Metabolic reprogramming in pancreatic cancer

No Pathway Network information available for Metabolic reprogramming in pancreatic cancer

Pathways in the Metabolic reprogramming in pancreatic cancer SuperPath

#	Name	Source	Genes
1	Metabolic reprogramming in pancreatic cancer	WikiPathways	ACLY BCAT2 BCKDHA CARM1 CS DLAT DLD FASN GFPT1 GLS2 GLUD1 GNPNAT1 GOT1 GOT2 GPI GPT HK1 HK2 HMGCR HMGCS2 KRAS LDHA LDLR MDH1 ME1 PDHA1 PDHB PDHX PFKL PGM3 PKM RPE RPIA SLC16A1 SLC16A4 SLC1A5 SLC2A1 SLC43A1 SLC7A5 SOAT1 TP53 UAP1 (see all 42) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC16A4	Solute Carrier Family 16 Member 4	Protein Coding	1
2	RPE	Ribulose-5-Phosphate-3-Epimerase	Protein Coding	1
3	HK2	Hexokinase 2	Protein Coding	1
4	GLUD1	Glutamate Dehydrogenase 1	Protein Coding	1
5	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
6	GFPT1	Glutamine--Fructose-6-Phosphate Transaminase 1	Protein Coding	1
7	GNPNAT1	Glucosamine-Phosphate N-Acetyltransferase 1	Protein Coding	1
8	PGM3	Phosphoglucomutase 3	Protein Coding	1
9	UAP1	UDP-N-Acetylglucosamine Pyrophosphorylase 1	Protein Coding	1
10	HK1	Hexokinase 1	Protein Coding	1
11	GLS2	Glutaminase 2	Protein Coding	1
12	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	1
13	BCKDHA	Branched Chain Keto Acid Dehydrogenase E1 Subunit Alpha	Protein Coding	1
14	BCAT2	Branched Chain Amino Acid Transaminase 2	Protein Coding	1
15	GOT1	Glutamic-Oxaloacetic Transaminase 1	Protein Coding	1
16	GOT2	Glutamic-Oxaloacetic Transaminase 2	Protein Coding	1
17	PDHX	Pyruvate Dehydrogenase Complex Component X	Protein Coding	1
18	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	1
19	LDHA	Lactate Dehydrogenase A	Protein Coding	1
20	ACLY	ATP Citrate Lyase	Protein Coding	1
21	FASN	Fatty Acid Synthase	Protein Coding	1
22	HMGCS2	3-Hydroxy-3-Methylglutaryl-CoA Synthase 2	Protein Coding	1
23	ME1	Malic Enzyme 1	Protein Coding	1
24	RPIA	Ribose 5-Phosphate Isomerase A	Protein Coding	1
25	PKM	Pyruvate Kinase M1/2	Protein Coding	1
26	SLC16A1	Solute Carrier Family 16 Member 1	Protein Coding	1
27	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
28	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
29	SLC43A1	Solute Carrier Family 43 Member 1	Protein Coding	1
30	PFKL	Phosphofructokinase, Liver Type	Protein Coding	1
31	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	1
32	SLC7A5	Solute Carrier Family 7 Member 5	Protein Coding	1
33	SOAT1	Sterol O-Acyltransferase 1	Protein Coding	1
34	LDLR	Low Density Lipoprotein Receptor	Protein Coding	1
35	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
36	TP53	Tumor Protein P53	Protein Coding	1
37	DLD	Dihydrolipoamide Dehydrogenase	Protein Coding	1
38	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
39	PDHB	Pyruvate Dehydrogenase E1 Subunit Beta	Protein Coding	1
40	CS	Citrate Synthase	Protein Coding	1
41	MDH1	Malate Dehydrogenase 1	Protein Coding	1
42	DLAT	Dihydrolipoamide S-Acetyltransferase	Protein Coding	1

