Metabolism of sphingolipids in ER and Golgi apparatus
Pathways in the Metabolism of sphingolipids in ER and Golgi apparatus SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Metabolism of sphingolipids in ER and Golgi apparatus | WikiPathways |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | SGPP1 | Sphingosine-1-Phosphate Phosphatase 1 | Protein Coding | 1 |
| 2 | B3GALT2 | Beta-1,3-Galactosyltransferase 2 | Protein Coding | 1 |
| 3 | GALNT16 | Polypeptide N-Acetylgalactosaminyltransferase 16 | Protein Coding | 1 |
| 4 | ST6GALNAC3 | ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 3 | Protein Coding | 1 |
| 5 | CERS3 | Ceramide Synthase 3 | Protein Coding | 1 |
| 6 | SGPP2 | Sphingosine-1-Phosphate Phosphatase 2 | Protein Coding | 1 |
| 7 | SGPL1 | Sphingosine-1-Phosphate Lyase 1 | Protein Coding | 1 |
| 8 | CERK | Ceramide Kinase | Protein Coding | 1 |
| 9 | UGCG | UDP-Glucose Ceramide Glucosyltransferase | Protein Coding | 1 |
| 10 | UGT8 | UDP Glycosyltransferase 8 | Protein Coding | 1 |
| 11 | KDSR | 3-Ketodihydrosphingosine Reductase | Protein Coding | 1 |
| 12 | SGMS1 | Sphingomyelin Synthase 1 | Protein Coding | 1 |
| 13 | SGMS2 | Sphingomyelin Synthase 2 | Protein Coding | 1 |
| 14 | B4GALT2 | Beta-1,4-Galactosyltransferase 2 | Protein Coding | 1 |
Disorders associated with Metabolism of sphingolipids in ER and Golgi apparatus SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Ichthyosis, congenital, autosomal recessive 9 | Enrichment | CERS3 | 2.99 |
| 2 | Reni syndrome | Enrichment | SGPL1 | 2.99 |
| 3 | Erythrokeratodermia variabilis et progressiva 4 | Enrichment | KDSR | 2.99 |
| 4 | Calvarial doughnut lesions with bone fragility | Enrichment | SGMS2 | 2.69 |
| 5 | Weill-marchesani syndrome 4 | Enrichment | CERS3 | 2.51 |
| 6 | Erythrokeratodermia variabilis et progressiva 1 | Enrichment | KDSR | 2.08 |
| 7 | Congenital nonbullous ichthyosiform erythroderma | Enrichment | CERS3 | 1.99 |
| 8 | Ichthyosis | Enrichment | CERS3 | 1.95 |
| 9 | Autosomal recessive congenital ichthyosis | Enrichment | CERS3 | 1.81 |
| 10 | Skin disease | Enrichment | CERS3 | 1.65 |
| 11 | Nephrotic syndrome | Enrichment | SGPL1 | 1.36 |
