MET promotes cell motility

Pathway network for the MET promotes cell motility SuperPath

Sources:

Reactome
PubChem

Pathways in the MET promotes cell motility SuperPath

#	Name	Source	Genes
1	MET promotes cell motility	Reactome	COL11A1 COL11A2 COL1A1 COL1A2 COL24A1 COL27A1 COL2A1 COL3A1 COL5A1 COL5A2 COL5A3 CRK CRKL DOCK7 FN1 GAB1 GRB2 HGF ITGA2 ITGA3 ITGB1 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 MET PTK2 RAC1 RAP1A RAP1B RAPGEF1 SRC TNS3 TNS4 (see all 41) (see less)
2	Signaling by MET	Reactome	ARF6 CBL COL11A1 COL11A2 COL1A1 COL1A2 COL24A1 COL27A1 COL2A1 COL3A1 COL5A1 COL5A2 COL5A3 CRK CRKL DOCK7 EPS15 FN1 GAB1 GGA3 GRB2 HGF HGFAC HGS HPN HRAS ITGA2 ITGA3 ITGB1 KRAS LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 LRIG1 MET MUC20 NRAS PIK3CA PIK3R1 PTK2 PTPN1 PTPN11 PTPN2 PTPRJ RAB4A RAB4B RAC1 RANBP10 RANBP9 RAP1A RAP1B RAPGEF1 RPS27A SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SHC1 SOS1 SPINT1 SPINT2 SRC STAM STAM2 STAT3 TNS3 TNS4 UBA52 UBB UBC USP8 (see all 79) (see less)
3	Beta1 integrin cell surface interactions	PubChem	CD14 CD81 COL11A1 COL11A2 COL18A1 COL1A1 COL1A2 COL2A1 COL3A1 COL5A1 COL5A2 COL6A1 COL6A2 COL6A3 COL7A1 CSPG4 F13A1 FBN1 FGA FGB FGG FN1 IGSF8 ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAV ITGB1 JAM2 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 MDK NID1 NPNT PLAU PLAUR SPP1 TGFBI TGM2 THBS1 THBS2 TNC VCAM1 VEGFA VTN (see all 61) (see less)
4	MET activates PTK2 signaling	Reactome	COL11A1 COL11A2 COL1A1 COL1A2 COL24A1 COL27A1 COL2A1 COL3A1 COL5A1 COL5A2 COL5A3 FN1 HGF ITGA2 ITGA3 ITGB1 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 MET PTK2 SRC (see all 30) (see less)
5	MET activates RAP1 and RAC1	Reactome	CRK CRKL DOCK7 GAB1 GRB2 HGF MET RAC1 RAP1A RAP1B RAPGEF1 (see all 11) (see less)
6	MET activates RAS signaling	Reactome	GRB2 HGF HRAS KRAS MET MUC20 NRAS RANBP10 RANBP9 SHC1 SOS1 (see all 11) (see less)
7	MET receptor recycling	Reactome	ARF6 CRK CRKL GAB1 GGA3 GRB2 HGF MET RAB4A RAB4B (see all 10) (see less)
8	MET Receptor Activation	Reactome	HGF HGFAC HPN MET SPINT1 SPINT2 (see all 6) (see less)
9	MET interacts with TNS proteins	Reactome	HGF ITGB1 MET TNS3 TNS4

