miRNA regulation of p53 pathway in prostate cancer

No Pathway Network information available for miRNA regulation of p53 pathway in prostate cancer

Pathways in the miRNA regulation of p53 pathway in prostate cancer SuperPath

#	Name	Source	Genes
1	miRNA regulation of p53 pathway in prostate cancer	WikiPathways	APAF1 ATM BAX BBC3 BID CASP3 CASP8 CASP9 CHEK2 CYS1 DDB2 EI24 MDM2 MIR1305 MIR182 MIR27B MIR320A MIR4482 MIR4491 MIR548B MIR548C PERP PMAIP1 PTEN SERPINE1 SESN3 SHISA5 SIAH1 TNFRSF10B TP53 TP53AIP1 ZMAT3 (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MIR548C	MicroRNA 548c	RNA Gene	1
2	EI24	EI24 Autophagy Associated Transmembrane Protein	Protein Coding	1
3	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
4	CASP9	Caspase 9	Protein Coding	1
5	CASP8	Caspase 8	Protein Coding	1
6	CASP3	Caspase 3	Protein Coding	1
7	TP53	Tumor Protein P53	Protein Coding	1
8	MIR548B	MicroRNA 548b	RNA Gene	1
9	ZMAT3	Zinc Finger Matrin-Type 3	Protein Coding	1
10	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
11	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
12	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
13	PMAIP1	Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Protein Coding	1
14	SERPINE1	Serpin Family E Member 1	Protein Coding	1
15	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
16	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
17	MIR320A	MicroRNA 320a	RNA Gene	1
18	MIR27B	MicroRNA 27b	RNA Gene	1
19	MIR182	MicroRNA 182	RNA Gene	1
20	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
21	BBC3	BCL2 Binding Component 3	Protein Coding	1
22	DDB2	Damage Specific DNA Binding Protein 2	Protein Coding	1
23	SESN3	Sestrin 3	Protein Coding	1
24	CHEK2	Checkpoint Kinase 2	Protein Coding	1
25	MIR4482	MicroRNA 4482	RNA Gene	1
26	CYS1	Cystin 1	Protein Coding	1
27	SIAH1	Siah E3 Ubiquitin Protein Ligase 1	Protein Coding	1
28	PERP	P53 Apoptosis Effector Related To PMP22	Protein Coding	1
29	TP53AIP1	Tumor Protein P53 Regulated Apoptosis Inducing Protein 1	Protein Coding	1
30	SHISA5	Shisa Family Member 5	Protein Coding	1
31	MIR4491	MicroRNA 4491	RNA Gene	1
32	MIR1305	MicroRNA 1305	RNA Gene	1

