Microtubule cytoskeleton regulation

No Pathway Network information available for Microtubule cytoskeleton regulation

Pathways in the Microtubule cytoskeleton regulation SuperPath

#	Name	Source	Genes
1	Microtubule cytoskeleton regulation	WikiPathways	ABL1 AKT1 APC AURKB CAMK4 CDC42 CDK1 CFL2 CLASP1 CLIP1 DIAPH1 DPYSL2 DVL1 EPHB2 F2RL2 GNAQ GSK3B KIF2C LIMK1 MAP1B MAPKAPK2 MAPRE1 MAPT MARK1 MARK2 PAK1 PARD6A PHLDB2 PIK3CA PRKACA PRKCA PTEN PTPRA RAC1 RHO ROCK1 SPRED1 SRC STAT3 STMN1 TAOK1 TESK2 TIAM1 TPPP TRIO WNT3A (see all 46) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TPPP	Tubulin Polymerization Promoting Protein	Protein Coding	1
2	LIMK1	LIM Domain Kinase 1	Protein Coding	1
3	CDC42	Cell Division Cycle 42	Protein Coding	1
4	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
5	AURKB	Aurora Kinase B	Protein Coding	1
6	PHLDB2	Pleckstrin Homology Like Domain Family B Member 2	Protein Coding	1
7	WNT3A	Wnt Family Member 3A	Protein Coding	1
8	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
9	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	1
10	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
11	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
12	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
13	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
14	RHO	Rhodopsin	Protein Coding	1
15	RAC1	Rac Family Small GTPase 1	Protein Coding	1
16	PTPRA	Protein Tyrosine Phosphatase Receptor Type A	Protein Coding	1
17	TAOK1	TAO Kinase 1	Protein Coding	1
18	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
19	PRKCA	Protein Kinase C Alpha	Protein Coding	1
20	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
21	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
22	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
23	MARK1	Microtubule Affinity Regulating Kinase 1	Protein Coding	1
24	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
25	STMN1	Stathmin 1	Protein Coding	1
26	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
27	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
28	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
29	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
30	MAPRE1	Microtubule Associated Protein RP/EB Family Member 1	Protein Coding	1
31	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
32	EPHB2	EPH Receptor B2	Protein Coding	1
33	MARK2	Microtubule Affinity Regulating Kinase 2	Protein Coding	1
34	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
35	DPYSL2	Dihydropyrimidinase Like 2	Protein Coding	1
36	DIAPH1	Diaphanous Related Formin 1	Protein Coding	1
37	SPRED1	Sprouty Related EVH1 Domain Containing 1	Protein Coding	1
38	KIF2C	Kinesin Family Member 2C	Protein Coding	1
39	CFL2	Cofilin 2	Protein Coding	1
40	TESK2	Testis Associated Actin Remodelling Kinase 2	Protein Coding	1
41	CLIP1	CAP-Gly Domain Containing Linker Protein 1	Protein Coding	1
42	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
43	MAP1B	Microtubule Associated Protein 1B	Protein Coding	1
44	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
45	CLASP1	Cytoplasmic Linker Associated Protein 1	Protein Coding	1
46	F2RL2	Coagulation Factor II Thrombin Receptor Like 2	Protein Coding	1

