Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics

Pathway network for the Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

Sources:

PharmGKB
WikiPathways
PubChem

Pathways in the Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

#	Name	Source	Genes
1	Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics	PharmGKB	ADA ATIC CBS DHFR FPGS GART GGH MTHFD1 MTHFR MTHFS MTR MTRR PPAT SHMT1 TYMS (see all 15) (see less)
2	One-carbon metabolism	WikiPathways	AHCY AHCYL2 ALDH1L1 AMT ATIC BHMT DHFR DNMT1 DNMT3A DNMT3B FOLH1 FTCD GART GLRX MAT1A MAT2B MTFMT MTHFD1 MTHFD1L MTHFD2 MTHFR MTHFS MTR MTRR SHMT1 SHMT2 TCN2 TYMS (see all 28) (see less)
3	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics	PharmGKB	ADA ATIC CBS DHFR GART MTHFD1 MTHFR MTHFS MTR MTRR NT5E PPAT SHMT1 TYMS (see all 14) (see less)
4	tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate	PubChem	GART MTHFD1

Gene overlap in member pathways for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MTHFD1	Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1	Protein Coding	4
2	GART	Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase	Protein Coding	4
3	SHMT1	Serine Hydroxymethyltransferase 1	Protein Coding	3
4	TYMS	Thymidylate Synthetase	Protein Coding	3
5	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	3
6	MTR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase	Protein Coding	3
7	MTRR	5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase	Protein Coding	3
8	DHFR	Dihydrofolate Reductase	Protein Coding	3
9	MTHFS	Methenyltetrahydrofolate Synthetase	Protein Coding	3
10	ATIC	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase	Protein Coding	3
11	PPAT	Phosphoribosyl Pyrophosphate Amidotransferase	Protein Coding	2
12	CBS	Cystathionine Beta-Synthase	Protein Coding	2
13	ADA	Adenosine Deaminase	Protein Coding	2
14	GGH	Gamma-Glutamyl Hydrolase	Protein Coding	1
15	FPGS	Folylpolyglutamate Synthase	Protein Coding	1
16	TCN2	Transcobalamin 2	Protein Coding	1
17	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	1
18	BHMT	Betaine--Homocysteine S-Methyltransferase	Protein Coding	1
19	MAT1A	Methionine Adenosyltransferase 1A	Protein Coding	1
20	AMT	Aminomethyltransferase	Protein Coding	1
21	FOLH1	Folate Hydrolase 1	Protein Coding	1
22	AHCYL2	Adenosylhomocysteinase Like 2	Protein Coding	1
23	AHCY	Adenosylhomocysteinase	Protein Coding	1
24	DNMT3B	DNA Methyltransferase 3 Beta	Protein Coding	1
25	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	1
26	DNMT1	DNA Methyltransferase 1	Protein Coding	1
27	MTFMT	Mitochondrial Methionyl-TRNA Formyltransferase	Protein Coding	1
28	FTCD	Formimidoyltransferase Cyclodeaminase	Protein Coding	1
29	ALDH1L1	Aldehyde Dehydrogenase 1 Family Member L1	Protein Coding	1
30	MTHFD2	Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase	Protein Coding	1
31	GLRX	Glutaredoxin	Protein Coding	1
32	MAT2B	Methionine Adenosyltransferase 2 Non-Catalytic Beta Subunit	Protein Coding	1
33	MTHFD1L	Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like	Protein Coding	1
34	NT5E	5''-Nucleotidase Ecto	Protein Coding	1