Gene overlap in member pathways for MET promotes cell motility SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HGF	Hepatocyte Growth Factor	Protein Coding	8
2	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	8
3	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	5
4	ITGB1	Integrin Subunit Beta 1	Protein Coding	5
5	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	4
6	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	4
7	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	4
8	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	4
9	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	4
10	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	4
11	COL11A1	Collagen Type XI Alpha 1 Chain	Protein Coding	4
12	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	4
13	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	4
14	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	4
15	FN1	Fibronectin 1	Protein Coding	4
16	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	4
17	LAMA1	Laminin Subunit Alpha 1	Protein Coding	4
18	ITGA2	Integrin Subunit Alpha 2	Protein Coding	4
19	ITGA3	Integrin Subunit Alpha 3	Protein Coding	4
20	LAMA2	Laminin Subunit Alpha 2	Protein Coding	4
21	LAMA3	Laminin Subunit Alpha 3	Protein Coding	4
22	LAMA4	Laminin Subunit Alpha 4	Protein Coding	4
23	LAMA5	Laminin Subunit Alpha 5	Protein Coding	4
24	LAMB1	Laminin Subunit Beta 1	Protein Coding	4
25	LAMB2	Laminin Subunit Beta 2	Protein Coding	4
26	LAMB3	Laminin Subunit Beta 3	Protein Coding	4
27	LAMC1	Laminin Subunit Gamma 1	Protein Coding	4
28	LAMC2	Laminin Subunit Gamma 2	Protein Coding	4
29	LAMC3	Laminin Subunit Gamma 3	Protein Coding	3
30	COL24A1	Collagen Type XXIV Alpha 1 Chain	Protein Coding	3
31	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	3
32	COL5A3	Collagen Type V Alpha 3 Chain	Protein Coding	3
33	PTK2	Protein Tyrosine Kinase 2	Protein Coding	3
34	RAC1	Rac Family Small GTPase 1	Protein Coding	3
35	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	3
36	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	3
37	TNS3	Tensin 3	Protein Coding	3
38	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	3
39	TNS4	Tensin 4	Protein Coding	3
40	COL27A1	Collagen Type XXVII Alpha 1 Chain	Protein Coding	3
41	DOCK7	Dedicator Of Cytokinesis 7	Protein Coding	3
42	RANBP9	RAN Binding Protein 9	Protein Coding	2
43	SPINT2	Serine Peptidase Inhibitor, Kunitz Type 2	Protein Coding	2
44	MUC20	Mucin 20, Cell Surface Associated	Protein Coding	2
45	GGA3	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3	Protein Coding	2
46	HGFAC	HGF Activator	Protein Coding	2
47	HPN	Hepsin	Protein Coding	2
48	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
49	ARF6	ARF GTPase 6	Protein Coding	2
50	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
51	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
52	RAB4B	RAB4B, Member RAS Oncogene Family	Protein Coding	2
53	RANBP10	RAN Binding Protein 10	Protein Coding	2
54	RAB4A	RAB4A, Member RAS Oncogene Family	Protein Coding	2
55	SHC1	SHC Adaptor Protein 1	Protein Coding	2
56	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
57	SPINT1	Serine Peptidase Inhibitor, Kunitz Type 1	Protein Coding	2
58	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	1
59	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	1
60	LRIG1	Leucine Rich Repeats And Immunoglobulin Like Domains 1	Protein Coding	1
61	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	1
62	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
63	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
64	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
65	PTPN2	Protein Tyrosine Phosphatase Non-Receptor Type 2	Protein Coding	1
66	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
67	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	1
68	RPS27A	Ribosomal Protein S27a	Protein Coding	1
69	SH3GL1	SH3 Domain Containing GRB2 Like 1, Endophilin A2	Protein Coding	1
70	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	1
71	SH3GL3	SH3 Domain Containing GRB2 Like 3, Endophilin A3	Protein Coding	1
72	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
73	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
74	UBB	Ubiquitin B	Protein Coding	1
75	UBC	Ubiquitin C	Protein Coding	1
76	STAM	Signal Transducing Adaptor Molecule	Protein Coding	1
77	CBL	Cbl Proto-Oncogene	Protein Coding	1
78	USP8	Ubiquitin Specific Peptidase 8	Protein Coding	1
79	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	1
80	IGSF8	Immunoglobulin Superfamily Member 8	Protein Coding	1
81	CSPG4	Chondroitin Sulfate Proteoglycan 4	Protein Coding	1
82	THBS2	Thrombospondin 2	Protein Coding	1
83	TGM2	Transglutaminase 2	Protein Coding	1
84	COL6A2	Collagen Type VI Alpha 2 Chain	Protein Coding	1
85	COL6A1	Collagen Type VI Alpha 1 Chain	Protein Coding	1
86	COL7A1	Collagen Type VII Alpha 1 Chain	Protein Coding	1
87	COL6A3	Collagen Type VI Alpha 3 Chain	Protein Coding	1
88	TGFBI	Transforming Growth Factor Beta Induced	Protein Coding	1
89	NPNT	Nephronectin	Protein Coding	1
90	CD14	CD14 Molecule	Protein Coding	1
91	CD81	CD81 Molecule	Protein Coding	1
92	MDK	Midkine	Protein Coding	1
93	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
94	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
95	F13A1	Coagulation Factor XIII A Chain	Protein Coding	1
96	JAM2	Junctional Adhesion Molecule 2	Protein Coding	1
97	FGA	Fibrinogen Alpha Chain	Protein Coding	1
98	FGB	Fibrinogen Beta Chain	Protein Coding	1
99	ITGA7	Integrin Subunit Alpha 7	Protein Coding	1
100	COL18A1	Collagen Type XVIII Alpha 1 Chain	Protein Coding	1
101	FGG	Fibrinogen Gamma Chain	Protein Coding	1
102	FBN1	Fibrillin 1	Protein Coding	1
103	TNC	Tenascin C	Protein Coding	1
104	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
105	NID1	Nidogen 1	Protein Coding	1
106	VTN	Vitronectin	Protein Coding	1
107	ITGA11	Integrin Subunit Alpha 11	Protein Coding	1
108	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
109	THBS1	Thrombospondin 1	Protein Coding	1
110	ITGA8	Integrin Subunit Alpha 8	Protein Coding	1
111	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
112	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
113	ITGA9	Integrin Subunit Alpha 9	Protein Coding	1
114	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
115	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
116	ITGA10	Integrin Subunit Alpha 10	Protein Coding	1
117	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
118	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1

