Methadone Pathway, Pharmacokinetics

Sources:

#	Name	Source	Genes
1	Methadone Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP2B6 CYP2C19 CYP2D6 CYP3A4 UGT2B4 UGT2B7 (see all 7) (see less)
2	Sertraline Pathway, Pharmacokinetics	PharmGKB	CYP2B6 CYP2C19 CYP2C9 CYP2D6 CYP2E1 CYP3A4 MAOA MAOB UGT1A3 UGT1A6 UGT2B4 UGT2B7 (see all 12) (see less)
3	Clopidogrel Pathway, Pharmacokinetics	PharmGKB	ABCB1 CES1 CYP1A2 CYP2B6 CYP2C19 CYP3A4 P2RY12 PON1 UGT2B4 UGT2B7 (see all 10) (see less)
4	Tramadol Pharmacokinetics	PharmGKB	ABCC2 CYP2B6 CYP2D6 CYP3A4 SLC22A1 UGT1A8 UGT2B7 (see all 7) (see less)
5	Oxycodone Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4 UGT2B4 UGT2B7
6	Meperidine Pathway, Pharmacokinetics	PharmGKB	CES1 CYP2B6 CYP2C19 CYP3A4

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	6
2	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	5
3	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	5
4	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	4
5	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	4
6	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	4
7	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	2
8	CES1	Carboxylesterase 1	Protein Coding	2
9	UGT1A6	UDP Glucuronosyltransferase Family 1 Member A6	Protein Coding	1
10	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	1
11	MAOA	Monoamine Oxidase A	Protein Coding	1
12	MAOB	Monoamine Oxidase B	Protein Coding	1
13	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	1
14	CYP2E1	Cytochrome P450 Family 2 Subfamily E Member 1	Protein Coding	1
15	PON1	Paraoxonase 1	Protein Coding	1
16	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
17	P2RY12	Purinergic Receptor P2Y12	Protein Coding	1
18	SLC22A1	Solute Carrier Family 22 Member 1	Protein Coding	1
19	UGT1A8	UDP Glucuronosyltransferase Family 1 Member A8	Protein Coding	1
20	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Crigler-najjar syndrome, type i	Enrichment	UGT1A3, UGT1A6	4.49
2	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A3, UGT1A6	4.49
3	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A3, UGT1A6	4.49
4	Crigler-najjar syndrome, type ii	Enrichment	UGT1A3, UGT1A6	4.49
5	Gilbert syndrome	Enrichment	UGT1A3, UGT1A6	4.41
6	Bilirubin metabolic disorder	Enrichment	UGT1A3, UGT1A6	4.41
7	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.53
8	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.53
9	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	3.53
10	Drug metabolism, altered, ces1-related	Enrichment	CES1	3.53
11	Efavirenz, poor metabolism of	Enrichment	CYP2B6	3.53
12	Colchicine resistance	Enrichment	ABCB1	3.29
13	Encephalopathy, acute transient	Enrichment	ABCB1	3.29
14	Inflammatory bowel disease 13	Enrichment	ABCB1	3.29
15	Brunner syndrome	Enrichment	MAOA	3.05
16	Bleeding disorder, platelet-type, 8	Enrichment	P2RY12	2.83
17	Microvascular complications of diabetes 5	Enrichment	PON1	2.83
18	Dubin-johnson syndrome	Enrichment	ABCC2	2.81
19	Nizon-isidor syndrome	Enrichment	P2RY12	2.66
20	Coumarin resistance	Enrichment	CYP2C9	2.58
21	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.51
22	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.25
23	Thrombocytopenia	Enrichment	P2RY12	1.46
24	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PON1	1.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Methadone Pathway, Pharmacokinetics