Metapathway biotransformation Phase I and II

Pathway network for the Metapathway biotransformation Phase I and II SuperPath

Sources:

WikiPathways
Reactome
GeneGo (Thomson Reuters)
PharmGKB

Pathways in the Metapathway biotransformation Phase I and II SuperPath

#	Name	Source	Genes
1	Metapathway biotransformation Phase I and II	WikiPathways	AKR1A1 AKR1B1 AKR1B10 AKR1C1 AKR1C2 AKR1C3 AKR1C4 AKR1D1 AKR7A2 AKR7A3 BAAT CHST1 CHST10 CHST11 CHST12 CHST13 CHST14 CHST2 CHST3 CHST4 CHST5 CHST6 CHST7 CHST8 CHST9 COMT CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP20A1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP27C1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP4V2 CYP4X1 CYP4Z1 CYP51A1 CYP7A1 CYP7B1 CYP8B1 EPHX1 EPHX2 FMO1 FMO2 FMO3 FMO4 FMO5 GAL3ST1 GAL3ST2 GAL3ST3 GAL3ST4 GLYAT GLYATL1 GLYATL2 GPX2 GPX3 GPX4 GPX5 GSR GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTCD GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT2 GSTT2B GSTZ1 HNMT HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS3ST6 HS6ST1 HS6ST2 HS6ST3 INMT KCNAB1 KCNAB2 KCNAB3 MGST1 MGST2 MGST3 NAA20 NAA30 NAA40 NAA50 NAA80 NAT1 NAT10 NAT14 NAT2 NAT8 NAT8L NAT9 NDST1 NDST2 NDST3 NDST4 NNMT SLX1A-SULT1A3 SULT1A1 SULT1A2 SULT1A4 SULT1B1 SULT1C2 SULT1C3 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 SULT6B1 TPMT UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 (see all 184) (see less)
2	Biological oxidations	Reactome	AADAC ABHD10 ABHD14B ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 ACSS1 ACSS2 ACY1 ACY3 ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 AHCY AHR AHRR AIP AKR1A1 AKR7A2 AKR7A3 AKR7L ALDH1A1 ALDH1B1 ALDH2 ALDH3A1 AOC1 AOC2 AOC3 ARNT ARNT2 AS3MT BPHL BPNT1 BPNT2 CBR3 CES1 CES2 CES3 CHAC1 CHAC2 CMBL CNDP2 COMT CYB5B CYB5R3 CYP11A1 CYP11B1 CYP11B2 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP3A7-CYP3A51P CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP4V2 CYP51A1 CYP7A1 CYP7B1 CYP8B1 DPEP1 DPEP2 EPHX1 ESD FDX1 FDX2 FDXR FMO1 FMO2 FMO3 GCLC GCLM GGCT GGT1 GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GLYATL3 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HEMK2 HPGDS HSP90AB1 MAOA MAOB MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTARC1 MTARC2 MTR MTRR NAT1 NAT2 NCOA1 NCOA2 NNMT NQO2 NR1H4 OPLAH PAOX PODXL2 POMC POR PTGES3 PTGIS PTGS1 RXRA SLC35D1 SLC35D2 SMOX SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 SULT6B1 TBXAS1 TPMT TPST1 TPST2 TRMT112 UGDH UGP2 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT3A1 UGT3A2 UXS1 (see all 217) (see less)
3	Phase I - Functionalization of compounds	Reactome	AADAC ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 AHR AHRR AIP ALDH1A1 ALDH1B1 ALDH2 ALDH3A1 AOC1 AOC2 AOC3 ARNT ARNT2 BPHL CBR3 CES1 CES2 CES3 CMBL CYB5B CYB5R3 CYP11A1 CYP11B1 CYP11B2 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP3A7-CYP3A51P CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP4V2 CYP51A1 CYP7A1 CYP7B1 CYP8B1 EPHX1 FDX1 FDX2 FDXR FMO1 FMO2 FMO3 HSP90AB1 MAOA MAOB MTARC1 MTARC2 NCOA1 NCOA2 NQO2 NR1H4 PAOX POMC POR PTGES3 PTGIS PTGS1 RXRA SMOX TBXAS1 (see all 106) (see less)
4	Phase II - Conjugation of compounds	Reactome	ABHD10 ABHD14B ACSM1 ACSM2A ACSM2B ACSM4 ACSM5 AHCY AKR1A1 AS3MT BPNT1 BPNT2 CHAC1 CHAC2 CNDP2 COMT CYP1A2 ESD GCLC GCLM GGCT GGT1 GGT5 GGT6 GGT7 GLYAT GLYATL1 GLYATL2 GLYATL3 GSS GSTA1 GSTA2 GSTA3 GSTA4 GSTA5 GSTK1 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1 GSTO2 GSTP1 GSTT1 GSTT2 GSTT2B GSTZ1 HEMK2 HPGDS MAT1A MAT2A MAT2B MGST1 MGST2 MGST3 MTR MTRR NAT1 NAT2 NNMT OPLAH PODXL2 SLC35D1 SLC35D2 SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 SULT6B1 TPMT TPST1 TPST2 TRMT112 UGDH UGP2 UGT1A1 UGT1A10 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT2A1 UGT2A2 UGT2A3 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 UGT2B4 UGT2B7 UGT3A1 UGT3A2 UXS1 (see all 105) (see less)
5	Cytochrome P450 - arranged by substrate type	Reactome	AHR AHRR ARNT ARNT2 CYP11A1 CYP11B1 CYP11B2 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP21A2 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP3A7-CYP3A51P CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP4V2 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX2 FDXR NCOA1 NCOA2 NR1H4 POMC POR PTGIS RXRA TBXAS1 (see all 66) (see less)
6	Oxidation by cytochrome P450	WikiPathways	CYB5A CYB5B CYB5R1 CYB5R2 CYB5R3 CYB5R4 CYP11A1 CYP11B1 CYP11B2 CYP17A1 CYP19A1 CYP1A1 CYP1A2 CYP1B1 CYP20A1 CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27A1 CYP27B1 CYP27C1 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2R1 CYP2S1 CYP2U1 CYP2W1 CYP39A1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP46A1 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP4V2 CYP4X1 CYP4Z1 CYP51A1 CYP7A1 CYP7B1 CYP8B1 POR (see all 61) (see less)
7	Endogenous sterols	Reactome	AHR AHRR ARNT ARNT2 CYP11A1 CYP11B1 CYP11B2 CYP19A1 CYP1B1 CYP21A2 CYP27A1 CYP39A1 CYP46A1 CYP4V2 CYP51A1 CYP7A1 CYP7B1 CYP8B1 FDX1 FDX2 FDXR NCOA1 NCOA2 NR1H4 POMC RXRA (see all 26) (see less)
