Meiosis

Pathway network for the Meiosis SuperPath

Sources:

Reactome

Pathways in the Meiosis SuperPath

#	Name	Source	Genes
1	Meiosis	Reactome	ACD ATM ATR BLM BRCA1 BRCA2 CDK2 CDK4 DIDO1 DMC1 FIGNL1 FIRRM FKBP6 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HSPA2 LMNA LMNB1 MLH1 MLH3 MND1 MRE11 MSH4 MSH5 NBN POT1 PRDM9 PSMC3IP RAD21 RAD50 RAD51 RAD51C RBBP8 REC8 RPA1 RPA2 RPA3 SMC1A SMC1B SMC3 SPO11 STAG1 STAG2 STAG3 SUN1 SUN2 SYCE1 SYCE2 SYCE3 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TEX12 TINF2 TOP3A UBE2I (see all 119) (see less)
2	Reproduction	Reactome	ACD ACR ADAM2 ADAM20 ADAM21 ADAM30 ATM ATR B4GALT1 BLM BMP4 BRCA1 BRCA2 CATSPER1 CATSPER2 CATSPER3 CATSPER4 CATSPERB CATSPERD CATSPERG CBFA2T2 CD9 CDK2 CDK4 CXCR4 DIDO1 DMC1 EOMES FIGNL1 FIRRM FKBP6 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HSPA2 HVCN1 IZUMO1 IZUMO2 IZUMO3 IZUMO4 KCNU1 LMNA LMNB1 MLH1 MLH3 MND1 MRE11 MSH4 MSH5 NANOG NANOS3 NBN OVGP1 PDPN POT1 POU5F1 PRDM1 PRDM9 PSMC3IP RAD21 RAD50 RAD51 RAD51C RBBP8 REC8 RPA1 RPA2 RPA3 SMC1A SMC1B SMC3 SOX17 SPAM1 SPO11 STAG1 STAG2 STAG3 SUN1 SUN2 SYCE1 SYCE2 SYCE3 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TET2 TEX12 TFAP2C TINF2 TOP3A UBE2I ZP1 ZP2 ZP3 ZP4 (see all 157) (see less)
3	Meiotic recombination	Reactome	ATM BLM BRCA1 BRCA2 CDK2 CDK4 DMC1 FIGNL1 FIRRM H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 MLH1 MLH3 MND1 MRE11 MSH4 MSH5 NBN PRDM9 PSMC3IP RAD50 RAD51 RAD51C RBBP8 RPA1 RPA2 RPA3 SPO11 TOP3A (see all 87) (see less)
4	Meiotic synapsis	Reactome	ACD ATR BRCA1 DIDO1 FKBP6 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-4 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HSPA2 LMNA LMNB1 POT1 RAD21 REC8 SMC1A SMC1B SMC3 STAG1 STAG2 STAG3 SUN1 SUN2 SYCE1 SYCE2 SYCE3 SYCP1 SYCP2 SYCP3 SYNE1 SYNE2 TERF1 TERF2 TERF2IP TEX12 TINF2 UBE2I (see all 78) (see less)
5	Specification of primordial germ cells	Reactome	BMP4 CBFA2T2 CXCR4 EOMES NANOG NANOS3 PDPN POU5F1 PRDM1 SOX17 TET2 TFAP2C (see all 12) (see less)

