Methionine de novo and salvage pathway

Sources:

#	Name	Source	Genes
1	Methionine de novo and salvage pathway	WikiPathways	ADI1 AHCY AMD1 APIP BHMT CHDH ENOPH1 IL4I1 MAT1A MAT2A MAT2B MRI1 MSRA MSRB2 MSRB3 MTAP MTR ODC1 SMS SRM TAT (see all 21) (see less)
2	methionine salvage cycle III	PubChem	ADI1 APIP ENOPH1 KYAT1 MAT1A MAT2A MAT2B MRI1 MTAP SRM (see all 10) (see less)
3	L-methionine salvage cycle III	PubChem	KYAT1 MAT1A MAT2A MAT2B MTAP SRM (see all 6) (see less)
4	S-methyl-5-thio-α-D-ribose 1-phosphate degradation	PubChem	ADI1 APIP ENOPH1 KYAT1 MRI1
5	S-methyl-5-thio-α-D-ribose 1-phosphate degradation I	PubChem	KYAT1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KYAT1	Kynurenine Aminotransferase 1	Protein Coding	4
2	SRM	Spermidine Synthase	Protein Coding	3
3	ENOPH1	Enolase-Phosphatase 1	Protein Coding	3
4	ADI1	Acireductone Dioxygenase 1	Protein Coding	3
5	MTAP	Methylthioadenosine Phosphorylase	Protein Coding	3
6	MAT2A	Methionine Adenosyltransferase 2A	Protein Coding	3
7	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	3
8	MRI1	Methylthioribose-1-Phosphate Isomerase 1	Protein Coding	3
9	APIP	APAF1 Interacting Protein	Protein Coding	3
10	MAT2B	Methionine Adenosyltransferase 2 Non-Catalytic Beta Subunit	Protein Coding	3
11	TAT	Tyrosine Aminotransferase	Protein Coding	1
12	SMS	Spermine Synthase	Protein Coding	1
13	BHMT	Betaine--Homocysteine S-Methyltransferase	Protein Coding	1
14	CHDH	Choline Dehydrogenase	Protein Coding	1
15	ODC1	Ornithine Decarboxylase 1	Protein Coding	1
16	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	1
17	MSRA	Methionine Sulfoxide Reductase A	Protein Coding	1
18	IL4I1	Interleukin 4 Induced 1	Protein Coding	1
19	MSRB3	Methionine Sulfoxide Reductase B3	Protein Coding	1
20	AHCY	Adenosylhomocysteinase	Protein Coding	1
21	AMD1	Adenosylmethionine Decarboxylase 1	Protein Coding	1
22	MSRB2	Methionine Sulfoxide Reductase B2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Diaphyseal medullary stenosis with malignant fibrous histiocytoma	Enrichment	MTAP	3.05
2	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	3.05
3	Diaphyseal medullary stenosis-bone malignancy syndrome	Enrichment	MTAP	3.05
4	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	3.05
5	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	2.81
6	Bachmann-bupp syndrome	Enrichment	ODC1	2.81
7	Intellectual developmental disorder, x-linked, syndromic, snyder-robinson type	Enrichment	SMS	2.81
8	Deafness, autosomal recessive 74	Enrichment	MSRB3	2.81
9	Syndromic x-linked intellectual disability snyder type	Enrichment	SMS	2.81
10	Striatonigral degeneration, infantile	Enrichment	IL4I1	2.51
11	Developmental and epileptic encephalopathy 87	Enrichment	AMD1	2.51
12	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.51
13	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	2.33
14	Homocystinuria	Enrichment	MTR	2.33
15	Tyrosinemia, type ii	Enrichment	TAT	2.21
16	Neural tube defects, folate-sensitive	Enrichment	MTR	2.21
17	Smith-magenis syndrome	Enrichment	SMS	2.11
18	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MAT2A	1.71
19	Epilepsy	Enrichment	MTR	1.22
20	Schizophrenia	Enrichment	MSRA	1.06
21	Deafness, autosomal recessive	Enrichment	MSRB3	1.03
22	Autosomal recessive nonsyndromic deafness	Enrichment	MSRB3	1.02
23	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MSRB3	0.89

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Methionine de novo and salvage pathway