Metabolic reprogramming in colon cancer

No Pathway Network information available for Metabolic reprogramming in colon cancer

Pathways in the Metabolic reprogramming in colon cancer SuperPath

#	Name	Source	Genes
1	Metabolic reprogramming in colon cancer	WikiPathways	ACLY ACO2 ALDOB DLST ENO1 FASN FH G6PD GAPDH GART GLS GLUD1 GOT2 GPI HK3 IDH2 IDH3A LDHA MDH2 PAICS PDHA1 PDHB PFKL PGAM1 PGD PGK1 PKM PPAT PSAT1 PSPH PYCR1 PYCR2 RPIA SDHB SHMT2 SLC16A3 SLC1A5 SLC2A1 SUCLG2 TALDO1 TIGAR TKT (see all 42) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PFKL	Phosphofructokinase, Liver Type	Protein Coding	1
2	DLST	Dihydrolipoamide S-Succinyltransferase	Protein Coding	1
3	SLC16A3	Solute Carrier Family 16 Member 3	Protein Coding	1
4	SUCLG2	Succinate-CoA Ligase GDP-Forming Subunit Beta	Protein Coding	1
5	TKT	Transketolase	Protein Coding	1
6	TALDO1	Transaldolase 1	Protein Coding	1
7	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
8	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
9	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	1
10	SDHB	Succinate Dehydrogenase Complex Iron Sulfur Subunit B	Protein Coding	1
11	PYCR1	Pyrroline-5-Carboxylate Reductase 1	Protein Coding	1
12	PSPH	Phosphoserine Phosphatase	Protein Coding	1
13	TIGAR	TP53 Induced Glycolysis Regulatory Phosphatase	Protein Coding	1
14	PPAT	Phosphoribosyl Pyrophosphate Amidotransferase	Protein Coding	1
15	PKM	Pyruvate Kinase M1/2	Protein Coding	1
16	PGK1	Phosphoglycerate Kinase 1	Protein Coding	1
17	PGD	Phosphogluconate Dehydrogenase	Protein Coding	1
18	PGAM1	Phosphoglycerate Mutase 1	Protein Coding	1
19	PDHB	Pyruvate Dehydrogenase E1 Subunit Beta	Protein Coding	1
20	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
21	ACO2	Aconitase 2	Protein Coding	1
22	ACLY	ATP Citrate Lyase	Protein Coding	1
23	MDH2	Malate Dehydrogenase 2	Protein Coding	1
24	LDHA	Lactate Dehydrogenase A	Protein Coding	1
25	IDH3A	Isocitrate Dehydrogenase (NAD(+)) 3 Catalytic Subunit Alpha	Protein Coding	1
26	IDH2	Isocitrate Dehydrogenase (NADP(+)) 2	Protein Coding	1
27	HK3	Hexokinase 3	Protein Coding	1
28	PSAT1	Phosphoserine Aminotransferase 1	Protein Coding	1
29	PYCR2	Pyrroline-5-Carboxylate Reductase 2	Protein Coding	1
30	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	1
31	GLUD1	Glutamate Dehydrogenase 1	Protein Coding	1
32	GLS	Glutaminase	Protein Coding	1
33	GART	Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase	Protein Coding	1
34	GAPDH	Glyceraldehyde-3-Phosphate Dehydrogenase	Protein Coding	1
35	G6PD	Glucose-6-Phosphate Dehydrogenase	Protein Coding	1
36	RPIA	Ribose 5-Phosphate Isomerase A	Protein Coding	1
37	ALDOB	Aldolase, Fructose-Bisphosphate B	Protein Coding	1
38	FH	Fumarate Hydratase	Protein Coding	1
39	FASN	Fatty Acid Synthase	Protein Coding	1
40	ENO1	Enolase 1	Protein Coding	1
41	PAICS	Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase	Protein Coding	1
42	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	1

