Metabolism of nucleotides

Pathway network for the Metabolism of nucleotides SuperPath

Sources:

Reactome
PubChem

Pathways in the Metabolism of nucleotides SuperPath

#	Name	Source	Genes
1	Metabolism of nucleotides	Reactome	ADA ADK ADPRM ADSL ADSS1 ADSS2 AGXT2 AK1 AK2 AK4 AK5 AK6 AK7 AK8 AK9 AMPD1 AMPD2 AMPD3 APRT ATIC CAD CDA CMPK1 CTPS1 CTPS2 DCK DCTD DCTPP1 DGUOK DHODH DNPH1 DPYD DPYS DTYMK DUT ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 GART GDA GLRX GMPR GMPR2 GMPS GSR GUK1 HPRT1 IMPDH1 IMPDH2 ITPA MAPDA NME1 NME2 NME3 NME4 NT5C NT5C1A NT5C1B NT5C1B-RDH14 NT5C2 NT5C3A NT5E NT5M NUDT1 NUDT13 NUDT15 NUDT16 NUDT18 NUDT5 NUDT9 PAICS PFAS PNP PPAT PUDP RRM1 RRM2 RRM2B SAMHD1 TK1 TK2 TXN TXNRD1 TYMP TYMS UCK1 UCK2 UCKL1 UMPS UPB1 UPP1 UPP2 XDH (see all 98) (see less)
2	Nucleotide catabolism	Reactome	ADPRM AGXT2 DNPH1 DPYD DPYS ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 GDA ITPA NT5C NT5C1A NT5C1B NT5C1B-RDH14 NT5C2 NT5C3A NT5E NT5M NUDT1 NUDT15 NUDT16 NUDT18 NUDT5 NUDT9 PNP SAMHD1 TYMP UPB1 UPP1 UPP2 XDH (see all 36) (see less)
3	Purine catabolism	Reactome	ADPRM DNPH1 GDA ITPA NT5C NT5C1A NT5C1B NT5C1B-RDH14 NT5C2 NT5E NUDT1 NUDT15 NUDT16 NUDT18 NUDT5 NUDT9 PNP XDH (see all 18) (see less)
4	Nucleotide biosynthesis	Reactome	ADSL ADSS1 ADSS2 ATIC CAD DHODH GART GMPS IMPDH1 IMPDH2 PAICS PFAS PPAT UMPS (see all 14) (see less)
5	superpathway of purine nucleotide salvage	PubChem	ADA ADK ADSL AK5 GUK1 HPRT1 IMPDH1 IMPDH2 NME1 NME2 PNP RRM1 RRM2 (see all 13) (see less)
6	Pyrimidine catabolism	Reactome	AGXT2 DPYD DPYS NT5C NT5C1A NT5C3A NT5E NT5M TYMP UPB1 UPP1 UPP2 (see all 12) (see less)
7	purine nucleotides degradation	PubChem	ADA GDA IMPDH1 IMPDH2 NT5C1A NT5C1B NT5C1B-RDH14 NT5C2 NT5C3A NT5E PNP XDH (see all 12) (see less)
8	Purine ribonucleoside monophosphate biosynthesis	Reactome	ADSL ADSS1 ADSS2 ATIC GART GMPS IMPDH1 IMPDH2 PAICS PFAS PPAT (see all 11) (see less)
9	adenosine nucleotides degradation	PubChem	ADA NT5C1A NT5C1B NT5C1B-RDH14 NT5C2 NT5C3A NT5E PNP XDH (see all 9) (see less)
10	purine nucleotides degradation II (aerobic)	PubChem	ADA GDA IMPDH1 IMPDH2 NT5C1A NT5C2 NT5E PNP XDH (see all 9) (see less)
11	Phosphate bond hydrolysis by NTPDase proteins	Reactome	ENTPD1 ENTPD2 ENTPD3 ENTPD4 ENTPD5 ENTPD6 ENTPD7 ENTPD8 (see all 8) (see less)
12	superpathway of guanosine nucleotides de novo biosynthesis I	PubChem	GUK1 IMPDH1 IMPDH2 NME1 NME2 RRM1 RRM2 (see all 7) (see less)
13	Phosphate bond hydrolysis by NUDT proteins	Reactome	ADPRM NUDT1 NUDT15 NUDT16 NUDT18 NUDT5 NUDT9 (see all 7) (see less)
14	purine deoxyribonucleosides salvage	PubChem	AK5 DCK DGUOK GUK1 NME1 NME2 (see all 6) (see less)
15	superpathway of adenosine nucleotides de novo biosynthesis I	PubChem	ADSL AK5 NME1 NME2 RRM1 RRM2 (see all 6) (see less)
16	adenosine nucleotides degradation II	PubChem	ADA NT5C1A NT5E PNP XDH
17	guanosine ribonucleotides de novo biosynthesis	PubChem	GUK1 IMPDH1 IMPDH2 NME1 NME2
18	adenosine ribonucleotides de novo biosynthesis	PubChem	ADSL AK5
19	oxidized GTP and dGTP detoxification	PubChem	NUDT1