Disorders associated with Microtubule cytoskeleton regulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	5.52
2	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	5.10
3	Hereditary breast carcinoma	Enrichment	AKT1, APC, PIK3CA, PTEN	4.85
4	Capillary malformations, congenital	Enrichment	GNAQ, PIK3CA	3.95
5	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	3.95
6	Breast cancer	Enrichment	AKT1, APC, PIK3CA, PTEN	3.93
7	Prostate cancer	Enrichment	EPHB2, PIK3CA, PTEN	3.90
8	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ, PIK3CA	3.78
9	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.78
10	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.78
11	Colorectal cancer	Enrichment	AKT1, APC, PIK3CA, SRC	3.68
12	Ovarian cancer	Enrichment	AKT1, APC, PIK3CA, PTEN	3.43
13	Gastric cancer	Enrichment	APC, PIK3CA, PTEN	3.39
14	Lip and oral cavity carcinoma	Enrichment	ABL1, PIK3CA	3.14
15	Diffuse large b-cell lymphoma	Enrichment	PTEN, STAT3	2.73
16	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.64
17	Hepatocellular carcinoma	Enrichment	APC, PIK3CA	2.60
18	Macrodactyly	Enrichment	PIK3CA	2.47
19	Proteus syndrome	Enrichment	AKT1	2.47
20	Vacterl association with hydrocephalus	Enrichment	PTEN	2.47
21	Legius syndrome	Enrichment	SPRED1	2.47
22	Night blindness, congenital stationary, autosomal dominant 1	Enrichment	RHO	2.47
23	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.47
24	Deafness, autosomal dominant 1, with or without thrombocytopenia	Enrichment	DIAPH1	2.47
25	Cowden syndrome 5	Enrichment	PIK3CA	2.47
26	Sturge-weber syndrome	Enrichment	GNAQ	2.47
27	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.47
28	Developmental delay with or without intellectual impairment or behavioral abnormalities	Enrichment	TAOK1	2.47
29	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.47
30	Parkinson-dementia syndrome	Enrichment	MAPT	2.47
31	Intellectual developmental disorder, autosomal dominant 76	Enrichment	MARK2	2.47
32	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.47
33	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.47
34	Papillary tumor of the pineal region	Enrichment	PTEN	2.47
35	Nemaline myopathy 7	Enrichment	CFL2	2.47
36	Prostate cancer/brain cancer susceptibility	Enrichment	EPHB2	2.47
37	Deafness, autosomal dominant 83	Enrichment	MAP1B	2.47
38	Progressive supranuclear palsy	Enrichment	MAPT	2.47
39	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.47
40	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.47
41	Cowden syndrome 6	Enrichment	AKT1	2.47
42	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.47
43	Retinitis pigmentosa 4	Enrichment	RHO	2.47
44	Glioma susceptibility 2	Enrichment	PTEN	2.47
45	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.47
46	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.47
47	Bleeding disorder, platelet-type, 22	Enrichment	EPHB2	2.47
48	Thrombocytopenia 6	Enrichment	SRC	2.47
49	Seizures, cortical blindness, and microcephaly syndrome	Enrichment	DIAPH1	2.47
50	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.47
51	Diaph1-related sensorineural hearing loss-thrombocytopenia syndrome	Enrichment	DIAPH1	2.47
52	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.47
53	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.47
54	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.47
55	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.47
56	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.47
57	Hypospadias	Enrichment	PIK3CA	2.47
58	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.47
59	Rare venous malformation	Enrichment	PIK3CA	2.47
60	Familial adenomatous polyposis	Enrichment	APC	2.47
61	Diaphragmatic eventration	Enrichment	PIK3CA	2.47
62	Nocarh syndrome	Enrichment	CDC42	2.47
63	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.47
64	Rare combined vascular malformation	Enrichment	PIK3CA	2.47
65	Cavernous lymphangioma	Enrichment	PIK3CA	2.47
66	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.47
67	Gardner syndrome	Enrichment	APC	2.47
68	5q22 microdeletion syndrome	Enrichment	APC	2.47
69	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.47
70	Attenuated familial adenomatous polyposis	Enrichment	APC	2.47
71	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.47