8	Xenobiotics	Reactome	AHR AHRR ARNT ARNT2 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C18 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2J2 CYP2S1 CYP2W1 CYP3A4 CYP3A43 CYP3A5 CYP3A7 CYP3A7-CYP3A51P (see all 25) (see less)
9	Estradiol metabolism	GeneGo (Thomson Reuters)	COMT CYP1A1 CYP1A2 CYP1B1 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP3A4 CYP3A5 SULT1A1 SULT1A3 SULT1A4 SULT1E1 SULT2A1 UGT1A1 UGT1A10 UGT2B11 UGT2B28 (see all 19) (see less)
10	Cytosolic sulfonation of small molecules	Reactome	ABHD14B BPNT1 BPNT2 PODXL2 SULT1A1 SULT1A2 SULT1A3 SULT1A4 SULT1B1 SULT1C2 SULT1C4 SULT1E1 SULT2A1 SULT2B1 SULT4A1 SULT6B1 TPST1 TPST2 (see all 18) (see less)
11	Tamoxifen Pathway, Pharmacokinetics	PharmGKB	CYP1A2 CYP2B6 CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP3A5 FMO1 FMO3 SULT1A1 SULT1E1 SULT2A1 UGT1A10 UGT1A3 UGT1A4 UGT1A8 UGT2B15 UGT2B7 (see all 18) (see less)
12	Acetaminophen metabolism	GeneGo (Thomson Reuters)	CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2D6 CYP2E1 CYP3A4 GSTP1 NQO1 SULT1A1 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15 (see all 16) (see less)
13	Fatty acid omega-oxidation	WikiPathways	ADH1A ADH1B ADH1C ADH4 ADH6 ADH7 ALDH1A1 ALDH2 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP3A4 CYP4A11 (see all 15) (see less)
14	Fatty acids	Reactome	CYP2A13 CYP2A7 CYP2B6 CYP2D6 CYP2F1 CYP2J2 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 (see all 15) (see less)
15	Methylation	Reactome	AHCY AS3MT COMT CYP1A2 GSTO1 HEMK2 MAT1A MAT2A MAT2B MTR MTRR NNMT TPMT TRMT112 (see all 14) (see less)
16	Benzo[a]pyrene metabolism	GeneGo (Thomson Reuters)	CYP1A1 CYP1A2 CYP1B1 CYP2C18 CYP2C8 CYP2C9 CYP3A4 EPHX1 GSTP1 UGT1A10 UGT1A6 UGT1A9 (see all 12) (see less)
17	Eicosanoids	Reactome	CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F12 CYP4F2 CYP4F22 CYP4F3 CYP4F8 CYP8B1 PTGIS TBXAS1 (see all 12) (see less)
18	Ethanol oxidation	Reactome	ACSS1 ACSS2 ADH1A ADH1B ADH1C ADH4 ADH5 ADH6 ADH7 ALDH1A1 ALDH1B1 ALDH2 (see all 12) (see less)
19	Miscellaneous substrates	Reactome	CYP2D6 CYP2S1 CYP2U1 CYP2W1 CYP3A43 CYP4A11 CYP4A22 CYP4B1 CYP4F11 CYP4F2 CYP4F22 CYP4F3 (see all 12) (see less)
20	Benzodiazepine Pathway, Pharmacokinetics	PharmGKB	CYP1A2 CYP2C19 CYP2D6 CYP3A4 CYP3A5 NAT2 UGT1A4 UGT1A9 UGT2B15 UGT2B4 UGT2B7 (see all 11) (see less)
21	Haloperidol Pathway, Pharmacokinetics	PharmGKB	CBR1 CYP1A1 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP3A4 CYP3A5 UGT1A4 UGT1A9 UGT2B7 (see all 11) (see less)
22	Cannabidiol Pathway, Pharmacokinetics	PharmGKB	CYP1A1 CYP1A2 CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP3A5 CYP3A7 UGT1A7 UGT1A9 UGT2B7 (see all 11) (see less)
23	CYP2E1 reactions	Reactome	CYP2A13 CYP2A6 CYP2A7 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP2F1 CYP2S1 (see all 11) (see less)
24	Benzo(a)pyrene metabolism	WikiPathways	AKR1A1 AKR1C1 AKR1C2 AKR1C3 AKR1C4 CYP1A1 CYP1B1 CYP3A4 EPHX1 (see all 9) (see less)
25	Arylamine metabolism	WikiPathways	CYP1A2 NAT1 NAT2 SULT1A1 SULT1A2 UGT1A4 UGT1A9 (see all 7) (see less)
26	Lidocaine Pathway, Pharmacokinetics	PharmGKB	CES1 CYP1A2 CYP2A6 CYP2B6 CYP2D6 CYP2E1 CYP3A4 (see all 7) (see less)
27	Cyclophosphamide Pathway, Pharmacokinetics	PharmGKB	CYP2A6 CYP2B6 CYP2C19 CYP2C8 CYP2C9 CYP3A4 CYP3A5 (see all 7) (see less)
28	Voriconazole Pathway, Pharmacokinetics	PharmGKB	CYP2C19 CYP2C9 CYP3A4 FMO1 FMO3 FMO5 UGT1A4 (see all 7) (see less)
29	Aflatoxin B1 metabolism	WikiPathways	AKR7A2 AKR7A3 CYP1A2 CYP2A13 CYP3A4 EPHX1 GSTM1 (see all 7) (see less)
30	Naproxen Pathway, Pharmacokinetics	PharmGKB	CYP1A2 CYP2C9 UGT1A1 UGT1A3 UGT1A6 UGT1A9 UGT2B7 (see all 7) (see less)
31	Fluvoxamine Pathway, Pharmacokinetics	PharmGKB	ADH1A ADH1B ADH1C CYP1A2 CYP2C19 CYP2D6 CYP3A4 (see all 7) (see less)
32	Aryl hydrocarbon receptor signalling	Reactome	AHR AHRR AIP ARNT ARNT2 HSP90AB1 PTGES3 (see all 7) (see less)
33	In progress: Buprenorphine Pathway, Pharmacokinetics	PharmGKB	CYP2C8 CYP3A4 CYP3A5 CYP3A7 UGT1A1 UGT1A3 UGT2B7 (see all 7) (see less)
34	Sorafenib Pharmacokinetics	PharmGKB	CYP2B6 CYP2C8 CYP2C9 CYP3A4 UGT1A1 UGT1A9 (see all 6) (see less)
35	Vitamin D2 (ergocalciferol) metabolism	GeneGo (Thomson Reuters)	CYP24A1 CYP27A1 CYP27B1 CYP2C9 CYP2R1 CYP3A4 (see all 6) (see less)
36	Prasugrel Pathway, Pharmacokinetics	PharmGKB	CES2 CYP2B6 CYP2C19 CYP2C9 CYP3A4 CYP3A5 (see all 6) (see less)
37	Atomoxetine Pathway, Pharmacokinetics	PharmGKB	CYP1A2 CYP2B6 CYP2C19 CYP2D6 CYP2E1 CYP3A4 (see all 6) (see less)
38	Vitamins	Reactome	CYP24A1 CYP26A1 CYP26B1 CYP26C1 CYP27B1 CYP2R1 (see all 6) (see less)
39	Toremifene Pathway, Pharmacokinetics	PharmGKB	CYP2B6 CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP3A5 (see all 6) (see less)
40	Artemisinin and Derivatives Pathway, Pharmacokinetics	PharmGKB	CYP2A6 CYP2B6 CYP3A4 CYP3A5 UGT1A9 UGT2B7 (see all 6) (see less)
41	Ospemifene Pathway, Pharmacokinetics	PharmGKB	CYP2B6 CYP2C19 CYP2C9 CYP3A4 CYP3A5
42	Belinostat Pathway, Pharmacokinetics	PharmGKB	CYP2A6 CYP2C9 CYP3A4 UGT1A1 UGT2B7
43	Fluoxetine Pathway, Pharmacokinetics	PharmGKB	CYP2C19 CYP2C9 CYP2D6 CYP3A4 CYP3A5
44	Ketamine Pathway, Pharmacokinetics	PharmGKB	CYP2A6 CYP2B6 CYP2C19 CYP3A4 CYP3A5
