Mitochondrial iron-sulfur cluster biogenesis

Pathway network for the Mitochondrial iron-sulfur cluster biogenesis SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Mitochondrial iron-sulfur cluster biogenesis SuperPath

#	Name	Source	Genes
1	Mitochondrial iron-sulfur cluster biogenesis	Reactome	FDX1 FDX2 FDXR FXN GLRX5 HSCB ISCA1 ISCA2 ISCU LYRM4 NFS1 SLC25A28 SLC25A37 (see all 13) (see less)
2	Iron-sulfur cluster biogenesis	WikiPathways	ABCB7 CIAO2B FDX1 FDXR FXN GLRX5 HSCB HSPA9 ISCU LYRM4 NARF NFS1 NFU1 NUBP1 NUBP2 (see all 15) (see less)
3	Maturation of replicase proteins	Reactome	ISCU

Gene overlap in member pathways for Mitochondrial iron-sulfur cluster biogenesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ISCU	Iron-Sulfur Cluster Assembly Enzyme	Protein Coding	3
2	HSCB	HscB Mitochondrial Iron-Sulfur Cluster Cochaperone	Protein Coding	2
3	FDX1	Ferredoxin 1	Protein Coding	2
4	FDXR	Ferredoxin Reductase	Protein Coding	2
5	FXN	Frataxin	Protein Coding	2
6	GLRX5	Glutaredoxin 5	Protein Coding	2
7	LYRM4	LYR Motif Containing 4	Protein Coding	2
8	NFS1	NFS1 Cysteine Desulfurase	Protein Coding	2
9	FDX2	Ferredoxin 2	Protein Coding	1
10	ISCA2	Iron-Sulfur Cluster Assembly 2	Protein Coding	1
11	SLC25A37	Solute Carrier Family 25 Member 37	Protein Coding	1
12	ISCA1	Iron-Sulfur Cluster Assembly 1	Protein Coding	1
13	SLC25A28	Solute Carrier Family 25 Member 28	Protein Coding	1
14	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	1
15	NFU1	NFU1 Iron-Sulfur Cluster Scaffold	Protein Coding	1
16	ABCB7	ATP Binding Cassette Subfamily B Member 7	Protein Coding	1
17	NUBP2	NUBP Iron-Sulfur Cluster Assembly Factor 2, Cytosolic	Protein Coding	1
18	CIAO2B	Cytosolic Iron-Sulfur Assembly Component 2B	Protein Coding	1
19	NUBP1	NUBP Iron-Sulfur Cluster Assembly Factor 1, Cytosolic	Protein Coding	1
20	NARF	Nuclear Prelamin A Recognition Factor	Protein Coding	1

Disorders associated with Mitochondrial iron-sulfur cluster biogenesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Covid-19	Direct
2	Multiple mitochondrial dysfunctions syndrome	Enrichment	ISCA1, ISCA2	6.07
3	Combined oxidative phosphorylation deficiency 19	Enrichment	LYRM4, NFS1	5.59
4	Multiple mitochondrial dysfunctions syndrome 4	Enrichment	ISCA2	3.02
5	Anemia, sideroblastic, 3, pyridoxine-refractory	Enrichment	GLRX5	3.02
6	Myopathy with lactic acidosis, hereditary	Enrichment	ISCU	3.02
7	Combined oxidative phosphorylation deficiency 52	Enrichment	NFS1	3.02
8	Spasticity, childhood-onset, with hyperglycinemia	Enrichment	GLRX5	3.02
9	Anemia, sideroblastic, 5	Enrichment	HSCB	3.02
10	Optic atrophy-ataxia-peripheral neuropathy-global developmental delay syndrome	Enrichment	FDXR	3.02
11	Spinocerebellar ataxia, x-linked 6, with or without sideroblastic anemia	Enrichment	ABCB7	2.96
12	Even-plus syndrome	Enrichment	HSPA9	2.96
13	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.96
14	Spastic paraplegia 93, autosomal recessive	Enrichment	NFU1	2.96
15	X-linked sideroblastic anemia with ataxia	Enrichment	ABCB7	2.96
16	Multiple mitochondrial dysfunctions syndrome 5	Enrichment	ISCA1	2.72
17	Multiple mitochondrial dysfunctions syndrome 1	Enrichment	NFU1	2.66
18	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.66
19	Mitochondrial myopathy, episodic, with or without optic atrophy and reversible leukoencephalopathy	Enrichment	FDX2	2.54
20	Friedreich ataxia	Enrichment	FXN	2.54
21	Auditory neuropathy and optic atrophy	Enrichment	FDXR	2.54
22	Multiple mitochondrial dysfunctions syndrome 9b	Enrichment	FDXR	2.54
23	Spastic quadriplegic cerebral palsy	Enrichment	ISCA2	2.42
24	Mitochondrial myopathy	Enrichment	FDX2	1.98
25	Auditory neuropathy	Enrichment	FDXR	1.61
26	Optic atrophy plus syndrome	Enrichment	ISCA2	1.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Mitochondrial iron-sulfur cluster biogenesis

Pathway Network for Mitochondrial iron-sulfur cluster biogenesis

Pathway network for the Mitochondrial iron-sulfur cluster biogenesis SuperPath

Member Pathways for Mitochondrial iron-sulfur cluster biogenesis

Pathways in the Mitochondrial iron-sulfur cluster biogenesis SuperPath

Gene overlap in member pathways for Mitochondrial iron-sulfur cluster biogenesis SuperPath

Associated Genes for Mitochondrial iron-sulfur cluster biogenesis

Associated Disorders for Mitochondrial iron-sulfur cluster biogenesis

Disorders associated with Mitochondrial iron-sulfur cluster biogenesis SuperPath

STRING Interaction Network for Mitochondrial iron-sulfur cluster biogenesis

Sources for Mitochondrial iron-sulfur cluster biogenesis