72	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.47
73	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.47
74	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.47
75	Macrodactyly of toe	Enrichment	PIK3CA	2.47
76	Bladder cancer	Enrichment	PIK3CA, PTEN	2.37
77	Autism spectrum disorder	Enrichment	MAP1B, MARK2, PTEN	2.22
78	Microcephalic osteodysplastic primordial dwarfism, type i	Enrichment	CLASP1	2.17
79	Lowry-wood syndrome	Enrichment	CLASP1	2.17
80	Macroglossia	Enrichment	TAOK1	2.17
81	Pick disease of brain	Enrichment	MAPT	2.17
82	Deafness, autosomal recessive 28	Enrichment	TRIO	2.17
83	Keratosis, seborrheic	Enrichment	PIK3CA	2.17
84	Noonan syndrome 8	Enrichment	PIK3CA	2.17
85	Roifman syndrome	Enrichment	CLASP1	2.17
86	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.17
87	Dystonia 30	Enrichment	PTPRA	2.17
88	Neuropathy, congenital hypomyelinating, 2	Enrichment	RHO	2.17
89	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.17
90	Neurodevelopmental disorder with developmental delay and with or without motor or speech delay	Enrichment	TAOK1	2.17
91	Periventricular nodular heterotopia 9	Enrichment	MAP1B	2.17
92	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.17
93	Optic disk drusen	Enrichment	RHO	2.17
94	Fibrolamellar carcinoma	Enrichment	PRKACA	2.17
95	Periampullary adenoma	Enrichment	APC	2.17
96	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.17
97	Immune system disease	Enrichment	CDC42	2.17
98	Rnu4atac-opathy	Enrichment	CLASP1	2.17
99	Vacterl with hydrocephalus	Enrichment	PTEN	2.17
100	Juvenile polyposis of infancy	Enrichment	PTEN	2.17
101	Phakomatosis cesioflammea	Enrichment	GNAQ	2.17
102	Microcephaly	Enrichment	ABL1, DIAPH1, TRIO	2.08
103	Desmoid disease, hereditary	Enrichment	APC	1.99
104	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.99
105	Spondyloepiphyseal dysplasia congenita	Enrichment	CLASP1	1.99
106	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.99
107	Osteoporosis, juvenile	Enrichment	WNT3A	1.99
108	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.99
109	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	MAP1B	1.99
110	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.99
111	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.99
112	Desmoid tumor	Enrichment	APC	1.99
113	Hyper ige syndrome	Enrichment	STAT3	1.99
114	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.99
115	Pyloric stenosis	Enrichment	MAP1B	1.99
116	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.99
117	Microcephaly 17, primary, autosomal recessive	Enrichment	RHO	1.99
118	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.99
119	Colon adenocarcinoma	Enrichment	APC	1.99
120	Anastomosing haemangioma	Enrichment	GNAQ	1.99
121	Keratoacanthoma	Enrichment	PIK3CA	1.99
122	Apc-associated polyposis conditions	Enrichment	APC	1.99
123	Autosomal dominant non-syndromic intellectual disability	Enrichment	DPYSL2, TAOK1	1.91
124	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1	1.87
125	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.87
126	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.87
127	Cerebrovascular disease	Enrichment	PIK3CA	1.87
128	Craniopharyngioma	Enrichment	APC	1.87
129	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.87
130	Autosomal dominant robinow syndrome	Enrichment	DVL1	1.87
131	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.87
132	Glioma	Enrichment	PTEN	1.87
133	Retinal detachment	Enrichment	RHO	1.77
134	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1	1.77
135	Macrocephaly/autism syndrome	Enrichment	PTEN	1.77
136	Familial adenomatous polyposis 1	Enrichment	APC	1.77
137	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1	1.77
138	Night blindness	Enrichment	RHO	1.77
139	Hemangioma	Enrichment	PTEN	1.77
140	Acute megakaryocytic leukemia	Enrichment	PTEN	1.77
141	Dementia	Enrichment	MAPT	1.77
142	Melanoma, uveal	Enrichment	GNAQ	1.70
143	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.70
144	Moyamoya disease 1	Enrichment	DIAPH1	1.70
145	Pendred syndrome	Enrichment	DIAPH1	1.70
146	Autosomal recessive robinow syndrome	Enrichment	DVL1	1.70
147	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.70
148	Typical nemaline myopathy	Enrichment	CFL2	1.70