Disorders associated with miRNA regulation of p53 pathway in prostate cancer SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	6.62
2	Squamous cell carcinoma, head and neck	Enrichment	PTEN, TNFRSF10B, TP53	6.38
3	Prostate cancer	Enrichment	ATM, CHEK2, PTEN, TP53	6.24
4	Breast cancer	Enrichment	ATM, CASP8, CHEK2, PTEN, TP53	6.09
5	Uterine corpus cancer	Enrichment	ATM, CHEK2, PTEN	5.71
6	Gastric cancer	Enrichment	ATM, CHEK2, PTEN, TP53	5.53
7	Hereditary breast carcinoma	Enrichment	ATM, CHEK2, PTEN, TP53	5.49
8	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	5.27
9	Sarcoma	Enrichment	CHEK2, TP53	5.27
10	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, CHEK2, PTEN, TP53	5.10
11	Diffuse large b-cell lymphoma	Enrichment	CHEK2, PTEN, TP53	4.95
12	Endometrial cancer	Enrichment	ATM, CHEK2, PTEN	4.81
13	Osteogenic sarcoma	Enrichment	CHEK2, TP53	4.79
14	Adenocarcinoma	Enrichment	ATM, TP53	4.79
15	Laryngeal squamous cell carcinoma	Enrichment	PTEN, TNFRSF10B	4.79
16	Bone osteosarcoma	Enrichment	CHEK2, TP53	4.79
17	Pancreatic cancer	Enrichment	ATM, CHEK2, TP53	4.58
18	Bladder cancer	Enrichment	ATM, PTEN, TP53	4.38
19	Colorectal cancer	Enrichment	ATM, BAX, CHEK2, TP53	4.31
20	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	4.27
21	Ovarian cancer	Enrichment	ATM, CHEK2, PTEN, TP53	4.05
22	Adult hepatocellular carcinoma	Enrichment	CASP8, TP53	3.72
23	Colonic benign neoplasm	Enrichment	ATM, CHEK2	3.72
24	Lynch syndrome 1	Enrichment	ATM, CHEK2	3.62
25	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	3.62
26	Melanoma	Enrichment	CHEK2, PTEN	3.62
27	Inherited cancer-predisposing syndrome	Enrichment	ATM, CHEK2, PTEN, TP53	3.60
28	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	3.53
29	Breast-ovarian cancer, familial 1	Enrichment	ATM, CHEK2	3.38
30	Rhabdomyosarcoma	Enrichment	PTEN, TP53	3.20
31	Gliosarcoma	Enrichment	ATM, TP53	3.20
32	Giant cell glioblastoma	Enrichment	ATM, TP53	3.14
33	Hepatocellular carcinoma	Enrichment	CASP8, TP53	2.92
34	Vacterl association with hydrocephalus	Enrichment	PTEN	2.63
35	Caspase 8 deficiency	Enrichment	CASP8	2.63
36	Accelerated tumor formation	Enrichment	MDM2	2.63
37	Lessel-kubisch syndrome	Enrichment	MDM2	2.63
38	Bone marrow failure syndrome 5	Enrichment	TP53	2.63
39	Papilloma of choroid plexus	Enrichment	TP53	2.63
40	Basal cell carcinoma 7	Enrichment	TP53	2.63
41	Anaplastic thyroid carcinoma	Enrichment	TP53	2.63
42	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.63
43	Papillary tumor of the pineal region	Enrichment	PTEN	2.63
44	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.63
45	Olmsted syndrome 2	Enrichment	PERP	2.63
46	Endometrial serous adenocarcinoma	Enrichment	ATM	2.63
47	Glioma susceptibility 2	Enrichment	PTEN	2.63
48	Ductal carcinoma in situ	Enrichment	TP53	2.63
49	Leiomyosarcoma	Enrichment	CHEK2	2.63
50	Erythrokeratodermia variabilis et progressiva 7	Enrichment	PERP	2.63
51	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.63
52	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.63
53	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.63
54	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.63
55	Choroid plexus cancer	Enrichment	TP53	2.63
56	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.63
57	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.63
58	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.63
59	Lung cancer	Enrichment	CASP8, CHEK2	2.59
60	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.33
61	Cervical cancer	Enrichment	TP53	2.33
62	Xeroderma pigmentosum, complementation group e	Enrichment	DDB2	2.33
63	Lymphoma, hodgkin, classic	Enrichment	TP53	2.33
64	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.33
65	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.33
66	Congenital fibrosarcoma	Enrichment	TP53	2.33
67	High grade glioma	Enrichment	ATM	2.33
68	Cervix carcinoma	Enrichment	TP53	2.33
69	Hodgkin's lymphoma	Enrichment	TP53	2.33
70	T-cell prolymphocytic leukemia	Enrichment	ATM	2.33
71	Buratti-harel syndrome	Enrichment	SIAH1	2.33
72	Vacterl with hydrocephalus	Enrichment	PTEN	2.33
73	Juvenile polyposis of infancy	Enrichment	PTEN	2.33
