mBDNF and proBDNF regulation of GABA neurotransmission

No Pathway Network information available for mBDNF and proBDNF regulation of GABA neurotransmission

Pathways in the mBDNF and proBDNF regulation of GABA neurotransmission SuperPath

#	Name	Source	Genes
1	mBDNF and proBDNF regulation of GABA neurotransmission	WikiPathways	AP2A1 AP2A2 AP2B1 BDNF CREB1 CREM GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ JAK2 NGFR NTRK2 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PTEN RHOA ROCK1 SHC1 SLC12A5 STAT3 (see all 38) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
2	SHC1	SHC Adaptor Protein 1	Protein Coding	1
3	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
4	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
5	SLC12A5	Solute Carrier Family 12 Member 5	Protein Coding	1
6	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
7	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
8	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
9	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
10	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
11	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
12	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
13	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
14	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
15	RHOA	Ras Homolog Family Member A	Protein Coding	1
16	JAK2	Janus Kinase 2	Protein Coding	1
17	GABRG3	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma3	Protein Coding	1
18	GABRG2	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma2	Protein Coding	1
19	GABRD	Gamma-Aminobutyric Acid Type A Receptor Subunit Delta	Protein Coding	1
20	GABRB3	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta3	Protein Coding	1
21	GABRB2	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta2	Protein Coding	1
22	GABRB1	Gamma-Aminobutyric Acid Type A Receptor Subunit Beta1	Protein Coding	1
23	GABRA6	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha6	Protein Coding	1
24	GABRA5	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha5	Protein Coding	1
25	GABRA4	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha4	Protein Coding	1
26	GABRA3	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha3	Protein Coding	1
27	GABRA2	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha2	Protein Coding	1
28	GABRA1	Gamma-Aminobutyric Acid Type A Receptor Subunit Alpha1	Protein Coding	1
29	CREM	CAMP Responsive Element Modulator	Protein Coding	1
30	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
31	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	1
32	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	1
33	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	1
34	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
35	GABRQ	Gamma-Aminobutyric Acid Type A Receptor Subunit Theta	Protein Coding	1
36	GABRP	Gamma-Aminobutyric Acid Type A Receptor Subunit Pi	Protein Coding	1
37	GABRG1	Gamma-Aminobutyric Acid Type A Receptor Subunit Gamma1	Protein Coding	1
38	GABRE	Gamma-Aminobutyric Acid Type A Receptor Subunit Epsilon	Protein Coding	1