Gene overlap in member pathways for Metabolism of nucleotides SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IMPDH1	Inosine Monophosphate Dehydrogenase 1	Protein Coding	8
2	IMPDH2	Inosine Monophosphate Dehydrogenase 2	Protein Coding	8
3	PNP	Purine Nucleoside Phosphorylase	Protein Coding	8
4	NT5E	5''-Nucleotidase Ecto	Protein Coding	8
5	NT5C1A	5''-Nucleotidase, Cytosolic IA	Protein Coding	8
6	XDH	Xanthine Dehydrogenase	Protein Coding	7
7	ADA	Adenosine Deaminase	Protein Coding	6
8	ADSL	Adenylosuccinate Lyase	Protein Coding	6
9	NT5C2	5''-Nucleotidase, Cytosolic II	Protein Coding	6
10	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	6
11	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	6
12	NT5C1B-RDH14	NT5C1B-RDH14 Readthrough	Protein Coding	5
13	AK5	Adenylate Kinase 5	Protein Coding	5
14	GUK1	Guanylate Kinase 1	Protein Coding	5
15	NUDT1	Nudix Hydrolase 1	Protein Coding	5
16	NT5C3A	5''-Nucleotidase, Cytosolic IIIA	Protein Coding	5
17	NT5C1B	5''-Nucleotidase, Cytosolic IB	Protein Coding	5
18	GDA	Guanine Deaminase	Protein Coding	5
19	NUDT5	Nudix Hydrolase 5	Protein Coding	4
20	NUDT16	Nudix Hydrolase 16	Protein Coding	4
21	NT5C	5'', 3''-Nucleotidase, Cytosolic	Protein Coding	4
22	NUDT9	Nudix Hydrolase 9	Protein Coding	4
23	NUDT15	Nudix Hydrolase 15	Protein Coding	4
24	ADPRM	ADP-Ribose/CDP-Alcohol Diphosphatase, Manganese Dependent	Protein Coding	4
25	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	4
26	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	4
27	NUDT18	Nudix Hydrolase 18	Protein Coding	4
28	DNPH1	2''-Deoxynucleoside 5''-Phosphate N-Hydrolase 1	Protein Coding	3
29	PAICS	Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase	Protein Coding	3
30	ADSS1	Adenylosuccinate Synthase 1	Protein Coding	3
31	UPP2	Uridine Phosphorylase 2	Protein Coding	3
32	ADSS2	Adenylosuccinate Synthase 2	Protein Coding	3
33	DPYD	Dihydropyrimidine Dehydrogenase	Protein Coding	3
34	DPYS	Dihydropyrimidinase	Protein Coding	3
35	TYMP	Thymidine Phosphorylase	Protein Coding	3
36	GART	Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase	Protein Coding	3
37	ITPA	Inosine Triphosphatase	Protein Coding	3
38	ENTPD8	Ectonucleoside Triphosphate Diphosphohydrolase 8	Protein Coding	3
39	ATIC	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase	Protein Coding	3
40	UPB1	Beta-Ureidopropionase 1	Protein Coding	3
41	PFAS	Phosphoribosylformylglycinamidine Synthase	Protein Coding	3
42	PPAT	Phosphoribosyl Pyrophosphate Amidotransferase	Protein Coding	3
43	NT5M	5'',3''-Nucleotidase, Mitochondrial	Protein Coding	3
44	ENTPD7	Ectonucleoside Triphosphate Diphosphohydrolase 7	Protein Coding	3
45	AGXT2	Alanine--Glyoxylate Aminotransferase 2	Protein Coding	3
46	UPP1	Uridine Phosphorylase 1	Protein Coding	3
47	GMPS	Guanine Monophosphate Synthase	Protein Coding	3