Gene overlap in member pathways for Meiosis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	H4C16	H4 Histone 16	Protein Coding	4
2	H2BC26	H2B Clustered Histone 26	Protein Coding	4
3	H2BC1	H2B Clustered Histone 1	Protein Coding	4
4	H2AC8	H2A Clustered Histone 8	Protein Coding	4
5	H2AC7	H2A Clustered Histone 7	Protein Coding	4
6	H2AX	H2A.X Variant Histone	Protein Coding	4
7	H2BC5	H2B Clustered Histone 5	Protein Coding	4
8	H2BC3	H2B Clustered Histone 3	Protein Coding	4
9	H2AB1	H2A.B Variant Histone 1	Protein Coding	4
10	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	4
11	H4C15	H4 Clustered Histone 15	Protein Coding	4
12	H2AJ	H2A.J Histone	Protein Coding	4
13	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	4
14	H2AC19	H2A Clustered Histone 19	Protein Coding	4
15	H3-4	H3.4 Histone, Cluster Member	Protein Coding	4
16	H4C9	H4 Clustered Histone 9	Protein Coding	4
17	H2AC14	H2A Clustered Histone 14	Protein Coding	4
18	H2AC6	H2A Clustered Histone 6	Protein Coding	4
19	H2AC4	H2A Clustered Histone 4	Protein Coding	4
20	H2AC18	H2A Clustered Histone 18	Protein Coding	4
21	H2AC20	H2A Clustered Histone 20	Protein Coding	4
22	H2BC8	H2B Clustered Histone 8	Protein Coding	4
23	H2BC13	H2B Clustered Histone 13	Protein Coding	4
24	H2BC15	H2B Clustered Histone 15	Protein Coding	4
25	H2BC14	H2B Clustered Histone 14	Protein Coding	4
26	H2BC7	H2B Clustered Histone 7	Protein Coding	4
27	H2BC6	H2B Clustered Histone 6	Protein Coding	4
28	H2BC9	H2B Clustered Histone 9	Protein Coding	4
29	H2BC10	H2B Clustered Histone 10	Protein Coding	4
30	H2BC4	H2B Clustered Histone 4	Protein Coding	4
31	H2BC17	H2B Clustered Histone 17	Protein Coding	4
32	H2BC21	H2B Clustered Histone 21	Protein Coding	4
33	H4C1	H4 Clustered Histone 1	Protein Coding	4
34	H4C4	H4 Clustered Histone 4	Protein Coding	4
35	H4C6	H4 Clustered Histone 6	Protein Coding	4
36	H4C12	H4 Clustered Histone 12	Protein Coding	4
37	H4C11	H4 Clustered Histone 11	Protein Coding	4
38	H4C3	H4 Clustered Histone 3	Protein Coding	4
39	H4C8	H4 Clustered Histone 8	Protein Coding	4
40	H4C2	H4 Clustered Histone 2	Protein Coding	4
41	H4C5	H4 Clustered Histone 5	Protein Coding	4
42	H4C13	H4 Clustered Histone 13	Protein Coding	4
43	H4C14	H4 Clustered Histone 14	Protein Coding	4
44	H2BC12	H2B Clustered Histone 12	Protein Coding	4
45	H2BC11	H2B Clustered Histone 11	Protein Coding	4
46	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	4
47	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	3
48	CDK2	Cyclin Dependent Kinase 2	Protein Coding	3
49	CDK4	Cyclin Dependent Kinase 4	Protein Coding	3
50	STAG1	STAG1 Cohesin Complex Component	Protein Coding	3
51	SYCP2	Synaptonemal Complex Protein 2	Protein Coding	3
52	STAG3	STAG3 Cohesin Complex Component	Protein Coding	3
53	STAG2	STAG2 Cohesin Complex Component	Protein Coding	3
54	DIDO1	Death Inducer-Obliterator 1	Protein Coding	3
