Mitochondrial Uncoupling
Pathways in the Mitochondrial Uncoupling SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Mitochondrial Uncoupling | Reactome | |
| 2 | The fatty acid cycling model | Reactome | |
| 3 | Oleoyl-phe metabolism | Reactome |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | PM20D1 | Peptidase M20 Domain Containing 1 | Protein Coding | 2 |
| 2 | UCP1 | Uncoupling Protein 1 | Protein Coding | 2 |
| 3 | UCP2 | Uncoupling Protein 2 | Protein Coding | 2 |
| 4 | UCP3 | Uncoupling Protein 3 | Protein Coding | 2 |
| 5 | SLC25A14 | Solute Carrier Family 25 Member 14 | Protein Coding | 2 |
| 6 | SLC25A27 | Solute Carrier Family 25 Member 27 | Protein Coding | 2 |
Disorders associated with Mitochondrial Uncoupling SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Body mass index quantitative trait locus 11 | Enrichment | UCP2, UCP3 | 3.88 |
| 2 | Body mass index quantitative trait locus 4 | Enrichment | UCP2 | 3.43 |
| 3 | Hyperinsulinism due to ucp2 deficiency | Enrichment | UCP2 | 3.43 |
| 4 | Leptin deficiency or dysfunction | Enrichment | UCP3 | 2.83 |