Disorders associated with mBDNF and proBDNF regulation of GABA neurotransmission SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Childhood absence epilepsy	Enrichment	GABRA1, GABRB3, GABRG2	6.39
2	Undetermined early-onset epileptic encephalopathy	Enrichment	GABRA2, GABRA5, GABRB2, GABRG2, NTRK2	6.34
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.64
4	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	4.64
5	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.34
6	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	4.12
7	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.94
8	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.94
9	Lennox-gastaut syndrome	Enrichment	GABRB3, GABRG2	3.67
10	Cowden syndrome	Enrichment	PIK3CA, PTEN	3.57
11	Dravet syndrome	Enrichment	GABRA1, GABRG2	3.47
12	Epilepsy, myoclonic juvenile	Enrichment	GABRA1, GABRD	3.38
13	Epilepsy, idiopathic generalized	Enrichment	GABRA1, GABRD	3.38
14	Meningioma	Enrichment	PIK3CA, PTEN	3.30
15	Generalized epilepsy with febrile seizures plus	Enrichment	GABRD, GABRG2	3.17
16	Breast cancer	Enrichment	PIK3CA, PTEN, SHC1	2.92
17	Diffuse large b-cell lymphoma	Enrichment	PTEN, STAT3	2.90
18	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.81
19	Macrodactyly	Enrichment	PIK3CA	2.55
20	Vacterl association with hydrocephalus	Enrichment	PTEN	2.55
21	Febrile seizures, familial, 8	Enrichment	GABRG2	2.55
22	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.55
23	Epilepsy, idiopathic generalized 13	Enrichment	GABRA1	2.55
24	Cowden syndrome 5	Enrichment	PIK3CA	2.55
25	Epilepsy, idiopathic generalized 14	Enrichment	SLC12A5	2.55
26	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.55
27	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	2.55
28	Developmental and epileptic encephalopathy 74	Enrichment	GABRG2	2.55
29	Developmental and epileptic encephalopathy 79	Enrichment	GABRA5	2.55
30	Short syndrome	Enrichment	PIK3R1	2.55
31	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.55
32	Epilepsy, x-linked 2, with or without impaired intellectual development and dysmorphic features	Enrichment	GABRA3	2.55
33	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.55
34	Epilepsy, idiopathic generalized 10	Enrichment	GABRD	2.55
35	Papillary tumor of the pineal region	Enrichment	PTEN	2.55
36	Developmental and epileptic encephalopathy 19	Enrichment	GABRA1	2.55
37	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.55
38	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.55
39	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.55
40	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.55
41	Epilepsy, childhood absence 5	Enrichment	GABRB3	2.55
42	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.55
43	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	2.55
44	Glioma susceptibility 2	Enrichment	PTEN	2.55
45	Developmental and epileptic encephalopathy 92	Enrichment	GABRB2	2.55
46	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.55
47	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.55
48	Developmental and epileptic encephalopathy 43	Enrichment	GABRB3	2.55
49	Developmental and epileptic encephalopathy 45	Enrichment	GABRB1	2.55
50	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.55
51	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.55
52	Hypospadias	Enrichment	PIK3CA	2.55
53	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.55
54	Rare venous malformation	Enrichment	PIK3CA	2.55
55	Diaphragmatic eventration	Enrichment	PIK3CA	2.55
56	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.55
57	Rare combined vascular malformation	Enrichment	PIK3CA	2.55
58	Cavernous lymphangioma	Enrichment	PIK3CA	2.55
59	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.55
60	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.55
61	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.55
62	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.55
63	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.55
64	Macrodactyly of toe	Enrichment	PIK3CA	2.55
65	Bladder cancer	Enrichment	PIK3CA, PTEN	2.53
66	Prostate cancer	Enrichment	PIK3CA, PTEN	2.53
67	Epilepsy	Enrichment	GABRA1, GABRB3	2.25
68	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.25
69	Keratosis, seborrheic	Enrichment	PIK3CA	2.25
70	Developmental and epileptic encephalopathy 34	Enrichment	SLC12A5	2.25
71	Noonan syndrome 8	Enrichment	PIK3CA	2.25
72	Thrombocythemia 3	Enrichment	JAK2	2.25
73	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.25
74	Developmental and epileptic encephalopathy 78	Enrichment	GABRA2	2.25
75	Polycythemia	Enrichment	JAK2	2.25
76	Vacterl with hydrocephalus	Enrichment	PTEN	2.25
77	Hypereosinophilic syndrome	Enrichment	JAK2	2.25
78	Juvenile polyposis of infancy	Enrichment	PTEN	2.25
79	Gastric cancer	Enrichment	PIK3CA, PTEN	2.19