Disorders associated with Metabolic reprogramming in pancreatic cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1, PDHX	4.25
2	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	4.25
3	Breast adenocarcinoma	Enrichment	KRAS, TP53	3.86
4	Gallbladder cancer	Enrichment	KRAS, TP53	3.71
5	Lung cancer susceptibility 3	Enrichment	KRAS, TP53	3.08
6	Pancreatic cancer	Enrichment	KRAS, TP53	2.57
7	Anemia, congenital, nonspherocytic hemolytic, 5	Enrichment	HK1	2.51
8	Oculoectodermal syndrome	Enrichment	KRAS	2.51
9	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	2.51
10	Erythrocyte lactate transporter defect	Enrichment	SLC16A1	2.51
11	Retinitis pigmentosa 79	Enrichment	HK1	2.51
12	Hypervalinemia and hyperleucine-isoleucinemia	Enrichment	BCAT2	2.51
13	Bone marrow failure syndrome 5	Enrichment	TP53	2.51
14	Papilloma of choroid plexus	Enrichment	TP53	2.51
15	Basal cell carcinoma 7	Enrichment	TP53	2.51
16	Anaplastic thyroid carcinoma	Enrichment	TP53	2.51
17	Ribose 5-phosphate isomerase deficiency	Enrichment	RPIA	2.51
18	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.51
19	Rhizomelic dysplasia, ain-naz type	Enrichment	GNPNAT1	2.51
20	Hyperinsulinemic hypoglycemia, familial, 6	Enrichment	GLUD1	2.51
21	Neuropathy, hereditary motor and sensory, russe type	Enrichment	HK1	2.51
22	Neurodevelopmental disorder with visual defects and brain anomalies	Enrichment	HK1	2.51
23	Aspartate aminotransferase, serum level of, quantitative trait locus 1	Enrichment	GOT1	2.51
24	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	2.51
25	Anemia, congenital, nonspherocytic hemolytic, 4	Enrichment	GPI	2.51
26	Ductal carcinoma in situ	Enrichment	TP53	2.51
27	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.51
28	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.51
29	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.51
30	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.51
31	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.51
32	Congenital pulmonary airway malformation	Enrichment	KRAS	2.51
33	Choroid plexus cancer	Enrichment	TP53	2.51
34	Epilepsy with myoclonic absences	Enrichment	SLC2A1	2.51
35	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.51
36	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	2.51
37	Bladder cancer	Enrichment	KRAS, TP53	2.44
38	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.21
39	Fanconi-bickel syndrome	Enrichment	LDHA	2.21
40	Dihydrolipoamide dehydrogenase deficiency	Enrichment	DLD	2.21
41	Dystonia 9	Enrichment	SLC2A1	2.21
42	Cervical cancer	Enrichment	TP53	2.21
43	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	2.21
44	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.21
45	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	2.21
46	Monocarboxylate transporter 1 deficiency	Enrichment	SLC16A1	2.21
47	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	DLD	2.21
48	Pyruvate dehydrogenase e2 deficiency	Enrichment	DLAT	2.21
49	Lymphoma, hodgkin, classic	Enrichment	TP53	2.21
50	Pyruvate dehydrogenase e1-beta deficiency	Enrichment	PDHB	2.21
51	Myasthenic syndrome, congenital, 12	Enrichment	GFPT1	2.21
52	Pyruvate dehydrogenase e3-binding protein deficiency	Enrichment	PDHX	2.21
53	Developmental and epileptic encephalopathy 82	Enrichment	GOT2	2.21
54	Immunodeficiency 23	Enrichment	PGM3	2.21
55	Developmental and epileptic encephalopathy 88	Enrichment	MDH1	2.21
56	Hyperlipoproteinemia, type iii	Enrichment	LDLR	2.21
57	3-hydroxy-3-methylglutaryl-coa synthase-2 deficiency	Enrichment	HMGCS2	2.21