149	Nevus, epidermal	Enrichment	PIK3CA	1.63
150	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.63
151	Fundus albipunctatus	Enrichment	RHO	1.63
152	Myelofibrosis	Enrichment	SRC	1.63
153	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.63
154	Coats disease	Enrichment	RHO	1.63
155	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.63
156	Leukemia, chronic myeloid	Enrichment	ABL1	1.63
157	Semantic dementia	Enrichment	MAPT	1.63
158	Gallbladder cancer	Enrichment	PIK3CA	1.63
159	Follicular thyroid carcinoma	Enrichment	PTEN	1.63
160	Moyamoya angiopathy	Enrichment	ABL1	1.63
161	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	1.63
162	Fanconi anemia, complementation group c	Enrichment	TAOK1	1.57
163	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.57
164	Neurofibromatosis, type i	Enrichment	SPRED1	1.52
165	Ellis-van creveld syndrome	Enrichment	PRKACA	1.52
166	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.52
167	Arteriovenous malformation	Enrichment	PIK3CA	1.52
168	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.52
169	Progressive non-fluent aphasia	Enrichment	MAPT	1.52
170	Colonic benign neoplasm	Enrichment	APC	1.52
171	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.52
172	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.48
173	Melanoma	Enrichment	PTEN	1.48
174	Frontotemporal dementia 1	Enrichment	MAPT	1.44
175	Meningioma, familial	Enrichment	PTEN	1.44
176	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.44
177	Uterine corpus cancer	Enrichment	PTEN	1.44
178	Acute promyelocytic leukemia	Enrichment	STAT3	1.36
179	Alzheimer's disease	Enrichment	MAPT	1.36
180	Nk-cell enteropathy	Enrichment	AURKB	1.36
181	Osteoporosis	Enrichment	SRC	1.33
182	Medulloblastoma	Enrichment	APC	1.33
183	Periventricular nodular heterotopia	Enrichment	MAP1B	1.33
184	Heart disease	Enrichment	ABL1	1.33
185	Cataract	Enrichment	RHO	1.33
186	Lynch syndrome	Enrichment	PIK3CA	1.30
187	Male infertility with spermatogenesis disorder	Enrichment	SPRED1	1.30
188	Noonan syndrome and noonan-related syndrome	Enrichment	SPRED1	1.30
189	Rhabdomyosarcoma	Enrichment	PTEN	1.28
190	Alzheimer disease, familial, 1	Enrichment	MAPT	1.25
191	Syndromic intellectual disability	Enrichment	TRIO	1.25
192	Williams-beuren syndrome	Enrichment	LIMK1	1.18
193	Centronuclear myopathy	Enrichment	CFL2	1.16
194	Hepatoblastoma	Enrichment	APC	1.16
195	Attention deficit-hyperactivity disorder	Enrichment	MAP1B	1.14
196	Inherited cancer-predisposing syndrome	Enrichment	APC, PTEN	1.13
197	Congenital stationary night blindness	Enrichment	RHO	1.12
198	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.12
199	Parkinson disease, late-onset	Enrichment	MAPT	1.11
200	Auditory neuropathy	Enrichment	DIAPH1	1.07
201	Lung cancer	Enrichment	PIK3CA	0.99
202	Epilepsy	Enrichment	DIAPH1	0.90
203	Thrombocytopenia	Enrichment	SRC	0.82
204	Hypertelorism	Enrichment	PIK3CA	0.79
205	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MAP1B	0.79
206	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.77
207	Undetermined early-onset epileptic encephalopathy	Enrichment	LIMK1	0.76
208	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT	0.75
209	Autosomal recessive non-syndromic intellectual disability	Enrichment	CLIP1	0.75
210	Cone-rod dystrophy 2	Enrichment	RHO	0.68
211	Rare genetic deafness	Enrichment	DIAPH1	0.63
212	Congenital nervous system abnormality	Enrichment	PTEN	0.52
213	Nervous system disease	Enrichment	PTEN	0.52
214	Complex neurodevelopmental disorder	Enrichment	TIAM1	0.46
215	Retinitis pigmentosa	Enrichment	RHO	0.29
216	Hereditary retinal dystrophy	Enrichment	RHO	0.20
217	Fundus dystrophy	Enrichment	RHO	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Microtubule cytoskeleton regulation

Pathway Network for Microtubule cytoskeleton regulation

Member Pathways for Microtubule cytoskeleton regulation

Pathways in the Microtubule cytoskeleton regulation SuperPath

Associated Genes for Microtubule cytoskeleton regulation

Associated Disorders for Microtubule cytoskeleton regulation

Disorders associated with Microtubule cytoskeleton regulation SuperPath

STRING Interaction Network for Microtubule cytoskeleton regulation

Sources for Microtubule cytoskeleton regulation