MAPK targets/ Nuclear events mediated by MAP kinases

Pathway network for the MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

Sources:

Reactome

Pathways in the MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

#	Name	Source	Genes
1	MAPK targets/ Nuclear events mediated by MAP kinases	Reactome	ATF1 ATF2 CREB1 DUSP3 DUSP4 DUSP6 DUSP7 ELK1 FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 VRK3 (see all 31) (see less)
2	ERK/MAPK targets	Reactome	DUSP3 DUSP4 DUSP6 DUSP7 ELK1 MAPK1 MAPK11 MAPK14 MAPK3 MAPK7 MEF2A MEF2C PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 VRK3 (see all 22) (see less)
3	ERKs are inactivated	Reactome	DUSP3 DUSP4 DUSP6 DUSP7 MAPK1 MAPK3 MAPK7 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D VRK3 (see all 13) (see less)
4	CREB phosphorylation	Reactome	ATF1 CREB1 MAPKAPK2 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 (see all 7) (see less)

Gene overlap in member pathways for MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DUSP3	Dual Specificity Phosphatase 3	Protein Coding	3
2	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	3
3	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	3
4	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	3
5	VRK3	VRK Serine/Threonine Kinase 3	Protein Coding	3
6	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	3
7	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	3
8	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	3
9	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	3
10	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	3
11	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
12	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
13	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	3
14	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	3
15	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	3
16	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	3
17	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	3
18	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
19	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
20	ELK1	ETS Transcription Factor ELK1	Protein Coding	2
21	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	2
22	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	2
23	ATF1	Activating Transcription Factor 1	Protein Coding	2
24	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
25	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	2
26	ATF2	Activating Transcription Factor 2	Protein Coding	1
27	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
28	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
29	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
30	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
31	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1

Disorders associated with MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melanoma of soft tissue	Enrichment	ATF1, CREB1	6.16
2	Specific learning disability	Enrichment	MAPK1, RPS6KA3	3.86
3	Coffin-lowry syndrome	Enrichment	RPS6KA3	3.29
4	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	3.29
5	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	3.29
6	Noonan syndrome 13	Enrichment	MAPK1	3.02
7	Houge-janssens syndrome 2	Enrichment	PPP2R1A	3.02
8	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	3.02
9	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	3.02
10	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.99
11	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.79
12	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.79
13	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.79
14	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.79
15	Mef2c-related disorder	Enrichment	MEF2C	2.79
16	Scoliosis, isolated 1	Enrichment	MAPK7	2.72
17	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.72
18	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.72
19	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.42
20	Gastroesophageal reflux	Enrichment	RPS6KA3	2.38
21	Orthostatic intolerance	Enrichment	RPS6KA3	2.38
22	Ventricular septal defect	Enrichment	RPS6KA3	2.33
23	Congenital generalized lipodystrophy	Enrichment	FOS	2.04
24	Histiocytoid hemangioma	Enrichment	FOS	1.94
25	Heart, malformation of	Enrichment	MAPK1	1.77
26	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	1.77
27	Lennox-gastaut syndrome	Enrichment	MAPK10	1.74
28	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	1.73
29	Kallmann syndrome	Enrichment	DUSP6	1.66
30	Hypertelorism	Enrichment	RPS6KA3	1.58
31	Lung cancer	Enrichment	PPP2R1B	1.52
32	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	1.05
33	Microcephaly	Enrichment	MAPK1	0.95
34	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.95
35	Breast cancer	Enrichment	JUN	0.80
36	Autism spectrum disorder	Enrichment	MEF2C	0.79

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MAPK targets/ Nuclear events mediated by MAP kinases

Pathway Network for MAPK targets/ Nuclear events mediated by MAP kinases

Pathway network for the MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

Member Pathways for MAPK targets/ Nuclear events mediated by MAP kinases

Pathways in the MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

Gene overlap in member pathways for MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

Associated Genes for MAPK targets/ Nuclear events mediated by MAP kinases

Associated Disorders for MAPK targets/ Nuclear events mediated by MAP kinases

Disorders associated with MAPK targets/ Nuclear events mediated by MAP kinases SuperPath

STRING Interaction Network for MAPK targets/ Nuclear events mediated by MAP kinases

Sources for MAPK targets/ Nuclear events mediated by MAP kinases