48	ENTPD1	Ectonucleoside Triphosphate Diphosphohydrolase 1	Protein Coding	3
49	ENTPD2	Ectonucleoside Triphosphate Diphosphohydrolase 2	Protein Coding	3
50	ENTPD6	Ectonucleoside Triphosphate Diphosphohydrolase 6	Protein Coding	3
51	ENTPD3	Ectonucleoside Triphosphate Diphosphohydrolase 3	Protein Coding	3
52	ENTPD5	Ectonucleoside Triphosphate Diphosphohydrolase 5 (Inactive)	Protein Coding	3
53	ENTPD4	Ectonucleoside Triphosphate Diphosphohydrolase 4	Protein Coding	3
54	ADK	Adenosine Kinase	Protein Coding	2
55	DCK	Deoxycytidine Kinase	Protein Coding	2
56	DGUOK	Deoxyguanosine Kinase	Protein Coding	2
57	DHODH	Dihydroorotate Dehydrogenase (Quinone)	Protein Coding	2
58	SAMHD1	SAM And HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase 1	Protein Coding	2
59	HPRT1	Hypoxanthine Phosphoribosyltransferase 1	Protein Coding	2
60	UMPS	Uridine Monophosphate Synthetase	Protein Coding	2
61	CAD	Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase	Protein Coding	2
62	AK6	Adenylate Kinase 6	Protein Coding	1
63	AK7	Adenylate Kinase 7	Protein Coding	1
64	CTPS1	CTP Synthase 1	Protein Coding	1
65	AK8	Adenylate Kinase 8	Protein Coding	1
66	MAPDA	N6-Methyl-AMP Deaminase	Protein Coding	1
67	DCTD	DCMP Deaminase	Protein Coding	1
68	DTYMK	Deoxythymidylate Kinase	Protein Coding	1
69	DUT	Deoxyuridine Triphosphatase	Protein Coding	1
70	AK1	Adenylate Kinase 1	Protein Coding	1
71	AK2	Adenylate Kinase 2	Protein Coding	1
72	AK4	Adenylate Kinase 4	Protein Coding	1
73	AK9	Adenylate Kinase 9	Protein Coding	1
74	NUDT13	Nudix Hydrolase 13	Protein Coding	1
75	AMPD1	Adenosine Monophosphate Deaminase 1	Protein Coding	1
76	AMPD2	Adenosine Monophosphate Deaminase 2	Protein Coding	1
77	AMPD3	Adenosine Monophosphate Deaminase 3	Protein Coding	1
78	GLRX	Glutaredoxin	Protein Coding	1
79	GMPR	Guanosine Monophosphate Reductase	Protein Coding	1
80	GSR	Glutathione-Disulfide Reductase	Protein Coding	1
81	APRT	Adenine Phosphoribosyltransferase	Protein Coding	1
82	NME3	NME/NM23 Nucleoside Diphosphate Kinase 3	Protein Coding	1
83	NME4	NME/NM23 Nucleoside Diphosphate Kinase 4	Protein Coding	1
84	RRM2B	Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B	Protein Coding	1
85	GMPR2	Guanosine Monophosphate Reductase 2	Protein Coding	1
86	CMPK1	Cytidine/Uridine Monophosphate Kinase 1	Protein Coding	1
87	UCKL1	Uridine-Cytidine Kinase 1 Like 1	Protein Coding	1
88	CTPS2	CTP Synthase 2	Protein Coding	1
89	TK1	Thymidine Kinase 1	Protein Coding	1
90	TK2	Thymidine Kinase 2	Protein Coding	1
91	TXN	Thioredoxin	Protein Coding	1
92	TXNRD1	Thioredoxin Reductase 1	Protein Coding	1
93	TYMS	Thymidylate Synthetase	Protein Coding	1
94	UCK2	Uridine-Cytidine Kinase 2	Protein Coding	1
95	DCTPP1	DCTP Pyrophosphatase 1	Protein Coding	1
96	PUDP	Pseudouridine 5''-Phosphatase	Protein Coding	1
97	UCK1	Uridine-Cytidine Kinase 1	Protein Coding	1
98	CDA	Cytidine Deaminase	Protein Coding	1

