Matrix metalloproteinases

Pathway network for the Matrix metalloproteinases SuperPath

Sources:

WikiPathways
QIAGEN
Reactome

Pathways in the Matrix metalloproteinases SuperPath

#	Name	Source	Genes
1	Matrix metalloproteinases	WikiPathways	BSG MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP2 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28 MMP3 MMP7 MMP8 MMP9 TCF20 TIMP1 TIMP2 TIMP3 TIMP4 TNF (see all 31) (see less)
2	Inhibition of Matrix Metalloproteinases	QIAGEN	A2M ADAM10 ADAM12 ADAM17 HSPG2 MMP1 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP2 MMP20 MMP21 MMP23B MMP24 MMP25 MMP26 MMP27 MMP28 MMP3 MMP7 MMP8 MMP9 RECK SDC2 TFPI2 THBS2 TIMP1 TIMP2 TIMP3 TIMP4 (see all 36) (see less)
3	Activation of Matrix Metalloproteinases	Reactome	CMA1 COL18A1 CTRB1 CTRB2 CTSG CTSK CTSV ELANE FURIN KLK2 KLKB1 MMP1 MMP10 MMP11 MMP13 MMP14 MMP15 MMP16 MMP17 MMP2 MMP24 MMP25 MMP3 MMP7 MMP8 MMP9 PLG PRSS1 PRSS2 SPOCK3 TIMP1 TIMP2 TPSAB1 (see all 33) (see less)

Gene overlap in member pathways for Matrix metalloproteinases SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MMP25	Matrix Metallopeptidase 25	Protein Coding	3
2	MMP17	Matrix Metallopeptidase 17	Protein Coding	3
3	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	3
4	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	3
5	MMP15	Matrix Metallopeptidase 15	Protein Coding	3
6	MMP14	Matrix Metallopeptidase 14	Protein Coding	3
7	MMP13	Matrix Metallopeptidase 13	Protein Coding	3
8	MMP11	Matrix Metallopeptidase 11	Protein Coding	3
9	MMP10	Matrix Metallopeptidase 10	Protein Coding	3
10	MMP9	Matrix Metallopeptidase 9	Protein Coding	3
11	MMP8	Matrix Metallopeptidase 8	Protein Coding	3
12	MMP7	Matrix Metallopeptidase 7	Protein Coding	3
13	MMP3	Matrix Metallopeptidase 3	Protein Coding	3
14	MMP2	Matrix Metallopeptidase 2	Protein Coding	3
15	MMP1	Matrix Metallopeptidase 1	Protein Coding	3
16	MMP24	Matrix Metallopeptidase 24	Protein Coding	3
17	MMP16	Matrix Metallopeptidase 16	Protein Coding	3
18	MMP20	Matrix Metallopeptidase 20	Protein Coding	2
19	TIMP4	TIMP Metallopeptidase Inhibitor 4	Protein Coding	2
20	TIMP3	TIMP Metallopeptidase Inhibitor 3	Protein Coding	2
21	MMP26	Matrix Metallopeptidase 26	Protein Coding	2
22	MMP19	Matrix Metallopeptidase 19	Protein Coding	2
23	MMP12	Matrix Metallopeptidase 12	Protein Coding	2
24	MMP21	Matrix Metallopeptidase 21	Protein Coding	2
25	MMP23B	Matrix Metallopeptidase 23B	Protein Coding	2
26	MMP28	Matrix Metallopeptidase 28	Protein Coding	2
27	MMP27	Matrix Metallopeptidase 27	Protein Coding	2
28	TNF	Tumor Necrosis Factor	Protein Coding	1
29	TCF20	Transcription Factor 20	Protein Coding	1
30	BSG	Basigin (Ok Blood Group)	Protein Coding	1
31	MMP23A	Matrix Metallopeptidase 23A (Pseudogene)	Pseudogene	1
32	A2M	Alpha-2-Macroglobulin	Protein Coding	1
33	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
34	ADAM12	ADAM Metallopeptidase Domain 12	Protein Coding	1
35	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
36	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	1
37	RECK	Reversion Inducing Cysteine Rich Protein With Kazal Motifs	Protein Coding	1
38	SDC2	Syndecan 2	Protein Coding	1
39	TFPI2	Tissue Factor Pathway Inhibitor 2	Protein Coding	1
40	THBS2	Thrombospondin 2	Protein Coding	1
41	CMA1	Chymase 1	Protein Coding	1
42	CTRB1	Chymotrypsinogen B1	Protein Coding	1
43	CTSG	Cathepsin G	Protein Coding	1
44	CTSK	Cathepsin K	Protein Coding	1
45	CTSV	Cathepsin V	Protein Coding	1
46	ELANE	Elastase, Neutrophil Expressed	Protein Coding	1
47	KLK2	Kallikrein Related Peptidase 2	Protein Coding	1
48	KLKB1	Kallikrein B1	Protein Coding	1
49	CTRB2	Chymotrypsinogen B2	Protein Coding	1
50	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	1
51	SPOCK3	SPARC (Osteonectin), Cwcv And Kazal Like Domains Proteoglycan 3	Protein Coding	1
52	PLG	Plasminogen	Protein Coding	1
53	PRSS1	Serine Protease 1	Protein Coding	1
54	PRSS2	Serine Protease 2	Protein Coding	1
55	TPSAB1	Tryptase Alpha/Beta 1	Protein Coding	1
56	COL18A1	Collagen Type XVIII Alpha 1 Chain	Protein Coding	1