Disorders associated with MET promotes cell motility SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL3A1, COL5A1, COL5A2, THBS2	9.80
2	Noonan syndrome and noonan-related syndrome	Enrichment	CBL, HRAS, KRAS, NRAS, PTPN11, SOS1	9.79
3	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2, COL5A1, COL5A2	9.50
4	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL5A1, COL5A2	9.50
5	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.80
6	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	8.68
7	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	8.46
8	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	7.86
9	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	7.86
10	Junctional epidermolysis bullosa	Enrichment	ITGA6, LAMA3, LAMB3, LAMC2	7.34
11	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	7.19
12	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.06
13	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	7.06
14	Collagen vi-related dystrophies	Enrichment	COL6A1, COL6A2, COL6A3	7.06
15	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	7.06
16	Intermediate collagen vi-related muscular dystrophy	Enrichment	COL6A1, COL6A2, COL6A3	7.06
17	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	LAMA3, LAMB3, LAMC2	6.71
18	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3, LAMB3, LAMC2	6.71
19	Junctional epidermolysis bullosa non-herlitz type	Enrichment	LAMA3, LAMB3, LAMC2	6.71
20	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.46
21	Bethlem muscular dystrophy	Enrichment	COL6A1, COL6A2, COL6A3	6.46
22	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, PTPN11	6.29
23	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.22
24	Ullrich congenital muscular dystrophy 1a	Enrichment	COL6A1, COL6A2, COL6A3	6.07
25	Epidermolysis bullosa	Enrichment	COL7A1, ITGA6, LAMB3	6.07
26	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	5.84
27	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1, COL5A1, COL5A2, FBN1	5.83
28	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.75
29	Nephrotic syndrome	Enrichment	FN1, ITGA3, LAMA5, LAMB2	5.65
30	Bethlem myopathy 1a	Enrichment	COL6A1, COL6A2, COL6A3	5.52
31	Osteoporosis	Enrichment	COL1A1, COL1A2, SRC	5.46
32	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.45
33	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	COL2A1, FN1	5.33
34	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	COL2A1, FN1	5.33
35	Otospondylomegaepiphyseal dysplasia, autosomal recessive	Enrichment	COL11A2, COL2A1	5.33
36	Otospondylomegaepiphyseal dysplasia, autosomal dominant	Enrichment	COL11A2, COL2A1	5.33
37	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	5.33
38	Fibrochondrogenesis	Enrichment	COL11A1, COL11A2	5.33
39	Stickler syndrome, type ii	Enrichment	COL11A1, COL1A1	5.33
40	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	5.33
41	Colorectal cancer	Enrichment	MET, NRAS, PIK3CA, PIK3R1, PTPRJ, SRC	4.95
42	Connective tissue disease	Enrichment	COL11A1, COL2A1, COL5A1, FBN1	4.92
43	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.90
44	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.90
45	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.90
46	Telecanthus	Enrichment	COL11A1, COL5A2	4.85
47	Ehlers-danlos syndrome, classic type, 2	Enrichment	COL5A1, COL5A2	4.85
48	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.85
49	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.78
50	Aortic dissection	Enrichment	COL3A1, FBN1	4.70
51	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.55
52	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.55
53	Myopathy	Enrichment	COL6A1, COL6A2, COL6A3, FBN1	4.52
54	Myopia	Enrichment	COL11A1, COL2A1, FBN1	4.42
55	Mccune-albright syndrome	Enrichment	COL2A1, FBN1	4.23
56	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	4.15
57	Keratoconus	Enrichment	COL1A1, COL5A2	4.15
58	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	4.01
59	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.00
60	Skin disease	Enrichment	COL7A1, LAMB3, LAMC2	3.90
61	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.70
62	Stickler syndrome	Enrichment	COL11A1, COL2A1	3.68
63	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.68
64	Bladder cancer	Enrichment	HRAS, KRAS	3.62
65	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.59
66	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.56
67	Lung cancer	Enrichment	KRAS, MET	3.53
68	Inguinal hernia	Enrichment	COL5A1, FBN1	3.53
69	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	3.44