45	Celecoxib Pathway, Pharmacokinetics	PharmGKB	ADH1A ADH1B CYP2C9 CYP2D6 CYP3A4
46	Amine Oxidase reactions	Reactome	MAOA MAOB PAOX SMOX
47	Trimipramine Pathway, Pharmacokinetics	PharmGKB	CYP2C19 CYP2C9 CYP2D6
48	Trazodone Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4 CYP3A5
49	Flurbiprofen Pathway, Pharmacokinetics	PharmGKB	CYP2C9 UGT1A9 UGT2B7
50	Disulfiram Pathway, Pharmacokinetics	PharmGKB	CYP2E1 GSR TPMT
51	Letrozole Pathway, Pharmacokinetics	PharmGKB	CYP2A6 CYP3A4 UGT2B7
52	Cilostazol Pathway, Pharmacokinetics	PharmGKB	CYP2C19 CYP3A4 CYP3A5
53	Hydralazine Pathway, Pharmacokinetics	PharmGKB	CYP1A2 NAT1 NAT2
54	Phenprocoumon Pathway, Pharmacokinetics	PharmGKB	CYP2C8 CYP2C9 CYP3A4
55	Acetylation	Reactome	NAT1 NAT2
56	Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	Reactome	MAOA MAOB
57	Defective CYP27A1 causes CTX	Reactome	CYP27A1
58	Sterols are 12-hydroxylated by CYP8B1	Reactome	CYP8B1
59	Defective MAOA causes BRUNS	Reactome	MAOA
60	Defective CYP26C1 causes FFDD4	Reactome	CYP26C1
61	Defective CYP4F22 causes ARCI5	Reactome	CYP4F22
62	Defective CYP27B1 causes VDDR1B	Reactome	CYP2R1
63	Defective CYP24A1 causes HCAI	Reactome	CYP24A1
64	Defective CYP26B1 causes RHFCA	Reactome	CYP26B1
65	Defective TPMT causes TPMT deficiency	Reactome	TPMT
66	Defective CYP27B1 causes VDDR1A	Reactome	CYP27B1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	36
2	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	26
3	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	24
4	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	23
5	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	22
6	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	21
7	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	18
8	CYP2A6	Cytochrome P450 Family 2 Subfamily A Member 6	Protein Coding	15
9	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	14
10	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	13
11	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	13
12	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	13
13	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	12
14	CYP2A13	Cytochrome P450 Family 2 Subfamily A Member 13	Protein Coding	10
15	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	9
16	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	9
17	CYP4F22	Cytochrome P450 Family 4 Subfamily F Member 22	Protein Coding	9
18	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	8
19	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	8
20	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	8
21	CYP4F3	Cytochrome P450 Family 4 Subfamily F Member 3	Protein Coding	8
22	CYP2S1	Cytochrome P450 Family 2 Subfamily S Member 1	Protein Coding	8
23	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	8
24	CYP27A1	Cytochrome P450 Family 27 Subfamily A Member 1	Protein Coding	8
25	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	8
26	CYP8B1	Cytochrome P450 Family 8 Subfamily B Member 1	Protein Coding	8
27	CYP4B1	Cytochrome P450 Family 4 Subfamily B Member 1	Protein Coding	8
28	CYP2F1	Cytochrome P450 Family 2 Subfamily F Member 1	Protein Coding	8
29	CYP3A7	Cytochrome P450 Family 3 Subfamily A Member 7	Protein Coding	8
30	CYP2A7	Cytochrome P450 Family 2 Subfamily A Member 7	Protein Coding	8
31	CYP2R1	Cytochrome P450 Family 2 Subfamily R Member 1	Protein Coding	8
32	CYP4F11	Cytochrome P450 Family 4 Subfamily F Member 11	Protein Coding	8
33	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	8
34	CYP4F12	Cytochrome P450 Family 4 Subfamily F Member 12	Protein Coding	7
35	CYP3A43	Cytochrome P450 Family 3 Subfamily A Member 43	Protein Coding	7
36	CYP26B1	Cytochrome P450 Family 26 Subfamily B Member 1	Protein Coding	7
37	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	7
38	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	7
39	CYP26C1	Cytochrome P450 Family 26 Subfamily C Member 1	Protein Coding	7
40	CYP2J2	Cytochrome P450 Family 2 Subfamily J Member 2	Protein Coding	7
41	CYP2C18	Cytochrome P450 Family 2 Subfamily C Member 18	Protein Coding	7
42	CYP4F8	Cytochrome P450 Family 4 Subfamily F Member 8	Protein Coding	7
43	NAT2	N-Acetyltransferase 2	Protein Coding	7
44	CYP2W1	Cytochrome P450 Family 2 Subfamily W Member 1	Protein Coding	7
45	CYP4A22	Cytochrome P450 Family 4 Subfamily A Member 22	Protein Coding	7
46	CYP51A1	Cytochrome P450 Family 51 Subfamily A Member 1	Protein Coding	6
47	CYP7B1	Cytochrome P450 Family 7 Subfamily B Member 1	Protein Coding	6
48	NAT1	N-Acetyltransferase 1	Protein Coding	6
49	UGT2B15	UDP Glucuronosyltransferase Family 2 Member B15	Protein Coding	6
50	TPMT	Thiopurine S-Methyltransferase	Protein Coding	6
51	SULT2A1	Sulfotransferase Family 2A Member 1	Protein Coding	6
52	SULT1E1	Sulfotransferase Family 1E Member 1	Protein Coding	6
53	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	6
54	CYP39A1	Cytochrome P450 Family 39 Subfamily A Member 1	Protein Coding	6
55	CYP4V2	Cytochrome P450 Family 4 Subfamily V Member 2	Protein Coding	6
56	EPHX1	Epoxide Hydrolase 1	Protein Coding	6
57	CYP26A1	Cytochrome P450 Family 26 Subfamily A Member 1	Protein Coding	6