Disorders associated with Metabolism of nucleotides SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adenosine monophosphate deaminase deficiency	Enrichment	AMPD1, AMPD3	4.29
2	Severe combined immunodeficiency	Enrichment	ADA, PNP	4.24
3	Adenylosuccinase deficiency	Enrichment	ADSL	3.83
4	Calcification of joints and arteries	Enrichment	NT5E	3.43
5	Purine nucleoside phosphorylase deficiency	Enrichment	PNP	3.43
6	Retinitis pigmentosa 10	Enrichment	IMPDH1	3.43
7	Impdh2 enzyme activity, variation in	Enrichment	IMPDH2	3.43
8	Leber congenital amaurosis 11	Enrichment	IMPDH1	3.43
9	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	3.35
10	Thiopurines, poor metabolism of, 2	Enrichment	NUDT15	3.29
11	Anemia, congenital, nonspherocytic hemolytic, 8	Enrichment	NT5C3A	3.18
12	Xanthinuria, type i	Enrichment	XDH	3.13
13	Mitochondrial dna depletion syndrome 21	Enrichment	GUK1	3.13
14	Aica-ribosiduria due to atic deficiency	Enrichment	ATIC	3.09
15	Myopathy, distal, 5	Enrichment	ADSS1	3.09
16	Early myoclonic encephalopathy	Enrichment	ADSL	3.05
17	Dihydropyrimidinase deficiency	Enrichment	DPYS	3.05
18	Beta-aminoisobutyric aciduria	Enrichment	AGXT2	3.05
19	Beta-ureidopropionase deficiency	Enrichment	UPB1	3.05
20	1p21.3 microdeletion syndrome	Enrichment	DPYD	3.05
21	Hypermethioninemia due to adenosine kinase deficiency	Enrichment	ADK	3.02
22	Orotic aciduria	Enrichment	UMPS	2.99
23	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	2.96
24	Xanthinuria, type ii	Enrichment	XDH	2.96
25	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	IMPDH2	2.96
26	Coenzyme q10 deficiency, primary, 6	Enrichment	ENTPD5	2.93
27	Spastic paraplegia 64, autosomal recessive	Enrichment	ENTPD1	2.93
28	Mitochondrial dna depletion syndrome 3	Enrichment	DGUOK	2.88
29	Portal hypertension, noncirrhotic, 1	Enrichment	DGUOK	2.88
30	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 4	Enrichment	DGUOK	2.88
31	Spastic paraplegia 45, autosomal recessive	Enrichment	NT5C2	2.88
32	Adenosine deaminase deficiency	Enrichment	ADA	2.83
33	Phosphoribosylaminoimidazole carboxylase deficiency	Enrichment	PAICS	2.79
34	Portal hypertension	Enrichment	DGUOK	2.75
35	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	RRM2B, TYMP	2.74
36	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	2.73
37	Developmental and epileptic encephalopathy 50	Enrichment	CAD	2.69
38	Miller syndrome	Enrichment	DHODH	2.69
39	Glomerulopathy with fibronectin deposits 2	Enrichment	ATIC	2.61
40	Cerebroretinal microangiopathy with calcifications and cysts 1	Enrichment	PFAS	2.61
41	Dihydropyrimidine dehydrogenase deficiency	Enrichment	DPYD	2.58
42	Inosine triphosphatase deficiency	Enrichment	ITPA	2.58
43	Developmental and epileptic encephalopathy 35	Enrichment	ITPA	2.58
44	Chilblain lupus 2	Enrichment	SAMHD1	2.58
45	Aicardi-goutieres syndrome 5	Enrichment	SAMHD1	2.58
46	Lesch-nyhan syndrome	Enrichment	HPRT1	2.54
47	Hyperuricemia, hprt-related	Enrichment	HPRT1	2.54
48	Omenn syndrome	Enrichment	ADA	2.43
49	Mitochondrial dna depletion syndrome 1	Enrichment	TYMP	2.28
50	Mitochondrial dna depletion syndrome 4b	Enrichment	TYMP	2.15
51	Erythrocyte amp deaminase deficiency	Enrichment	AMPD3	2.14
52	Immunodeficiency 24	Enrichment	CTPS1	2.14
53	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	2.14
54	Spermatogenic failure 27	Enrichment	AK7	2.14
55	Mitochondrial dna depletion syndrome 8b	Enrichment	RRM2B	2.14
56	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 3	Enrichment	TK2	2.14
57	Myopathy due to myoadenylate deaminase deficiency	Enrichment	AMPD1	2.14
58	Bone marrow failure and diabetes mellitus syndrome	Enrichment	DUT	2.14
