP53	0.87
536	Gastroesophageal reflux	Enrichment	RPS6KA3	0.87
537	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	0.87
538	Orthostatic intolerance	Enrichment	RPS6KA3	0.87
539	Ewing sarcoma	Enrichment	NF1	0.87
540	Alternating hemiplegia of childhood	Enrichment	CACNA1A	0.87
541	Difference of sex development	Enrichment	CACNA1A	0.87
542	Developmental and epileptic encephalopathy	Enrichment	CACNA1E, CACNA2D2	0.86
543	Orofacial cleft 1	Enrichment	FGF10	0.82
544	Neurofibromatosis, type i	Enrichment	NF1	0.82
545	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	0.82
546	Charge syndrome	Enrichment	TNFRSF1A	0.82
547	Coronary heart disease 5	Enrichment	IKBKG	0.82
548	Leukemia, acute lymphoblastic 3	Enrichment	NF1	0.82
549	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	0.82
550	Hypogonadotropic hypogonadism	Enrichment	FGFR1	0.82
551	Congenital central hypoventilation syndrome	Enrichment	BDNF	0.82
552	Progressive non-fluent aphasia	Enrichment	MAPT	0.82
553	Cowden syndrome	Enrichment	AKT1	0.82
554	Autosomal dominant cerebellar ataxia	Enrichment	LRRK2	0.82
555	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	0.82
556	Renal agenesis, bilateral	Enrichment	FGF20	0.82
557	Cerebral palsy	Enrichment	CACNA1A, PDGFRB	0.81
558	Leukemia, chronic lymphocytic	Enrichment	TP53	0.78
559	Meier-gorlin syndrome 1	Enrichment	FGFR2	0.78
560	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	0.78
561	Polymicrogyria	Enrichment	AKT3	0.78
562	Nemaline myopathy	Enrichment	FLNC	0.78
563	Melanoma	Enrichment	BRAF	0.78
564	Familial colorectal cancer	Enrichment	TP53	0.78
565	Primary bone dysplasia	Enrichment	FGFR3	0.78
566	Type 2 diabetes mellitus	Enrichment	AKT2, MAPK8IP1	0.76
567	Pectus excavatum	Enrichment	TGFBR1	0.74
568	Epilepsy, myoclonic juvenile	Enrichment	CACNB4	0.74
569	Asthma	Enrichment	TNF	0.74
570	Frontotemporal dementia 1	Enrichment	MAPT	0.74
571	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	0.74
572	Meningioma, familial	Enrichment	PDGFB	0.74
573	Myelodysplastic syndrome	Enrichment	TP53	0.74
574	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	0.74
575	Osteochondrodysplasia	Enrichment	FGFR3	0.74
576	Cardiac conduction defect	Enrichment	FLNC	0.71
577	Septooptic dysplasia	Enrichment	FGFR1	0.71
578	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	0.71
579	Early-onset parkinson's disease	Enrichment	LRRK2	0.71
580	Restrictive cardiomyopathy	Enrichment	FLNC	0.71
581	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	0.71
582	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	0.71
583	Protein-deficiency anemia	Enrichment	NRAS	0.68
584	Multiple sclerosis	Enrichment	TNFRSF1A	0.65
585	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.65
586	Periventricular nodular heterotopia	Enrichment	FLNA	0.65
587	Generalized epilepsy with febrile seizures plus	Enrichment	FGF13	0.65
588	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.65
589	Wilms tumor 1	Enrichment	BRAF	0.62
590	Congenital myopathy 4a, autosomal dominant	Enrichment	MAP3K20	0.62
591	Myopia	Enrichment	CACNA1F	0.62
592	Septopreoptic holoprosencephaly	Enrichment	FGF8	0.62
593	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	0.62
594	Hypertelorism	Enrichment	FGFR2, RPS6KA3	0.62
595	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	FLNC	0.60
596	Alzheimer disease, familial, 1	Enrichment	MAPT	0.58
597	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.58
598	Cleft palate, isolated	Enrichment	FLNA	0.58
599	Alobar holoprosencephaly	Enrichment	FGF8	0.58
600	Heart, malformation of	Enrichment	MAPK1	0.55
601	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT, MEF2C	0.55
602	Congenital myopathy	Enrichment	CACNA1S	0.53
603	Parkinson's disease	Enrichment	LRRK2	0.53
604	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C, NF1	0.51
605	Cardiomyopathy, dilated, 1a	Enrichment	FLNC	0.50
606	Endometrial cancer	Enrichment	FGFR2	0.50
607	Hepatocellular carcinoma	Enrichment	TP53	0.48
608	Tooth agenesis	Enrichment	FGFR1	0.48
609	Skin disease	Enrichment	NF1	0.48
610	Diamond-blackfan anemia 1	Enrichment	TP53	0.47
611	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.47
612	Cone-rod dystrophy 2	Enrichment	CACNA1F, CACNA2D4	0.46
613	Cone dystrophy	Enrichment	CACNA2D4	0.45
614	Autoinflammatory disease	Enrichment	TNFRSF1A	0.45
615	Tetralogy of fallot	Enrichment	FLNC	0.42
616	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.42
617	Auditory neuropathy	Enrichment	CACNA1A	0.42
618	Strabismus	Enrichment	CACNA1A	0.41
619	Prostate cancer	Enrichment	TP53	0.39
620	Long qt syndrome	Enrichment	CACNA1S	0.37
621	Cystic fibrosis	Enrichment	TGFB1	0.36
622	Peripheral nervous system disease	Enrichment	NGF	0.36
623	Neuropathy	Enrichment	NGF	0.36
624	Left ventricular noncompaction	Enrichment	RAF1	0.33
625	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.32
626	Diamond-blackfan anemia	Enrichment	TP53	0.32
627	Systemic lupus erythematosus	Enrichment	TNF	0.29
628	Charcot-marie-tooth disease	Enrichment	HSPB1	0.28
629	Optic atrophy plus syndrome	Enrichment	CACNA1F	0.26
630	West syndrome	Enrichment	NTRK2	0.26
631	Congenital nervous system abnormality	Enrichment	CACNA1A, FGFR3	0.24
632	Nervous system disease	Enrichment	CACNA1A, FGFR3	0.24
633	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.22
634	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.21
635	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	0.19
636	Complex neurodevelopmental disorder	Enrichment	MAPK8IP3, RAC3	0.18
637	Primary ovarian insufficiency	Enrichment	NTRK1	0.18
638	Microcephaly	Enrichment	MAPK1	0.05
639	Retinitis pigmentosa	Enrichment	CACNA1F, CACNA2D4	0.05
640	Hereditary retinal dystrophy	Enrichment	CACNA1F, CACNA2D4	0.01
641	Fundus dystrophy	Enrichment	CACNA1F, CACNA2D4	0.01

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAPK signaling pathway

Pathway Network for MAPK signaling pathway

Member Pathways for MAPK signaling pathway

Pathways in the MAPK signaling pathway SuperPath

Associated Genes for MAPK signaling pathway

Associated Disorders for MAPK signaling pathway

Disorders associated with MAPK signaling pathway SuperPath

STRING Interaction Network for MAPK signaling pathway

Sources for MAPK signaling pathway