Metabolism of steroid hormones

Pathway network for the Metabolism of steroid hormones SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Metabolism of steroid hormones SuperPath

#	Name	Source	Genes
1	Metabolism of steroid hormones	Reactome	AKR1B1 AKR1B15 CGA CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP21A2 FDX1 FDX2 FDXR HSD11B1 HSD11B2 HSD17B1 HSD17B11 HSD17B12 HSD17B14 HSD17B2 HSD17B3 HSD3B1 HSD3B2 LHB POMC SERPINA6 SRD5A1 SRD5A2 SRD5A3 STAR STARD3 STARD3NL STARD4 STARD6 STS TSPO TSPOAP1 (see all 36) (see less)
2	Pregnenolone biosynthesis	Reactome	AKR1B1 CYP11A1 FDX1 FDX2 FDXR STAR STARD3 STARD3NL STARD4 STARD6 TSPO TSPOAP1 (see all 12) (see less)
3	Androgen biosynthesis	Reactome	CGA CYP17A1 HSD17B12 HSD17B3 HSD3B1 HSD3B2 LHB POMC SRD5A1 SRD5A2 SRD5A3 (see all 11) (see less)
4	Glucocorticoid biosynthesis	Reactome	CYP11B1 CYP11B2 CYP17A1 CYP21A2 HSD11B1 HSD11B2 HSD3B1 HSD3B2 POMC SERPINA6 (see all 10) (see less)
5	Glucocorticoid and Mineralcorticoid Metabolism	WikiPathways	CYP11A1 CYP11B2 CYP17A1 CYP21A2 HSD11B1 HSD11B2 HSD3B1 HSD3B2 (see all 8) (see less)
6	Mineralocorticoid biosynthesis	Reactome	CGA CYP11B2 CYP21A2 HSD3B1 HSD3B2 LHB (see all 6) (see less)
7	Estrogen biosynthesis	Reactome	AKR1B15 CYP19A1 HSD17B1 HSD17B11 HSD17B14 HSD17B2 (see all 6) (see less)
8	Defective CYP11A1 causes AICSR	Reactome	CYP11A1 FDX1 FDX2 FDXR
9	Electron transport from NADPH to Ferredoxin	Reactome	FDX1 FDX2 FDXR
10	Defective CYP21A2 causes AH3	Reactome	CYP21A2
11	Defective CYP11B1 causes AH4	Reactome	CYP11B1

Gene overlap in member pathways for Metabolism of steroid hormones SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	5
2	HSD3B1	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1	Protein Coding	5
3	HSD3B2	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 2	Protein Coding	5
4	FDX2	Ferredoxin 2	Protein Coding	4
5	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	4
6	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	4
7	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	4
8	FDX1	Ferredoxin 1	Protein Coding	4
9	FDXR	Ferredoxin Reductase	Protein Coding	4
10	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	3
11	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	3
12	HSD11B1	Hydroxysteroid 11-Beta Dehydrogenase 1	Protein Coding	3
13	HSD11B2	Hydroxysteroid 11-Beta Dehydrogenase 2	Protein Coding	3
14	LHB	Luteinizing Hormone Subunit Beta	Protein Coding	3
15	POMC	Proopiomelanocortin	Protein Coding	3
16	STARD3	StAR Related Lipid Transfer Domain Containing 3	Protein Coding	2
17	STARD4	StAR Related Lipid Transfer Domain Containing 4	Protein Coding	2
18	STARD6	StAR Related Lipid Transfer Domain Containing 6	Protein Coding	2
19	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	2
20	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	2
21	HSD17B1	Hydroxysteroid 17-Beta Dehydrogenase 1	Protein Coding	2
22	HSD17B3	Hydroxysteroid 17-Beta Dehydrogenase 3	Protein Coding	2
23	HSD17B2	Hydroxysteroid 17-Beta Dehydrogenase 2	Protein Coding	2
24	AKR1B15	Aldo-Keto Reductase Family 1 Member B15	Protein Coding	2
25	HSD17B12	Hydroxysteroid 17-Beta Dehydrogenase 12	Protein Coding	2
26	HSD17B11	Hydroxysteroid 17-Beta Dehydrogenase 11	Protein Coding	2
27	HSD17B14	Hydroxysteroid 17-Beta Dehydrogenase 14	Protein Coding	2
28	SRD5A1	Steroid 5 Alpha-Reductase 1	Protein Coding	2
29	SRD5A2	Steroid 5 Alpha-Reductase 2	Protein Coding	2
30	STAR	Steroidogenic Acute Regulatory Protein	Protein Coding	2
31	TSPO	Translocator Protein	Protein Coding	2
32	SRD5A3	Steroid 5 Alpha-Reductase 3	Protein Coding	2
33	STARD3NL	STARD3 N-Terminal Like	Protein Coding	2
34	SERPINA6	Serpin Family A Member 6	Protein Coding	2
35	TSPOAP1	TSPO Associated Protein 1	Protein Coding	2
36	STS	Steroid Sulfatase	Protein Coding	1