55	DMC1	DNA Meiotic Recombinase 1	Protein Coding	3
56	H3C14	H3 Clustered Histone 14	Protein Coding	3
57	SYNE2	Spectrin Repeat Containing Nuclear Envelope Protein 2	Protein Coding	3
58	SYNE1	Spectrin Repeat Containing Nuclear Envelope Protein 1	Protein Coding	3
59	SUN1	Sad1 And UNC84 Domain Containing 1	Protein Coding	3
60	SPO11	SPO11 Initiator Of Meiotic Double Strand Breaks	Protein Coding	3
61	SYCE2	Synaptonemal Complex Central Element Protein 2	Protein Coding	3
62	SUN2	Sad1 And UNC84 Domain Containing 2	Protein Coding	3
63	POT1	Protection Of Telomeres 1	Protein Coding	3
64	TINF2	TERF1 Interacting Nuclear Factor 2	Protein Coding	3
65	MLH3	MutL Homolog 3	Protein Coding	3
66	SMC1B	Structural Maintenance Of Chromosomes 1B	Protein Coding	3
67	PSMC3IP	PSMC3 Interacting Protein	Protein Coding	3
68	H3-3A	H3.3 Histone A	Protein Coding	3
69	H3-3B	H3.3 Histone B	Protein Coding	3
70	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	3
71	H3C15	H3 Clustered Histone 15	Protein Coding	3
72	LMNA	Lamin A/C	Protein Coding	3
73	LMNB1	Lamin B1	Protein Coding	3
74	MLH1	MutL Homolog 1	Protein Coding	3
75	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	3
76	MSH4	MutS Homolog 4	Protein Coding	3
77	MSH5	MutS Homolog 5	Protein Coding	3
78	NBN	Nibrin	Protein Coding	3
79	ATM	ATM Serine/Threonine Kinase	Protein Coding	3
80	SYCP3	Synaptonemal Complex Protein 3	Protein Coding	3
81	TERF2IP	TERF2 Interacting Protein	Protein Coding	3
82	ATR	ATR Checkpoint Kinase	Protein Coding	3
83	FIRRM	FIGNL1 Interacting Regulator Of Recombination And Mitosis	Protein Coding	3
84	TEX12	Testis Expressed 12	Protein Coding	3
85	PRDM9	PR/SET Domain 9	Protein Coding	3
86	RAD21	RAD21 Cohesin Complex Component	Protein Coding	3
87	RAD51	RAD51 Recombinase	Protein Coding	3
88	RAD51C	RAD51 Paralog C	Protein Coding	3
89	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	3
90	RPA1	Replication Protein A1	Protein Coding	3
91	RPA2	Replication Protein A2	Protein Coding	3
92	RPA3	Replication Protein A3	Protein Coding	3
93	FIGNL1	Fidgetin Like 1	Protein Coding	3
94	BLM	BLM RecQ Like Helicase	Protein Coding	3
95	SYCE3	Synaptonemal Complex Central Element Protein 3	Protein Coding	3
96	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	3
97	H3C13	H3 Clustered Histone 13	Protein Coding	3
98	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	3
99	SYCP1	Synaptonemal Complex Protein 1	Protein Coding	3
100	TERF1	Telomeric Repeat Binding Factor 1	Protein Coding	3
101	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	3
102	TOP3A	DNA Topoisomerase III Alpha	Protein Coding	3
103	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	3
104	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	3
105	H3C1	H3 Clustered Histone 1	Protein Coding	3
106	H3C4	H3 Clustered Histone 4	Protein Coding	3
107	H3C3	H3 Clustered Histone 3	Protein Coding	3
