Metal ion SLC transporters

Pathway network for the Metal ion SLC transporters SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Metal ion SLC transporters SuperPath

#	Name	Source	Genes
1	Metal ion SLC transporters	Reactome	CP HEPH SLC11A1 SLC11A2 SLC30A1 SLC30A10 SLC30A2 SLC30A3 SLC30A5 SLC30A8 SLC31A1 SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC40A1 SLC41A1 SLC41A2 (see all 24) (see less)
2	Zinc homeostasis	WikiPathways	MT1A MT1B MT1E MT1F MT1G MT1H MT1L MT1M MT1X MT2A MT3 MT4 MTF1 SLC30A1 SLC30A10 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 SLC39A1 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 (see all 37) (see less)
3	Zinc transporters	Reactome	SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A8 SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 (see all 15) (see less)
4	Response to metal ions	Reactome	CSRP1 MT1A MT1B MT1E MT1F MT1G MT1H MT1M MT1X MT2A MT3 MT4 MTF1 SNCB (see all 14) (see less)
5	Metallothioneins bind metals	Reactome	MT1A MT1B MT1E MT1F MT1G MT1H MT1M MT1X MT2A MT3 MT4 (see all 11) (see less)
6	Zinc influx into cells by the SLC39 gene family	Reactome	SLC39A1 SLC39A10 SLC39A14 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 (see all 10) (see less)
7	Zinc efflux and compartmentalization by the SLC30 family	Reactome	SLC30A1 SLC30A2 SLC30A3 SLC30A5 SLC30A8
8	MTF1 activates gene expression	Reactome	CSRP1 MTF1 SNCB
9	Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)	Reactome	SLC39A4

Gene overlap in member pathways for Metal ion SLC transporters SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC39A4	Solute Carrier Family 39 Member 4	Protein Coding	5
2	SLC30A8	Solute Carrier Family 30 Member 8	Protein Coding	4
3	SLC39A14	Solute Carrier Family 39 Member 14	Protein Coding	4
4	SLC39A6	Solute Carrier Family 39 Member 6	Protein Coding	4
5	SLC39A1	Solute Carrier Family 39 Member 1	Protein Coding	4
6	SLC39A5	Solute Carrier Family 39 Member 5	Protein Coding	4
7	SLC39A3	Solute Carrier Family 39 Member 3	Protein Coding	4
8	SLC39A2	Solute Carrier Family 39 Member 2	Protein Coding	4
9	SLC39A10	Solute Carrier Family 39 Member 10	Protein Coding	4
10	SLC39A8	Solute Carrier Family 39 Member 8	Protein Coding	4
11	SLC30A5	Solute Carrier Family 30 Member 5	Protein Coding	4
12	SLC30A1	Solute Carrier Family 30 Member 1	Protein Coding	4
13	SLC30A2	Solute Carrier Family 30 Member 2	Protein Coding	4
14	SLC30A3	Solute Carrier Family 30 Member 3	Protein Coding	4
15	SLC39A7	Solute Carrier Family 39 Member 7	Protein Coding	4
16	MT4	Metallothionein 4	Protein Coding	3
17	MTF1	Metal Regulatory Transcription Factor 1	Protein Coding	3
18	MT3	Metallothionein 3	Protein Coding	3
19	MT2A	Metallothionein 2A	Protein Coding	3
20	MT1G	Metallothionein 1G	Protein Coding	3
21	MT1F	Metallothionein 1F	Protein Coding	3
22	MT1E	Metallothionein 1E	Protein Coding	3
23	MT1A	Metallothionein 1A	Protein Coding	3
24	MT1X	Metallothionein 1X	Protein Coding	3
25	MT1M	Metallothionein 1M	Protein Coding	3
26	MT1H	Metallothionein 1H	Protein Coding	3
27	MT1B	Metallothionein 1B	Protein Coding	3
28	SLC30A10	Solute Carrier Family 30 Member 10	Protein Coding	2
29	CSRP1	Cysteine And Glycine Rich Protein 1	Protein Coding	2
30	SNCB	Synuclein Beta	Protein Coding	2
31	SLC31A1	Solute Carrier Family 31 Member 1	Protein Coding	1
32	CP	Ceruloplasmin	Protein Coding	1
33	SLC41A1	Solute Carrier Family 41 Member 1	Protein Coding	1
34	SLC40A1	Solute Carrier Family 40 Member 1	Protein Coding	1
35	SLC11A2	Solute Carrier Family 11 Member 2	Protein Coding	1
36	SLC11A1	Solute Carrier Family 11 Member 1	Protein Coding	1
37	SLC41A2	Solute Carrier Family 41 Member 2	Protein Coding	1
38	HEPH	Hephaestin	Protein Coding	1
39	SLC39A13	Solute Carrier Family 39 Member 13	Protein Coding	1
40	SLC30A4	Solute Carrier Family 30 Member 4	Protein Coding	1
41	SLC30A6	Solute Carrier Family 30 Member 6	Protein Coding	1
42	SLC39A12	Solute Carrier Family 39 Member 12	Protein Coding	1
43	SLC30A7	Solute Carrier Family 30 Member 7	Protein Coding	1
44	SLC30A9	Solute Carrier Family 30 Member 9	Protein Coding	1
45	SLC39A9	Solute Carrier Family 39 Member 9	Protein Coding	1
46	MT1L	Metallothionein 1L (Pseudogene)	Pseudogene	1
47	SLC39A11	Solute Carrier Family 39 Member 11	Protein Coding	1

