Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

No Pathway Network information available for Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Pathways in the Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms SuperPath

#	Name	Source	Genes
1	Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms	WikiPathways	ACTB ACTC1 ACTG1 ACTG2 CDH1 CTNNA1 CTNNB1 ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 LATS1 LIMD1 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MAP4K5 MAPK8 MAPK9 MST1 NF2 SGMS1 SRC TEAD1 YWHAQ (see all 30) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SGMS1	Sphingomyelin Synthase 1	Protein Coding	1
2	CDH1	Cadherin 1	Protein Coding	1
3	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	1
4	LATS1	Large Tumor Suppressor Kinase 1	Protein Coding	1
5	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
6	ACTG1	Actin Gamma 1	Protein Coding	1
7	TEAD1	TEA Domain Transcription Factor 1	Protein Coding	1
8	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
9	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
10	ACTB	Actin Beta	Protein Coding	1
11	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
12	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
13	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	1
14	MST1	Macrophage Stimulating 1	Protein Coding	1
15	ITGB8	Integrin Subunit Beta 8	Protein Coding	1
16	ITGB6	Integrin Subunit Beta 6	Protein Coding	1
17	ITGB5	Integrin Subunit Beta 5	Protein Coding	1
18	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
19	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
20	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
21	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
22	CTNNB1	Catenin Beta 1	Protein Coding	1
23	CTNNA1	Catenin Alpha 1	Protein Coding	1
24	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
25	LIMD1	LIM Domain Containing 1	Protein Coding	1
26	MAP4K3	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3	Protein Coding	1
27	MAP4K1	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1	Protein Coding	1
28	MAP4K5	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5	Protein Coding	1
29	MAP4K2	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2	Protein Coding	1
30	ITGB7	Integrin Subunit Beta 7	Protein Coding	1