70	Deafness, autosomal recessive 39	Enrichment	HGF	3.43
71	Osteofibrous dysplasia	Enrichment	MET	3.43
72	Deafness, autosomal recessive 97	Enrichment	MET	3.43
73	Autism 9	Enrichment	MET	3.43
74	Arthrogryposis, distal, type 11	Enrichment	MET	3.43
75	Thrombophilia due to thrombin defect	Enrichment	F13A1, FGA	3.39
76	Intervertebral disc disease	Enrichment	COL11A1, THBS2	3.39
77	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	3.38
78	Multiple sclerosis	Enrichment	LAMA5, LAMB1	3.37
79	Syndromic congenital sodium diarrhea	Enrichment	SPINT2	3.35
80	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.34
81	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	3.31
82	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	3.31
83	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.31
84	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1, FGG	3.26
85	Orthostatic intolerance	Enrichment	COL5A1, FBN1	3.26
86	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.16
87	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.16
88	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1, FBN1	3.15
89	Renal agenesis, bilateral	Enrichment	ITGA8, NPNT	3.15
90	Heart, malformation of	Enrichment	COL11A2, COL2A1	3.15
91	Childhood hepatocellular carcinoma	Enrichment	MET	3.13
92	Papillary renal cell carcinoma	Enrichment	MET	3.13
93	Deafness, autosomal recessive 26	Enrichment	GAB1	3.13
94	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	3.09
95	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	3.09
96	Oculoectodermal syndrome	Enrichment	KRAS	3.09
97	Noonan syndrome 4	Enrichment	SOS1	3.09
98	Melanosis, neurocutaneous	Enrichment	NRAS	3.09
99	Noonan syndrome 6	Enrichment	NRAS	3.09
100	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.09
101	Congenital pulmonary airway malformation	Enrichment	KRAS	3.09
102	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.09
103	Neurocutaneous melanocytosis	Enrichment	NRAS	3.09
104	Marfan syndrome	Enrichment	COL2A1, FBN1	3.06
105	Renal cell carcinoma	Enrichment	MET	2.96
106	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.93
107	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	2.93
108	Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies	Enrichment	SPINT2	2.88
109	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	2.84
110	Nephrotic syndrome, type 17	Enrichment	GGA3	2.83
111	Breast cancer	Enrichment	KRAS, SHC1	2.79
112	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.79
113	Hypobetalipoproteinemia, familial, 2	Enrichment	DOCK7	2.79
114	Developmental and epileptic encephalopathy 23	Enrichment	DOCK7	2.79
115	Fibromatosis, gingival, 1	Enrichment	SOS1	2.79
116	Costello syndrome	Enrichment	HRAS	2.79
117	Pulmonic stenosis	Enrichment	SOS1	2.79
118	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.79
119	Wooly hair nevus	Enrichment	HRAS	2.79
120	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	COL11A1, COL11A2, TNC	2.79
121	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1, FBN1	2.76
122	Cataract	Enrichment	COL18A1, COL5A1	2.76
123	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.67
124	Stickler syndrome, type i	Enrichment	COL2A1	2.66
125	Epiphyseal dysplasia, multiple, with myopia and conductive deafness	Enrichment	COL2A1	2.66
126	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.66
127	Spondylometaphyseal dysplasia, algerian type	Enrichment	COL2A1	2.66
128	Deafness, autosomal recessive 53	Enrichment	COL11A2	2.66
129	Osteoarthritis with mild chondrodysplasia	Enrichment	COL2A1	2.66
130	Avascular necrosis of femoral head, primary, 1	Enrichment	COL2A1	2.66
131	Czech dysplasia	Enrichment	COL2A1	2.66
132	Marshall syndrome	Enrichment	COL11A1	2.66
133	Kniest dysplasia	Enrichment	COL2A1	2.66
134	Cardiomyopathy, dilated, 1jj	Enrichment	LAMA4	2.66
135	Platyspondylic lethal skeletal dysplasia, torrance type	Enrichment	COL2A1	2.66
136	Fibrochondrogenesis 1	Enrichment	COL11A1	2.66
137	Spondyloepiphyseal dysplasia, stanescu type	Enrichment	COL2A1	2.66
138	Lissencephaly 5	Enrichment	LAMB1	2.66
139	Acrogeria, gottron type	Enrichment	COL3A1	2.66
140	Achondrogenesis, type ii	Enrichment	COL2A1	2.66
141	Nephrotic syndrome, type 26	Enrichment	LAMA5	2.66
142	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.66
143	Spondyloperipheral dysplasia	Enrichment	COL2A1	2.66
144	Deafness, autosomal dominant 37	Enrichment	COL11A1	2.66
145	Deafness, autosomal dominant 13	Enrichment	COL11A2	2.66
146	Stickler syndrome, type i, nonsyndromic ocular	Enrichment	COL2A1	2.66
147	Cortical malformations, occipital	Enrichment	LAMC3	2.66
148	Fibrochondrogenesis 2	Enrichment	COL11A2	2.66
