Metalloprotease DUBs

No Pathway Network information available for Metalloprotease DUBs

Pathways in the Metalloprotease DUBs SuperPath

#	Name	Source	Genes
1	Metalloprotease DUBs	Reactome	ABRAXAS1 ABRAXAS2 BABAM1 BABAM2 BARD1 BRCA1 BRCC3 EP300 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 KAT2B MYSM1 NLRP3 PSMD14 RPS27A STAM STAMBP STAMBPL1 UBA52 UBB UBC UIMC1 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	1
2	STAMBP	STAM Binding Protein	Protein Coding	1
3	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1
4	MYSM1	Myb Like, SWIRM And MPN Domains 1	Protein Coding	1
5	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
6	H2AC1	H2A Clustered Histone 1	Protein Coding	1
7	ABRAXAS2	Abraxas 2, BRISC Complex Subunit	Protein Coding	1
8	BABAM1	BRISC And BRCA1 A Complex Member 1	Protein Coding	1
9	H2AC8	H2A Clustered Histone 8	Protein Coding	1
10	H2AC7	H2A Clustered Histone 7	Protein Coding	1
11	H2AC21	H2A Clustered Histone 21	Protein Coding	1
12	UIMC1	Ubiquitin Interaction Motif Containing 1	Protein Coding	1
13	STAMBPL1	STAM Binding Protein Like 1	Protein Coding	1
14	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	1
15	RPS27A	Ribosomal Protein S27a	Protein Coding	1
16	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
17	H2AC19	H2A Clustered Histone 19	Protein Coding	1
18	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
19	UBB	Ubiquitin B	Protein Coding	1
20	UBC	Ubiquitin C	Protein Coding	1
21	BRCC3	BRCA1/BRCA2-Containing Complex Subunit 3	Protein Coding	1
22	STAM	Signal Transducing Adaptor Molecule	Protein Coding	1
23	H2AC13	H2A Clustered Histone 13	Protein Coding	1
24	H2AC15	H2A Clustered Histone 15	Protein Coding	1
25	H2AC14	H2A Clustered Histone 14	Protein Coding	1
26	H2AC16	H2A Clustered Histone 16	Protein Coding	1
27	H2AC6	H2A Clustered Histone 6	Protein Coding	1
28	H2AC4	H2A Clustered Histone 4	Protein Coding	1
29	H2AC17	H2A Clustered Histone 17	Protein Coding	1
30	H2AC18	H2A Clustered Histone 18	Protein Coding	1
31	H2AC20	H2A Clustered Histone 20	Protein Coding	1
32	ABRAXAS1	Abraxas 1, BRCA1 A Complex Subunit	Protein Coding	1
33	H2AC12	H2A Clustered Histone 12	Protein Coding	1
34	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
35	H2AC11	H2A Clustered Histone 11	Protein Coding	1
36	H2AC25	H2A Clustered Histone 25	Protein Coding	1
37	BABAM2	BRISC And BRCA1 A Complex Member 2	Protein Coding	1

Disorders associated with Metalloprotease DUBs SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Myeloma, multiple	Enrichment	BARD1, H2AC16, H2AC17	3.33
2	Breast cancer	Enrichment	ABRAXAS1, BARD1, BRCA1	2.96
3	Endometrial cancer	Enrichment	BARD1, BRCA1	2.83
4	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.56
5	Cinca syndrome	Enrichment	NLRP3	2.56
6	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	2.56
7	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	2.56
8	Muckle-wells syndrome	Enrichment	NLRP3	2.56
9	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	2.56
10	Bone marrow failure syndrome 4	Enrichment	MYSM1	2.56
11	Infant-type hemispheric glioma	Enrichment	BRCA1	2.56
12	Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome	Enrichment	BRCC3	2.56
13	Congenital progressive bone marrow failure-b-cell immunodeficiency-skeletal dysplasia syndrome	Enrichment	MYSM1	2.56
14	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	2.56
15	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	2.56
16	Primary peritoneal carcinoma	Enrichment	BRCA1	2.56
17	Moyamoya disease 4 with short stature, hypergonadotropic hypogonadism, and facial dysmorphism	Enrichment	BRCC3	2.26
18	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.26
19	Menke-hennekam syndrome 2	Enrichment	EP300	2.26
20	Pancreatic cancer 4	Enrichment	BRCA1	2.26
21	Pericardial effusion	Enrichment	NLRP3	2.26
22	Microcephaly-capillary malformation syndrome	Enrichment	STAMBP	2.26
23	Inflammatory breast carcinoma	Enrichment	BRCA1	2.26
24	Peritoneum cancer	Enrichment	BRCA1	2.26
25	Bilateral breast cancer	Enrichment	BRCA1	2.26
26	Submucosal cleft palate	Enrichment	UBB	2.26
27	Cleft hard palate	Enrichment	UBB	2.26
28	Inherited cancer-predisposing syndrome	Enrichment	ABRAXAS1, BARD1, BRCA1	2.26
29	Gastric cancer	Enrichment	BARD1, BRCA1	2.22
30	Hereditary breast carcinoma	Enrichment	BARD1, BRCA1	2.20
31	Uvula, bifid	Enrichment	UBB	2.09
32	Cleft soft palate	Enrichment	UBB	2.09
33	Hereditary breast ovarian cancer syndrome	Enrichment	BARD1, BRCA1	2.01
34	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.96
35	Cholangiocarcinoma	Enrichment	BRCA1	1.96
36	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.87
37	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.87
38	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.79
39	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.79
40	Colorectal cancer	Enrichment	BRCA1, EP300	1.63
41	Charge syndrome	Enrichment	EP300	1.61
42	Uterine corpus cancer	Enrichment	BRCA1	1.53
43	Ovarian cancer	Enrichment	BARD1, BRCA1	1.51
44	Breast-ovarian cancer, familial 1	Enrichment	BRCA1	1.46
45	Periventricular nodular heterotopia	Enrichment	BRCA1	1.43
46	Polydactyly, postaxial, type a1	Enrichment	EP300	1.40
47	Rare genetic intellectual disability	Enrichment	EP300	1.40
48	Rhabdomyosarcoma	Enrichment	BRCA1	1.37
49	Arteriovenous malformations of the brain	Enrichment	NLRP3	1.30
50	Hepatoblastoma	Enrichment	BARD1	1.25
51	Autoinflammatory disease	Enrichment	NLRP3	1.20
52	Pancreatic cancer	Enrichment	BRCA1	1.18
53	Bladder cancer	Enrichment	BRCA1	1.12
54	Prostate cancer	Enrichment	BRCA1	1.12
55	Lung cancer	Enrichment	BRCA1	1.08
56	Fanconi anemia, complementation group a	Enrichment	BRCA1	1.04
57	Microcephaly	Enrichment	EP300	0.54

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metalloprotease DUBs

Pathway Network for Metalloprotease DUBs

Member Pathways for Metalloprotease DUBs

Pathways in the Metalloprotease DUBs SuperPath

Associated Genes for Metalloprotease DUBs

Associated Disorders for Metalloprotease DUBs

Disorders associated with Metalloprotease DUBs SuperPath

STRING Interaction Network for Metalloprotease DUBs

Sources for Metalloprotease DUBs