Mitochondrial unfolded protein response (UPRmt)

No Pathway Network information available for Mitochondrial unfolded protein response (UPRmt)

#	Name	Source	Genes
1	Mitochondrial unfolded protein response (UPRmt)	Reactome	AKT1 ATF5 CAT DEFA5 DNAJA1 ESR1 FOXO3 HSF1 HSPA1A HSPA1B HSPA9 HSPD1 HSPE1 HTRA2 LONP1 NRF1 SIRT3 SOD2 (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DEFA5	Defensin Alpha 5	Protein Coding	1
2	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
3	ESR1	Estrogen Receptor 1	Protein Coding	1
4	ATF5	Activating Transcription Factor 5	Protein Coding	1
5	FOXO3	Forkhead Box O3	Protein Coding	1
6	SIRT3	Sirtuin 3	Protein Coding	1
7	HTRA2	HtrA Serine Peptidase 2	Protein Coding	1
8	HSF1	Heat Shock Transcription Factor 1	Protein Coding	1
9	DNAJA1	DnaJ Heat Shock Protein Family (Hsp40) Member A1	Protein Coding	1
10	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
11	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	1
12	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	1
13	HSPD1	Heat Shock Protein Family D (Hsp60) Member 1	Protein Coding	1
14	HSPE1	Heat Shock Protein Family E (Hsp10) Member 1	Protein Coding	1
15	NRF1	Nuclear Respiratory Factor 1	Protein Coding	1
16	SOD2	Superoxide Dismutase 2	Protein Coding	1
17	CAT	Catalase	Protein Coding	1
18	LONP1	Lon Peptidase 1, Mitochondrial	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	2.88
2	Codas syndrome	Enrichment	LONP1	2.88
3	Parkinson disease 13, autosomal dominant	Enrichment	HTRA2	2.88
4	Microvascular complications of diabetes 6	Enrichment	SOD2	2.88
5	Even-plus syndrome	Enrichment	HSPA9	2.88
6	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.88
7	Spastic paraplegia 13, autosomal dominant	Enrichment	HSPD1	2.88
8	Acatalasemia	Enrichment	CAT	2.88
9	Cowden syndrome 6	Enrichment	AKT1	2.88
10	Hereditary breast carcinoma	Enrichment	AKT1, ESR1	2.82
11	Leukodystrophy, hypomyelinating, 4	Enrichment	HSPD1	2.58
12	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.58
13	Estrogen resistance	Enrichment	ESR1	2.40
14	Migraine without aura	Enrichment	ESR1	2.40
15	Breast cancer	Enrichment	AKT1, ESR1	2.36
16	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	LONP1	2.28
17	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.28
18	3-methylglutaconic aciduria, type viii	Enrichment	HTRA2	2.28
19	Breast adenocarcinoma	Enrichment	AKT1	2.10
20	Cowden syndrome	Enrichment	AKT1	1.93
21	Migraine with or without aura 1	Enrichment	ESR1	1.84
22	Early-onset parkinson's disease	Enrichment	HTRA2	1.80
23	Meningioma	Enrichment	AKT1	1.80
24	Diaphragmatic hernia, congenital	Enrichment	LONP1	1.77
25	Leukodystrophy	Enrichment	HSPD1	1.58
26	Myocardial infarction	Enrichment	ESR1	1.54
27	Colorectal cancer	Enrichment	AKT1	0.96
28	Ovarian cancer	Enrichment	AKT1	0.90

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Mitochondrial unfolded protein response (UPRmt)