Disorders associated with Metabolic reprogramming in colon cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	DLST, FH, MDH2, SDHB	6.34
2	Esophageal atresia/tracheoesophageal fistula	Enrichment	GART, GLS	2.81
3	Developmental and epileptic encephalopathy 1	Enrichment	MDH2, SLC2A1	2.57
4	Hereditary leiomyomatosis and renal cell cancer	Enrichment	FH	2.51
5	Phosphoglycerate kinase 1 deficiency	Enrichment	PGK1	2.51
6	Fumarase deficiency	Enrichment	FH	2.51
7	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.51
8	Short stature, developmental delay, and congenital heart defects	Enrichment	TKT	2.51
9	Cutis laxa, autosomal recessive, type iiib	Enrichment	PYCR1	2.51
10	Retinitis pigmentosa 90	Enrichment	IDH3A	2.51
11	Leukodystrophy, hypomyelinating, 10	Enrichment	PYCR2	2.51
12	Casgid syndrome	Enrichment	GLS	2.51
13	Pheochromocytoma/paraganglioma syndrome 7	Enrichment	DLST	2.51
14	Phosphoserine aminotransferase deficiency	Enrichment	PSAT1	2.51
15	Ribose 5-phosphate isomerase deficiency	Enrichment	RPIA	2.51
16	Leiomyoma cutis	Enrichment	FH	2.51
17	Hyperinsulinemic hypoglycemia, familial, 6	Enrichment	GLUD1	2.51
18	Gemistocytic astrocytoma	Enrichment	IDH2	2.51
19	Protoplasmic astrocytoma	Enrichment	IDH2	2.51
20	Developmental and epileptic encephalopathy 71	Enrichment	GLS	2.51
21	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.51
22	D-2-hydroxyglutaric aciduria 2	Enrichment	IDH2	2.51
23	Phosphoserine phosphatase deficiency	Enrichment	PSPH	2.51
24	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	2.51
25	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	2.51
26	Cutis laxa, autosomal recessive, type iib	Enrichment	PYCR1	2.51
27	Developmental and epileptic encephalopathy 51	Enrichment	MDH2	2.51
28	Fumarate hydratase deficiency	Enrichment	FH	2.51
29	Mixed oligodendroglioma-astrocytoma	Enrichment	IDH2	2.51
30	Anaplastic oligoastrocytoma	Enrichment	IDH2	2.51
31	Neu-laxova syndrome 2	Enrichment	PSAT1	2.51
32	Fibrillary astrocytoma	Enrichment	IDH2	2.51
33	Acute myocardial infarction	Enrichment	IDH2	2.51
34	Spastic ataxia-dysarthria due to glutaminase deficiency	Enrichment	GLS	2.51
35	Congenital nonspherocytic hemolytic anemia	Enrichment	G6PD	2.51
36	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.51
37	Neurometabolic disorder due to serine deficiency	Enrichment	PSAT1	2.51
38	Neu-laxova syndrome due to 3-phosphoserine phosphatase deficiency	Enrichment	PSPH	2.51
39	Male infertility due to obstructive azoospermia	Enrichment	PGK1	2.51
40	Pycr2-related microcephaly-progressive leukoencephalopathy	Enrichment	PYCR2	2.51
41	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.51
42	Leiomyoma, uterine	Enrichment	FH	2.21
43	Fanconi-bickel syndrome	Enrichment	LDHA	2.21
44	Fructose intolerance, hereditary	Enrichment	ALDOB	2.21
45	Dystonia 9	Enrichment	SLC2A1	2.21
46	Porphyria, acute intermittent	Enrichment	ACO2	2.21
47	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.21
48	Pyruvate dehydrogenase e1-beta deficiency	Enrichment	PDHB	2.21
49	Global developmental delay, progressive ataxia, and elevated glutamine	Enrichment	GLS	2.21
50	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.21
51	Phosphoribosylaminoimidazole carboxylase deficiency	Enrichment	PAICS	2.21
52	Microcephaly 21, primary, autosomal recessive	Enrichment	GAPDH	2.21
53	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.21
54	Transaldolase deficiency	Enrichment	TALDO1	2.21
55	Oligodendroglioma	Enrichment	IDH2	2.21
56	Acute porphyria	Enrichment	ACO2	2.21
57	Congenital hemolytic anemia	Enrichment	G6PD	2.21
58	Glucosephosphate dehydrogenase deficiency	Enrichment	G6PD	2.21
59	Anaplastic oligodendroglioma	Enrichment	IDH2	2.21