58	CYP19A1	Cytochrome P450 Family 19 Subfamily A Member 1	Protein Coding	6
59	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	6
60	CYP11B1	Cytochrome P450 Family 11 Subfamily B Member 1	Protein Coding	6
61	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	6
62	CYP7A1	Cytochrome P450 Family 7 Subfamily A Member 1	Protein Coding	6
63	CYP2U1	Cytochrome P450 Family 2 Subfamily U Member 1	Protein Coding	6
64	CYP46A1	Cytochrome P450 Family 46 Subfamily A Member 1	Protein Coding	6
65	ADH1A	Alcohol Dehydrogenase 1A (Class I), Alpha Polypeptide	Protein Coding	6
66	ADH1B	Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide	Protein Coding	6
67	AHR	Aryl Hydrocarbon Receptor	Protein Coding	6
68	ARNT	Aryl Hydrocarbon Receptor Nuclear Translocator	Protein Coding	6
69	AHRR	Aryl Hydrocarbon Receptor Repressor	Protein Coding	6
70	ARNT2	Aryl Hydrocarbon Receptor Nuclear Translocator 2	Protein Coding	6
71	SULT1A2	Sulfotransferase Family 1A Member 2	Protein Coding	5
72	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	5
73	FMO3	Flavin Containing Dimethylaniline Monoxygenase 3	Protein Coding	5
74	FMO1	Flavin Containing Dimethylaniline Monoxygenase 1	Protein Coding	5
75	CYP21A2	Cytochrome P450 Family 21 Subfamily A Member 2	Protein Coding	5
76	COMT	Catechol-O-Methyltransferase	Protein Coding	5
77	SULT1A4	Sulfotransferase Family 1A Member 4	Protein Coding	5
78	ADH1C	Alcohol Dehydrogenase 1C (Class I), Gamma Polypeptide	Protein Coding	5
79	MAOA	Monoamine Oxidase A	Protein Coding	5
80	UGT1A7	UDP Glucuronosyltransferase Family 1 Member A7	Protein Coding	4
81	UGT2B28	UDP Glucuronosyltransferase Family 2 Member B28	Protein Coding	4
82	GSTO1	Glutathione S-Transferase Omega 1	Protein Coding	4
83	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	4
84	SULT2B1	Sulfotransferase Family 2B Member 1	Protein Coding	4
85	SULT1C2	Sulfotransferase Family 1C Member 2	Protein Coding	4
86	NNMT	Nicotinamide N-Methyltransferase	Protein Coding	4
87	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	4
88	SULT1B1	Sulfotransferase Family 1B Member 1	Protein Coding	4
89	UGT2B11	UDP Glucuronosyltransferase Family 2 Member B11	Protein Coding	4
90	AKR1A1	Aldo-Keto Reductase Family 1 Member A1	Protein Coding	4
91	SULT6B1	Sulfotransferase Family 6B Member 1	Protein Coding	4
92	SULT1C4	Sulfotransferase Family 1C Member 4	Protein Coding	4
93	SULT4A1	Sulfotransferase Family 4A Member 1	Protein Coding	4
94	CYP3A7-CYP3A51P	CYP3A7-CYP3A51P Readthrough	Protein Coding	4
95	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	4
96	FDX2	Ferredoxin 2	Protein Coding	4
97	ADH4	Alcohol Dehydrogenase 4 (Class II), Pi Polypeptide	Protein Coding	4
98	ADH6	Alcohol Dehydrogenase 6 (Class V)	Protein Coding	4
99	ADH7	Alcohol Dehydrogenase 7 (Class IV), Mu Or Sigma Polypeptide	Protein Coding	4
100	ALDH1A1	Aldehyde Dehydrogenase 1 Family Member A1	Protein Coding	4
101	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	4
102	FDX1	Ferredoxin 1	Protein Coding	4
103	FDXR	Ferredoxin Reductase	Protein Coding	4
104	MAOB	Monoamine Oxidase B	Protein Coding	4
105	POMC	Proopiomelanocortin	Protein Coding	4
106	POR	Cytochrome P450 Oxidoreductase	Protein Coding	4
107	PTGIS	Prostaglandin I2 Synthase	Protein Coding	4
108	RXRA	Retinoid X Receptor Alpha	Protein Coding	4
109	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	4
110	TBXAS1	Thromboxane A Synthase 1	Protein Coding	4
111	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	4
112	NR1H4	Nuclear Receptor Subfamily 1 Group H Member 4	Protein Coding	4
113	UGT2A2	UDP Glucuronosyltransferase Family 2 Member A2	Protein Coding	3
114	UGT1A5	UDP Glucuronosyltransferase Family 1 Member A5	Protein Coding	3
115	AKR7A2	Aldo-Keto Reductase Family 7 Member A2	Protein Coding	3
116	UGT2A3	UDP Glucuronosyltransferase Family 2 Member A3	Protein Coding	3
117	UGT2B17	UDP Glucuronosyltransferase Family 2 Member B17	Protein Coding	3
118	MGST1	Microsomal Glutathione S-Transferase 1	Protein Coding	3
119	GSTK1	Glutathione S-Transferase Kappa 1	Protein Coding	3
120	GSTZ1	Glutathione S-Transferase Zeta 1	Protein Coding	3
121	GSTT2	Glutathione S-Transferase Theta 2 (Gene/Pseudogene)	Protein Coding	3
122	GSTM5	Glutathione S-Transferase Mu 5	Protein Coding	3
123	GSTM4	Glutathione S-Transferase Mu 4	Protein Coding	3
124	GSTM3	Glutathione S-Transferase Mu 3	Protein Coding	3
125	GSTM2	Glutathione S-Transferase Mu 2	Protein Coding	3
126	GSTA4	Glutathione S-Transferase Alpha 4	Protein Coding	3
127	GSTA3	Glutathione S-Transferase Alpha 3	Protein Coding	3
128	GSTA2	Glutathione S-Transferase Alpha 2	Protein Coding	3
129	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	3
130	GSS	Glutathione Synthetase	Protein Coding	3
131	FMO2	Flavin Containing Dimethylaniline Monoxygenase 2	Protein Coding	3
132	AKR7A3	Aldo-Keto Reductase Family 7 Member A3	Protein Coding	3
133	GSTA5	Glutathione S-Transferase Alpha 5	Protein Coding	3
134	GSTO2	Glutathione S-Transferase Omega 2	Protein Coding	3
135	UGT2A1	UDP Glucuronosyltransferase Family 2 Member A1 Complex Locus	Protein Coding	3
136	GLYAT	Glycine-N-Acyltransferase	Protein Coding	3
137	GSTT2B	Glutathione S-Transferase Theta 2B	Protein Coding	3
138	MGST3	Microsomal Glutathione S-Transferase 3	Protein Coding	3
139	MGST2	Microsomal Glutathione S-Transferase 2	Protein Coding	3
140	GLYATL1	Glycine-N-Acyltransferase Like 1	Protein Coding	3
141	GLYATL2	Glycine-N-Acyltransferase Like 2	Protein Coding	3
142	BPNT1	3''(2''), 5''-Bisphosphate Nucleotidase 1	Protein Coding	3
143	CES1	Carboxylesterase 1	Protein Coding	3
144	PTGES3	Prostaglandin E Synthase 3	Protein Coding	3
145	ADH5	Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide	Protein Coding	3
146	CYB5R3	Cytochrome B5 Reductase 3	Protein Coding	3
147	AHCY	Adenosylhomocysteinase	Protein Coding	3
148	PAOX	Polyamine Oxidase	Protein Coding	3
149	ALDH1B1	Aldehyde Dehydrogenase 1 Family Member B1	Protein Coding	3
150	MAT2B	Methionine Adenosyltransferase 2 Non-Catalytic Beta Subunit	Protein Coding	3
151	HEMK2	HemK Methyltransferase 2, ETF1 Glutamine And Histone H4 Lysine	Protein Coding	3
152	HSP90AB1	Heat Shock Protein 90 Alpha Family Class B Member 1	Protein Coding	3
153	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	3
154	MAT2A	Methionine Adenosyltransferase 2A	Protein Coding	3
155	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	3
156	MTRR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase	Protein Coding	3
157	PODXL2	Podocalyxin Like 2	Protein Coding	3
158	TRMT112	TRNA Methyltransferase Activator Subunit 11-2	Protein Coding	3
159	SMOX	Spermine Oxidase	Protein Coding	3
160	UGT1A8	UDP Glucuronosyltransferase Family 1 Member A8	Protein Coding	3
161	BPNT2	3''(2''), 5''-Bisphosphate Nucleotidase 2	Protein Coding	3
162	ACSS2	Acyl-CoA Synthetase Short Chain Family Member 2	Protein Coding	3
163	AS3MT	Arsenite Methyltransferase	Protein Coding	3
164	CYB5B	Cytochrome B5 Type B	Protein Coding	3
165	ACSS1	Acyl-CoA Synthetase Short Chain Family Member 1	Protein Coding	3
166	TPST2	Tyrosylprotein Sulfotransferase 2	Protein Coding	3
167	TPST1	Tyrosylprotein Sulfotransferase 1	Protein Coding	3
168	ABHD14B	Abhydrolase Domain Containing 14B	Protein Coding	3
169	CES2	Carboxylesterase 2	Protein Coding	3
170	AIP	AHR Interacting HSP90 Co-Chaperone	Protein Coding	3
171	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	2
172	CYP27C1	Cytochrome P450 Family 27 Subfamily C Member 1	Protein Coding	2
173	GSR	Glutathione-Disulfide Reductase	Protein Coding	2
174	CYP4X1	Cytochrome P450 Family 4 Subfamily X Member 1	Protein Coding	2
175	CYP4Z1	Cytochrome P450 Family 4 Subfamily Z Member 1	Protein Coding	2
176	AKR1C2	Aldo-Keto Reductase Family 1 Member C2	Protein Coding	2
177	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	2
178	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	2
179	AKR1C4	Aldo-Keto Reductase Family 1 Member C4	Protein Coding	2
180	CYP20A1	Cytochrome P450 Family 20 Subfamily A Member 1	Protein Coding	2
181	FMO5	Flavin Containing Dimethylaniline Monoxygenase 5	Protein Coding	2
182	SLC35D2	Solute Carrier Family 35 Member D2	Protein Coding	2
183	ACSM1	Acyl-CoA Synthetase Medium Chain Family Member 1	Protein Coding	2
184	ACSM2A	Acyl-CoA Synthetase Medium Chain Family Member 2A	Protein Coding	2
185	GGT6	Gamma-Glutamyltransferase 6	Protein Coding	2
186	AADAC	Arylacetamide Deacetylase	Protein Coding	2
187	UGT3A1	UDP Glycosyltransferase Family 3 Member A1	Protein Coding	2
188	CMBL	Carboxymethylenebutenolidase Homolog	Protein Coding	2
189	UGT3A2	UDP Glycosyltransferase Family 3 Member A2	Protein Coding	2
190	ESD	Esterase D	Protein Coding	2
191	ALDH3A1	Aldehyde Dehydrogenase 3 Family Member A1	Protein Coding	2
192	SLC35D1	Solute Carrier Family 35 Member D1	Protein Coding	2
193	CES3	Carboxylesterase 3	Protein Coding	2
194	AOC1	Amine Oxidase Copper Containing 1	Protein Coding	2
195	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	2
196	GGT7	Gamma-Glutamyltransferase 7	Protein Coding	2
197	GGT5	Gamma-Glutamyltransferase 5	Protein Coding	2
198	OPLAH	5-Oxoprolinase, ATP-Hydrolysing	Protein Coding	2
199	GCLC	Glutamate-Cysteine Ligase Catalytic Subunit	Protein Coding	2
200	GCLM	Glutamate-Cysteine Ligase Modifier Subunit	Protein Coding	2
201	HPGDS	Hematopoietic Prostaglandin D Synthase	Protein Coding	2
202	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	2
203	AOC2	Amine Oxidase Copper Containing 2	Protein Coding	2
204	ACSM4	Acyl-CoA Synthetase Medium Chain Family Member 4	Protein Coding	2
205	ACSM2B	Acyl-CoA Synthetase Medium Chain Family Member 2B	Protein Coding	2
206	GLYATL3	Glycine-N-Acyltransferase Like 3	Protein Coding	2
207	NQO2	N-Ribosyldihydronicotinamide:Quinone Dehydrogenase 2	Protein Coding	2
208	CHAC2	ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 2	Protein Coding	2
209	ACSM5	Acyl-CoA Synthetase Medium Chain Family Member 5	Protein Coding	2
210	MTARC2	Mitochondrial Amidoxime Reducing Component 2	Protein Coding	2
211	ABHD10	Abhydrolase Domain Containing 10, Depalmitoylase	Protein Coding	2
212	CNDP2	Carnosine Dipeptidase 2	Protein Coding	2
213	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	2
214	MTARC1	Mitochondrial Amidoxime Reducing Component 1	Protein Coding	2
215	BPHL	Biphenyl Hydrolase Like	Protein Coding	2
216	UGDH	UDP-Glucose 6-Dehydrogenase	Protein Coding	2
217	UGP2	UDP-Glucose Pyrophosphorylase 2	Protein Coding	2
218	UGT2B10	UDP Glucuronosyltransferase Family 2 Member B10	Protein Coding	2
219	GGCT	Gamma-Glutamylcyclotransferase	Protein Coding	2
220	CHAC1	ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1	Protein Coding	2
221	UXS1	UDP-Glucuronate Decarboxylase 1	Protein Coding	2
222	AOC3	Amine Oxidase Copper Containing 3	Protein Coding	2
223	CBR3	Carbonyl Reductase 3	Protein Coding	2
224	HS3ST1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 1	Protein Coding	1
225	HS3ST2	Heparan Sulfate-Glucosamine 3-Sulfotransferase 2	Protein Coding	1
226	HS3ST3A1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3A1	Protein Coding	1
227	HS2ST1	Heparan Sulfate 2-O-Sulfotransferase 1	Protein Coding	1
228	CHST2	Carbohydrate Sulfotransferase 2	Protein Coding	1
229	NDST3	N-Deacetylase And N-Sulfotransferase 3	Protein Coding	1
230	HS6ST2	Heparan Sulfate 6-O-Sulfotransferase 2	Protein Coding	1
231	CHST1	Carbohydrate Sulfotransferase 1	Protein Coding	1
232	CHST9	Carbohydrate Sulfotransferase 9	Protein Coding	1
233	GAL3ST4	Galactose-3-O-Sulfotransferase 4	Protein Coding	1
234	GAL3ST2	Galactose-3-O-Sulfotransferase 2	Protein Coding	1
235	BAAT	Bile Acid-CoA:Amino Acid N-Acyltransferase	Protein Coding	1
236	CHST7	Carbohydrate Sulfotransferase 7	Protein Coding	1
237	HS6ST3	Heparan Sulfate 6-O-Sulfotransferase 3	Protein Coding	1
238	HS3ST3B1	Heparan Sulfate-Glucosamine 3-Sulfotransferase 3B1	Protein Coding	1
239	HS3ST4	Heparan Sulfate-Glucosamine 3-Sulfotransferase 4	Protein Coding	1
240	GAL3ST1	Galactose-3-O-Sulfotransferase 1	Protein Coding	1
241	CHST10	Carbohydrate Sulfotransferase 10	Protein Coding	1
242	CHST3	Carbohydrate Sulfotransferase 3	Protein Coding	1
243	HS6ST1	Heparan Sulfate 6-O-Sulfotransferase 1	Protein Coding	1
244	NAT8	N-Acetyltransferase 8 (Putative)	Protein Coding	1
245	GAL3ST3	Galactose-3-O-Sulfotransferase 3	Protein Coding	1
246	KCNAB2	Potassium Voltage-Gated Channel Subfamily A Regulatory Beta Subunit 2	Protein Coding	1
247	NDST2	N-Deacetylase And N-Sulfotransferase 2	Protein Coding	1
248	GSTCD	Glutathione S-Transferase C-Terminal Domain Containing	Protein Coding	1
249	AKR1D1	Aldo-Keto Reductase Family 1 Member D1	Protein Coding	1
250	HS3ST6	Heparan Sulfate-Glucosamine 3-Sulfotransferase 6	Protein Coding	1
251	NDST4	N-Deacetylase And N-Sulfotransferase 4	Protein Coding	1
252	CHST8	Carbohydrate Sulfotransferase 8	Protein Coding	1
253	AKR1B10	Aldo-Keto Reductase Family 1 Member B10	Protein Coding	1
254	CHST12	Carbohydrate Sulfotransferase 12	Protein Coding	1
255	CHST11	Carbohydrate Sulfotransferase 11	Protein Coding	1
256	SULT1C3	Sulfotransferase Family 1C Member 3	Protein Coding	1
257	CHST6	Carbohydrate Sulfotransferase 6	Protein Coding	1
258	NDST1	N-Deacetylase And N-Sulfotransferase 1	Protein Coding	1
259	HNMT	Histamine N-Methyltransferase	Protein Coding	1
260	GPX5	Glutathione Peroxidase 5	Protein Coding	1
261	GPX4	Glutathione Peroxidase 4	Protein Coding	1
262	GPX3	Glutathione Peroxidase 3	Protein Coding	1
263	GPX2	Glutathione Peroxidase 2	Protein Coding	1
264	CHST5	Carbohydrate Sulfotransferase 5	Protein Coding	1
265	FMO4	Flavin Containing Dimethylaniline Monoxygenase 4	Protein Coding	1
266	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	1
267	HS3ST5	Heparan Sulfate-Glucosamine 3-Sulfotransferase 5	Protein Coding	1
268	EPHX2	Epoxide Hydrolase 2	Protein Coding	1
269	CHST13	Carbohydrate Sulfotransferase 13	Protein Coding	1
270	CHST14	Carbohydrate Sulfotransferase 14	Protein Coding	1
271	INMT	Indolethylamine N-Methyltransferase	Protein Coding	1
272	CHST4	Carbohydrate Sulfotransferase 4	Protein Coding	1
273	NAA30	N-Alpha-Acetyltransferase 30, NatC Catalytic Subunit	Protein Coding	1
274	NAA50	N-Alpha-Acetyltransferase 50, NatE Catalytic Subunit	Protein Coding	1
275	NAA40	N-Alpha-Acetyltransferase 40, NatD Catalytic Subunit	Protein Coding	1
276	KCNAB1	Potassium Voltage-Gated Channel Subfamily A Regulatory Beta Subunit 1	Protein Coding	1
277	NAT14	N-Acetyltransferase 14 (Putative)	Protein Coding	1
278	NAT10	N-Acetyltransferase 10	Protein Coding	1
279	NAA20	N-Alpha-Acetyltransferase 20, NatB Catalytic Subunit	Protein Coding	1
280	NAT8L	N-Acetyltransferase 8 Like	Protein Coding	1
281	SLX1A-SULT1A3	SLX1A-SULT1A3 Readthrough (NMD Candidate)	RNA Gene	1
282	KCNAB3	Potassium Voltage-Gated Channel Subfamily A Regulatory Beta Subunit 3	Protein Coding	1
283	NAT9	N-Acetyltransferase 9	Protein Coding	1
284	NAA80	N-Alpha-Acetyltransferase 80, NatH Catalytic Subunit	Protein Coding	1
285	DPEP1	Dipeptidase 1	Protein Coding	1
286	AKR7L	Aldo-Keto Reductase Family 7 Like (Gene/Pseudogene)	Protein Coding	1
287	DPEP2	Dipeptidase 2	Protein Coding	1
288	ACY3	Aminoacylase 3	Protein Coding	1
289	ACY1	Aminoacylase 1	Protein Coding	1
290	CYB5R1	Cytochrome B5 Reductase 1	Protein Coding	1
291	CYB5R2	Cytochrome B5 Reductase 2	Protein Coding	1
292	CYB5R4	Cytochrome B5 Reductase 4	Protein Coding	1
293	CYB5A	Cytochrome B5 Type A	Protein Coding	1
294	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
295	CBR1	Carbonyl Reductase 1	Protein Coding	1

Disorders associated with Metapathway biotransformation Phase I and II SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cerebrotendinous xanthomatosis	Direct
2	Disease of mental health	Direct
3	Skin benign neoplasm	Direct
4	Autosomal recessive congenital ichthyosis	Direct
5	Rickets	Direct
6	Hypercalcemia	Direct
7	Craniosynostosis	Direct
8	Inherited metabolic disorder	Direct
9	Gilbert syndrome	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A9	16.00
10	Crigler-najjar syndrome, type i	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A9	16.00
11	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A9	16.00
12	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A9	16.00
13	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A9	16.00
14	Bilirubin metabolic disorder	Enrichment	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A9	16.00
15	Alcohol dependence	Enrichment	ADH1B, ADH1C, ALDH2	7.97
16	Coumarin resistance	Enrichment	CYP2A6, CYP2C9	6.49
17	Lipoid congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP11B1, CYP17A1, POR	6.45
18	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	CYP27B1, CYP2R1	6.31
19	Amed syndrome, digenic	Enrichment	ADH5, ALDH2	6.14
20	46,xy sex reversal 8	Enrichment	AKR1C2, AKR1C4	5.93
21	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR, MTRR	5.53
22	Neural tube defects, folate-sensitive	Enrichment	MTR, MTRR	5.23
23	Hereditary methemoglobinemia	Enrichment	CYB5A, CYB5R3	4.70
24	Pulmonary disease, chronic obstructive	Enrichment	CYP2R1, CYP46A1, MGST1, MGST3	4.67
25	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP11A1, CYP17A1, CYP21A2	4.32
26	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP11A1, CYP17A1, CYP21A2	4.32
27	Hyperaldosteronism, familial, type i	Enrichment	CYP11B1, CYP11B2	4.28
28	Adrenal hyperplasia, congenital, due to 17-alpha-hydroxylase deficiency	Enrichment	CYB5A, CYP17A1	4.23
29	Acetylation, slow	Enrichment	NAT2	3.83
30	Brunner syndrome	Enrichment	MAOA	3.83
31	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	3.66
32	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.66
33	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.66
34	Thiopurines, poor metabolism of, 1	Enrichment	TPMT	3.66
35	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	3.66
36	Letrozole toxicity	Enrichment	CYP2A6	3.66
37	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.66
38	Efavirenz, poor metabolism of	Enrichment	CYP2B6	3.43
39	Radiohumeral fusions with other skeletal and craniofacial anomalies	Enrichment	CYP26B1	3.35
40	Focal facial dermal dysplasia 4	Enrichment	CYP26C1	3.35
41	Lethal occipital encephalocele-skeletal dysplasia syndrome	Enrichment	CYP26B1	3.35
42	Drug metabolism, altered, ces1-related	Enrichment	CES1	3.29
43	Severe primary trimethylaminuria	Enrichment	FMO3	3.29
44	Genetic lipodystrophy	Enrichment	EPHX1	3.29
45	Retinitis pigmentosa 85	Enrichment	AHR	3.29
46	Foveal hypoplasia 3	Enrichment	AHR	3.29
47	Webb-dattani syndrome	Enrichment	ARNT2	3.29
48	Megalencephalic leukoencephalopathy with subcortical cysts 1	Enrichment	GSTT2, GSTT2B	3.23
49	Tobacco addiction	Enrichment	CYP2A6	3.05
50	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	CYP2R1	3.05
51	Hypercalcemia, infantile, 1	Enrichment	CYP24A1	3.05
52	Autosomal recessive infantile hypercalcemia	Enrichment	CYP24A1	3.05
53	Ghosal hematodiaphyseal dysplasia	Enrichment	TBXAS1	3.05
54	Ichthyosis, congenital, autosomal recessive 5	Enrichment	CYP4F22	3.05
55	Alcohol sensitivity, acute	Enrichment	ALDH2	3.05
56	Trimethylaminuria	Enrichment	FMO3	2.99
57	Primary trimethylaminuria	Enrichment	FMO3	2.99
58	Acromegaly	Enrichment	AIP	2.99
59	Null pituitary adenoma	Enrichment	AIP	2.99
60	Familial isolated pituitary adenoma	Enrichment	AIP	2.99
61	Silent pituitary adenoma	Enrichment	AIP	2.99
62	Gigantism	Enrichment	AIP	2.99
63	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	2.99
64	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	2.99
65	Homocystinuria without methylmalonic aciduria	Enrichment	MTRR	2.99
66	Glaucoma 1, open angle, a	Enrichment	CYP1B1	2.88
67	Anterior segment dysgenesis 6	Enrichment	CYP1B1	2.88
68	Cic-rearranged sarcoma	Enrichment	AKR1C2	2.88
69	Primary congenital glaucoma	Enrichment	CYP1B1	2.88
70	Chondrodysplasia with joint dislocations, gpapp type	Enrichment	BPNT2	2.88
71	Ichthyosis, congenital, autosomal recessive 14	Enrichment	SULT2B1	2.88
72	Pituitary adenoma 1, multiple types	Enrichment	AIP	2.81
73	Growth hormone secreting pituitary adenoma	Enrichment	AIP	2.81
74	Aip familial isolated pituitary adenomas	Enrichment	AIP	2.81
75	Kala-azar 2	Enrichment	GSTP1	2.75
76	Bleeding disorder, platelet-type, 14	Enrichment	TBXAS1	2.75
77	Adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	Enrichment	CYP11A1	2.72
78	Bile acid synthesis defect, congenital, 3	Enrichment	CYP7B1	2.72
79	Cholestasis, progressive familial intrahepatic, 5	Enrichment	NR1H4	2.72
80	Congenital cataract-severe neonatal hepatopathy-global developmental delay syndrome	Enrichment	CYP51A1	2.72
81	Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency	Enrichment	CYP7A1	2.72
82	Inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	Enrichment	CYP11A1	2.72
83	Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome	Enrichment	FDXR	2.72
84	Parkinson disease, mitochondrial	Enrichment	ADH1C	2.69
85	Prolactinoma	Enrichment	AIP	2.69
86	Homocystinuria-megaloblastic anemia, cble type	Enrichment	MTRR	2.69
87	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	2.69
88	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.69
89	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	2.69
90	Primary ovarian insufficiency	Enrichment	CYP17A1, CYP19A1, POR	2.63
91	Familial hypercholanemia	Enrichment	BAAT, EPHX1	2.58
92	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	2.58
93	Hereditary spastic paraplegia 56	Enrichment	CYP2U1	2.58
94	Spastic paraplegia 56, autosomal recessive, with or without pseudoxanthoma elasticum	Enrichment	CYP2U1	2.58
95	Hypertension, essential	Enrichment	CYP3A5, PTGIS	2.52
96	Homocystinuria	Enrichment	MTR	2.51
97	Juvenile glaucoma	Enrichment	CYP1B1	2.48
98	Corticosterone methyloxidase type i deficiency	Enrichment	CYP11B2	2.42
99	Corticosterone methyloxidase type ii deficiency	Enrichment	CYP11B2	2.42
100	Spastic paraplegia 5a, autosomal recessive	Enrichment	CYP7B1	2.42
101	Familial hypoaldosteronism	Enrichment	CYP11B2	2.42
102	Early-onset familial hypoaldosteronism	Enrichment	CYP11B2	2.42
103	Glaucoma, primary open angle	Enrichment	CYP1B1	2.40
104	Developmental dysplasia of the hip 1	Enrichment	AKR1C1	2.40
105	Anterior segment dysgenesis 5	Enrichment	CYP1B1	2.40
106	Ichthyosis, congenital, autosomal recessive 1	Enrichment	SULT2B1	2.40
107	Down syndrome	Enrichment	MTRR	2.38
108	Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development	Enrichment	POR	2.35
109	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	2.33
110	Adrenal hyperplasia, congenital, due to steroid 11-beta-hydroxylase deficiency	Enrichment	CYP11B1	2.24
111	Mitochondrial myopathy, episodic, with or without optic atrophy and reversible leukoencephalopathy	Enrichment	FDX2	2.24
112	Bietti crystalline corneoretinal dystrophy	Enrichment	CYP4V2	2.24
113	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	2.24
114	Aromatase excess syndrome	Enrichment	CYP19A1	2.24
115	Auditory neuropathy and optic atrophy	Enrichment	FDXR	2.24
116	Multiple mitochondrial dysfunctions syndrome 9b	Enrichment	FDXR	2.24
117	Aromatase deficiency	Enrichment	CYP19A1	2.24
118	Deficiency of steroid 11-beta-monooxygenase	Enrichment	CYP11B1	2.24
119	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	2.24
120	Septooptic dysplasia	Enrichment	ARNT2	2.21
121	Multiple sclerosis	Enrichment	CYP27B1	2.21
122	Peters-plus syndrome	Enrichment	CYP1B1	2.18
123	Ichthyosis, congenital, autosomal recessive 2	Enrichment	SULT2B1	2.18
124	Lung cancer	Enrichment	CYP2A6	2.15
125	Choroideremia	Enrichment	CYP4V2	2.12
126	Intrahepatic cholestasis of pregnancy	Enrichment	NR1H4	2.12
127	Glutathione synthetase deficiency	Enrichment	GSS	2.11
128	Bone mineral density quantitative trait locus 12	Enrichment	UGT2B17	2.11
129	Glutathionuria	Enrichment	GGT1	2.11
130	Anemia, congenital, nonspherocytic hemolytic, 6	Enrichment	GSS	2.11
131	Anemia, congenital, nonspherocytic hemolytic, 7	Enrichment	GCLC	2.11
132	5-oxoprolinase deficiency	Enrichment	OPLAH	2.11
133	Developmental and epileptic encephalopathy 84	Enrichment	UGDH	2.11
134	Maleylacetoacetate isomerase deficiency	Enrichment	GSTZ1	2.11
135	Developmental and epileptic encephalopathy 83	Enrichment	UGP2	2.11
136	Orofacial cleft 1	Enrichment	ACSS2	2.10
137	Methemoglobinemia and ambiguous genitalia	Enrichment	CYB5A	2.05
138	Antley-bixler syndrome with genital anomalies and disordered steroidogenesis	Enrichment	POR	2.05
139	Methemoglobinemia due to deficiency of methemoglobin reductase	Enrichment	CYB5R3	2.05
140	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	POR	2.05
141	Disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.05
142	Cytochrome p450 oxidoreductase deficiency	Enrichment	POR	2.05
143	Anterior segment dysgenesis	Enrichment	CYP1B1	2.00
144	Cholestasis, progressive familial intrahepatic, 1	Enrichment	NR1H4	1.94
145	Digeorge syndrome	Enrichment	COMT	1.91
146	Parkinson disease, late-onset	Enrichment	ADH1C	1.91
147	Myocardial infarction	Enrichment	GCLC, GCLM	1.91
148	Congenital nonbullous ichthyosiform erythroderma	Enrichment	SULT2B1	1.88
149	Macular dystrophy, corneal	Enrichment	CHST6	1.87
150	Bile acid synthesis defect, congenital, 2	Enrichment	AKR1D1	1.87
151	Spondylometaphyseal dysplasia, sedaghatian type	Enrichment	GPX4	1.87
152	Intellectual developmental disorder, autosomal recessive 51	Enrichment	HNMT	1.87
153	Neurofacioskeletal syndrome with or without renal agenesis	Enrichment	HS2ST1	1.87
154	Intellectual developmental disorder, autosomal recessive 46	Enrichment	NDST1	1.87
155	Angioedema, hereditary, 8	Enrichment	HS3ST6	1.87
156	Paganini-miozzo syndrome	Enrichment	HS6ST2	1.87
157	Intellectual developmental disorder, autosomal recessive 73	Enrichment	NAA20	1.87
158	Osteochondrodysplasia, brachydactyly, and overlapping malformed digits	Enrichment	CHST11	1.87
159	Hypogonadotropic hypogonadism 15 with or without anosmia	Enrichment	HS6ST1	1.87
160	N-acetylaspartate deficiency	Enrichment	NAT8L	1.87
161	Arteriosclerosis	Enrichment	HS3ST1	1.87
162	Hypercholanemia, familial 3	Enrichment	BAAT	1.87
163	Cystic fibrosis	Enrichment	EPHX1, GCLC, GSTM3	1.85
164	Hereditary spastic paraplegia	Enrichment	CYP2U1, CYP7B1	1.82
165	Schneckenbecken dysplasia	Enrichment	SLC35D1	1.81
166	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	CYB5R3	1.75
167	Congenital myopathy 1a	Enrichment	CYB5R3	1.75
168	Mitochondrial myopathy	Enrichment	FDX2	1.68
169	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	BPHL	1.63
170	Ehlers-danlos syndrome, musculocontractural type, 1	Enrichment	CHST14	1.57
171	Congenital bile acid synthesis defect	Enrichment	AKR1D1	1.57
172	Auroneurodental syndrome	Enrichment	NAA80	1.57
173	Larsen syndrome	Enrichment	CHST3	1.40
174	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Enrichment	CHST3	1.40
175	Larsen-like syndrome b3gat3 type	Enrichment	CHST3	1.40
176	Musculocontractural ehlers-danlos syndrome	Enrichment	CHST14	1.40
177	Epilepsy	Enrichment	MTR	1.39
178	Bardet-biedl syndrome	Enrichment	COMT	1.37
179	Autosomal recessive non-syndromic intellectual disability	Enrichment	HNMT, NAA20, NDST1	1.36
180	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MAT2A	1.35
181	Keratoconus	Enrichment	ALDH3A1	1.34
182	Auditory neuropathy	Enrichment	FDXR	1.31
183	Peeling skin syndrome 3	Enrichment	CHST8	1.27
184	Coronary artery anomaly	Enrichment	HS3ST1	1.27
185	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	HS3ST6	1.27
186	Schizophrenia	Enrichment	COMT	1.23
187	Retinitis pigmentosa	Enrichment	AHR, CYP4V2	1.21
188	Aminoacylase 1 deficiency	Enrichment	ACY1	1.20
189	Inherited cancer-predisposing syndrome	Enrichment	AIP	1.18
190	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	CHST3	1.10
191	Optic atrophy plus syndrome	Enrichment	CYP4V2	1.09
192	Congenital nervous system abnormality	Enrichment	CYP2U1	1.05
193	Nervous system disease	Enrichment	CYP2U1	1.05
194	Body mass index quantitative trait locus 11	Enrichment	POMC	1.04
195	Spastic ataxia	Enrichment	CYP7B1	1.01
196	Myeloma, multiple	Enrichment	RXRA	0.99
197	Asthma	Enrichment	HNMT	0.86
198	Hypercholesterolemia, familial, 1	Enrichment	EPHX2	0.79
199	Chromosome 1p36 deletion syndrome	Enrichment	KCNAB2	0.79
200	Familial hypercholesterolemia	Enrichment	EPHX2	0.73
201	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	HS6ST1	0.66
202	Kallmann syndrome	Enrichment	HS6ST1	0.57
203	Breast cancer	Enrichment	CYP17A1	0.54
204	West syndrome	Enrichment	UGDH	0.54
205	Hereditary breast carcinoma	Enrichment	NQO2	0.53
206	Hereditary retinal dystrophy	Enrichment	CYP4V2	0.37
207	Fundus dystrophy	Enrichment	CYP4V2	0.37
208	Complex neurodevelopmental disorder	Enrichment	HS2ST1	0.09

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metapathway biotransformation Phase I and II

Pathway Network for Metapathway biotransformation Phase I and II

Pathway network for the Metapathway biotransformation Phase I and II SuperPath

Member Pathways for Metapathway biotransformation Phase I and II

Pathways in the Metapathway biotransformation Phase I and II SuperPath

Associated Genes for Metapathway biotransformation Phase I and II

Associated Disorders for Metapathway biotransformation Phase I and II

Disorders associated with Metapathway biotransformation Phase I and II SuperPath

STRING Interaction Network for Metapathway biotransformation Phase I and II

Sources for Metapathway biotransformation Phase I and II