Metoclopramide Pathway, Pharmacokinetics

Sources:

#	Name	Source	Genes
1	Metoclopramide Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4
2	Losartan Pathway, Pharmacokinetics	PharmGKB	AGTR1 CYP2C9 CYP3A4 UGT1A1 UGT2B7
3	Metabolism of tetrahydrocannabinol (THC)	WikiPathways	CYP2C9 CYP3A4
4	Cariprazine Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4
5	Brexpiprazole Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4
6	Meloxicam Pathway, Pharmacokinetics	PharmGKB	CYP2C9 CYP3A4
7	Tamsulosin Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4
8	Avacopan Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	C5AR1 CYP3A4
9	Quetiapine Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4
10	Tolterodine Pathway, Pharmacokinetics	PharmGKB	CYP2D6 CYP3A4
11	Piroxicam Pathway, Pharmacokinetics	PharmGKB	CYP2C9
12	Milnacipran Pathway, Pharmacokinetics	PharmGKB	CYP3A4
13	morphine biosynthesis	PubChem	CYP3A4
14	Lornoxicam Pathway, Pharmacokinetics	PharmGKB	CYP2C9
15	Colchicine metabolic pathway	WikiPathways	CYP3A4

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	13
2	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	6
3	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	5
4	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	1
5	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	1
6	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	1
7	C5AR1	Complement C5a Receptor 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	4.13
2	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.83
3	Coumarin resistance	Enrichment	CYP2C9	3.66
4	Renal tubular dysgenesis	Enrichment	AGTR1	2.66
5	Crigler-najjar syndrome, type i	Enrichment	UGT1A1	2.43
6	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1	2.43
7	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1	2.43
8	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1	2.43
9	Gilbert syndrome	Enrichment	UGT1A1	2.39
10	Bilirubin metabolic disorder	Enrichment	UGT1A1	2.39
11	Hypertension, essential	Enrichment	AGTR1	2.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Metoclopramide Pathway, Pharmacokinetics