149	Thrombocytopenia 6	Enrichment	SRC	2.66
150	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	2.66
151	Vitreoretinopathy with phalangeal epiphyseal dysplasia	Enrichment	COL2A1	2.66
152	Asphyxia neonatorum	Enrichment	COL1A1	2.66
153	Occipital pachygyria and polymicrogyria	Enrichment	LAMC3	2.66
154	Autosomal dominant rhegmatogenous retinal detachment	Enrichment	COL2A1	2.66
155	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.66
156	Multiple epiphyseal dysplasia with myopia and deafness	Enrichment	COL2A1	2.66
157	Hypochondrogenesis	Enrichment	COL2A1	2.66
158	Pneumothorax	Enrichment	COL5A1	2.66
159	Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome	Enrichment	COL11A1	2.66
160	Dysspondyloenchondromatosis	Enrichment	COL2A1	2.66
161	Cystic lymphangioma	Enrichment	COL11A2	2.66
162	Abdominal aortic aneurysm	Enrichment	COL3A1	2.66
163	Type 2 collagen-related bone disorder	Enrichment	COL2A1	2.66
164	Lama5-related multisystemic syndrome	Enrichment	LAMA5	2.66
165	Laminin subunit alpha 2-related muscular dystrophy	Enrichment	LAMA2	2.66
166	Nuchal bleb, familial	Enrichment	SOS1	2.61
167	Langerhans cell histiocytosis	Enrichment	NRAS	2.61
168	Spermatocytoma	Enrichment	HRAS	2.61
169	Renal cell carcinoma, papillary, 1	Enrichment	MET	2.59
170	Ovarian cancer	Enrichment	KRAS, MET	2.54
171	Beckwith-wiedemann syndrome	Enrichment	COL6A1, COL7A1	2.54
172	Arthrogryposis, distal, type 1a	Enrichment	MET	2.53
173	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.53
174	Fetal akinesia deformation sequence 3	Enrichment	DOCK7	2.49
175	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.49
176	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.49
177	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.49
178	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.49
179	Pilocytic astrocytoma	Enrichment	KRAS	2.49
180	Epidermolytic nevus	Enrichment	HRAS	2.49
181	Gingival fibromatosis	Enrichment	SOS1	2.49
182	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.48
183	Hypertelorism	Enrichment	COL11A1, COL1A1, PIK3CA	2.47
184	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.42
185	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.35
186	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.35
187	Amelogenesis imperfecta, type ia	Enrichment	LAMB3	2.35
188	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.35
189	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	2.35
190	Bruck syndrome 1	Enrichment	COL1A2	2.35
191	Myasthenic syndrome, congenital, 5	Enrichment	LAMB2	2.35
192	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.35
193	Legg-calve-perthes disease	Enrichment	COL2A1	2.35
194	Lissencephaly 1	Enrichment	LAMB1	2.35
195	Pierson syndrome	Enrichment	LAMB2	2.35
196	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.35
197	Epidermolysis bullosa, junctional 3b, severe	Enrichment	LAMC2	2.35
198	Epidermolysis bullosa, junctional 3a, intermediate	Enrichment	LAMC2	2.35
199	Fibromuscular dysplasia, multifocal	Enrichment	COL5A1	2.35
200	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	2.35
201	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.35
202	Nephrotic syndrome, type 5, with or without ocular abnormalities	Enrichment	LAMB2	2.35
203	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	2.35
204	Steel syndrome	Enrichment	COL27A1	2.35
205	Familial avascular necrosis of the femoral head	Enrichment	COL2A1	2.35
206	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	2.35
207	Dentinogenesis imperfecta	Enrichment	COL1A2	2.35
208	Corneal dystrophy, epithelial basement membrane	Enrichment	TGFBI	2.35
209	Corneal dystrophy, groenouw type i	Enrichment	TGFBI	2.35
210	Ectopia lentis 1, isolated, autosomal dominant	Enrichment	FBN1	2.35
211	Epidermolysis bullosa dystrophica, pretibial	Enrichment	COL7A1	2.35
212	Epidermolysis bullosa dystrophica, autosomal dominant	Enrichment	COL7A1	2.35
213	Epidermolysis bullosa dystrophica, autosomal recessive	Enrichment	COL7A1	2.35
214	Corneal dystrophy, avellino type	Enrichment	TGFBI	2.35
215	Nail disorder, nonsyndromic congenital, 8	Enrichment	COL7A1	2.35
216	Transient bullous dermolysis of the newborn	Enrichment	COL7A1	2.35
217	Corneal dystrophy, lattice type i	Enrichment	TGFBI	2.35
218	Epidermolysis bullosa with congenital localized absence of skin and deformity of nails	Enrichment	COL7A1	2.35
219	Weill-marchesani syndrome 2	Enrichment	FBN1	2.35
220	Immunodeficiency, common variable, 6	Enrichment	CD81	2.35
221	Deafness, autosomal dominant 56	Enrichment	TNC	2.35
222	Geleophysic dysplasia 2	Enrichment	FBN1	2.35
