Mitochondrial RNA degradation

No Pathway Network information available for Mitochondrial RNA degradation

#	Name	Source	Genes
1	Mitochondrial RNA degradation	Reactome	FASTK FASTKD2 FASTKD5 GRSF1 LRPPRC PNPT1 REXO2 SLIRP SUPV3L1 TBRG4 (see all 10) (see less)
2	FASTK family proteins regulate processing and stability of mitochondrial RNAs	Reactome	FASTK FASTKD2 FASTKD5 TBRG4

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FASTK	Fas Activated Serine/Threonine Kinase	Protein Coding	2
2	FASTKD2	FAST Kinase Domains 2	Protein Coding	2
3	FASTKD5	FAST Kinase Domains 5	Protein Coding	2
4	TBRG4	Transforming Growth Factor Beta Regulator 4	Protein Coding	2
5	LRPPRC	Leucine Rich Pentatricopeptide Repeat Containing	Protein Coding	1
6	REXO2	RNA Exonuclease 2	Protein Coding	1
7	GRSF1	G-Rich RNA Sequence Binding Factor 1	Protein Coding	1
8	SUPV3L1	Suv3 Like RNA Helicase	Protein Coding	1
9	SLIRP	SRA Stem-Loop Interacting RNA Binding Protein	Protein Coding	1
10	PNPT1	Polyribonucleotide Nucleotidyltransferase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Leigh syndrome, nuclear	Enrichment	FASTKD2, FASTKD5	3.82
2	Leigh disease	Enrichment	FASTKD2, FASTKD5	3.73
3	Fastkd2-related infantile mitochondrial encephalomyopathy	Enrichment	FASTKD2	3.53
4	Combined oxidative phosphorylation deficiency 44	Enrichment	FASTKD2	3.23
5	Spinocerebellar ataxia 25	Enrichment	PNPT1	3.13
6	Combined oxidative phosphorylation deficiency 13	Enrichment	PNPT1	3.13
7	Deafness, autosomal recessive 70, with or without adult-onset neurodegeneration	Enrichment	PNPT1	2.83
8	Autosomal recessive nonsyndromic deafness 70	Enrichment	PNPT1	2.83
9	Mitochondrial complex iv deficiency, nuclear type 5	Enrichment	LRPPRC	2.66
10	Mitochondrial complex iv deficiency, nuclear type 1	Enrichment	FASTKD2	2.19
11	Mitochondrial encephalomyopathy	Enrichment	SLIRP	2.13
12	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	PNPT1	1.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Mitochondrial RNA degradation