74	Xeroderma pigmentosum group e	Enrichment	DDB2	2.33
75	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.33
76	Ataxia-telangiectasia	Enrichment	ATM	2.15
77	Polycythemia vera	Enrichment	ATM	2.15
78	Nasopharyngeal carcinoma	Enrichment	TP53	2.15
79	Koolen-de vries syndrome	Enrichment	ATM	2.15
80	Dedifferentiated liposarcoma	Enrichment	MDM2	2.15
81	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	PERP	2.15
82	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.15
83	Anaplastic astrocytoma	Enrichment	TP53	2.15
84	Squamous cell carcinoma	Enrichment	TP53	2.15
85	T-cell acute lymphoblastic leukemia	Enrichment	BAX	2.15
86	Well-differentiated liposarcoma	Enrichment	MDM2	2.15
87	Myeloma, multiple	Enrichment	ATM, TP53	2.12
88	Small cell cancer of the lung	Enrichment	TP53	2.03
89	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.03
90	Mantle cell lymphoma	Enrichment	ATM	2.03
91	Lung sarcomatoid carcinoma	Enrichment	TP53	2.03
92	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.03
93	Hemoglobin c disease	Enrichment	CHEK2	2.03
94	Glioma	Enrichment	PTEN	2.03
95	Oculomotor apraxia	Enrichment	ATM	2.03
96	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	2.03
97	Rhabdomyosarcoma 2	Enrichment	TP53	1.93
98	Macrocephaly/autism syndrome	Enrichment	PTEN	1.93
99	Lymphoma	Enrichment	TP53	1.93
100	Glioblastoma	Enrichment	ATM	1.93
101	Hemangioma	Enrichment	PTEN	1.93
102	Hemimegalencephaly	Enrichment	PTEN	1.93
103	Cowden syndrome 1	Enrichment	PTEN	1.85
104	Wilms tumor 5	Enrichment	CHEK2	1.85
105	Adrenocortical carcinoma	Enrichment	TP53	1.85
106	Clear cell renal cell carcinoma	Enrichment	ATM	1.85
107	Breast adenocarcinoma	Enrichment	TP53	1.85
108	Esophageal cancer	Enrichment	TP53	1.79
109	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.79
110	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.79
111	Essential thrombocythemia	Enrichment	TP53	1.79
112	Gallbladder cancer	Enrichment	TP53	1.79
113	Follicular thyroid carcinoma	Enrichment	PTEN	1.79
114	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.79
115	Glioma susceptibility 1	Enrichment	TP53	1.73
116	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	CYS1	1.73
117	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.73
118	Primary hyperaldosteronism	Enrichment	TP53	1.68
119	Cowden syndrome	Enrichment	PTEN	1.68
120	Familial colorectal cancer	Enrichment	TP53	1.63
121	Immune deficiency disease	Enrichment	ATM	1.59
122	Xeroderma pigmentosum, variant type	Enrichment	DDB2	1.59
123	Meningioma, familial	Enrichment	PTEN	1.59
124	Myelodysplastic syndrome	Enrichment	TP53	1.59
125	Meningioma	Enrichment	PTEN	1.55
126	Lip and oral cavity carcinoma	Enrichment	TP53	1.55
127	Nk-cell enteropathy	Enrichment	CHEK2	1.52
128	Lung cancer susceptibility 3	Enrichment	TP53	1.49
129	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.46
130	Wilms tumor 1	Enrichment	CHEK2	1.46
131	Lynch syndrome	Enrichment	CHEK2	1.46
132	Hepatoblastoma	Enrichment	TP53	1.31
133	Diamond-blackfan anemia 1	Enrichment	TP53	1.28
134	Diamond-blackfan anemia	Enrichment	TP53	1.09
135	Leukemia, acute myeloid	Enrichment	TP53	1.04
136	Primary ovarian insufficiency	Enrichment	CHEK2	0.88
137	Congenital nervous system abnormality	Enrichment	PTEN	0.65
138	Nervous system disease	Enrichment	PTEN	0.65
139	Autism spectrum disorder	Enrichment	PTEN	0.64
140	Complex neurodevelopmental disorder	Enrichment	SIAH1	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

miRNA regulation of p53 pathway in prostate cancer

Pathway Network for miRNA regulation of p53 pathway in prostate cancer

Member Pathways for miRNA regulation of p53 pathway in prostate cancer

Pathways in the miRNA regulation of p53 pathway in prostate cancer SuperPath

Associated Genes for miRNA regulation of p53 pathway in prostate cancer

Associated Disorders for miRNA regulation of p53 pathway in prostate cancer

Disorders associated with miRNA regulation of p53 pathway in prostate cancer SuperPath

STRING Interaction Network for miRNA regulation of p53 pathway in prostate cancer

Sources for miRNA regulation of p53 pathway in prostate cancer