Metabolism of cofactors

Pathway network for the Metabolism of cofactors SuperPath

Sources:

Reactome

Pathways in the Metabolism of cofactors SuperPath

#	Name	Source	Genes
1	Metabolism of cofactors	Reactome	ACO1 AKT1 CALM1 CALM2 CALM3 COQ2 COQ3 COQ4 COQ5 COQ6 COQ7 COQ8A COQ8B COQ9 DHFR GCH1 GCHFR HPDL HSP90AA1 IDH1 NOS3 PDSS1 PDSS2 PRKG2 PTS SPR STARD7 (see all 27) (see less)
2	Ubiquinol biosynthesis	Reactome	COQ2 COQ3 COQ4 COQ5 COQ6 COQ7 COQ8A COQ8B COQ9 HPDL PDSS1 PDSS2 STARD7 (see all 13) (see less)
3	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	Reactome	AKT1 CALM1 CALM2 CALM3 DHFR GCH1 GCHFR HSP90AA1 NOS3 PRKG2 PTS SPR (see all 12) (see less)

Gene overlap in member pathways for Metabolism of cofactors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	COQ7	Coenzyme Q7, Hydroxylase	Protein Coding	2
2	DHFR	Dihydrofolate Reductase	Protein Coding	2
3	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
4	PDSS1	Decaprenyl Diphosphate Synthase Subunit 1	Protein Coding	2
5	GCH1	GTP Cyclohydrolase 1	Protein Coding	2
6	GCHFR	GTP Cyclohydrolase I Feedback Regulator	Protein Coding	2
7	COQ2	Coenzyme Q2, Polyprenyltransferase	Protein Coding	2
8	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
9	NOS3	Nitric Oxide Synthase 3	Protein Coding	2
10	COQ6	Coenzyme Q6, Monooxygenase	Protein Coding	2
11	COQ4	Coenzyme Q4	Protein Coding	2
12	COQ3	Coenzyme Q3, Methyltransferase	Protein Coding	2
13	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	2
14	STARD7	StAR Related Lipid Transfer Domain Containing 7	Protein Coding	2
15	COQ8A	Coenzyme Q8A	Protein Coding	2
16	COQ9	Coenzyme Q9	Protein Coding	2
17	PDSS2	Decaprenyl Diphosphate Synthase Subunit 2	Protein Coding	2
18	PTS	6-Pyruvoyltetrahydropterin Synthase	Protein Coding	2
19	SPR	Sepiapterin Reductase	Protein Coding	2
20	COQ8B	Coenzyme Q8B	Protein Coding	2
21	CALM1	Calmodulin 1	Protein Coding	2
22	CALM2	Calmodulin 2	Protein Coding	2
23	CALM3	Calmodulin 3	Protein Coding	2
24	COQ5	Coenzyme Q5, Methyltransferase	Protein Coding	2
25	HPDL	4-Hydroxyphenylpyruvate Dioxygenase Like	Protein Coding	2
26	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	1
27	ACO1	Aconitase 1	Protein Coding	1