223	Protrusio acetabuli	Enrichment	FBN1	2.35
224	Basal ganglia calcification, idiopathic, 8, autosomal recessive	Enrichment	JAM2	2.35
225	Corneal dystrophy, thiel-behnke type	Enrichment	TGFBI	2.35
226	Ullrich congenital muscular dystrophy 1b	Enrichment	COL6A2	2.35
227	Myosclerosis, autosomal recessive	Enrichment	COL6A2	2.35
228	Ullrich congenital muscular dystrophy 1c	Enrichment	COL6A3	2.35
229	Lymphoplasmacytic lymphoma	Enrichment	FBN1	2.35
230	Epithelial-stromal tgfbi dystrophy	Enrichment	TGFBI	2.35
231	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.35
232	Corneal dystrophy, lattice type iiia	Enrichment	TGFBI	2.35
233	Epidermolysis bullosa pruriginosa	Enrichment	COL7A1	2.35
234	Corneal dystrophy, reis-bucklers type	Enrichment	TGFBI	2.35
235	Granular corneal dystrophy	Enrichment	TGFBI	2.35
236	Dystonia 27	Enrichment	COL6A3	2.35
237	Thyroid gland disease	Enrichment	COL7A1	2.35
238	Factor xiii, a subunit, deficiency of	Enrichment	F13A1	2.35
239	Qualitative or quantitative defects of collagen 6	Enrichment	COL6A2	2.35
240	Recessive dystrophic epidermolysis bullosa-generalized other	Enrichment	COL7A1	2.35
241	Bethlem myopathy 1b	Enrichment	COL6A2	2.35
242	Epithelial basement membrane dystrophy	Enrichment	TGFBI	2.35
243	Congenital fibrinogen deficiency	Enrichment	FGG	2.35
244	Bethlem myopathy 1c	Enrichment	COL6A3	2.35
245	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.35
246	Localized dystrophic epidermolysis bullosa, acral form	Enrichment	COL7A1	2.35
247	Neonatal marfan syndrome	Enrichment	FBN1	2.35
248	Recessive dystrophic epidermolysis bullosa inversa	Enrichment	COL7A1	2.35
249	Generalized dominant dystrophic epidermolysis bullosa	Enrichment	COL7A1	2.35
250	Neural tube defects	Enrichment	ITGB1	2.32
251	Sensorineural hearing loss	Enrichment	COL11A2, HGF	2.30
252	Scoliosis	Enrichment	COL2A1, FBN1	2.29
253	Renal cell carcinoma, nonpapillary	Enrichment	MET	2.26
254	Pilomyxoid astrocytoma	Enrichment	KRAS	2.25
255	Macrodactyly	Enrichment	PIK3CA	2.23
256	Metachondromatosis	Enrichment	PTPN11	2.23
257	Immunodeficiency 61	Enrichment	SH3KBP1	2.23
258	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.23
259	Leopard syndrome 1	Enrichment	PTPN11	2.23
260	Cowden syndrome 5	Enrichment	PIK3CA	2.23
261	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.23
262	Short syndrome	Enrichment	PIK3R1	2.23
263	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.23
264	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.23
265	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.23
266	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.23
267	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.23
268	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.23
269	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.23
270	Autosomal recessive spastic paraplegia type 59	Enrichment	USP8	2.23
271	Hypospadias	Enrichment	PIK3CA	2.23
272	Thrombocytopenia 10	Enrichment	PTPRJ	2.23
273	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.23
274	Rare venous malformation	Enrichment	PIK3CA	2.23
275	Diaphragmatic eventration	Enrichment	PIK3CA	2.23
276	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.23
277	Rare combined vascular malformation	Enrichment	PIK3CA	2.23
278	Cavernous lymphangioma	Enrichment	PIK3CA	2.23
279	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.23
280	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.23
281	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.23
282	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.23
283	Macrodactyly of toe	Enrichment	PIK3CA	2.23
284	Malignant astrocytoma	Enrichment	PTPN11	2.23
285	Spondyloepiphyseal dysplasia congenita	Enrichment	COL2A1	2.18
286	Megalocornea	Enrichment	COL11A1	2.18
287	Hypophosphatasia, infantile	Enrichment	COL11A2	2.18
288	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	2.18
289	Muscular dystrophy, congenital merosin-deficient, 1a	Enrichment	LAMA2	2.18
290	Caffey disease	Enrichment	COL1A1	2.18
291	Poretti-boltshauser syndrome	Enrichment	LAMA1	2.18
292	Multiple epiphyseal dysplasia	Enrichment	COL2A1	2.18
293	Lama2-related muscular dystrophy	Enrichment	LAMA2	2.18
294	Hepatocellular carcinoma	Enrichment	MET, PIK3CA	2.14
295	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	2.14
296	Stargardt disease 1	Enrichment	COL18A1, COL2A1	2.10
297	Phenylketonuria	Enrichment	COL1A1	2.05
298	Acromicric dysplasia	Enrichment	FBN1	2.05
299	Stiff skin syndrome	Enrichment	FBN1	2.05
300	Quebec platelet disorder	Enrichment	PLAU	2.05
301	Beaulieu-boycott-innes syndrome	Enrichment	FBN1	2.05