60	Spinocerebellar ataxia 45	Enrichment	FH	2.21
61	D-2-hydroxyglutaric aciduria	Enrichment	IDH2	2.21
62	West syndrome	Enrichment	MDH2, SLC2A1	2.09
63	Pheochromocytoma/paraganglioma syndrome 4	Enrichment	SDHB	2.03
64	Geroderma osteodysplasticum	Enrichment	PYCR1	2.03
65	Carney triad	Enrichment	SDHB	2.03
66	Mitochondrial complex iv deficiency, nuclear type 2	Enrichment	SDHB	2.03
67	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.03
68	Infantile cerebellar-retinal degeneration	Enrichment	ACO2	2.03
69	Optic atrophy 9	Enrichment	ACO2	2.03
70	Paraganglioma	Enrichment	SDHB	2.03
71	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.03
72	Anaplastic astrocytoma	Enrichment	IDH2	2.03
73	Renal cell carcinoma	Enrichment	SDHB	2.03
74	Pheochromocytoma/paraganglioma syndrome 1	Enrichment	SDHB	1.91
75	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1	1.91
76	Mitochondrial complex ii deficiency	Enrichment	SDHB	1.91
77	Autosomal recessive isolated optic atrophy	Enrichment	ACO2	1.91
78	Enchondromatosis, multiple, ollier type	Enrichment	IDH2	1.81
79	Von hippel-lindau syndrome	Enrichment	SDHB	1.81
80	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	G6PD	1.81
81	Paraganglioma and gastric stromal sarcoma	Enrichment	SDHB	1.81
82	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GLUD1	1.73
83	Hereditary spherocytosis	Enrichment	GPI	1.73
84	Nonsyndromic genetic hyperinsulinism	Enrichment	GLUD1	1.73
85	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	SDHB	1.73
86	Gastrointestinal stromal tumor	Enrichment	SDHB	1.67
87	Multiple enchondromatosis, maffucci type	Enrichment	IDH2	1.67
88	Hemolytic anemia	Enrichment	GPI	1.67
89	Paroxysmal dystonia	Enrichment	SLC2A1	1.67
90	Glioma susceptibility 1	Enrichment	IDH2	1.61
91	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.61
92	Coronary heart disease 5	Enrichment	G6PD	1.56
93	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.56
94	Cowden syndrome	Enrichment	SDHB	1.56
95	Isolated tracheo-esophageal fistula	Enrichment	GART	1.52
96	Cutis laxa	Enrichment	PYCR1	1.44
97	Pheochromocytoma	Enrichment	SDHB	1.37
98	Isolated macular dystrophy	Enrichment	ACO2	1.37
99	Sudden infant death syndrome	Enrichment	PDHA1	1.29
100	Leukodystrophy	Enrichment	PYCR2	1.22
101	Inherited cancer-predisposing syndrome	Enrichment	FH, SDHB	1.20
102	Hepatocellular carcinoma	Enrichment	FH	1.18
103	Malaria	Enrichment	G6PD	1.16
104	Strabismus	Enrichment	SLC2A1	1.09
105	Primary autosomal recessive microcephaly	Enrichment	PYCR2	1.02
106	Connective tissue disease	Enrichment	PYCR1	1.02
107	Developmental and epileptic encephalopathy	Enrichment	GOT2	0.98
108	Leukemia, acute myeloid	Enrichment	IDH2	0.93
109	Epilepsy	Enrichment	SLC2A1	0.93
110	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	0.92
111	Centralopathic epilepsy	Enrichment	SLC2A1	0.90
112	Optic atrophy plus syndrome	Enrichment	ACO2	0.89
113	Hereditary retinal dystrophy	Enrichment	ACO2, IDH3A	0.65
114	Fundus dystrophy	Enrichment	ACO2, IDH3A	0.65
115	Ovarian cancer	Enrichment	FH	0.57
116	Microcephaly	Enrichment	SLC2A1	0.50
117	Retinitis pigmentosa	Enrichment	IDH3A	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metabolic reprogramming in colon cancer

Pathway Network for Metabolic reprogramming in colon cancer

Member Pathways for Metabolic reprogramming in colon cancer

Pathways in the Metabolic reprogramming in colon cancer SuperPath

Associated Genes for Metabolic reprogramming in colon cancer

Associated Disorders for Metabolic reprogramming in colon cancer

Disorders associated with Metabolic reprogramming in colon cancer SuperPath

STRING Interaction Network for Metabolic reprogramming in colon cancer

Sources for Metabolic reprogramming in colon cancer