108	H3C6	H3 Clustered Histone 6	Protein Coding	3
109	H3C11	H3 Clustered Histone 11	Protein Coding	3
110	H3C8	H3 Clustered Histone 8	Protein Coding	3
111	H3C12	H3 Clustered Histone 12	Protein Coding	3
112	H3C10	H3 Clustered Histone 10	Protein Coding	3
113	H3C2	H3 Clustered Histone 2	Protein Coding	3
114	MND1	Meiotic Nuclear Divisions 1	Protein Coding	3
115	FKBP6	FKBP Prolyl Isomerase Family Member 6 (Inactive)	Protein Coding	3
116	H3C7	H3 Clustered Histone 7	Protein Coding	3
117	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	3
118	SYCE1	Synaptonemal Complex Central Element Protein 1	Protein Coding	3
119	REC8	REC8 Meiotic Recombination Protein	Protein Coding	3
120	PDPN	Podoplanin	Protein Coding	2
121	NANOS3	Nanos C2HC-Type Zinc Finger 3	Protein Coding	2
122	POU5F1	POU Class 5 Homeobox 1	Protein Coding	2
123	TET2	Tet Methylcytosine Dioxygenase 2	Protein Coding	2
124	PRDM1	PR/SET Domain 1	Protein Coding	2
125	SOX17	SRY-Box Transcription Factor 17	Protein Coding	2
126	BMP4	Bone Morphogenetic Protein 4	Protein Coding	2
127	TFAP2C	Transcription Factor AP-2 Gamma	Protein Coding	2
128	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	2
129	NANOG	Nanog Homeobox	Protein Coding	2
130	EOMES	Eomesodermin	Protein Coding	2
131	CBFA2T2	CBFA2/RUNX1 Partner Transcriptional Co-Repressor 2	Protein Coding	2
132	IZUMO3	IZUMO Family Member 3	Protein Coding	1
133	ADAM30	ADAM Metallopeptidase Domain 30	Protein Coding	1
134	IZUMO4	IZUMO Family Member 4	Protein Coding	1
135	CATSPER1	Cation Channel Sperm Associated 1	Protein Coding	1
136	CATSPER2	Cation Channel Sperm Associated 2	Protein Coding	1
137	IZUMO2	IZUMO Family Member 2	Protein Coding	1
138	KCNU1	Potassium Calcium-Activated Channel Subfamily U Member 1	Protein Coding	1
139	ZP1	Zona Pellucida Glycoprotein 1	Protein Coding	1
140	ADAM2	ADAM Metallopeptidase Domain 2	Protein Coding	1
141	CATSPERD	Catsper Channel Auxiliary Subunit Delta	Protein Coding	1
142	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	1
143	IZUMO1	Izumo Sperm-Oocyte Fusion 1	Protein Coding	1
144	CATSPER3	Cation Channel Sperm Associated 3	Protein Coding	1
145	CATSPER4	Cation Channel Sperm Associated 4	Protein Coding	1
146	ACR	Acrosin	Protein Coding	1
147	OVGP1	Oviductal Glycoprotein 1	Protein Coding	1
148	CATSPERG	Catsper Channel Auxiliary Subunit Gamma	Protein Coding	1
149	ZP4	Zona Pellucida Glycoprotein 4	Protein Coding	1
150	SPAM1	Sperm Adhesion Molecule 1	Protein Coding	1
151	ZP2	Zona Pellucida Glycoprotein 2	Protein Coding	1
152	ZP3	Zona Pellucida Glycoprotein 3	Protein Coding	1
153	CATSPERB	Catsper Channel Auxiliary Subunit Beta	Protein Coding	1
154	HVCN1	Hydrogen Voltage Gated Channel 1	Protein Coding	1
155	ADAM21	ADAM Metallopeptidase Domain 21	Protein Coding	1
156	ADAM20	ADAM Metallopeptidase Domain 20	Protein Coding	1
157	CD9	CD9 Molecule	Protein Coding	1

