Metabolic States and Circadian Oscillators

Sources:

#	Name	Source	Genes
1	Metabolic States and Circadian Oscillators	QIAGEN	BMAL1 CLOCK CRY1 CRY2 LDHA LDHB LDHC LDHD NPAS2 PER1 (see all 10) (see less)
2	Circadian rhythm pathway	PubChem	ATR BHLHE40 BMAL1 CHEK1 CLOCK CRY1 CRY2 CSNK1E HMOX1 NONO NPAS2 NR1D1 PER1 TIMELESS WDR5 (see all 15) (see less)
3	lactate fermentation (reoxidation of cytosolic NADH)	PubChem	LDHA LDHB LDHC
4	methylglyoxal degradation VI	PubChem	LDHD

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BMAL1	Basic Helix-Loop-Helix ARNT Like 1	Protein Coding	2
2	CLOCK	Clock Circadian Regulator	Protein Coding	2
3	CRY1	Cryptochrome Circadian Regulator 1	Protein Coding	2
4	CRY2	Cryptochrome Circadian Regulator 2	Protein Coding	2
5	LDHA	Lactate Dehydrogenase A	Protein Coding	2
6	LDHB	Lactate Dehydrogenase B	Protein Coding	2
7	LDHC	Lactate Dehydrogenase C	Protein Coding	2
8	LDHD	Lactate Dehydrogenase D	Protein Coding	2
9	NPAS2	Neuronal PAS Domain Protein 2	Protein Coding	2
10	PER1	Period Circadian Regulator 1	Protein Coding	2
11	NONO	Non-POU Domain Containing Octamer Binding	Protein Coding	1
12	NR1D1	Nuclear Receptor Subfamily 1 Group D Member 1	Protein Coding	1
13	HMOX1	Heme Oxygenase 1	Protein Coding	1
14	WDR5	WD Repeat Domain 5	Protein Coding	1
15	BHLHE40	Basic Helix-Loop-Helix Family Member E40	Protein Coding	1
16	TIMELESS	Timeless Circadian Regulator	Protein Coding	1
17	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
18	ATR	ATR Checkpoint Kinase	Protein Coding	1
19	CHEK1	Checkpoint Kinase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	D-lactic aciduria with gout	Enrichment	LDHD	4.13
2	Lactate dehydrogenase b deficiency	Enrichment	LDHB	3.66
3	Fanconi-bickel syndrome	Enrichment	LDHA	3.35
4	Delayed sleep phase disorder	Enrichment	CRY1	3.13
5	Seckel syndrome 1	Enrichment	ATR	2.96
6	Intellectual developmental disorder, x-linked, syndromic 34	Enrichment	NONO	2.96
7	Advanced sleep phase syndrome, familial, 4	Enrichment	TIMELESS	2.96
8	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.96
9	Syndromic x-linked intellectual disability 34	Enrichment	NONO	2.96
10	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.96
11	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.96
12	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.96
13	Hypothyroidism, congenital, nongoitrous, 6	Enrichment	NR1D1	2.66
14	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	2.35
15	Renal cell carcinoma with mit translocations	Enrichment	NONO	2.11
16	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.85
17	Seckel syndrome	Enrichment	ATR	1.81
18	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E	1.56
19	Cystic fibrosis	Enrichment	HMOX1	1.46
20	West syndrome	Enrichment	CSNK1E	1.32

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Metabolic States and Circadian Oscillators