Disorders associated with Metabolism of cofactors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	7.53
2	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	5.67
3	Hyperphenylalaninemia, bh4-deficient, b	Enrichment	GCH1, PTS	5.67
4	Coenzyme q10 deficiency, primary, 1	Enrichment	COQ2, COQ8A	5.59
5	Coenzyme q10 deficiency, primary, 5	Enrichment	COQ7, COQ9	5.59
6	Nephrotic syndrome	Enrichment	COQ2, COQ8B, PDSS2	5.08
7	Hyperphenylalaninemia, bh4-deficient, a	Enrichment	GCH1, PTS	4.97
8	Long qt syndrome	Enrichment	CALM1, CALM2	3.48
9	Dystonia	Enrichment	GCH1, SPR	3.38
10	Proteus syndrome	Enrichment	AKT1	3.05
11	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	3.05
12	Long qt syndrome 16	Enrichment	CALM3	3.05
13	Cowden syndrome 6	Enrichment	AKT1	3.05
14	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	3.05
15	Long qt syndrome 15	Enrichment	CALM2	3.05
16	Epilepsy, familial adult myoclonic, 2	Enrichment	STARD7	3.02
17	Coenzyme q10 deficiency, primary, 4	Enrichment	COQ8A	3.02
18	Coenzyme q10 deficiency, primary, 9	Enrichment	COQ5	3.02
19	Nephrotic syndrome, type 9	Enrichment	COQ8B	3.02
20	Coenzyme q10 deficiency, primary, 2	Enrichment	PDSS1	3.02
21	Coenzyme q10 deficiency, primary, 3	Enrichment	PDSS2	3.02
22	Multiple system atrophy, parkinsonian type	Enrichment	COQ2	3.02
23	Spastic ataxia	Enrichment	COQ4, HPDL	2.94
24	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.75
25	Long qt syndrome 14	Enrichment	CALM1	2.75
26	Acromesomelic dysplasia 4	Enrichment	PRKG2	2.75
27	Dystonia, dopa-responsive, due to sepiapterin reductase deficiency	Enrichment	SPR	2.75
28	Multiple system atrophy 1	Enrichment	COQ2	2.72
29	Coenzyme q10 deficiency, primary, 6	Enrichment	COQ6	2.72
30	Spastic ataxia 10, autosomal recessive	Enrichment	COQ4	2.72
31	Spastic paraplegia 83, autosomal recessive	Enrichment	HPDL	2.72
32	Multiple system atrophy	Enrichment	COQ2	2.72
33	Multiple system atrophy, cerebellar type	Enrichment	COQ2	2.72
34	Metaphyseal enchondromatosis with d-2-hydroxyglutaric aciduria	Enrichment	IDH1	2.70
35	Dystonia, dopa-responsive	Enrichment	GCH1	2.58
36	Familial adenomatous polyposis 4	Enrichment	DHFR	2.58
37	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	GCH1	2.58
38	Hyperphenylalaninemia due to tetrahydrobiopterin deficiency	Enrichment	PTS	2.58
39	Neuronopathy, distal hereditary motor, autosomal recessive 9	Enrichment	COQ7	2.54
40	Coenzyme q10 deficiency, primary, 7	Enrichment	COQ4	2.54
41	Coenzyme q10 deficiency, primary, 8	Enrichment	COQ7	2.54
42	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Enrichment	HPDL	2.42
43	Full schwannomatosis	Enrichment	COQ6	2.42
44	Alzheimer disease 2	Enrichment	NOS3	2.35
45	Pre-eclampsia	Enrichment	NOS3	2.35
46	Sleep disorder	Enrichment	GCH1	2.35
47	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.28
48	Breast adenocarcinoma	Enrichment	AKT1	2.28
49	Enchondromatosis	Enrichment	IDH1	2.22
50	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.15
51	Cowden syndrome	Enrichment	AKT1	2.10
52	Stroke, ischemic	Enrichment	NOS3	2.05
53	Enchondromatosis, multiple, ollier type	Enrichment	IDH1	2.00
54	Paroxysmal extreme pain disorder	Enrichment	IDH1	2.00
55	Meningioma	Enrichment	AKT1	1.98
56	Multiple enchondromatosis, maffucci type	Enrichment	IDH1	1.86
57	Alzheimer disease, familial, 1	Enrichment	NOS3	1.83
58	Hypertension, essential	Enrichment	NOS3	1.83
59	Sudden infant death syndrome	Enrichment	CALM2	1.83
60	Glioma susceptibility 1	Enrichment	IDH1	1.80
61	Endometrial cancer	Enrichment	DHFR	1.73
62	Focal segmental glomerulosclerosis	Enrichment	COQ2	1.72
63	Gliosarcoma	Enrichment	IDH1	1.50
64	Genetic steroid-resistant nephrotic syndrome	Enrichment	COQ8B	1.49
65	Giant cell glioblastoma	Enrichment	IDH1	1.48
66	Hereditary breast carcinoma	Enrichment	AKT1	1.42
67	Primary ovarian insufficiency	Enrichment	NOS3	1.29
68	Breast cancer	Enrichment	AKT1	1.19
69	Colorectal cancer	Enrichment	AKT1	1.13
70	Leukemia, acute myeloid	Enrichment	IDH1	1.12
71	Mitochondrial disease	Enrichment	COQ8A	1.10
72	Ovarian cancer	Enrichment	AKT1	1.07
73	Congenital nervous system abnormality	Enrichment	COQ8A	1.01
74	Nervous system disease	Enrichment	COQ8A	1.01
75	Inherited cancer-predisposing syndrome	Enrichment	DHFR	0.96
76	Complex neurodevelopmental disorder	Enrichment	HPDL	0.95
77	Retinitis pigmentosa	Enrichment	COQ8B	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metabolism of cofactors

Pathway Network for Metabolism of cofactors

Pathway network for the Metabolism of cofactors SuperPath

Member Pathways for Metabolism of cofactors

Pathways in the Metabolism of cofactors SuperPath

Gene overlap in member pathways for Metabolism of cofactors SuperPath

Associated Genes for Metabolism of cofactors

Associated Disorders for Metabolism of cofactors

Disorders associated with Metabolism of cofactors SuperPath

STRING Interaction Network for Metabolism of cofactors

Sources for Metabolism of cofactors