Disorders associated with Meiosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BLM, BRCA1, BRCA2, MLH1, MRE11, NBN, RAD50, RAD51, RAD51C	10.83
2	Breast cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, MLH1, MRE11, NBN, RAD50, RAD51, RAD51C	10.48
3	Endometrial cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, MLH1, MLH3, RAD51C	10.37
4	Hereditary breast carcinoma	Enrichment	ATM, BLM, BRCA1, BRCA2, MLH1, NBN, RAD50, RAD51	9.52
5	Gastric cancer	Enrichment	ATM, BRCA1, BRCA2, CDK4, MLH1, NBN, RAD51C	8.03
6	Inherited cancer-predisposing syndrome	Enrichment	ATM, BLM, BRCA1, BRCA2, CDK4, MLH1, MRE11, NBN, RAD50, RAD51C	7.94
7	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, NBN, RAD51C	7.92
8	Ovarian cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, MLH3, MRE11, NBN, RAD50, RAD51C	7.81
9	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	6.74
10	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, NBN, RBBP8	6.33
11	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, RAD51C	6.30
12	Primary ovarian insufficiency	Enrichment	MLH3, MND1, MSH4, NBN, RAD51C, REC8, STAG3	6.11
13	Emery-dreifuss muscular dystrophy 2, autosomal dominant	Enrichment	LMNA, SYNE1, SYNE2	5.44
14	Premature menopause	Enrichment	MSH4, NBN, REC8, STAG3	5.42
15	Oocyte/zygote/embryo maturation arrest 1	Enrichment	ZP1, ZP2, ZP3	5.22
16	Melanoma, cutaneous malignant 1	Enrichment	ACD, CDK4, POT1, TERF2IP	4.91
17	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC1A, SMC3	4.82
18	Cornelia de lange syndrome	Enrichment	RAD21, SMC1A, SMC3	4.82
19	Colorectal cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, MLH1, MLH3	4.71
20	Colonic benign neoplasm	Enrichment	ATM, MLH1, MRE11	4.68
21	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.49
22	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.49
23	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, NBN	4.48
24	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	4.39
25	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.39
26	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	4.39
27	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, RAD51, RAD51C	4.15
28	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.01
29	Oocyte/zygote/embryo maturation arrest 3	Enrichment	ZP1, ZP3	3.88
30	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	3.62
31	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	3.62
32	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	3.62
33	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2	3.40
34	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	3.32
35	Hoyeraal-hreidarsson syndrome	Enrichment	ACD, TINF2	3.32
36	Azoospermia	Enrichment	DMC1, MSH5, REC8	3.17
37	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2	3.08
38	Vesicoureteral reflux 3	Enrichment	SOX17	3.05
39	Whim syndrome 1	Enrichment	CXCR4	3.05
40	Microphthalmia, syndromic 6	Enrichment	BMP4	3.05
41	Orofacial cleft 11	Enrichment	BMP4	3.05
42	Pulmonary hypertension, primary, 7	Enrichment	SOX17	3.05
43	Myelodysplastic neoplasm with increased blasts type 2	Enrichment	TET2	3.05
44	Myelodysplastic neoplasm with increased blasts type 1	Enrichment	TET2	3.05
45	Microcephaly-polymicrogyria-corpus callosum agenesis syndrome	Enrichment	EOMES	3.05
46	Myelodysplastic neoplasm with low blasts	Enrichment	TET2	3.05
47	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	2.95
48	Immunodeficiency 75 with lymphoproliferation	Enrichment	TET2	2.75
49	Lynch syndrome 1	Enrichment	ATM, MLH1	2.75
50	Familial colorectal cancer type x	Enrichment	ATM, BRCA2	2.67
51	46 xx gonadal dysgenesis	Enrichment	MSH4, PSMC3IP	2.59
52	Familial vesicoureteral reflux	Enrichment	SOX17	2.58
53	Myelodysplastic syndrome with ring sideroblasts	Enrichment	TET2	2.58
54	Third-degree atrioventricular block	Enrichment	SYNE1, TET2	2.57
55	Leukemia, chronic lymphocytic	Enrichment	ATM, POT1	2.48
56	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	TET2	2.45
57	Myeloma, multiple	Enrichment	ATM, BRCA2, H3C1, TET2	2.40
58	Aggressive systemic mastocytosis	Enrichment	TET2	2.35
59	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2	2.34
60	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	2.33