Disorders associated with Matrix metalloproteinases SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Metaphyseal anadysplasia	Enrichment	MMP13, MMP9	5.30
2	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14, MMP2	4.82
3	Chromosome 1p36 deletion syndrome	Enrichment	HSPG2, MMP23B	3.28
4	Pancreatitis, hereditary	Enrichment	PRSS1, PRSS2	3.12
5	Cavitary optic disc anomalies	Enrichment	MMP19	2.64
6	Winchester syndrome	Enrichment	MMP14	2.64
7	Heterotaxy, visceral, 7, autosomal	Enrichment	MMP21	2.64
8	Coronary heart disease 6	Enrichment	MMP3	2.64
9	Developmental delay with variable intellectual impairment and behavioral abnormalities	Enrichment	TCF20	2.64
10	Pycnodysostosis	Enrichment	CTSK	2.61
11	Prekallikrein deficiency	Enrichment	KLKB1	2.61
12	Angioedema, hereditary, 4	Enrichment	PLG	2.61
13	Inherited prekallikrein deficiency	Enrichment	KLKB1	2.61
14	Alzheimer disease 18	Enrichment	ADAM10	2.58
15	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.58
16	Sorsby fundus dystrophy	Enrichment	TIMP3	2.34
17	Metaphyseal dysplasia, spahr type	Enrichment	MMP13	2.34
18	Spondyloepimetaphyseal dysplasia, missouri type	Enrichment	MMP13	2.34
19	Amelogenesis imperfecta, hypomaturation type, iia2	Enrichment	MMP20	2.34
20	Immunodeficiency 127	Enrichment	TNF	2.34
21	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.34
22	Preterm premature rupture of the membranes	Enrichment	MMP8	2.34
23	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.34
24	Cyclic neutropenia	Enrichment	ELANE	2.31
25	Plasminogen deficiency, type i	Enrichment	PLG	2.31
26	Neutropenia, severe congenital, x-linked	Enrichment	ELANE	2.31
27	Glaucoma, primary closed-angle	Enrichment	COL18A1	2.31
28	Hereditary angioedema	Enrichment	PLG	2.31
29	Trypsinogen deficiency	Enrichment	PRSS1	2.31
30	Schwartz-jampel syndrome, type 1	Enrichment	HSPG2	2.28
31	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.28
32	Psoriatic arthritis	Enrichment	TNF	2.16
33	Migraine without aura	Enrichment	TNF	2.16
34	Angioedema, hereditary, 1	Enrichment	PLG	2.14
35	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	ELANE	2.14
36	Nail disorder, nonsyndromic congenital, 9	Enrichment	CTSK	2.14
37	Dyssegmental dysplasia, silverman-handmaker type	Enrichment	HSPG2	2.10
38	Ehlers-danlos syndrome, classic-like, 3	Enrichment	THBS2	2.10
39	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17	2.10
40	Cerebral malaria	Enrichment	TNF	2.04
41	Knobloch syndrome	Enrichment	COL18A1	2.01
42	Dowling-degos disease 1	Enrichment	ADAM10	1.98
43	Vascular dementia	Enrichment	TNF	1.94
44	Vitamin d-dependent rickets, type 2a	Enrichment	PRSS1	1.92
45	Knobloch syndrome 1	Enrichment	COL18A1	1.92
46	Autosomal dominant severe congenital neutropenia	Enrichment	ELANE	1.92
47	Amelogenesis imperfecta type 2	Enrichment	MMP20	1.80
48	Neutropenia	Enrichment	ELANE	1.77
49	Intervertebral disc disease	Enrichment	THBS2	1.73
50	Primary bone dysplasia	Enrichment	CTSK	1.62
51	Pectus excavatum	Enrichment	TCF20	1.60
52	Asthma	Enrichment	TNF	1.60
53	Osteochondrodysplasia	Enrichment	CTSK	1.58
54	Alzheimer's disease	Enrichment	TNF	1.53
55	Cataract	Enrichment	COL18A1	1.47
56	Hereditary chronic pancreatitis	Enrichment	PRSS1	1.47
57	Arteriovenous malformations of the brain	Enrichment	TIMP3	1.37
58	Craniosynostosis	Enrichment	TCF20	1.35
59	Attention deficit-hyperactivity disorder	Enrichment	TCF20	1.31
60	Visceral heterotaxy	Enrichment	MMP21	1.31
61	Ehlers-danlos syndrome	Enrichment	THBS2	1.31
62	Malaria	Enrichment	TNF	1.29
63	Autoinflammatory disease	Enrichment	ELANE	1.25
64	Scoliosis	Enrichment	CTSK	1.25
65	Visceral heterotaxy 5	Enrichment	MMP21	1.16
66	Stargardt disease 1	Enrichment	COL18A1	1.15
67	Cystic fibrosis	Enrichment	PLG	1.12
68	Systemic lupus erythematosus	Enrichment	TNF	1.07
69	Autism	Enrichment	TCF20	0.82
70	Autism spectrum disorder	Enrichment	TCF20	0.65
71	Complex neurodevelopmental disorder	Enrichment	TCF20	0.61
72	Retinitis pigmentosa	Enrichment	COL18A1	0.39
73	Hereditary retinal dystrophy	Enrichment	TIMP3	0.31
74	Fundus dystrophy	Enrichment	TIMP3	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Matrix metalloproteinases

Pathway Network for Matrix metalloproteinases

Pathway network for the Matrix metalloproteinases SuperPath

Member Pathways for Matrix metalloproteinases

Pathways in the Matrix metalloproteinases SuperPath

Gene overlap in member pathways for Matrix metalloproteinases SuperPath

Associated Genes for Matrix metalloproteinases

Associated Disorders for Matrix metalloproteinases

Disorders associated with Matrix metalloproteinases SuperPath

STRING Interaction Network for Matrix metalloproteinases

Sources for Matrix metalloproteinases