Melatonin metabolism and effects

No Pathway Network information available for Melatonin metabolism and effects

Pathways in the Melatonin metabolism and effects SuperPath

#	Name	Source	Genes
1	Melatonin metabolism and effects	WikiPathways	AANAT ACHE ADRB1 ASMT BMAL1 CALM1 CAMK2A CLOCK CRY1 CRY2 CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2D6 ECE1 EDN1 FOXO1 GSK3B IRAK1 MAP2 MTNR1A MTNR1B NFKB1 PER1 PER2 PER3 PRKCA SIRT1 SULT1A1 TRAF6 (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PER2	Period Circadian Regulator 2	Protein Coding	1
2	PER3	Period Circadian Regulator 3	Protein Coding	1
3	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
4	CALM1	Calmodulin 1	Protein Coding	1
5	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
6	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	1
7	PRKCA	Protein Kinase C Alpha	Protein Coding	1
8	PER1	Period Circadian Regulator 1	Protein Coding	1
9	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
10	MTNR1B	Melatonin Receptor 1B	Protein Coding	1
11	MTNR1A	Melatonin Receptor 1A	Protein Coding	1
12	ASMT	Acetylserotonin O-Methyltransferase	Protein Coding	1
13	ACHE	Acetylcholinesterase (Yt Blood Group)	Protein Coding	1
14	MAP2	Microtubule Associated Protein 2	Protein Coding	1
15	BMAL1	Basic Helix-Loop-Helix ARNT Like 1	Protein Coding	1
16	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
17	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
18	SIRT1	Sirtuin 1	Protein Coding	1
19	FOXO1	Forkhead Box O1	Protein Coding	1
20	EDN1	Endothelin 1	Protein Coding	1
21	ECE1	Endothelin Converting Enzyme 1	Protein Coding	1
22	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	1
23	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	1
24	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	1
25	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
26	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
27	ADRB1	Adrenoceptor Beta 1	Protein Coding	1
28	AANAT	Aralkylamine N-Acetyltransferase	Protein Coding	1
29	CRY2	Cryptochrome Circadian Regulator 2	Protein Coding	1
30	CRY1	Cryptochrome Circadian Regulator 1	Protein Coding	1
31	CLOCK	Clock Circadian Regulator	Protein Coding	1

Disorders associated with Melatonin metabolism and effects SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Advanced sleep phase syndrome	Enrichment	PER2, PER3	4.82
2	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.64
3	Advanced sleep phase syndrome, familial, 1	Enrichment	PER2	2.64
4	Resting heart rate, variation in	Enrichment	ADRB1	2.64
5	Yt blood group antigen	Enrichment	ACHE	2.64
6	Advanced sleep phase syndrome, familial, 3	Enrichment	PER3	2.64
7	Auriculocondylar syndrome 3	Enrichment	EDN1	2.64
8	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.64
9	Question mark ears, isolated	Enrichment	EDN1	2.64
10	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.64
11	Hirschsprung disease, cardiac defects, and autonomic dysfunction	Enrichment	ECE1	2.64
12	Delayed sleep phase disorder	Enrichment	CRY1	2.64
13	Short sleep, familial natural, 2	Enrichment	ADRB1	2.64
14	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.64
15	Glaucoma 1, open angle, a	Enrichment	CYP1B1	2.34
16	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.34
17	Homocystinuria-megaloblastic anemia, cble type	Enrichment	PER3	2.34
18	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.34
19	Long qt syndrome 14	Enrichment	CALM1	2.34
20	Anterior segment dysgenesis 6	Enrichment	CYP1B1	2.34
21	Primary congenital glaucoma	Enrichment	CYP1B1	2.34
22	Common variable immunodeficiency 12	Enrichment	NFKB1	2.34
23	Auriculocondylar syndrome 1	Enrichment	EDN1	2.04
24	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	2.04
25	Pediatric systemic lupus erythematosus	Enrichment	IRAK1	2.04
26	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.94
27	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.94
28	Juvenile glaucoma	Enrichment	CYP1B1	1.94
29	Glaucoma, primary open angle	Enrichment	CYP1B1	1.87
30	Anterior segment dysgenesis 5	Enrichment	CYP1B1	1.87
31	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.87
32	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	1.80
33	Common variable immunodeficiency	Enrichment	NFKB1	1.80
34	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.74
35	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.74
36	Peters-plus syndrome	Enrichment	CYP1B1	1.65
37	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.65
38	Anterior segment dysgenesis	Enrichment	CYP1B1	1.47
39	Hypertension, essential	Enrichment	ECE1	1.42
40	Diffuse large b-cell lymphoma	Enrichment	FOXO1	1.37
41	Hirschsprung disease 1	Enrichment	ECE1	1.19
42	Long qt syndrome 1	Enrichment	CALM1	1.18
43	Long qt syndrome	Enrichment	CALM1	1.16
44	Systemic lupus erythematosus	Enrichment	IRAK1	1.07
45	Type 2 diabetes mellitus	Enrichment	MTNR1B	1.04
46	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A	0.97

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Melatonin metabolism and effects

Pathway Network for Melatonin metabolism and effects

Member Pathways for Melatonin metabolism and effects

Pathways in the Melatonin metabolism and effects SuperPath

Associated Genes for Melatonin metabolism and effects

Associated Disorders for Melatonin metabolism and effects

Disorders associated with Melatonin metabolism and effects SuperPath

STRING Interaction Network for Melatonin metabolism and effects

Sources for Melatonin metabolism and effects