61	Dyskeratosis congenita	Enrichment	POT1, TINF2	2.28
62	Anterior segment dysgenesis 5	Enrichment	BMP4	2.28
63	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.24
64	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	2.24
65	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.24
66	Holoprosencephaly 13, x-linked	Enrichment	STAG2	2.24
67	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	2.24
68	Seckel syndrome 1	Enrichment	ATR	2.24
69	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	2.24
70	Tumor predisposition syndrome 3	Enrichment	POT1	2.24
71	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8	Enrichment	POT1	2.24
72	Mullegama-klein-martinez syndrome	Enrichment	STAG2	2.24
73	Infant-type hemispheric glioma	Enrichment	BRCA1	2.24
74	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	2.24
75	Spermatogenic failure 15	Enrichment	SYCE1	2.24
76	Premature ovarian failure 8	Enrichment	STAG3	2.24
77	Intellectual developmental disorder, autosomal dominant 47	Enrichment	STAG1	2.24
78	Mungan syndrome	Enrichment	RAD21	2.24
79	High-grade astrocytoma with piloid features	Enrichment	POT1	2.24
80	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.24
81	Emery-dreifuss muscular dystrophy 5, autosomal dominant	Enrichment	SYNE2	2.24
82	Cerebroretinal microangiopathy with calcifications and cysts 3	Enrichment	POT1	2.24
83	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	2.24
84	Premature ovarian failure 12	Enrichment	SYCE1	2.24
85	Autosomal recessive myogenic arthrogryposis multiplex congenita	Enrichment	SYNE1	2.24
86	Atypical werner syndrome	Enrichment	LMNA	2.24
87	Xq25 microduplication syndrome	Enrichment	STAG2	2.24
88	Spermatogenic failure 61	Enrichment	STAG3	2.24
89	Spermatogenic failure 77	Enrichment	FKBP6	2.24
90	Mandibuloacral dysplasia	Enrichment	LMNA	2.24
91	Atrioventricular block	Enrichment	LMNA	2.24
92	Lmna-related cardiocutaneous progeria syndrome	Enrichment	LMNA	2.24
93	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.24
94	Autosomal semi-dominant severe lipodystrophic laminopathy	Enrichment	LMNA	2.24
95	Primary peritoneal carcinoma	Enrichment	BRCA1	2.24
96	Autosomal recessive axonal hereditary motor and sensory neuropathy	Enrichment	LMNA	2.24
97	Laminopathy	Enrichment	LMNA	2.24
98	Myelofibrosis	Enrichment	TET2	2.21
99	Essential thrombocythemia	Enrichment	TET2	2.21
100	Cardiomyopathy, dilated, 1a	Enrichment	LMNA, SYNE1	2.19
101	Bloom syndrome	Enrichment	BLM	2.19
102	Seckel syndrome 2	Enrichment	RBBP8	2.19
103	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.19
104	Spermatogenic failure 2	Enrichment	MSH4	2.19
105	Glioma susceptibility 3	Enrichment	BRCA2	2.19
106	Mirror movements 2	Enrichment	RAD51	2.19
107	Colorectal cancer, hereditary nonpolyposis, type 7	Enrichment	MLH3	2.19
108	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.19
109	Fanconi anemia, complementation group r	Enrichment	RAD51	2.19
110	Lynch syndrome 2	Enrichment	MLH1	2.19
111	Pancreatic cancer 2	Enrichment	BRCA2	2.19
112	Jawad syndrome	Enrichment	RBBP8	2.19
113	Premature ovarian failure 20	Enrichment	MSH4	2.19
114	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.19
115	Endometrial serous adenocarcinoma	Enrichment	ATM	2.19
116	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.19
117	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 5	Enrichment	TOP3A	2.19
118	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.19
119	Diffuse large b-cell lymphoma	Enrichment	BRCA2, NBN	2.19
120	Seckel syndrome	Enrichment	ATR, RBBP8	2.19
121	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	TET2	2.10
122	Hepatocellular carcinoma	Enrichment	NBN, RAD50	2.06
123	Peters-plus syndrome	Enrichment	BMP4	2.05
124	Stickler syndrome	Enrichment	BMP4	2.05
125	Myelodysplastic syndrome	Enrichment	TET2	2.01
126	Heritable pulmonary arterial hypertension	Enrichment	SOX17	2.01
127	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.98
128	Pulmonary hypertension, primary, 1	Enrichment	SOX17	1.94
129	Chromosome 1p36 deletion syndrome	Enrichment	PDPN	1.94
130	Mandibuloacral dysplasia with type a lipodystrophy	Enrichment	LMNA	1.94
131	Revesz syndrome	Enrichment	TINF2	1.94