59	Neurodegeneration, childhood-onset, with progressive microcephaly	Enrichment	DTYMK	2.14
60	Rrm2b mitochondrial dna maintenance defects	Enrichment	RRM2B	2.14
61	Familial chilblain lupus	Enrichment	SAMHD1	2.10
62	Isolated tracheo-esophageal fistula	Enrichment	GART	2.09
63	Dyskeratosis congenita	Enrichment	PFAS, TYMS	2.09
64	Tooth agenesis, selective, 1	Enrichment	ITPA	1.93
65	Dystonia	Enrichment	IMPDH2	1.89
66	Developmental and epileptic encephalopathy 1	Enrichment	CAD, ITPA	1.86
67	Fanconi renotubular syndrome 1	Enrichment	RRM2B	1.84
68	Immunoerythromyeloid hypoplasia	Enrichment	AK2	1.84
69	Reticular dysgenesis	Enrichment	AK2	1.84
70	Rod-cone dystrophy, sensorineural deafness, and fanconi-type renal dysfunction	Enrichment	RRM2B	1.84
71	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 5	Enrichment	RRM2B	1.84
72	Mitochondrial dna depletion syndrome 2	Enrichment	TK2	1.84
73	Mitochondrial dna depletion syndrome 8a	Enrichment	RRM2B	1.84
74	Adenine phosphoribosyltransferase deficiency	Enrichment	APRT	1.84
75	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 2	Enrichment	RRM2B	1.84
76	Spermatogenic failure 89	Enrichment	AK9	1.84
77	Anemia, congenital, nonspherocytic hemolytic, 3	Enrichment	AK1	1.84
78	Autosomal recessive progressive external ophthalmoplegia	Enrichment	TK2	1.84
79	Dyskeratosis congenita, digenic	Enrichment	TYMS	1.84
80	Esophageal atresia/tracheoesophageal fistula	Enrichment	GART	1.82
81	Severe covid-19	Enrichment	ENTPD2	1.77
82	Pontocerebellar hypoplasia, type 9	Enrichment	AMPD2	1.67
83	Spastic paraplegia 63, autosomal recessive	Enrichment	AMPD2	1.67
84	Idiopathic camptocormia	Enrichment	RRM2B	1.67
85	Aicardi-goutiares syndrome	Enrichment	SAMHD1	1.63
86	Aicardi-goutieres syndrome	Enrichment	SAMHD1	1.58
87	Tooth agenesis	Enrichment	ITPA	1.54
88	Fetal akinesia deformation sequence 1	Enrichment	ADSS1	1.53
89	Distal arthrogryposis	Enrichment	ADSS1	1.47
90	Nephrotic syndrome	Enrichment	ATIC	1.46
91	Leber plus disease	Enrichment	IMPDH1	1.46
92	Kearns-sayre syndrome	Enrichment	RRM2B	1.45
93	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	RRM2B	1.37
94	Mitochondrial dna depletion syndrome	Enrichment	TK2	1.37
95	Developmental and epileptic encephalopathy	Enrichment	ITPA	1.33
96	Retinitis pigmentosa	Enrichment	IMPDH1	1.12
97	Postsynaptic congenital myasthenic syndromes	Enrichment	AK9	1.08
98	Cerebral palsy	Enrichment	SAMHD1	1.01
99	Hereditary retinal dystrophy	Enrichment	IMPDH1	0.99
100	Fundus dystrophy	Enrichment	IMPDH1	0.99
101	Pontocerebellar hypoplasia	Enrichment	AMPD2	0.91
102	Mitochondrial disease	Enrichment	RRM2B, TK2	0.88
103	Myeloma, multiple	Enrichment	SAMHD1	0.86
104	Non-syndromic male infertility due to sperm motility disorder	Enrichment	AK7	0.81
105	Myopathy	Enrichment	TK2	0.60
106	Sensorineural hearing loss	Enrichment	RRM2B	0.53
107	Spastic ataxia	Enrichment	AMPD2	0.50
108	Congenital nervous system abnormality	Enrichment	AMPD2	0.27
109	Nervous system disease	Enrichment	AMPD2	0.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metabolism of nucleotides

Pathway Network for Metabolism of nucleotides

Pathway network for the Metabolism of nucleotides SuperPath

Member Pathways for Metabolism of nucleotides

Pathways in the Metabolism of nucleotides SuperPath

Gene overlap in member pathways for Metabolism of nucleotides SuperPath

Associated Genes for Metabolism of nucleotides

Associated Disorders for Metabolism of nucleotides

Disorders associated with Metabolism of nucleotides SuperPath

STRING Interaction Network for Metabolism of nucleotides

Sources for Metabolism of nucleotides