58	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	2.21
59	Congenital fibrosarcoma	Enrichment	TP53	2.21
60	Li-fraumeni syndrome 1	Enrichment	TP53	2.21
61	Sarcoma	Enrichment	TP53	2.21
62	Hyperinsulinemic hypoglycemia, familial, 7	Enrichment	SLC16A1	2.21
63	Cervix carcinoma	Enrichment	TP53	2.21
64	Hodgkin's lymphoma	Enrichment	TP53	2.21
65	Ketoacidosis due to monocarboxylate transporter-1 deficiency	Enrichment	SLC16A1	2.21
66	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.21
67	Leukemia, acute myeloid	Enrichment	KRAS, TP53	2.17
68	Gastric cancer	Enrichment	KRAS, TP53	2.11
69	Hereditary breast carcinoma	Enrichment	KRAS, TP53	2.09
70	Hypercholesterolemia, familial, 2	Enrichment	LDLR	2.03
71	Maple syrup urine disease, type ia	Enrichment	BCKDHA	2.03
72	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.03
73	Osteogenic sarcoma	Enrichment	TP53	2.03
74	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	2.03
75	Hypercholesterolemia, familial, 4	Enrichment	LDLR	2.03
76	Nasopharyngeal carcinoma	Enrichment	TP53	2.03
77	Hyper ige syndrome	Enrichment	PGM3	2.03
78	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	2.03
79	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.03
80	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.03
81	Anaplastic astrocytoma	Enrichment	TP53	2.03
82	Squamous cell carcinoma	Enrichment	TP53	2.03
83	Adenocarcinoma	Enrichment	TP53	2.03
84	Bone osteosarcoma	Enrichment	TP53	2.03
85	Intermittent maple syrup urine disease	Enrichment	BCKDHA	2.03
86	Classic maple syrup urine disease	Enrichment	BCKDHA	2.03
87	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	1.91
88	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.91
89	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.91
90	Small cell cancer of the lung	Enrichment	TP53	1.91
91	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.91
92	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.91
93	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	1.91
94	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.91
95	Pilocytic astrocytoma	Enrichment	KRAS	1.91
96	Intermediate maple syrup urine disease	Enrichment	BCKDHA	1.91
97	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, TP53	1.90
98	Myeloma, multiple	Enrichment	KRAS, TP53	1.89
99	Hyperlipidemia, familial combined, 3	Enrichment	LDLR	1.81
100	Rhabdomyosarcoma 2	Enrichment	TP53	1.81
101	Lymphoma	Enrichment	TP53	1.81
102	Acute megakaryocytic leukemia	Enrichment	TP53	1.81
103	Congenital myasthenic syndromes with glycosylation defect	Enrichment	GFPT1	1.81
104	Li-fraumeni syndrome	Enrichment	TP53	1.73
105	Cowden syndrome 1	Enrichment	LDLR	1.73
106	Hyperinsulinemic hypoglycemia, familial, 1	Enrichment	GLUD1	1.73
107	Lipid metabolism disorder	Enrichment	LDLR	1.73
108	Adrenocortical carcinoma	Enrichment	TP53	1.73
109	Hereditary spherocytosis	Enrichment	GPI	1.73
110	Lung squamous cell carcinoma	Enrichment	KRAS	1.73
111	Nonsyndromic genetic hyperinsulinism	Enrichment	GLUD1	1.73
112	Esophageal cancer	Enrichment	TP53	1.67
113	Nevus, epidermal	Enrichment	KRAS	1.67
114	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.67
115	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.67
116	Leukemia, chronic myeloid	Enrichment	KRAS	1.67
117	Noonan syndrome 3	Enrichment	KRAS	1.67
118	Essential thrombocythemia	Enrichment	TP53	1.67
119	Pilomyxoid astrocytoma	Enrichment	KRAS	1.67
120	Hemolytic anemia	Enrichment	GPI	1.67
121	Paroxysmal dystonia	Enrichment	SLC2A1	1.67
122	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.67
