Metabolism of amine-derived hormones

Sources:

#	Name	Source	Genes
1	Metabolism of amine-derived hormones	Reactome	AANAT ASMT CGA DBH DDC DIO1 DIO2 DIO3 DUOX1 DUOX2 IYD PNMT SLC5A5 TH TPH1 TPH2 TPO TSHB (see all 18) (see less)
2	Thyroxine biosynthesis	Reactome	CGA DIO1 DIO2 DIO3 DUOX1 DUOX2 IYD SLC5A5 TPO TSHB (see all 10) (see less)
3	Regulation of thyroid hormone activity	Reactome	DIO1 DIO2 DIO3
4	Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)	Reactome	SLC5A5

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DIO1	Iodothyronine Deiodinase 1	Protein Coding	3
2	DIO2	Iodothyronine Deiodinase 2	Protein Coding	3
3	DIO3	Iodothyronine Deiodinase 3	Protein Coding	3
4	SLC5A5	Solute Carrier Family 5 Member 5	Protein Coding	3
5	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	2
6	IYD	Iodotyrosine Deiodinase	Protein Coding	2
7	DUOX2	Dual Oxidase 2	Protein Coding	2
8	DUOX1	Dual Oxidase 1	Protein Coding	2
9	TPO	Thyroid Peroxidase	Protein Coding	2
10	TSHB	Thyroid Stimulating Hormone Subunit Beta	Protein Coding	2
11	TPH2	Tryptophan Hydroxylase 2	Protein Coding	1
12	AANAT	Aralkylamine N-Acetyltransferase	Protein Coding	1
13	DBH	Dopamine Beta-Hydroxylase	Protein Coding	1
14	DDC	Dopa Decarboxylase	Protein Coding	1
15	ASMT	Acetylserotonin O-Methyltransferase	Protein Coding	1
16	PNMT	Phenylethanolamine N-Methyltransferase	Protein Coding	1
17	TH	Tyrosine Hydroxylase	Protein Coding	1
18	TPH1	Tryptophan Hydroxylase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital hypothyroidism	Direct
2	Familial thyroid dyshormonogenesis	Enrichment	DUOX2, IYD, SLC5A5, TPO	11.45
3	Thyroid hormone metabolism, abnormal, 2	Enrichment	DIO1	3.66
4	Thyroid dyshormonogenesis 4	Enrichment	IYD	3.13
5	Thyroid dyshormonogenesis 1	Enrichment	SLC5A5	3.13
6	Thyroid dyshormonogenesis 6	Enrichment	DUOX2	3.13
7	Hypothyroidism, congenital, nongoitrous, 4	Enrichment	TSHB	3.13
8	Thyroid dyshormonogenesis 2a	Enrichment	TPO	2.83
9	Major affective disorder 1	Enrichment	TPH2	2.58
10	Segawa syndrome, autosomal recessive	Enrichment	TH	2.58
11	Orthostatic hypotension 1	Enrichment	DBH	2.58
12	Aromatic l-amino acid decarboxylase deficiency	Enrichment	DDC	2.58
13	Dopamine beta-hydroxylase deficiency	Enrichment	DBH	2.58
14	Dystonia, dopa-responsive	Enrichment	TH	2.40
15	Major depressive disorder	Enrichment	TPH2	2.18
16	Rasopathy	Enrichment	DDC	1.47
17	Dystonia	Enrichment	TH	1.34

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Metabolism of amine-derived hormones