80	Hereditary breast carcinoma	Enrichment	PIK3CA, PTEN	2.17
81	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.08
82	Polycythemia vera	Enrichment	JAK2	2.08
83	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.08
84	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.08
85	Hyper ige syndrome	Enrichment	STAT3	2.08
86	Immunodeficiency 14	Enrichment	PIK3R1	2.08
87	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.08
88	Melanoma of soft tissue	Enrichment	CREB1	2.08
89	Thyrotoxic periodic paralysis	Enrichment	GABRA3	2.08
90	Keratoacanthoma	Enrichment	PIK3CA	2.08
91	Erythrocytosis, familial, 1	Enrichment	JAK2	1.95
92	Budd-chiari syndrome	Enrichment	JAK2	1.95
93	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.95
94	Autosomal dominant nocturnal frontal lobe epilepsy	Enrichment	GABRG2	1.95
95	Cerebrovascular disease	Enrichment	PIK3CA	1.95
96	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.95
97	Glioma	Enrichment	PTEN	1.95
98	Capillary malformations, congenital	Enrichment	PIK3CA	1.86
99	Macrocephaly/autism syndrome	Enrichment	PTEN	1.86
100	Myeloproliferative neoplasm	Enrichment	JAK2	1.86
101	Hemangioma	Enrichment	PTEN	1.86
102	Acute megakaryocytic leukemia	Enrichment	PTEN	1.86
103	Angelman syndrome	Enrichment	GABRG3	1.78
104	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.78
105	Alcohol dependence	Enrichment	GABRA2	1.78
106	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	1.78
107	Epilepsy, childhood absence 1	Enrichment	GABRB3	1.78
108	Breast adenocarcinoma	Enrichment	PIK3CA	1.78
109	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.78
110	Nevus, epidermal	Enrichment	PIK3CA	1.71
111	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.71
112	Myelofibrosis	Enrichment	JAK2	1.71
113	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.71
114	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.71
115	Essential thrombocythemia	Enrichment	JAK2	1.71
116	Gallbladder cancer	Enrichment	PIK3CA	1.71
117	Pilomyxoid astrocytoma	Enrichment	NTRK2	1.71
118	Follicular thyroid carcinoma	Enrichment	PTEN	1.71
119	Overgrowth syndrome	Enrichment	PIK3R1	1.71
120	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.65
121	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.61
122	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.60
123	Developmental and epileptic encephalopathy 14	Enrichment	SLC12A5	1.60
124	Arteriovenous malformation	Enrichment	PIK3CA	1.60
125	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.60
126	Congenital central hypoventilation syndrome	Enrichment	BDNF	1.60
127	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.56
128	Melanoma	Enrichment	PTEN	1.56
129	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.56
130	Meningioma, familial	Enrichment	PTEN	1.52
131	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.52
132	Uterine corpus cancer	Enrichment	PTEN	1.52
133	Ovarian cancer	Enrichment	PIK3CA, PTEN	1.49
134	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.48
135	Acute promyelocytic leukemia	Enrichment	STAT3	1.45
136	Chromosome 1p36 deletion syndrome	Enrichment	GABRD	1.45
137	Nk-cell enteropathy	Enrichment	PIK3CB	1.45
138	Lynch syndrome	Enrichment	PIK3CA	1.38
139	Rhabdomyosarcoma	Enrichment	PTEN	1.36
140	Hepatocellular carcinoma	Enrichment	PIK3CA	1.22
141	Lung cancer	Enrichment	PIK3CA	1.07
142	Leukemia, acute myeloid	Enrichment	JAK2	0.97
143	Benign epilepsy with centrotemporal spikes	Enrichment	GABRG2	0.96
144	Centralopathic epilepsy	Enrichment	GABRG2	0.94
145	West syndrome	Enrichment	NTRK2	0.93
146	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.88
147	Hypertelorism	Enrichment	PIK3CA	0.87
148	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.84
149	Myeloma, multiple	Enrichment	PIK3R2	0.84
150	Schizophrenia	Enrichment	GABRB2	0.82
151	Primary ovarian insufficiency	Enrichment	JAK2	0.82
152	Congenital nervous system abnormality	Enrichment	PTEN	0.59
153	Nervous system disease	Enrichment	PTEN	0.59
154	Autism spectrum disorder	Enrichment	PTEN	0.58
155	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.51

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

mBDNF and proBDNF regulation of GABA neurotransmission

Pathway Network for mBDNF and proBDNF regulation of GABA neurotransmission

Member Pathways for mBDNF and proBDNF regulation of GABA neurotransmission

Pathways in the mBDNF and proBDNF regulation of GABA neurotransmission SuperPath

Associated Genes for mBDNF and proBDNF regulation of GABA neurotransmission

Associated Disorders for mBDNF and proBDNF regulation of GABA neurotransmission

Disorders associated with mBDNF and proBDNF regulation of GABA neurotransmission SuperPath

STRING Interaction Network for mBDNF and proBDNF regulation of GABA neurotransmission

Sources for mBDNF and proBDNF regulation of GABA neurotransmission