Disorders associated with Metal ion SLC transporters SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Acrodermatitis enteropathica	Direct
2	Zinc deficiency, transient neonatal	Enrichment	SLC30A2	3.43
3	Hyperostosis cranialis interna	Enrichment	SLC39A14	3.13
4	Acrodermatitis enteropathica, zinc-deficiency type	Enrichment	SLC39A4	3.13
5	Agammaglobulinemia 9, autosomal recessive	Enrichment	SLC39A7	3.13
6	Myopia 24, autosomal dominant	Enrichment	SLC39A5	3.13
7	Hypermanganesemia with dystonia 2	Enrichment	SLC39A14	3.13
8	Dementia, lewy body	Enrichment	SNCB	2.96
9	Buruli ulcer	Enrichment	SLC11A1	2.75
10	Aceruloplasminemia	Enrichment	CP	2.75
11	Anemia, hypochromic microcytic, with iron overload 1	Enrichment	SLC11A2	2.75
12	Neurodegeneration and seizures due to copper transport defect	Enrichment	SLC31A1	2.75
13	Nephronophthisis-like nephropathy 2	Enrichment	SLC41A1	2.75
14	Hemochromatosis, type 4	Enrichment	SLC40A1	2.75
15	Hypermanganesemia with dystonia 1	Enrichment	SLC30A10	2.75
16	Congenital disorder of glycosylation, type iin	Enrichment	SLC39A8	2.66
17	Ehlers-danlos syndrome, spondylodysplastic type, 3	Enrichment	SLC39A13	2.56
18	Birk-landau-perez syndrome	Enrichment	SLC30A9	2.56
19	Psychomotor regression-oculomotor apraxia-movement disorder-nephropathy syndrome	Enrichment	SLC30A9	2.56
20	Hydrops fetalis	Enrichment	SLC30A5	2.48
21	Hermansky-pudlak syndrome 3	Enrichment	CP	2.45
22	Rare isolated myopia	Enrichment	SLC39A5	2.43
23	Ziegler-huang syndrome	Enrichment	SLC30A7	2.26
24	Neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties	Enrichment	SLC30A7	2.26
25	Tuberculosis	Enrichment	SLC11A1	2.15
26	Left ventricular noncompaction	Enrichment	SLC30A5	1.89
27	Type 2 diabetes mellitus	Enrichment	SLC30A8	1.81
28	Hypertrophic cardiomyopathy	Enrichment	SLC30A5	1.80
29	Neurodegeneration with brain iron accumulation	Enrichment	CP	1.76
30	Hermansky-pudlak syndrome	Enrichment	CP	1.58
31	Hermansky-pudlak syndrome 1	Enrichment	CP	1.55
32	Cystic fibrosis	Enrichment	SLC11A1	1.26
33	Joubert syndrome 1	Enrichment	SLC30A7	0.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metal ion SLC transporters

Pathway Network for Metal ion SLC transporters

Pathway network for the Metal ion SLC transporters SuperPath

Member Pathways for Metal ion SLC transporters

Pathways in the Metal ion SLC transporters SuperPath

Gene overlap in member pathways for Metal ion SLC transporters SuperPath

Associated Genes for Metal ion SLC transporters

Associated Disorders for Metal ion SLC transporters

Disorders associated with Metal ion SLC transporters SuperPath

STRING Interaction Network for Metal ion SLC transporters

Sources for Metal ion SLC transporters