Disorders associated with Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neural tube defects, folate-sensitive	Enrichment	MTHFD1, MTHFR, MTR, MTRR	10.68
2	Homocystinuria-megaloblastic anemia, cblg type	Enrichment	MTR, MTRR	5.53
3	Homocystinuria	Enrichment	CBS, MTR	5.53
4	Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia	Enrichment	MTHFD1	3.53
5	Severe combined immunodeficiency	Enrichment	ADA, MTHFD1	3.29
6	Calcification of joints and arteries	Enrichment	NT5E	2.99
7	Aica-ribosiduria due to atic deficiency	Enrichment	ATIC	2.99
8	Homocystinuria due to deficiency of n -methylenetetrahydrofolate reductase activity	Enrichment	MTHFR	2.99
9	Hyperhomocysteinemia	Enrichment	CBS	2.99
10	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.99
11	Homocystinuria without methylmalonic aciduria	Enrichment	MTRR	2.99
12	Isolated tracheo-esophageal fistula	Enrichment	GART	2.83
13	Homocystinuria-megaloblastic anemia, cble type	Enrichment	MTRR	2.69
14	Neurodevelopmental disorder with microcephaly, epilepsy, and hypomyelination	Enrichment	MTHFS	2.69
15	Disorders of intracellular cobalamin metabolism	Enrichment	MTR	2.69
16	Dyskeratosis congenita, digenic	Enrichment	TYMS	2.69
17	Isolated anencephaly	Enrichment	MTHFR	2.69
18	Isolated exencephaly	Enrichment	MTHFR	2.69
19	Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency	Enrichment	AHCY	2.69
20	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	2.69
21	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	2.69
22	Combined oxidative phosphorylation deficiency 15	Enrichment	MTFMT	2.69
23	Mitochondrial complex i deficiency, nuclear type 27	Enrichment	MTFMT	2.69
24	Esophageal atresia/tracheoesophageal fistula	Enrichment	GART	2.55
25	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	2.51
26	Homocystinuria due to cystathionine beta-synthase deficiency	Enrichment	CBS	2.51
27	Glomerulopathy with fibronectin deposits 2	Enrichment	ATIC	2.51
28	Familial adenomatous polyposis 4	Enrichment	DHFR	2.51
29	Down syndrome	Enrichment	MTRR	2.38
30	Adenosine deaminase deficiency	Enrichment	ADA	2.38
31	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	Enrichment	DNMT3B	2.38
32	Glutamate formiminotransferase deficiency	Enrichment	FTCD	2.38
33	Transcobalamin ii deficiency	Enrichment	TCN2	2.38
34	Methionine adenosyltransferase i/iii deficiency	Enrichment	MAT1A	2.38
35	Waardenburg syndrome, type 2f	Enrichment	MTFMT	2.38
36	Glycine encephalopathy 2	Enrichment	AMT	2.38
37	Facioscapulohumeral muscular dystrophy 4, digenic	Enrichment	DNMT3B	2.38
38	Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant	Enrichment	DNMT1	2.38
39	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	2.38
40	Methionine adenosyltransferase deficiency	Enrichment	MAT1A	2.38
41	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	2.29
42	Neuropathy, hereditary sensory, type ie	Enrichment	DNMT1	2.21
43	Thrombophilia due to thrombin defect	Enrichment	MTHFR	2.14
44	Atypical glycine encephalopathy	Enrichment	AMT	2.08
45	Omenn syndrome	Enrichment	ADA	1.99
46	Myeloproliferative neoplasm	Enrichment	DNMT3A	1.99
47	Glioblastoma	Enrichment	DNMT3A	1.99
48	Mitochondrial oxidative phosphorylation disorder	Enrichment	MTFMT	1.99
49	Facioscapulohumeral muscular dystrophy 1	Enrichment	DNMT3B	1.91
50	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	DNMT3B	1.91
51	Pancytopenia	Enrichment	TCN2	1.91
52	Glycine encephalopathy	Enrichment	AMT	1.91
53	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	1.91
54	Neural tube defects	Enrichment	MTHFR	1.87
55	Hereditary sensory and autonomic neuropathy type 1	Enrichment	DNMT1	1.84
56	Glycine encephalopathy 1	Enrichment	AMT	1.79
57	Dyskeratosis congenita	Enrichment	TYMS	1.71
58	Melanoma	Enrichment	DNMT3A	1.69
59	Endometrial cancer	Enrichment	DHFR	1.67
60	Specific learning disability	Enrichment	DNMT3A	1.65
61	Pituitary stalk interruption syndrome	Enrichment	DNMT1	1.54
62	Rare genetic intellectual disability	Enrichment	DNMT3A	1.52
63	Gliosarcoma	Enrichment	DNMT3A	1.49
64	Connective tissue disease	Enrichment	CBS	1.49
65	Giant cell glioblastoma	Enrichment	DNMT3A	1.46
66	Diffuse large b-cell lymphoma	Enrichment	DNMT3A	1.41
67	Epilepsy	Enrichment	MTR	1.39
68	Nephrotic syndrome	Enrichment	ATIC	1.36
69	West syndrome	Enrichment	MTHFR	1.35
70	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	CBS	1.35
71	Schizophrenia	Enrichment	MTHFR	1.23
72	Leukemia, acute myeloid	Enrichment	DNMT3A	1.10
73	Body mass index quantitative trait locus 11	Enrichment	DNMT3A	1.01
74	Spastic ataxia	Enrichment	DNMT1	0.98
75	Myeloma, multiple	Enrichment	DNMT3A	0.96
76	Inherited cancer-predisposing syndrome	Enrichment	DHFR	0.89
77	Leigh syndrome, nuclear	Enrichment	MTFMT	0.88
78	Leigh disease	Enrichment	MTFMT	0.84
79	Congenital nervous system abnormality	Enrichment	DNMT3A	0.70
80	Nervous system disease	Enrichment	DNMT3A	0.70
81	Autism spectrum disorder	Enrichment	DNMT3A	0.69

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics

Pathway Network for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics

Pathway network for the Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

Member Pathways for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics

Pathways in the Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

Gene overlap in member pathways for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

Associated Genes for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics

Associated Disorders for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics

Disorders associated with Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics SuperPath

STRING Interaction Network for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics

Sources for Methotrexate Pathway (Cancer Cell), Pharmacodynamics and Pharmacokinetics