Mitochondrial calcium ion transport

No Pathway Network information available for Mitochondrial calcium ion transport

Pathways in the Mitochondrial calcium ion transport SuperPath

#	Name	Source	Genes
1	Mitochondrial calcium ion transport	Reactome	AFG3L2 AKAP1 LETM1 MAIP1 MCU MCUB MICU1 MICU2 MICU3 PARL PHB1 PHB2 PMPCA PMPCB SLC8A3 SLC8B1 SMDT1 SPG7 STOML2 VDAC1 VDAC2 VDAC3 YME1L1 (see all 23) (see less)
2	Processing of SMDT1	Reactome	AFG3L2 MAIP1 MCU MCUB MICU1 MICU2 MICU3 PARL PHB1 PHB2 PMPCA PMPCB SMDT1 SPG7 STOML2 YME1L1 (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MICU1	Mitochondrial Calcium Uptake 1	Protein Coding	2
2	YME1L1	YME1 Like 1 ATPase	Protein Coding	2
3	AFG3L2	AFG3 Like Matrix AAA Peptidase Subunit 2	Protein Coding	2
4	PHB2	Prohibitin 2	Protein Coding	2
5	MICU2	Mitochondrial Calcium Uptake 2	Protein Coding	2
6	PMPCA	Peptidase, Mitochondrial Processing Subunit Alpha	Protein Coding	2
7	MICU3	Mitochondrial Calcium Uptake 3	Protein Coding	2
8	STOML2	Stomatin Like 2	Protein Coding	2
9	PHB1	Prohibitin 1	Protein Coding	2
10	MCUB	Mitochondrial Calcium Uniporter Dominant Negative Subunit Beta	Protein Coding	2
11	PARL	Presenilin Associated Rhomboid Like	Protein Coding	2
12	SPG7	SPG7 Matrix AAA Peptidase Subunit, Paraplegin	Protein Coding	2
13	MAIP1	Matrix AAA Peptidase Interacting Protein 1	Protein Coding	2
14	MCU	Mitochondrial Calcium Uniporter	Protein Coding	2
15	SMDT1	Single-Pass Membrane Protein With Aspartate Rich Tail 1	Protein Coding	2
16	PMPCB	Peptidase, Mitochondrial Processing Subunit Beta	Protein Coding	2
17	LETM1	Leucine Zipper And EF-Hand Containing Transmembrane Protein 1	Protein Coding	1
18	SLC8A3	Solute Carrier Family 8 Member A3	Protein Coding	1
19	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	1
20	VDAC2	Voltage Dependent Anion Channel 2	Protein Coding	1
21	VDAC3	Voltage Dependent Anion Channel 3	Protein Coding	1
22	SLC8B1	Solute Carrier Family 8 Member B1	Protein Coding	1
23	AKAP1	A-Kinase Anchoring Protein 1	Protein Coding	1

Disorders associated with Mitochondrial calcium ion transport SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Optic atrophy plus syndrome	Enrichment	AFG3L2, PMPCA, SPG7	4.76
2	Myopathy with extrapyramidal signs	Enrichment	MICU1	2.93
3	Spastic ataxia 5, autosomal recessive	Enrichment	AFG3L2	2.93
4	Spinocerebellar ataxia 28	Enrichment	AFG3L2	2.93
5	Spastic ataxia 5	Enrichment	AFG3L2	2.93
6	Optic atrophy 11	Enrichment	YME1L1	2.93
7	Lateral sclerosis	Enrichment	SPG7	2.93
8	Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction	Enrichment	LETM1	2.77
9	Spastic ataxia	Enrichment	AFG3L2, SPG7	2.76
10	Hydrocephalus, normal-pressure, 1	Enrichment	PMPCA	2.63
11	Glycogen storage disease iii	Enrichment	AFG3L2	2.63
12	Spastic paraplegia 79b, autosomal recessive	Enrichment	SPG7	2.63
13	Optic atrophy 12	Enrichment	AFG3L2	2.63
14	Frontotemporal dementia and/or amyotrophic lateral sclerosis 2	Enrichment	SPG7	2.63
15	Multiple mitochondrial dysfunctions syndrome 6	Enrichment	PMPCB	2.63
16	Normal pressure hydrocephalus	Enrichment	PMPCA	2.63
17	Spinocerebellar ataxia, autosomal recessive 2	Enrichment	PMPCA	2.45
18	Spastic paraplegia 7, autosomal recessive	Enrichment	SPG7	2.45
19	Cerebellar disease	Enrichment	AFG3L2	2.45
20	3-methylglutaconic aciduria	Enrichment	YME1L1	2.45
21	Autosomal recessive isolated optic atrophy	Enrichment	YME1L1	2.33
22	Polyneuropathy	Enrichment	SPG7	2.23
23	Choreatic disease	Enrichment	AFG3L2	2.03
24	Wolf-hirschhorn syndrome	Enrichment	LETM1	1.99
25	Hereditary chronic pancreatitis	Enrichment	SPG7	1.79
26	Pancreatitis, hereditary	Enrichment	SPG7	1.70
27	Dystonia	Enrichment	AFG3L2	1.39
28	Hereditary spastic paraplegia	Enrichment	SPG7	1.31
29	Hypertrophic cardiomyopathy	Enrichment	PMPCA	1.30
30	Sensorineural hearing loss	Enrichment	AFG3L2	1.26
31	Breast cancer	Enrichment	PHB1	1.07
32	Mitochondrial disease	Enrichment	SPG7	1.01
33	Congenital nervous system abnormality	Enrichment	MICU1	0.93
34	Nervous system disease	Enrichment	MICU1	0.93
35	Hereditary retinal dystrophy	Enrichment	SPG7	0.53
36	Fundus dystrophy	Enrichment	SPG7	0.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Mitochondrial calcium ion transport

Pathway Network for Mitochondrial calcium ion transport

Member Pathways for Mitochondrial calcium ion transport

Pathways in the Mitochondrial calcium ion transport SuperPath

Associated Genes for Mitochondrial calcium ion transport

Associated Disorders for Mitochondrial calcium ion transport

Disorders associated with Mitochondrial calcium ion transport SuperPath

STRING Interaction Network for Mitochondrial calcium ion transport

Sources for Mitochondrial calcium ion transport