MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

No Pathway Network information available for MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Pathways in the MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement SuperPath

#	Name	Source	Genes
1	MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement	WikiPathways	ACTN1 CREB1 ITGAV ITGB3 ITPR1 JUN LPP MAPK1 MAPK3 MFAP5 MYL2 MYLK PLCG1 PRKCQ PTK2 PXN TJP1 VCL (see all 18) (see less)
2	MFAP5-mediated ovarian cancer cell motility and invasiveness	WikiPathways	CREB1 ITGAV ITGB3 ITPR3 JUN MAPK1 MAPK3 MFAP5 PLCG1 PRKCQ PTK2 RYR3 TNNC1 (see all 13) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MFAP5	Microfibril Associated Protein 5	Protein Coding	2
2	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
3	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
4	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
5	PRKCQ	Protein Kinase C Theta	Protein Coding	2
6	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
7	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
8	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
9	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
10	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
11	ACTN1	Actinin Alpha 1	Protein Coding	1
12	VCL	Vinculin	Protein Coding	1
13	TJP1	Tight Junction Protein 1	Protein Coding	1
14	PXN	Paxillin	Protein Coding	1
15	MYLK	Myosin Light Chain Kinase	Protein Coding	1
16	MYL2	Myosin Light Chain 2	Protein Coding	1
17	LPP	LIM Domain Containing Preferred Translocation Partner In Lipoma	Protein Coding	1
18	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
19	TNNC1	Troponin C1, Slow Skeletal And Cardiac Type	Protein Coding	1
20	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
21	RYR3	Ryanodine Receptor 3	Protein Coding	1

Disorders associated with MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1, ITGB3	4.13
2	Noonan syndrome 13	Enrichment	MAPK1	3.02
3	Congenital myopathy 20	Enrichment	RYR3	3.02
4	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	3.02
5	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.02
6	Aortic aneurysm, familial thoracic 9	Enrichment	MFAP5	3.02
7	Cardiomyopathy, dilated, 1z	Enrichment	TNNC1	3.02
8	Cardiomyopathy, familial hypertrophic, 13	Enrichment	TNNC1	3.02
9	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	3.02
10	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	3.02
11	Cardiomyopathy, dilated, 1w	Enrichment	VCL	2.88
12	Cardiomyopathy, familial hypertrophic, 15	Enrichment	VCL	2.88
13	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.88
14	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	MFAP5, MYLK	2.82
15	Thrombocytopenia	Enrichment	ACTN1, ITGB3	2.74
16	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.72
17	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.58
18	Cardiomyopathy, familial hypertrophic, 10	Enrichment	MYL2	2.58
19	Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathy	Enrichment	MYL2	2.58
20	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.54
21	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.54
22	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.54
23	Melanoma of soft tissue	Enrichment	CREB1	2.54
24	Amyotrophy, monomelic	Enrichment	RYR3	2.42
25	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.42
26	Gillespie syndrome	Enrichment	ITPR1	2.40
27	Aortic aneurysm, familial thoracic 7	Enrichment	MYLK	2.40
28	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.32
29	Dilated cardiomyopathy	Enrichment	MYL2, VCL	2.31
30	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	MYLK	2.28
31	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.28
32	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	2.24
33	Visceral myopathy 1	Enrichment	MYLK	2.18
34	Glanzmann thrombasthenia 1	Enrichment	ITGB3	2.17
35	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	2.10
36	Inflammatory bowel disease 1	Enrichment	PRKCQ	2.07
37	Hydrops fetalis	Enrichment	RYR3	2.07
38	Familial isolated restrictive cardiomyopathy	Enrichment	MYL2	2.03
39	Specific learning disability	Enrichment	MAPK1	1.98
40	Congenital long qt syndrome	Enrichment	ITPR3	1.94
41	Familial thoracic aortic aneurysm and dissection	Enrichment	MYLK	1.93
42	Cardiomyopathy, dilated, 1e	Enrichment	TNNC1	1.79
43	Heart, malformation of	Enrichment	MAPK1	1.77
44	Multiple sclerosis	Enrichment	ITPR1	1.73
45	Aortic aneurysm, familial thoracic 1	Enrichment	MYLK	1.73
46	Heart disease	Enrichment	MYL2	1.73
47	Congenital myopathy 4a, autosomal dominant	Enrichment	MYL2	1.70
48	Anterior segment dysgenesis	Enrichment	ITPR1	1.70
49	Myocardial infarction	Enrichment	ITGB3	1.68
50	Severe covid-19	Enrichment	ITGAV	1.56
51	Long qt syndrome 1	Enrichment	ITPR3	1.55
52	Hypertrophic cardiomyopathy	Enrichment	TNNC1	1.39
53	Familial hypertrophic cardiomyopathy	Enrichment	MYL2	1.37
54	Familial isolated dilated cardiomyopathy	Enrichment	TNNC1	1.30
55	Leukemia, acute myeloid	Enrichment	LPP	1.29
56	Primary ovarian insufficiency	Enrichment	RYR3	1.26
57	Spastic ataxia	Enrichment	ITPR1	1.17
58	Breast cancer	Enrichment	JUN	1.16
59	Schizophrenia	Enrichment	LPP	1.12
60	Microcephaly	Enrichment	MAPK1	0.95

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Pathway Network for MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Member Pathways for MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Pathways in the MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement SuperPath

Associated Genes for MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Associated Disorders for MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Disorders associated with MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement SuperPath

STRING Interaction Network for MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement

Sources for MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement