Methylphenidate Pathway, Pharmacodynamics

No Pathway Network information available for Methylphenidate Pathway, Pharmacodynamics

#	Name	Source	Genes
1	Methylphenidate Pathway, Pharmacodynamics	PharmGKB	ADRA2A COMT DBH DRD1 DRD2 DRD3 DRD4 DRD5 HTR1A HTR1B MAOA MAOB SLC18A2 SLC6A2 SLC6A3 SLC6A4 TH TPH2 (see all 18) (see less)
2	Dopamine receptors	Reactome	DRD1 DRD2 DRD3 DRD4 DRD5

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DRD1	Dopamine Receptor D1	Protein Coding	2
2	DRD2	Dopamine Receptor D2	Protein Coding	2
3	DRD3	Dopamine Receptor D3	Protein Coding	2
4	DRD4	Dopamine Receptor D4	Protein Coding	2
5	DRD5	Dopamine Receptor D5	Protein Coding	2
6	TH	Tyrosine Hydroxylase	Protein Coding	1
7	SLC6A2	Solute Carrier Family 6 Member 2	Protein Coding	1
8	SLC6A3	Solute Carrier Family 6 Member 3	Protein Coding	1
9	SLC6A4	Solute Carrier Family 6 Member 4	Protein Coding	1
10	SLC18A2	Solute Carrier Family 18 Member A2	Protein Coding	1
11	MAOA	Monoamine Oxidase A	Protein Coding	1
12	MAOB	Monoamine Oxidase B	Protein Coding	1
13	COMT	Catechol-O-Methyltransferase	Protein Coding	1
14	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	1
15	HTR1B	5-Hydroxytryptamine Receptor 1B	Protein Coding	1
16	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	1
17	DBH	Dopamine Beta-Hydroxylase	Protein Coding	1
18	TPH2	Tryptophan Hydroxylase 2	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Attention deficit-hyperactivity disorder	Enrichment	DRD4, DRD5	4.60
2	Blepharospasm, benign essential	Enrichment	DRD5	3.43
3	Tremor, hereditary essential, 1	Enrichment	DRD3	3.43
4	Autonomic nervous system disease	Enrichment	DRD4	3.43
5	Blepharospasm	Enrichment	DRD5	3.43
6	Brunner syndrome	Enrichment	MAOA	2.88
7	Parkinsonism-dystonia 1, infantile-onset	Enrichment	SLC6A3	2.88
8	Periodic fever, menstrual cycle-dependent	Enrichment	HTR1A	2.88
9	Postural orthostatic tachycardia syndrome	Enrichment	SLC6A2	2.88
10	Classic dopamine transporter deficiency syndrome	Enrichment	SLC6A3	2.88
11	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	2.88
12	Catechol-o-methyltransferase activity, variation in	Enrichment	COMT	2.88
13	Parkinsonism-dystonia, infantile	Enrichment	SLC6A3	2.88
14	Dystonia 11, myoclonic	Enrichment	DRD2	2.66
15	Major affective disorder 1	Enrichment	TPH2	2.58
16	Obsessive-compulsive disorder	Enrichment	SLC6A4	2.58
17	Segawa syndrome, autosomal recessive	Enrichment	TH	2.58
18	Orthostatic hypotension 1	Enrichment	DBH	2.58
19	Parkinsonism-dystonia 2, infantile-onset	Enrichment	SLC18A2	2.58
20	Dopamine beta-hydroxylase deficiency	Enrichment	DBH	2.58
21	Schizophrenia	Enrichment	COMT, DRD3	2.57
22	Essential tremor	Enrichment	DRD3	2.53
23	Dystonia, dopa-responsive	Enrichment	TH	2.40
24	Tobacco addiction	Enrichment	SLC6A3	2.28
25	Major depressive disorder	Enrichment	TPH2	2.18
26	Anxiety	Enrichment	SLC6A4	2.10
27	Orthostatic intolerance	Enrichment	SLC6A2	1.98
28	Digeorge syndrome	Enrichment	COMT	1.80
29	Dystonia	Enrichment	TH	1.34
30	Bardet-biedl syndrome	Enrichment	COMT	1.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Methylphenidate Pathway, Pharmacodynamics