302	Recessive dystrophic epidermolysis bullosa	Enrichment	COL7A1	2.05
303	Marfanoid-progeroid-lipodystrophy syndrome	Enrichment	FBN1	2.05
304	Glaucoma, primary closed-angle	Enrichment	COL18A1	2.05
305	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD81	2.05
306	Epidermolysis bullosa dystrophica	Enrichment	COL7A1	2.05
307	Factor xiii deficiency	Enrichment	F13A1	2.05
308	Lens subluxation	Enrichment	FBN1	2.05
309	Hereditary retinal dystrophy	Enrichment	COL11A2, COL18A1, COL2A1, ITGA4, LAMA1	2.01
310	Fundus dystrophy	Enrichment	COL11A2, COL18A1, COL2A1, ITGA4, LAMA1	2.01
311	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.00
312	Aortic valve disease 1	Enrichment	SOS1	1.98
313	Protein-deficiency anemia	Enrichment	NRAS	1.98
314	Retinal detachment	Enrichment	COL2A1	1.96
315	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	LAMA2	1.96
316	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.96
317	Lung cancer susceptibility 3	Enrichment	KRAS	1.95
318	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.95
319	Pituitary adenoma 4, acth-secreting	Enrichment	USP8	1.94
320	Ovarian germ cell cancer	Enrichment	CBL	1.94
321	Keratosis, seborrheic	Enrichment	PIK3CA	1.94
322	Noonan syndrome 8	Enrichment	PIK3CA	1.94
323	Werner syndrome	Enrichment	PTPN11	1.94
324	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.94
325	Malignant germ cell tumor of ovary	Enrichment	CBL	1.94
326	Submucosal cleft palate	Enrichment	UBB	1.94
327	Cleft hard palate	Enrichment	UBB	1.94
328	Developmental dysplasia of the hip 1	Enrichment	COL2A1	1.88
329	Pain disorder	Enrichment	COL5A1	1.88
330	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2	1.88
331	Contractural arachnodactyly, congenital	Enrichment	FBN1	1.87
332	Achondroplasia	Enrichment	FBN1	1.87
333	Nail disorder, nonsyndromic congenital, 4	Enrichment	COL7A1	1.87
334	Muscular dystrophy, congenital, due to integrin alpha-7 deficiency	Enrichment	ITGA7	1.87
335	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.87
336	Ehlers-danlos syndrome, classic-like, 3	Enrichment	THBS2	1.87
337	Weill-marchesani syndrome 1	Enrichment	FBN1	1.87
338	Isolated ectopia lentis	Enrichment	FBN1	1.87
339	Geleophysic dysplasia	Enrichment	FBN1	1.87
340	Hyperpigmentation of the skin	Enrichment	COL7A1	1.87
341	Isolated dandy-walker malformation without hydrocephalus	Enrichment	NID1	1.87
342	Arteriovenous malformations of the brain	Enrichment	KRAS	1.82
343	Myelofibrosis	Enrichment	SRC	1.81
344	Multiple enchondromatosis, maffucci type	Enrichment	COL2A1	1.81
345	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.76
346	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.76
347	Uvula, bifid	Enrichment	UBB	1.76
348	Cleft soft palate	Enrichment	UBB	1.76
349	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.76
350	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.76
351	Hyper ige syndrome	Enrichment	STAT3	1.76
352	Immunodeficiency 14	Enrichment	PIK3R1	1.76
353	Tricuspid valve insufficiency	Enrichment	PTPN11	1.76
354	Keratoacanthoma	Enrichment	PIK3CA	1.76
355	Gastroesophageal reflux	Enrichment	COL5A1	1.76
356	Congenital muscular dystrophy	Enrichment	LAMA2	1.76
357	Retinitis pigmentosa 26	Enrichment	ITGA4	1.75
358	Weill-marchesani syndrome	Enrichment	FBN1	1.75
359	Aortic aneurysm	Enrichment	FBN1	1.75
360	Corneal dystrophy	Enrichment	TGFBI	1.75
361	Epidermolytic hyperkeratosis	Enrichment	COL7A1	1.75
362	Knobloch syndrome	Enrichment	COL18A1	1.75
363	Mitral valve insufficiency	Enrichment	FBN1	1.75
364	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.75
365	Pancreatic cancer	Enrichment	KRAS	1.70
366	Amelogenesis imperfecta, type ie	Enrichment	LAMB3	1.66
367	Polycystic liver disease 1 with or without kidney cysts	Enrichment	FBN1	1.65
368	Alzheimer disease 2	Enrichment	PLAU	1.65
369	Epidermolytic hyperkeratosis 1	Enrichment	COL7A1	1.65
370	Amyloidosis, hereditary systemic 2	Enrichment	FGA	1.65
371	Arthrogryposis, renal dysfunction, and cholestasis 1	Enrichment	FBN1	1.65
372	Knobloch syndrome 1	Enrichment	COL18A1	1.65
373	Goldberg-shprintzen syndrome	Enrichment	FBN1	1.65
374	Polycystic liver disease 1	Enrichment	FBN1	1.65
375	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.64
376	Cerebrovascular disease	Enrichment	PIK3CA	1.64
377	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.64
378	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.64
379	Presynaptic congenital myasthenic syndromes	Enrichment	LAMA5	1.62
380	Gastric cancer	Enrichment	KRAS, PIK3CA	1.59
381	Cutis laxa	Enrichment	COL5A1	1.58
382	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6	1.57
