Methotrexate Pathway, Pharmacokinetics

No Pathway Network information available for Methotrexate Pathway, Pharmacokinetics

#	Name	Source	Genes
1	Methotrexate Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC1 ABCC2 ABCC3 ABCG2 FOLR1 SLC19A1 SLC22A6 SLC22A8 SLC46A1 SLCO1A2 SLCO1B1 SLCO1B3 (see all 13) (see less)
2	Methotrexate Pathway (Brain Cell), Pharmacokinetics	PharmGKB	ABCB1 ABCC1 ABCC4 ABCG2 SLC22A6 SLC22A8 SLCO1A2 (see all 7) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLCO1A2	Solute Carrier Organic Anion Transporter Family Member 1A2	Protein Coding	2
2	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	2
3	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	2
4	SLC22A6	Solute Carrier Family 22 Member 6	Protein Coding	2
5	SLC22A8	Solute Carrier Family 22 Member 8	Protein Coding	2
6	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	2
7	SLC19A1	Solute Carrier Family 19 Member 1	Protein Coding	1
8	ABCC3	ATP Binding Cassette Subfamily C Member 3	Protein Coding	1
9	FOLR1	Folate Receptor Alpha	Protein Coding	1
10	SLCO1B3	Solute Carrier Organic Anion Transporter Family Member 1B3	Protein Coding	1
11	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1
12	SLCO1B1	Solute Carrier Organic Anion Transporter Family Member 1B1	Protein Coding	1
13	SLC46A1	Solute Carrier Family 46 Member 1	Protein Coding	1
14	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B1, SLCO1B3	5.59
2	Colchicine resistance	Enrichment	ABCB1	3.29
3	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	3.29
4	Encephalopathy, acute transient	Enrichment	ABCB1	3.29
5	Deafness, autosomal dominant 77	Enrichment	ABCC1	3.29
6	Inflammatory bowel disease 13	Enrichment	ABCB1	3.29
7	Blood group, junior system	Enrichment	ABCG2	3.29
8	Megaloblastic anemia, folate-responsive	Enrichment	SLC19A1	3.02
9	Neurodegeneration due to cerebral folate transport deficiency	Enrichment	FOLR1	3.02
10	Immunodeficiency 114, folate-responsive	Enrichment	SLC19A1	3.02
11	Neurodegenerative syndrome due to cerebral folate transport deficiency	Enrichment	FOLR1	3.02
12	Glaucoma, primary closed-angle	Enrichment	SLC19A1	2.72
13	Dubin-johnson syndrome	Enrichment	ABCC2	2.54
14	Folate malabsorption, hereditary	Enrichment	SLC46A1	2.54
15	Knobloch syndrome	Enrichment	SLC19A1	2.42
16	Knobloch syndrome 1	Enrichment	SLC19A1	2.32
17	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.25
18	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.24
19	Gilbert syndrome	Enrichment	SLCO1B1	1.98
20	Cataract	Enrichment	SLC19A1	1.87
21	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.58
22	Stargardt disease 1	Enrichment	SLC19A1	1.55
23	Lung cancer	Enrichment	SLC19A1	1.52
24	Retinitis pigmentosa	Enrichment	SLC19A1	0.73
25	Hereditary retinal dystrophy	Enrichment	SLC19A1	0.61
26	Fundus dystrophy	Enrichment	SLC19A1	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Methotrexate Pathway, Pharmacokinetics