Miro GTPase Cycle

Sources:

#	Name	Source	Genes
1	Miro GTPase Cycle	Reactome	MFN1 MFN2 MYO19 RAP1GDS1 RHOT1 RHOT2 TRAK1 TRAK2 (see all 8) (see less)
2	RHOT2 GTPase cycle	Reactome	MFN1 MFN2 MYO19 RAP1GDS1 RHOT2 TRAK1 TRAK2 (see all 7) (see less)
3	RHOT1 GTPase cycle	Reactome	MYO19 RAP1GDS1 RHOT1 TRAK1 TRAK2

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TRAK1	Trafficking Kinesin Protein 1	Protein Coding	3
2	RAP1GDS1	Rap1 GTPase-GDP Dissociation Stimulator 1	Protein Coding	3
3	TRAK2	Trafficking Kinesin Protein 2	Protein Coding	3
4	MYO19	Myosin XIX	Protein Coding	3
5	RHOT1	Ras Homolog Family Member T1	Protein Coding	2
6	MFN1	Mitofusin 1	Protein Coding	2
7	RHOT2	Ras Homolog Family Member T2	Protein Coding	2
8	MFN2	Mitofusin 2	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Alfadhel syndrome	Enrichment	RAP1GDS1	3.43
2	Developmental and epileptic encephalopathy 68	Enrichment	TRAK1	3.43
3	Multiple symmetric lipomatosis	Enrichment	MFN2	3.29
4	Charcot-marie-tooth disease, axonal, autosomal dominant, type 2a2a	Enrichment	MFN2	3.29
5	Charcot-marie-tooth disease, axonal, autosomal recessive, type 2a2b	Enrichment	MFN2	3.29
6	Charcot-marie-tooth disease type 5	Enrichment	MFN2	3.29
7	Charcot-marie-tooth disease type 2a2b	Enrichment	MFN2	3.29
8	Glycosylphosphatidylinositol biosynthesis defect 11	Enrichment	MYO19	3.13
9	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	MFN2	2.99
10	Axonal neuropathy	Enrichment	MFN2	2.99
11	Multiple system atrophy, cerebellar type	Enrichment	MFN2	2.99
12	Neuropathy, hereditary motor and sensory, type via, with optic atrophy	Enrichment	MFN2	2.81
13	Hyperpigmentation of the skin	Enrichment	MFN2	2.81
14	Genetic motor neuron disease	Enrichment	MFN2	2.59
15	Cleft palate, isolated	Enrichment	MYO19	2.20
16	Beckwith-wiedemann syndrome	Enrichment	MFN2	2.03
17	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MFN2	2.01
18	Auditory neuropathy	Enrichment	MFN2	1.87
19	Peripheral nervous system disease	Enrichment	MFN2	1.79
20	Neuropathy	Enrichment	MFN2	1.79
21	Cerebral palsy	Enrichment	MFN2	1.70
22	Undetermined early-onset epileptic encephalopathy	Enrichment	TRAK1	1.69
23	Charcot-marie-tooth disease	Enrichment	MFN2	1.68
24	Microcephaly	Enrichment	MFN2	1.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Miro GTPase Cycle