Disorders associated with Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.33
2	Anus, imperforate	Enrichment	CTNNB1, MAP4K4	4.85
3	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1	4.55
4	Colorectal cancer	Enrichment	CDH1, CTNNA1, CTNNB1, SRC	4.42
5	Inherited cancer-predisposing syndrome	Enrichment	CDH1, CTNNA1, MAP4K2, NF2	3.71
6	Baraitser-winter syndrome 1	Enrichment	ACTB	2.66
7	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.66
8	Schwannomatosis, vestibular	Enrichment	NF2	2.66
9	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.66
10	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.66
11	Becker nevus syndrome	Enrichment	ACTB	2.66
12	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.66
13	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.66
14	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.66
15	Thrombocytopenia 6	Enrichment	SRC	2.66
16	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.66
17	Adenoid ameloblastoma	Enrichment	CTNNB1	2.66
18	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.66
19	Baraitser-winter syndrome	Enrichment	ACTB	2.66
20	Breast lobular carcinoma	Enrichment	CDH1	2.66
21	Acoustic neuroma	Enrichment	NF2	2.66
22	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.66
23	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.66
24	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.66
25	Microcystic stromal tumor	Enrichment	CTNNB1	2.66
26	Actg2 visceral myopathy	Enrichment	ACTG2	2.66
27	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1	2.61
28	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.35
29	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	2.35
30	Sveinsson chorioretinal atrophy	Enrichment	TEAD1	2.35
31	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.35
32	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.35
33	Schwannomatosis 1	Enrichment	NF2	2.35
34	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.35
35	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.35
36	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	2.35
37	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.35
38	Atrial septal defect 5	Enrichment	ACTC1	2.35
39	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	2.35
40	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.35
41	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.35
42	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	2.35
43	Teratoma	Enrichment	CTNNB1	2.35
44	Intestinal obstruction	Enrichment	ACTG2	2.35
45	Malignant peritoneal mesothelioma	Enrichment	LATS1	2.35
46	Thrombocytopenia	Enrichment	ITGB3, SRC	2.30
47	Desmoid disease, hereditary	Enrichment	CTNNB1	2.18
48	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.18
49	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.18
50	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.18
51	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.18
52	Desmoid tumor	Enrichment	CTNNB1	2.18
53	Cellular ependymoma	Enrichment	NF2	2.18
54	Tanycytic ependymoma	Enrichment	NF2	2.18
55	Papillary ependymoma	Enrichment	NF2	2.18
56	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.18
57	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.18
58	Spindle cell sarcoma	Enrichment	NF2	2.18
59	Clear cell ependymoma	Enrichment	NF2	2.18
60	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	2.18
61	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	2.05
62	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	2.05
63	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	2.05
64	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	2.05
65	Pilomatrixoma	Enrichment	CTNNB1	2.05
66	Aminoacylase 1 deficiency	Enrichment	ACTB	2.05
67	Alazami syndrome	Enrichment	CTNNB1	2.05
68	Craniopharyngioma	Enrichment	CTNNB1	2.05
69	Full schwannomatosis	Enrichment	NF2	2.05
70	Benign ependymoma	Enrichment	NF2	2.05
71	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.05
72	Visceral myopathy 1	Enrichment	ACTG2	1.96
73	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.96
74	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.96
75	Cholangitis, primary sclerosing	Enrichment	MST1	1.96
76	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.96
77	Aplasia cutis congenita	Enrichment	ITGB4	1.96
78	Coloboma of choroid and retina	Enrichment	ACTG1	1.96
79	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.88
80	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.88
81	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGB4	1.88
82	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.88
83	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.88
84	Adrenocortical carcinoma	Enrichment	CTNNB1	1.88
85	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	1.88
86	Cleft lip with or without cleft palate	Enrichment	CDH1	1.88
87	Multiple endocrine neoplasia, type i	Enrichment	MAP4K2	1.81
88	Myelofibrosis	Enrichment	SRC	1.81
89	Glanzmann thrombasthenia 1	Enrichment	ITGB3	1.81
90	Gallbladder cancer	Enrichment	CTNNB1	1.81
91	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.81
92	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	1.76
93	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.76
94	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.70
95	Junctional epidermolysis bullosa	Enrichment	ITGB4	1.70
96	Ovarian cancer	Enrichment	CDH1, CTNNB1	1.68
97	Cat eye syndrome	Enrichment	ACTG1	1.66
98	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.66
99	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	1.66
100	Meningioma, familial	Enrichment	NF2	1.62
101	Meningioma	Enrichment	NF2	1.58
102	Neural tube defects	Enrichment	ITGB1	1.55
103	Multiple sclerosis	Enrichment	ITGB4	1.52
104	Osteoporosis	Enrichment	SRC	1.52
105	Medulloblastoma	Enrichment	CTNNB1	1.52
106	Cleft lip/palate	Enrichment	CDH1	1.52
107	Polycystic liver disease	Enrichment	CTNNB1	1.43
108	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.43
109	Patent foramen ovale	Enrichment	ACTC1	1.41
110	Arteriovenous malformations of the brain	Enrichment	MAP4K4	1.38
111	Craniosynostosis	Enrichment	CTNNA1	1.36
112	Endometrial cancer	Enrichment	CDH1	1.34
113	Lissencephaly	Enrichment	ACTG1	1.34
114	Hepatoblastoma	Enrichment	CTNNB1	1.34
115	Hepatocellular carcinoma	Enrichment	CTNNB1	1.32
116	Myocardial infarction	Enrichment	ITGB3	1.32
117	Skin disease	Enrichment	ITGB4	1.32
118	Bladder cancer	Enrichment	CTNNB1	1.21
119	Prostate cancer	Enrichment	CDH1	1.21
120	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	1.15
121	Cakut	Enrichment	ACTG1	1.14
122	Left ventricular noncompaction	Enrichment	ACTC1	1.13
123	Non-syndromic genetic deafness	Enrichment	ACTG1	1.12
124	Distal arthrogryposis	Enrichment	ACTC1	1.05
125	Nonsyndromic hearing loss	Enrichment	ACTG1	1.05
126	Gastric cancer	Enrichment	CDH1	1.04
127	Hypertrophic cardiomyopathy	Enrichment	ACTC1	1.04
128	Hereditary breast carcinoma	Enrichment	CDH1	1.03
129	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.96
130	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1	0.95
131	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1	0.94
132	Myeloma, multiple	Enrichment	LATS1	0.93
133	Breast cancer	Enrichment	CDH1	0.81
134	Rare genetic deafness	Enrichment	ACTG1	0.79
135	Dilated cardiomyopathy	Enrichment	ACTC1	0.79
136	Congenital nervous system abnormality	Enrichment	CTNNB1	0.68
137	Nervous system disease	Enrichment	CTNNB1	0.68
138	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.32
139	Fundus dystrophy	Enrichment	CTNNA1	0.32

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Pathway Network for Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Member Pathways for Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Pathways in the Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms SuperPath

Associated Genes for Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Associated Disorders for Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Disorders associated with Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms SuperPath

STRING Interaction Network for Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms

Sources for Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms