Metformin Pathway, Pharmacodynamics

No Pathway Network information available for Metformin Pathway, Pharmacodynamics

Pathways in the Metformin Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Metformin Pathway, Pharmacodynamics	PharmGKB	ACACA ACACB ATM CRTC2 CYP3A4 GPAM HMGCR IRS1 MLXIPL MLYCD MTOR NDUFA1 NDUFA11 NDUFA2 NDUFAB1 NDUFB4 NDUFS1 NDUFS2 NDUFS4 NDUFS6 NDUFV1 NR1I2 PPARGC1A PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RPTOR SIRT1 SLC22A3 SLC2A4 SREBF1 STK11 (see all 36) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	STK11	Serine/Threonine Kinase 11	Protein Coding	1
2	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
3	SLC22A3	Solute Carrier Family 22 Member 3	Protein Coding	1
4	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
5	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
6	MLXIPL	MLX Interacting Protein Like	Protein Coding	1
7	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
8	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	1
9	NDUFS1	NADH:Ubiquinone Oxidoreductase Core Subunit S1	Protein Coding	1
10	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
11	NDUFS2	NADH:Ubiquinone Oxidoreductase Core Subunit S2	Protein Coding	1
12	NDUFV1	NADH:Ubiquinone Oxidoreductase Core Subunit V1	Protein Coding	1
13	NDUFS4	NADH:Ubiquinone Oxidoreductase Subunit S4	Protein Coding	1
14	NDUFS6	NADH:Ubiquinone Oxidoreductase Subunit S6	Protein Coding	1
15	ACACA	Acetyl-CoA Carboxylase Alpha	Protein Coding	1
16	HMGCR	3-Hydroxy-3-Methylglutaryl-CoA Reductase	Protein Coding	1
17	ACACB	Acetyl-CoA Carboxylase Beta	Protein Coding	1
18	SIRT1	Sirtuin 1	Protein Coding	1
19	MLYCD	Malonyl-CoA Decarboxylase	Protein Coding	1
20	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
21	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1
22	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
23	NDUFA1	NADH:Ubiquinone Oxidoreductase Subunit A1	Protein Coding	1
24	NDUFA2	NADH:Ubiquinone Oxidoreductase Subunit A2	Protein Coding	1
25	NDUFAB1	NADH:Ubiquinone Oxidoreductase Subunit AB1	Protein Coding	1
26	NDUFB4	NADH:Ubiquinone Oxidoreductase Subunit B4	Protein Coding	1
27	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
28	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
29	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
30	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
31	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	1
32	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
33	NDUFA11	NADH:Ubiquinone Oxidoreductase Subunit A11	Protein Coding	1
34	CRTC2	CREB Regulated Transcription Coactivator 2	Protein Coding	1
35	GPAM	Glycerol-3-Phosphate Acyltransferase, Mitochondrial	Protein Coding	1
36	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1

