Methionine metabolism

No Pathway Network information available for Methionine metabolism

Pathways in the Methionine metabolism SuperPath

#	Name	Source	Genes
1	Methionine metabolism	GeneGo (Thomson Reuters)	AHCY AHCYL1 AHCYL2 BHMT BHMT2 CBS CTH DNMT1 DNMT3A DNMT3B MARS1 MAT1A MAT2A MTFMT MTR (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AHCY	Adenosylhomocysteinase	Protein Coding	1
2	BHMT	Betaine--Homocysteine S-Methyltransferase	Protein Coding	1
3	CBS	Cystathionine Beta-Synthase	Protein Coding	1
4	CTH	Cystathionine Gamma-Lyase	Protein Coding	1
5	DNMT1	DNA Methyltransferase 1	Protein Coding	1
6	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	1
7	DNMT3B	DNA Methyltransferase 3 Beta	Protein Coding	1
8	MARS1	Methionyl-TRNA Synthetase 1	Protein Coding	1
9	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	1
10	MAT2A	Methionine Adenosyltransferase 2A	Protein Coding	1
11	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	1
12	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	1
13	AHCYL2	Adenosylhomocysteinase Like 2	Protein Coding	1
14	BHMT2	Betaine--Homocysteine S-Methyltransferase 2	Protein Coding	1
15	MTFMT	Mitochondrial Methionyl-TRNA Formyltransferase	Protein Coding	1

Disorders associated with Methionine metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Homocystinuria	Enrichment	CBS, MTR	5.47
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS, MAT2A	2.98
3	Cystathioninuria	Enrichment	CTH	2.96
4	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	2.96
5	Hyperhomocysteinemia	Enrichment	CBS	2.96
6	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	2.96
7	Combined oxidative phosphorylation deficiency 15	Enrichment	MTFMT	2.96
8	Mitochondrial complex i deficiency, nuclear type 27	Enrichment	MTFMT	2.96
9	Charcot-marie-tooth disease, axonal, type 2u	Enrichment	MARS1	2.96
10	Trichothiodystrophy 9, nonphotosensitive	Enrichment	MARS1	2.96
11	Pulmonary alveolar proteinosis	Enrichment	MARS1	2.96
12	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Enrichment	DNMT3B	2.66
13	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	2.66
14	Waardenburg syndrome, type 2f	Enrichment	MTFMT	2.66
15	Spastic paraplegia 70, autosomal recessive	Enrichment	MARS1	2.66
16	Facioscapulohumeral muscular dystrophy 4, digenic	Enrichment	DNMT3B	2.66
17	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.66
18	Interstitial lung and liver disease	Enrichment	MARS1	2.66
19	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	2.66
20	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.66
21	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	2.66
22	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR	2.48
23	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	2.48
24	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	2.48
25	Neural tube defects, folate-sensitive	Enrichment	MTR	2.35
26	Myeloproliferative neoplasm	Enrichment	DNMT3A	2.26
27	Glioblastoma	Enrichment	DNMT3A	2.26
28	Mitochondrial oxidative phosphorylation disorder	Enrichment	MTFMT	2.26
29	Facioscapulohumeral muscular dystrophy 1	Enrichment	DNMT3B	2.18
30	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	DNMT3B	2.18
31	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	2.18
32	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	2.11
33	Melanoma	Enrichment	DNMT3A	1.96
34	Specific learning disability	Enrichment	DNMT3A	1.92
35	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.81
36	Rare genetic intellectual disability	Enrichment	DNMT3A	1.78
37	Gliosarcoma	Enrichment	DNMT3A	1.76
38	Giant cell glioblastoma	Enrichment	DNMT3A	1.73
39	Diffuse large b-cell lymphoma	Enrichment	DNMT3A	1.68
40	Connective tissue disease	Enrichment	CBS	1.46
41	Leukemia, acute myeloid	Enrichment	DNMT3A	1.36
42	Epilepsy	Enrichment	MTR	1.36
43	Body mass index quantitative trait locus 11	Enrichment	DNMT3A	1.27
44	Spastic ataxia	Enrichment	DNMT1	1.24
45	Myeloma, multiple	Enrichment	DNMT3A	1.22
46	Leigh syndrome, nuclear	Enrichment	MTFMT	1.13
47	Leigh disease	Enrichment	MTFMT	1.09
48	Congenital nervous system abnormality	Enrichment	DNMT3A	0.95
49	Nervous system disease	Enrichment	DNMT3A	0.95
50	Autism spectrum disorder	Enrichment	DNMT3A	0.94

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Methionine metabolism

Pathway Network for Methionine metabolism

Member Pathways for Methionine metabolism

Pathways in the Methionine metabolism SuperPath

Associated Genes for Methionine metabolism

Associated Disorders for Methionine metabolism

Disorders associated with Methionine metabolism SuperPath

STRING Interaction Network for Methionine metabolism

Sources for Methionine metabolism