132	Spermatogenic failure 4	Enrichment	SYCP3	1.94
133	Cornelia de lange syndrome 2	Enrichment	SMC1A	1.94
134	Heart-hand syndrome, slovenian type	Enrichment	LMNA	1.94
135	Charcot-marie-tooth disease, axonal, type 2b1	Enrichment	LMNA	1.94
136	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	Enrichment	LMNA	1.94
137	Cardiomyopathy, dilated, 1d	Enrichment	LMNA	1.94
138	Restrictive dermopathy 2	Enrichment	LMNA	1.94
139	Emery-dreifuss muscular dystrophy 3, autosomal recessive	Enrichment	LMNA	1.94
140	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.94
141	Dyskeratosis congenita, autosomal dominant 3	Enrichment	TINF2	1.94
142	Pancreatic cancer 4	Enrichment	BRCA1	1.94
143	Lipodystrophy, familial partial, type 1	Enrichment	LMNA	1.94
144	Oligodendroglioma	Enrichment	POT1	1.94
145	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.94
146	Anaplastic oligodendroglioma	Enrichment	POT1	1.94
147	Peritoneum cancer	Enrichment	BRCA1	1.94
148	Familial partial lipodystrophy	Enrichment	LMNA	1.94
149	Charcot-marie-tooth disease type 2b1	Enrichment	LMNA	1.94
150	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	1.94
151	Spermatogenic failure 79	Enrichment	KCNU1	1.94
152	Oocyte/zygote/embryo maturation arrest 6	Enrichment	ZP2	1.94
153	Spermatogenic failure 87	Enrichment	ACR	1.94
154	Combined low ldl and fibrinogen	Enrichment	B4GALT1	1.94
155	Cleft lip/palate	Enrichment	BMP4	1.91
156	Muir-torre syndrome	Enrichment	MLH1	1.89
157	Ovarian dysgenesis 3	Enrichment	PSMC3IP	1.89
158	Premature ovarian failure 13	Enrichment	MSH5	1.89
159	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.89
160	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2	1.89
161	Spermatogenic failure 74	Enrichment	MSH5	1.89
162	High grade glioma	Enrichment	ATM	1.89
163	Fanconi anemia, complementation group d1	Enrichment	BRCA2	1.89
164	T-cell prolymphocytic leukemia	Enrichment	ATM	1.89
165	Microcephaly, growth restriction, and increased sister chromatid exchange 2	Enrichment	TOP3A	1.89
166	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	1.89
167	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	MSH5, STAG3, SYCE1	1.89
168	Restrictive dermopathy 1	Enrichment	LMNA	1.77
169	Lipodystrophy, familial partial, type 2	Enrichment	LMNA	1.77
170	Dyskeratosis congenita, autosomal dominant 6	Enrichment	ACD	1.77
171	Muscular dystrophy, congenital, lmna-related	Enrichment	LMNA	1.77
172	Restrictive dermopathy	Enrichment	LMNA	1.77
173	Lung cancer	Enrichment	BRCA1, MLH1	1.75
174	Ataxia-telangiectasia	Enrichment	ATM	1.72
175	Nijmegen breakage syndrome	Enrichment	NBN	1.72
176	Polycythemia vera	Enrichment	ATM	1.72
177	Breast-ovarian cancer, familial 3	Enrichment	RAD51C	1.72
178	Tumor predisposition syndrome 1	Enrichment	BRCA2	1.72
179	Fanconi anemia, complementation group o	Enrichment	RAD51C	1.72
180	Koolen-de vries syndrome	Enrichment	ATM	1.72
181	Dedifferentiated liposarcoma	Enrichment	CDK4	1.72
182	Adenocarcinoma	Enrichment	ATM	1.72
183	Hereditary site-specific ovarian cancer syndrome	Enrichment	RAD51C	1.72
184	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	1.72
185	Well-differentiated liposarcoma	Enrichment	CDK4	1.72
186	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	1.64
187	Hutchinson-gilford progeria syndrome	Enrichment	LMNA	1.64
188	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	LMNA	1.64
189	Microtia-anotia	Enrichment	LMNA	1.64
190	Spermatogenic failure 1	Enrichment	SYCP2	1.64
191	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	SYNE1	1.64
192	Emery-dreifuss muscular dystrophy	Enrichment	LMNA	1.64
193	Sick sinus syndrome	Enrichment	LMNA	1.64
194	Spermatogenic failure 7	Enrichment	CATSPER1	1.64
195	Mirror movements 1	Enrichment	RAD51	1.59
196	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.59
197	Chordoma	Enrichment	BRCA2	1.59
198	Mismatch repair cancer syndrome 1	Enrichment	MLH1	1.59
199	Mantle cell lymphoma	Enrichment	ATM	1.59
200	Oculomotor apraxia	Enrichment	ATM	1.59
201	Glutaric acidemia i	Enrichment	SYCE2	1.55
202	Spinocerebellar ataxia, autosomal recessive 8	Enrichment	SYNE1	1.55
203	Autosomal recessive cerebellar ataxia	Enrichment	SYNE1	1.55