Disorders associated with Metformin Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	NDUFA1, NDUFA11, NDUFS1, NDUFS2, NDUFS4, NDUFS6, NDUFV1	11.12
2	Renal cell carcinoma, papillary, 1	Enrichment	ATM, MTOR	3.85
3	Renal cell carcinoma, nonpapillary	Enrichment	ATM, MTOR	3.15
4	Leigh disease	Enrichment	NDUFS1, NDUFS4, NDUFV1	2.98
5	Pancreatic cancer	Enrichment	ATM, STK11	2.70
6	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.58
7	Mitochondrial complex i deficiency, nuclear type 9	Enrichment	NDUFS6	2.58
8	Acetyl-coa carboxylase-alpha deficiency	Enrichment	ACACA	2.58
9	Ifap syndrome 2	Enrichment	SREBF1	2.58
10	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.58
11	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.58
12	Endometrial serous adenocarcinoma	Enrichment	ATM	2.58
13	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.58
14	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.58
15	Mitochondrial complex i deficiency, nuclear type 6	Enrichment	NDUFS2	2.58
16	Low density lipoprotein cholesterol level quantitative trait locus 3	Enrichment	HMGCR	2.58
17	Muscular dystrophy, limb-girdle, autosomal recessive 28	Enrichment	HMGCR	2.58
18	Leber-like hereditary optic neuropathy, autosomal recessive 2	Enrichment	NDUFS2	2.58
19	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.58
20	Intestinal polyposis syndrome	Enrichment	STK11	2.58
21	Peutz-jeghers syndrome	Enrichment	STK11	2.28
22	Leukoencephalopathy, cystic, without megalencephaly	Enrichment	NDUFA2	2.28
23	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.28
24	Cebalid syndrome	Enrichment	MTOR	2.28
25	Mitochondrial complex i deficiency, nuclear type 14	Enrichment	NDUFA11	2.28
26	Mitochondrial complex i deficiency, nuclear type 12	Enrichment	NDUFA1	2.28
27	High grade glioma	Enrichment	ATM	2.28
28	T-cell prolymphocytic leukemia	Enrichment	ATM	2.28
29	Smith-kingsmore syndrome	Enrichment	MTOR	2.28
30	Nuclear type mitochondrial complex i deficiency	Enrichment	NDUFV1	2.28
31	Mitochondrial complex i deficiency, nuclear type 13	Enrichment	NDUFA2	2.28
32	Type 2 diabetes mellitus	Enrichment	IRS1, SLC2A4	2.26
33	Gastric cancer	Enrichment	ATM, STK11	2.24
34	Ataxia-telangiectasia	Enrichment	ATM	2.10
35	Polycythemia vera	Enrichment	ATM	2.10
36	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	2.10
37	Mitochondrial complex v deficiency, nuclear type 5	Enrichment	NDUFV1	2.10
38	Koolen-de vries syndrome	Enrichment	ATM	2.10
39	Testicular germ cell cancer	Enrichment	STK11	2.10
40	Mitochondrial complex v deficiency, nuclear type 1	Enrichment	NDUFS1	2.10
41	Adenocarcinoma	Enrichment	ATM	2.10
42	Testicular cancer	Enrichment	STK11	2.10
43	Apc-associated polyposis conditions	Enrichment	STK11	2.10
44	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.98
45	Malonyl-coa decarboxylase deficiency	Enrichment	MLYCD	1.98
46	Mantle cell lymphoma	Enrichment	ATM	1.98
47	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.98
48	Oculomotor apraxia	Enrichment	ATM	1.98
49	Familial adenomatous polyposis 1	Enrichment	STK11	1.88
50	Glioblastoma	Enrichment	ATM	1.88
51	Hemimegalencephaly	Enrichment	MTOR	1.88
52	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	STK11	1.88
53	Leigh syndrome, nuclear	Enrichment	NDUFS4, NDUFV1	1.84
54	Testicular germ cell tumor	Enrichment	STK11	1.80
55	Clear cell renal cell carcinoma	Enrichment	ATM	1.80
56	Overgrowth syndrome	Enrichment	MTOR	1.73
57	Mitochondrial disease	Enrichment	NDUFS1, NDUFS4	1.65
58	Colonic benign neoplasm	Enrichment	ATM	1.63
59	Limb-girdle muscular dystrophy	Enrichment	HMGCR	1.63
60	Lynch syndrome 1	Enrichment	ATM	1.58
61	Leukemia, chronic lymphocytic	Enrichment	ATM	1.58
62	Melanoma	Enrichment	STK11	1.58
63	Immune deficiency disease	Enrichment	ATM	1.54
64	Uterine corpus cancer	Enrichment	ATM	1.54
65	Familial colorectal cancer type x	Enrichment	ATM	1.54
66	Lactic acidosis	Enrichment	NDUFS4	1.50
67	Lip and oral cavity carcinoma	Enrichment	STK11	1.50
68	Breast-ovarian cancer, familial 1	Enrichment	ATM	1.47
69	Rare genetic intellectual disability	Enrichment	MTOR	1.41
70	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.38
71	Gliosarcoma	Enrichment	ATM	1.38
72	Melanoma, cutaneous malignant 1	Enrichment	STK11	1.35
73	Giant cell glioblastoma	Enrichment	ATM	1.35
74	Inherited cancer-predisposing syndrome	Enrichment	ATM, STK11	1.32
75	Endometrial cancer	Enrichment	ATM	1.27
76	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	NDUFV1	1.25
77	Bladder cancer	Enrichment	ATM	1.13
78	Hirschsprung disease 1	Enrichment	SREBF1	1.13
79	Prostate cancer	Enrichment	ATM	1.13
80	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.08
81	Leber hereditary optic neuropathy, modifier of	Enrichment	NDUFS2	1.03
82	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	NDUFS1	1.02
83	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.97
84	Hereditary breast carcinoma	Enrichment	ATM	0.96
85	Hereditary breast ovarian cancer syndrome	Enrichment	ATM	0.87
86	Myeloma, multiple	Enrichment	ATM	0.86
87	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.84
88	Breast cancer	Enrichment	ATM	0.74
89	Colorectal cancer	Enrichment	ATM	0.68
90	Leber plus disease	Enrichment	NDUFS2	0.65
91	Ovarian cancer	Enrichment	ATM	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Metformin Pathway, Pharmacodynamics

Pathway Network for Metformin Pathway, Pharmacodynamics

Member Pathways for Metformin Pathway, Pharmacodynamics

Pathways in the Metformin Pathway, Pharmacodynamics SuperPath

Associated Genes for Metformin Pathway, Pharmacodynamics

Associated Disorders for Metformin Pathway, Pharmacodynamics

Disorders associated with Metformin Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Metformin Pathway, Pharmacodynamics

Sources for Metformin Pathway, Pharmacodynamics