123	Breast cancer	Enrichment	KRAS, TP53	1.65
124	Glioma susceptibility 1	Enrichment	TP53	1.61
125	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.61
126	Alternating hemiplegia of childhood	Enrichment	SLC2A1	1.61
127	Homozygous familial hypercholesterolemia	Enrichment	LDLR	1.61
128	Coronary heart disease 5	Enrichment	LDLR	1.56
129	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	1.56
130	Adult hepatocellular carcinoma	Enrichment	TP53	1.56
131	Primary hyperaldosteronism	Enrichment	TP53	1.56
132	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.56
133	Leukemia, chronic lymphocytic	Enrichment	TP53	1.52
134	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	GFPT1	1.52
135	Familial colorectal cancer	Enrichment	TP53	1.52
136	Myelodysplastic syndrome	Enrichment	TP53	1.47
137	Lung non-small cell carcinoma	Enrichment	KRAS	1.47
138	Juvenile myelomonocytic leukemia	Enrichment	KRAS	1.44
139	Lactic acidosis	Enrichment	DLD	1.44
140	Lip and oral cavity carcinoma	Enrichment	TP53	1.44
141	Ovarian cancer	Enrichment	KRAS, TP53	1.41
142	Hypercholesterolemia, familial, 1	Enrichment	LDLR	1.40
143	Congenital myasthenic syndrome	Enrichment	GFPT1	1.37
144	Familial hypercholesterolemia	Enrichment	LDLR	1.34
145	Lynch syndrome	Enrichment	KRAS	1.34
146	Noonan syndrome and noonan-related syndrome	Enrichment	KRAS	1.34
147	Rhabdomyosarcoma	Enrichment	TP53	1.31
148	Gliosarcoma	Enrichment	TP53	1.31
149	Sudden infant death syndrome	Enrichment	PDHA1	1.29
150	Giant cell glioblastoma	Enrichment	TP53	1.29
151	Arteriovenous malformations of the brain	Enrichment	KRAS	1.24
152	Diffuse large b-cell lymphoma	Enrichment	TP53	1.24
153	Hepatoblastoma	Enrichment	TP53	1.20
154	Hepatocellular carcinoma	Enrichment	TP53	1.18
155	Diamond-blackfan anemia 1	Enrichment	TP53	1.16
156	Noonan syndrome 1	Enrichment	KRAS	1.16
157	Developmental and epileptic encephalopathy 1	Enrichment	SLC2A1	1.13
158	Rasopathy	Enrichment	KRAS	1.11
159	Strabismus	Enrichment	SLC2A1	1.09
160	Prostate cancer	Enrichment	TP53	1.07
161	Differentiated thyroid carcinoma	Enrichment	KRAS	1.07
162	Non-immune hydrops fetalis	Enrichment	KRAS	1.04
163	Lung cancer	Enrichment	KRAS	1.02
164	Severe combined immunodeficiency	Enrichment	PGM3	1.01
165	Developmental and epileptic encephalopathy	Enrichment	GOT2	0.98
166	Diamond-blackfan anemia	Enrichment	TP53	0.98
167	Epilepsy	Enrichment	SLC2A1	0.93
168	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	0.92
169	Centralopathic epilepsy	Enrichment	SLC2A1	0.90
170	West syndrome	Enrichment	SLC2A1	0.89
171	Colorectal cancer	Enrichment	TP53	0.63
172	Mitochondrial disease	Enrichment	PDHX	0.63
173	Autism spectrum disorder	Enrichment	HK1	0.54
174	Microcephaly	Enrichment	SLC2A1	0.50
175	Inherited cancer-predisposing syndrome	Enrichment	TP53	0.47
176	Retinitis pigmentosa	Enrichment	HK1	0.31
177	Hereditary retinal dystrophy	Enrichment	HK1	0.22
178	Fundus dystrophy	Enrichment	HK1	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metabolic reprogramming in pancreatic cancer

Pathway Network for Metabolic reprogramming in pancreatic cancer

Member Pathways for Metabolic reprogramming in pancreatic cancer

Pathways in the Metabolic reprogramming in pancreatic cancer SuperPath

Associated Genes for Metabolic reprogramming in pancreatic cancer

Associated Disorders for Metabolic reprogramming in pancreatic cancer

Disorders associated with Metabolic reprogramming in pancreatic cancer SuperPath

STRING Interaction Network for Metabolic reprogramming in pancreatic cancer

Sources for Metabolic reprogramming in pancreatic cancer