Disorders associated with Metabolism of steroid hormones SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	Direct
2	Adrenal gland disease	Direct
3	Lipoid congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP11B1, CYP17A1, CYP21A2, HSD3B2, STAR	16.00
4	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP11A1, CYP17A1, CYP21A2	8.56
5	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP17A1, CYP21A2	8.56
6	Hyperaldosteronism, familial, type i	Enrichment	CYP11B1, CYP11B2	5.14
7	Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome	Enrichment	FDXR	3.66
8	Hypogonadotropic hypogonadism 23 with or without anosmia	Enrichment	LHB	3.35
9	Apparent mineralocorticoid excess	Enrichment	HSD11B2	3.23
10	Inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	Enrichment	CYP11A1	3.23
11	Mitochondrial myopathy, episodic, with or without optic atrophy and reversible leukoencephalopathy	Enrichment	FDX2	3.18
12	Auditory neuropathy and optic atrophy	Enrichment	FDXR	3.18
13	Multiple mitochondrial dysfunctions syndrome 9b	Enrichment	FDXR	3.18
14	Corticosteroid-binding globulin deficiency	Enrichment	SERPINA6	3.13
15	Kahrizi syndrome	Enrichment	SRD5A3	3.09
16	46,xy disorder of sex development due to 5-alpha-reductase 2 deficiency	Enrichment	SRD5A2	3.09
17	Corticosterone methyloxidase type i deficiency	Enrichment	CYP11B2	3.05
18	Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency	Enrichment	HSD3B2	3.05
19	Corticosterone methyloxidase type ii deficiency	Enrichment	CYP11B2	3.05
20	Hypospadias 1, x-linked	Enrichment	HSD3B2	3.05
21	3 beta-hydroxysteroid dehydrogenase deficiency	Enrichment	HSD3B2	3.05
22	Familial hypoaldosteronism	Enrichment	CYP11B2	3.05
23	Early-onset familial hypoaldosteronism	Enrichment	CYP11B2	3.05
24	Dystonia 22, adult-onset	Enrichment	TSPOAP1	3.05
25	Non-classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	3.05
26	Classic congenital lipoid adrenal hyperplasia due to star deficency	Enrichment	STAR	3.05
27	Cortisone reductase deficiency 2	Enrichment	HSD11B1	2.93
28	Cortisone reductase deficiency	Enrichment	HSD11B1	2.93
29	Aromatase excess syndrome	Enrichment	CYP19A1	2.88
30	Aromatase deficiency	Enrichment	CYP19A1	2.88
31	Xanthinuria, type i	Enrichment	SRD5A2	2.79
32	17-beta hydroxysteroid dehydrogenase iii deficiency	Enrichment	HSD17B3	2.79
33	Congenital disorder of glycosylation, type iq	Enrichment	SRD5A3	2.79
34	Adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency	Enrichment	CYP17A1	2.75
35	Toe syndactyly, telecanthus, and anogenital and renal malformations	Enrichment	STAR	2.75
36	Segawa syndrome, autosomal recessive	Enrichment	TSPOAP1	2.75
37	Dystonia 22, juvenile-onset	Enrichment	TSPOAP1	2.75
38	Adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency	Enrichment	CYP11B1	2.66
39	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	2.66
40	Deficiency of steroid 11-beta-monooxygenase	Enrichment	CYP11B1	2.66
41	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	2.66
42	Mitochondrial myopathy	Enrichment	FDX2	2.61
43	Syndromic recessive x-linked ichthyosis	Enrichment	STS	2.58
44	Pseudovaginal perineoscrotal hypospadias	Enrichment	SRD5A2	2.39
45	Pseudohermaphroditism	Enrichment	HSD17B3	2.39
46	Familial glucocorticoid deficiency	Enrichment	STAR	2.35
47	Ichthyosis, x-linked	Enrichment	STS	2.28
48	Auditory neuropathy	Enrichment	FDXR	2.24
49	Difference of sex development	Enrichment	HSD17B3	2.19
50	Optic nerve disease	Enrichment	SRD5A3	2.09
51	Epilepsy, myoclonic juvenile	Enrichment	HSD17B3	2.05
52	Primary ovarian insufficiency	Enrichment	CYP17A1, CYP19A1	1.97
53	Congenital disorder of glycosylation, type in	Enrichment	SRD5A3	1.86
54	Cone dystrophy	Enrichment	SRD5A3	1.71
55	Prostate cancer	Enrichment	SRD5A2	1.63
56	Body mass index quantitative trait locus 11	Enrichment	POMC	1.44
57	Bardet-biedl syndrome	Enrichment	TSPOAP1	1.44
58	Breast cancer	Enrichment	CYP17A1	1.36
59	Autism	Enrichment	SRD5A3	1.25
60	Congenital nervous system abnormality	Enrichment	SRD5A3	1.08
61	Nervous system disease	Enrichment	SRD5A3	1.08
62	Autism spectrum disorder	Enrichment	SRD5A2	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metabolism of steroid hormones

Pathway Network for Metabolism of steroid hormones

Pathway network for the Metabolism of steroid hormones SuperPath

Member Pathways for Metabolism of steroid hormones

Pathways in the Metabolism of steroid hormones SuperPath

Gene overlap in member pathways for Metabolism of steroid hormones SuperPath

Associated Genes for Metabolism of steroid hormones

Associated Disorders for Metabolism of steroid hormones

Disorders associated with Metabolism of steroid hormones SuperPath

STRING Interaction Network for Metabolism of steroid hormones

Sources for Metabolism of steroid hormones