383	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	1.57
384	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	COL5A1	1.55
385	Clubfoot	Enrichment	COL5A1	1.55
386	Amelogenesis imperfecta	Enrichment	LAMB3	1.55
387	Capillary malformations, congenital	Enrichment	PIK3CA	1.54
388	Lymphoma	Enrichment	PTPN11	1.54
389	Myeloproliferative neoplasm	Enrichment	CBL	1.54
390	Hemimegalencephaly	Enrichment	PIK3CA	1.54
391	Aggressive systemic mastocytosis	Enrichment	CBL	1.54
392	Brugada syndrome 1	Enrichment	FBN1	1.51
393	Focal epilepsy	Enrichment	NID1	1.51
394	Thrombocytopenia	Enrichment	PTPN11, SRC	1.50
395	Kidney disease	Enrichment	LAMB2	1.49
396	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.46
397	Cowden syndrome 1	Enrichment	PIK3CA	1.46
398	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.46
399	Patent ductus arteriosus	Enrichment	PTPN11	1.46
400	Creatine phosphokinase, elevated serum	Enrichment	LAMA2	1.46
401	Isolated elevated serum creatine phosphokinase levels	Enrichment	LAMA2	1.46
402	Basal ganglia calcification, idiopathic, 1	Enrichment	JAM2	1.45
403	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.45
404	Cleft palate, isolated	Enrichment	COL11A1	1.43
405	Loeys-dietz syndrome	Enrichment	FBN1	1.40
406	Oligoarticular juvenile idiopathic arthritis	Enrichment	PTPN2	1.40
407	Overgrowth syndrome	Enrichment	PIK3R1	1.40
408	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	PTPN2	1.40
409	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.36
410	Stroke, ischemic	Enrichment	FBN1	1.36
411	Melanoma	Enrichment	FBN1	1.36
412	Myeloma, multiple	Enrichment	KRAS	1.35
413	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.34
414	Inherited cancer-predisposing syndrome	Enrichment	MET	1.32
415	Pectus excavatum	Enrichment	FBN1	1.32
416	Ichthyosis	Enrichment	COL7A1	1.32
417	Dilated cardiomyopathy	Enrichment	FBN1, LAMA2	1.30
418	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.29
419	Primary hyperaldosteronism	Enrichment	USP8	1.29
420	Cowden syndrome	Enrichment	PIK3CA	1.29
421	Ear malformation	Enrichment	COL11A2	1.29
422	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.25
423	Diaphragmatic hernia, congenital	Enrichment	FBN1	1.24
424	Isolated macular dystrophy	Enrichment	ITGA4	1.21
425	Specific learning disability	Enrichment	PTPN11	1.21
426	Congenital myopathy 4a, autosomal dominant	Enrichment	ITGA7	1.18
427	Hydrocephalus	Enrichment	NID1	1.18
428	Epicanthus	Enrichment	PTPN11	1.17
429	Meningioma	Enrichment	PIK3CA	1.17
430	Congenital long qt syndrome	Enrichment	PTPN11	1.17
431	Perrault syndrome 1	Enrichment	FBN1	1.16
432	Genetic steroid-resistant nephrotic syndrome	Enrichment	LAMA5	1.14
433	Acute promyelocytic leukemia	Enrichment	STAT3	1.14
434	Alzheimer disease, familial, 1	Enrichment	PLAU	1.13
435	Charcot-marie-tooth disease	Enrichment	LAMA2	1.06
436	Nonsyndromic hearing loss	Enrichment	COL11A2	1.05
437	Hepatoblastoma	Enrichment	COL7A1	1.04
438	Myocardial infarction	Enrichment	F13A1	1.02
439	Patent foramen ovale	Enrichment	PTPN11	1.00
440	Muscular dystrophy	Enrichment	COL6A2	0.99
441	Diffuse large b-cell lymphoma	Enrichment	STAT3	0.98
442	Familial isolated dilated cardiomyopathy	Enrichment	LAMA4	0.95
443	Endometrial cancer	Enrichment	PIK3CA	0.94
444	Severe covid-19	Enrichment	ITGAV	0.91
445	Strabismus	Enrichment	PTPN11	0.84
446	Autism	Enrichment	COL11A1	0.83
447	Prostate cancer	Enrichment	PIK3CA	0.81
448	Long qt syndrome 1	Enrichment	PTPN11	0.79
449	Rare genetic deafness	Enrichment	COL11A2	0.79
450	Systemic lupus erythematosus	Enrichment	SPP1	0.79
451	Type 2 diabetes mellitus	Enrichment	PTPN1	0.66
452	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.65
453	Primary ovarian insufficiency	Enrichment	THBS1	0.63
454	Cone-rod dystrophy 2	Enrichment	ITGA4	0.58
455	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.55
456	Microcephaly	Enrichment	COL7A1	0.37
457	Autism spectrum disorder	Enrichment	PTPN11	0.33
458	Retinitis pigmentosa	Enrichment	COL18A1	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MET promotes cell motility

Pathway Network for MET promotes cell motility

Pathway network for the MET promotes cell motility SuperPath

Member Pathways for MET promotes cell motility

Pathways in the MET promotes cell motility SuperPath

Gene overlap in member pathways for MET promotes cell motility SuperPath

Associated Genes for MET promotes cell motility

Associated Disorders for MET promotes cell motility

Disorders associated with MET promotes cell motility SuperPath

STRING Interaction Network for MET promotes cell motility

Sources for MET promotes cell motility