204	Autosomal recessive limb-girdle muscular dystrophy type 2b	Enrichment	LMNA	1.55
205	Emery-dreifuss muscular dystrophy 4, autosomal dominant	Enrichment	SYNE1	1.55
206	Histiocytoid hemangioma	Enrichment	LMNA	1.55
207	Glioblastoma	Enrichment	ATM	1.50
208	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TINF2	1.47
209	Hyperphenylalaninemia, bh4-deficient, a	Enrichment	TEX12	1.47
210	Complex neurodevelopmental disorder	Enrichment	H4C3, H4C5, H4C9	1.46
211	Leukemia, acute myeloid	Enrichment	TET2	1.46
212	Spastic ataxia	Enrichment	SYNE1, SYNE2	1.43
213	Kabuki syndrome 1	Enrichment	BRCA2	1.42
214	Clear cell renal cell carcinoma	Enrichment	ATM	1.42
215	Bethlem myopathy 1a	Enrichment	LMNA	1.40
216	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TINF2	1.40
217	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.36
218	Rett syndrome, congenital variant	Enrichment	SMC1A	1.35
219	Congenital muscular dystrophy	Enrichment	LMNA	1.35
220	Myocarditis	Enrichment	LMNA	1.35
221	Deafness-infertility syndrome	Enrichment	CATSPER2	1.34
222	Cerebral palsy	Enrichment	BRCA2, SYNE2	1.34
223	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2	1.30
224	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	LMNA	1.30
225	Juvenile amyotrophic lateral sclerosis	Enrichment	SYNE1	1.30
226	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2	1.25
227	Polydactyly	Enrichment	BRCA2	1.25
228	Male infertility	Enrichment	CATSPERB, FKBP6	1.23
229	Aplastic anemia	Enrichment	NBN	1.21
230	Familial colorectal cancer	Enrichment	MLH1	1.21
231	Isolated tracheo-esophageal fistula	Enrichment	BRCA2	1.21
232	Cardiac conduction defect	Enrichment	LMNA	1.17
233	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	LMNA	1.17
234	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	LMNA	1.17
235	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	LMNA	1.17
236	Immune deficiency disease	Enrichment	ATM	1.17
237	Leukemia, acute lymphoblastic	Enrichment	NBN	1.17
238	Periventricular nodular heterotopia	Enrichment	BRCA1	1.11
239	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	LMNA	1.11
240	Oligospermia	Enrichment	MSH4	1.10
241	Medulloblastoma	Enrichment	BRCA2	1.06
242	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	LMNA	1.05
243	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.04
244	Wilms tumor 1	Enrichment	BRCA2	1.04
245	Lynch syndrome	Enrichment	MLH1	1.04
246	Cardiomyopathy, dilated, 1e	Enrichment	LMNA	1.03
247	Alobar holoprosencephaly	Enrichment	STAG2	1.03
248	Gliosarcoma	Enrichment	ATM	1.01
249	Neuromuscular disease	Enrichment	LMNA	1.01
250	Giant cell glioblastoma	Enrichment	ATM	0.98
251	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	LMNA	0.98
252	Williams-beuren syndrome	Enrichment	FKBP6	0.96
253	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2	0.94
254	Lissencephaly	Enrichment	NBN	0.90
255	Hepatoblastoma	Enrichment	BRCA2	0.90
256	Cardiomyopathy, familial hypertrophic, 1	Enrichment	LMNA	0.89
257	Muscular dystrophy	Enrichment	LMNA	0.89
258	Brugada syndrome	Enrichment	LMNA	0.86
259	Long qt syndrome	Enrichment	LMNA	0.79
260	Peripheral nervous system disease	Enrichment	LMNA	0.77
261	Neuropathy	Enrichment	LMNA	0.77
262	Left ventricular noncompaction	Enrichment	LMNA	0.74
263	Charcot-marie-tooth disease	Enrichment	LMNA	0.68
264	Non-syndromic male infertility due to sperm motility disorder	Enrichment	CATSPER1	0.63
265	Familial isolated dilated cardiomyopathy	Enrichment	LMNA	0.58
266	Microcephaly	Enrichment	NBN, SMC1A	0.53
267	Dilated cardiomyopathy	Enrichment	LMNA	0.43
268	Mitochondrial disease	Enrichment	TOP3A	0.37
269	Congenital nervous system abnormality	Enrichment	SMC1A	0.34
270	Nervous system disease	Enrichment	SMC1A	0.34
271	Autism spectrum disorder	Enrichment	SMC3	0.33
272	Rare genetic deafness	Enrichment	CATSPER2	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Meiosis

Pathway Network for Meiosis

Pathway network for the Meiosis SuperPath

Member Pathways for Meiosis

Pathways in the Meiosis SuperPath

Gene overlap in member pathways for Meiosis SuperPath

Associated Genes for Meiosis

Associated Disorders for Meiosis

Disorders associated with Meiosis SuperPath

STRING Interaction Network for Meiosis

Sources for Meiosis