Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

No Pathway Network information available for Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Pathways in the Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) SuperPath

#	Name	Source	Genes
1	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)	GeneGo (Thomson Reuters)	ADH5 AHSA1 CFTR CP DNAJB6 DNAJC5 HSP90AA1 HSP90AB1 HSP90B1 HSPA14 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA5 HSPA6 HSPA7 HSPA8 HSPA9 NOS1 NOS2 NOS3 SOD1 SP1 SP3 TRAP1 TXNRD1 TXNRD2 TXNRD3 (see all 30) (see less)
2	CFTR folding and maturation (norm and CF)	GeneGo (Thomson Reuters)	AHSA1 CANX CFTR DAD1 DDOST DNAJA1 DNAJB1 DNAJB6 EDEM1 HSP90AA1 HSP90AB1 HSPA14 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA5 HSPA6 HSPA7 HSPA8 HSPA9 HSPBP1 MAN1B1 RPN1 RPN2 STT3A STT3B UGGT1 (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	2
2	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	2
3	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	2
4	HSPA1L	Heat Shock Protein Family A (Hsp70) Member 1 Like	Protein Coding	2
5	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	2
6	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	2
7	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	2
8	HSPA6	Heat Shock Protein Family A (Hsp70) Member 6	Protein Coding	2
9	HSPA7	Heat Shock Protein Family A (Hsp70) Member 7 (Pseudogene)	Pseudogene	2
10	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	2
11	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	2
12	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
13	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	2
14	DNAJB6	DnaJ Heat Shock Protein Family (Hsp40) Member B6	Protein Coding	2
15	AHSA1	Activator Of HSP90 ATPase Activity 1	Protein Coding	2
16	HSPA14	Heat Shock Protein Family A (Hsp70) Member 14	Protein Coding	2
17	ADH5	Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide	Protein Coding	1
18	CP	Ceruloplasmin	Protein Coding	1
19	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
20	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
21	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
22	SOD1	Superoxide Dismutase 1	Protein Coding	1
23	SP1	Sp1 Transcription Factor	Protein Coding	1
24	SP3	Sp3 Transcription Factor	Protein Coding	1
25	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
26	TXNRD1	Thioredoxin Reductase 1	Protein Coding	1
27	TRAP1	TNF Receptor Associated Protein 1	Protein Coding	1
28	TXNRD2	Thioredoxin Reductase 2	Protein Coding	1
29	DNAJC5	DnaJ Heat Shock Protein Family (Hsp40) Member C5	Protein Coding	1
30	TXNRD3	Thioredoxin Reductase 3	Protein Coding	1
31	CANX	Calnexin	Protein Coding	1
32	DAD1	Defender Against Cell Death 1	Protein Coding	1
33	DDOST	Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Non-Catalytic Subunit	Protein Coding	1
34	DNAJA1	DnaJ Heat Shock Protein Family (Hsp40) Member A1	Protein Coding	1
35	DNAJB1	DnaJ Heat Shock Protein Family (Hsp40) Member B1	Protein Coding	1
36	STT3A	STT3 Oligosaccharyltransferase Complex Catalytic Subunit A	Protein Coding	1
37	RPN1	Ribophorin I	Protein Coding	1
38	RPN2	Ribophorin II	Protein Coding	1
39	EDEM1	ER Degradation Enhancing Alpha-Mannosidase Like Protein 1	Protein Coding	1
40	MAN1B1	Mannosidase Alpha Class 1B Member 1	Protein Coding	1
41	HSPBP1	HSPA (Hsp70) Binding Protein 1	Protein Coding	1
42	UGGT1	UDP-Glucose Glycoprotein Glucosyltransferase 1	Protein Coding	1
43	STT3B	STT3 Oligosaccharyltransferase Complex Catalytic Subunit B	Protein Coding	1

Disorders associated with Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Muscular dystrophy, limb-girdle, autosomal dominant 1	Enrichment	DNAJB6	2.67
2	Congenital disorder of glycosylation, type iw, autosomal recessive	Enrichment	STT3A	2.67
3	Even-plus syndrome	Enrichment	HSPA9	2.67
4	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.67
5	Congenital disorder of glycosylation, type ir	Enrichment	DDOST	2.67
6	Congenital disorder of glycosylation, type iicc	Enrichment	UGGT1	2.67
7	Congenital disorder of glycosylation iw	Enrichment	STT3A	2.67
8	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.67
9	Man1b1-congenital disorder of glycosylation	Enrichment	MAN1B1	2.67
10	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.66
11	Ceroid lipofuscinosis, neuronal, 4	Enrichment	DNAJC5	2.66
12	Aceruloplasminemia	Enrichment	CP	2.66
13	Glucocorticoid deficiency 5	Enrichment	TXNRD2	2.66
14	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	2.37
15	Rafiq syndrome	Enrichment	MAN1B1	2.37
16	Congenital disorder of glycosylation, type ix	Enrichment	STT3B	2.37
17	Fibrolamellar carcinoma	Enrichment	DNAJB1	2.37
18	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	STT3A	2.37
19	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.37
20	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	RPN1	2.37
21	Hermansky-pudlak syndrome 3	Enrichment	CP	2.35
22	Amed syndrome, digenic	Enrichment	ADH5	2.35
23	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.35
24	Nuchal bleb, familial	Enrichment	CFTR	2.19
25	Idiopathic bronchiectasis	Enrichment	CFTR	2.07
26	Idiopathic achalasia	Enrichment	NOS1	2.05
27	Alzheimer disease 2	Enrichment	NOS3	1.96
28	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.96
29	Pre-eclampsia	Enrichment	NOS3	1.96
30	Familial glucocorticoid deficiency	Enrichment	TXNRD2	1.96
31	Congenital anomalies of kidney and urinary tract 1	Enrichment	TRAP1	1.88
32	Motor neuron disease	Enrichment	SOD1	1.81
33	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.72
34	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.72
35	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.66
36	Stroke, ischemic	Enrichment	NOS3	1.66
37	Neurodegeneration with brain iron accumulation	Enrichment	CP	1.66
38	Hereditary chronic pancreatitis	Enrichment	CFTR	1.53
39	Lynch syndrome	Enrichment	CFTR	1.50
40	Neuronal ceroid lipofuscinosis	Enrichment	DNAJC5	1.49
41	Hermansky-pudlak syndrome	Enrichment	CP	1.49
42	Hermansky-pudlak syndrome 1	Enrichment	CP	1.46
43	Pancreatitis, hereditary	Enrichment	CFTR	1.45
44	Alzheimer disease, familial, 1	Enrichment	NOS3	1.43
45	Hypertension, essential	Enrichment	NOS3	1.43
46	Parkinson's disease	Enrichment	DNAJB6	1.40
47	Malaria	Enrichment	NOS2	1.30
48	Parkinson disease, late-onset	Enrichment	DNAJB6	1.30
49	Cystic fibrosis	Enrichment	CFTR	1.18
50	Male infertility	Enrichment	CFTR	1.15
51	Cakut	Enrichment	TRAP1	1.14
52	Familial isolated dilated cardiomyopathy	Enrichment	TXNRD2	0.95
53	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.95
54	Autosomal recessive non-syndromic intellectual disability	Enrichment	MAN1B1	0.93
55	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	0.92
56	Primary ovarian insufficiency	Enrichment	NOS3	0.91

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Pathway Network for Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Member Pathways for Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Pathways in the Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) SuperPath

Associated Genes for Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Associated Disorders for Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Disorders associated with Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) SuperPath

STRING Interaction Network for Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)

Sources for Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)