Metabolism of nitric oxide: NOS3 activation and regulation

Pathway network for the Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

Sources:

Reactome

Pathways in the Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

#	Name	Source	Genes
1	Metabolism of nitric oxide: NOS3 activation and regulation	Reactome	AKT1 CALM1 CALM2 CALM3 CAV1 CYB5B CYGB DDAH1 DNM2 HSP90AA1 LYPLA1 NMT2 NOS3 NOSIP NOSTRIN SPR WASL ZDHHC21 (see all 18) (see less)
2	eNOS activation	Reactome	AKT1 CALM1 CALM2 CALM3 CAV1 CYB5B CYGB DDAH1 HSP90AA1 LYPLA1 NMT2 NOS3 SPR ZDHHC21 (see all 14) (see less)
3	NOSTRIN mediated eNOS trafficking	Reactome	CAV1 DNM2 NOS3 NOSTRIN WASL
4	NOSIP mediated eNOS trafficking	Reactome	NOS3 NOSIP

Gene overlap in member pathways for Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOS3	Nitric Oxide Synthase 3	Protein Coding	4
2	CAV1	Caveolin 1	Protein Coding	3
3	LYPLA1	Lysophospholipase 1	Protein Coding	2
4	CYGB	Cytoglobin	Protein Coding	2
5	NOSTRIN	Nitric Oxide Synthase Trafficking	Protein Coding	2
6	DNM2	Dynamin 2	Protein Coding	2
7	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
8	DDAH1	Dimethylarginine Dimethylaminohydrolase 1	Protein Coding	2
9	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	2
10	ZDHHC21	ZDHHC Palmitoyltransferase 21	Protein Coding	2
11	NOSIP	Nitric Oxide Synthase Interacting Protein	Protein Coding	2
12	SPR	Sepiapterin Reductase	Protein Coding	2
13	CALM1	Calmodulin 1	Protein Coding	2
14	CALM2	Calmodulin 2	Protein Coding	2
15	CYB5B	Cytochrome B5 Type B	Protein Coding	2
16	CALM3	Calmodulin 3	Protein Coding	2
17	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	2
18	NMT2	N-Myristoyltransferase 2	Protein Coding	2

Disorders associated with Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	7.31
2	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	5.46
3	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	3.43
4	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	3.43
5	Pulmonary hypertension, primary, 3	Enrichment	CAV1	3.43
6	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	3.43
7	Lethal congenital contracture syndrome 5	Enrichment	DNM2	3.43
8	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	3.43
9	Long qt syndrome	Enrichment	CALM1, CALM2	3.34
10	Alzheimer disease 2	Enrichment	NOS3	3.13
11	Pre-eclampsia	Enrichment	NOS3	3.13
12	Proteus syndrome	Enrichment	AKT1	2.99
13	Long qt syndrome 16	Enrichment	CALM3	2.99
14	Cowden syndrome 6	Enrichment	AKT1	2.99
15	Long qt syndrome 15	Enrichment	CALM2	2.99
16	Myopathy, centronuclear, x-linked	Enrichment	DNM2	2.96
17	Stroke, ischemic	Enrichment	NOS3	2.83
18	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	2.73
19	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.69
20	Long qt syndrome 14	Enrichment	CALM1	2.69
21	Retinitis pigmentosa 36	Enrichment	CYGB	2.69
22	Dystonia, dopa-responsive, due to sepiapterin reductase deficiency	Enrichment	SPR	2.69
23	Myopathy, centronuclear, 1	Enrichment	DNM2	2.66
24	Limited scleroderma	Enrichment	CAV1	2.66
25	Alzheimer disease, familial, 1	Enrichment	NOS3	2.60
26	Hypertension, essential	Enrichment	NOS3	2.60
27	Heritable pulmonary arterial hypertension	Enrichment	CAV1	2.39
28	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.21
29	Breast adenocarcinoma	Enrichment	AKT1	2.21
30	Centronuclear myopathy	Enrichment	DNM2	2.11
31	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.08
32	Primary ovarian insufficiency	Enrichment	NOS3	2.06
33	Cowden syndrome	Enrichment	AKT1	2.03
34	Meningioma	Enrichment	AKT1	1.91
35	Myopathy	Enrichment	DNM2	1.83
36	Charcot-marie-tooth disease	Enrichment	DNM2	1.82
37	Sudden infant death syndrome	Enrichment	CALM2	1.76
38	Dystonia	Enrichment	SPR	1.45
39	Hereditary breast carcinoma	Enrichment	AKT1	1.35
40	Breast cancer	Enrichment	AKT1	1.13
41	Colorectal cancer	Enrichment	AKT1	1.06
42	Ovarian cancer	Enrichment	AKT1	1.00
43	Retinitis pigmentosa	Enrichment	CYGB	0.70
44	Hereditary retinal dystrophy	Enrichment	CYGB	0.58
45	Fundus dystrophy	Enrichment	CYGB	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metabolism of nitric oxide: NOS3 activation and regulation

Pathway Network for Metabolism of nitric oxide: NOS3 activation and regulation

Pathway network for the Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

Member Pathways for Metabolism of nitric oxide: NOS3 activation and regulation

Pathways in the Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

Gene overlap in member pathways for Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

Associated Genes for Metabolism of nitric oxide: NOS3 activation and regulation

Associated Disorders for Metabolism of nitric oxide: NOS3 activation and regulation

Disorders associated with Metabolism of nitric oxide: NOS3 activation and regulation SuperPath

STRING Interaction Network for Metabolism of nitric oxide: NOS3 activation and regulation

Sources for Metabolism of nitric oxide: NOS3 activation and regulation