Mitophagy

Pathway network for the Mitophagy SuperPath

Sources:

Reactome

Pathways in the Mitophagy SuperPath

#	Name	Source	Genes
1	Mitophagy	Reactome	ATG12 ATG5 ATG9A CSNK2A1 CSNK2A2 CSNK2B FUNDC1 MAP1LC3A MAP1LC3B MFN1 MFN2 MTERF3 OPTN PGAM5 PINK1 PRKN RPS27A SQSTM1 SRC TBK1 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 UBA52 UBB UBC UBE2D2 UBE2D3 UBE2L3 UBE2N UBE2V1 ULK1 VDAC1 VDAC2 VDAC3 (see all 39) (see less)
2	PINK1-PRKN Mediated Mitophagy	Reactome	ATG12 ATG5 ATG9A MAP1LC3A MAP1LC3B MFN1 MFN2 MTERF3 OPTN PINK1 PRKN RPS27A SQSTM1 TBK1 TOMM20 TOMM22 TOMM40 TOMM5 TOMM6 TOMM7 TOMM70 UBA52 UBB UBC UBE2D2 UBE2D3 UBE2L3 UBE2N UBE2V1 VDAC1 VDAC2 VDAC3 (see all 32) (see less)
3	Receptor Mediated Mitophagy	Reactome	ATG12 ATG5 CSNK2A1 CSNK2A2 CSNK2B FUNDC1 MAP1LC3A MAP1LC3B PGAM5 SRC ULK1 (see all 11) (see less)

Gene overlap in member pathways for Mitophagy SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	3
2	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	3
3	ATG12	Autophagy Related 12	Protein Coding	3
4	ATG5	Autophagy Related 5	Protein Coding	3
5	TOMM6	Translocase Of Outer Mitochondrial Membrane 6	Protein Coding	2
6	OPTN	Optineurin	Protein Coding	2
7	TOMM40	Translocase Of Outer Mitochondrial Membrane 40	Protein Coding	2
8	FUNDC1	FUN14 Domain Containing 1	Protein Coding	2
9	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	2
10	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	2
11	CSNK2B	Casein Kinase 2 Beta	Protein Coding	2
12	PGAM5	PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase	Protein Coding	2
13	TBK1	TANK Binding Kinase 1	Protein Coding	2
14	TOMM5	Translocase Of Outer Mitochondrial Membrane 5	Protein Coding	2
15	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	2
16	MTERF3	Mitochondrial Transcription Termination Factor 3	Protein Coding	2
17	TOMM7	Translocase Of Outer Mitochondrial Membrane 7	Protein Coding	2
18	MFN1	Mitofusin 1	Protein Coding	2
19	TOMM22	Translocase Of Outer Mitochondrial Membrane 22	Protein Coding	2
20	RPS27A	Ribosomal Protein S27a	Protein Coding	2
21	PINK1	PTEN Induced Kinase 1	Protein Coding	2
22	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
23	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
24	UBB	Ubiquitin B	Protein Coding	2
25	UBC	Ubiquitin C	Protein Coding	2
26	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
27	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	2
28	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	2
29	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	2
30	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	2
31	VDAC1	Voltage Dependent Anion Channel 1	Protein Coding	2
32	VDAC2	Voltage Dependent Anion Channel 2	Protein Coding	2
33	VDAC3	Voltage Dependent Anion Channel 3	Protein Coding	2
34	ATG9A	Autophagy Related 9A	Protein Coding	2
35	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	2
36	SQSTM1	Sequestosome 1	Protein Coding	2
37	TOMM20	Translocase Of Outer Mitochondrial Membrane 20	Protein Coding	2
38	TOMM70	Translocase Of Outer Mitochondrial Membrane 70	Protein Coding	2
39	MFN2	Mitofusin 2	Protein Coding	2

Disorders associated with Mitophagy SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Motor neuron disease	Enrichment	OPTN, TBK1	3.95
2	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1, TBK1	3.62
3	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	OPTN, SQSTM1, TBK1	3.47
4	Early-onset parkinson's disease	Enrichment	PINK1, PRKN	3.46
5	Spinocerebellar ataxia, autosomal recessive 25	Enrichment	ATG5	3.09
6	Thrombocytopenia 6	Enrichment	SRC	3.09
7	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	3.09
8	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	3.09
9	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	2.79
10	Paget disease of bone 3	Enrichment	SQSTM1	2.63
11	Leprosy 2	Enrichment	PRKN	2.63
12	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.63
13	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.63
14	Multiple symmetric lipomatosis	Enrichment	MFN2	2.63
15	Charcot-marie-tooth disease, axonal, autosomal dominant, type 2a2a	Enrichment	MFN2	2.63
16	Autoinflammation with arthritis and vasculitis	Enrichment	TBK1	2.63
17	Charcot-marie-tooth disease, axonal, autosomal recessive, type 2a2b	Enrichment	MFN2	2.63
18	Corticobasal syndrome	Enrichment	TBK1	2.63
19	Encephalopathy, acute, infection-induced 8	Enrichment	TBK1	2.63
20	Garg-mishra progeroid syndrome	Enrichment	TOMM7	2.63
21	Charcot-marie-tooth disease type 5	Enrichment	MFN2	2.63
22	Charcot-marie-tooth disease type 2a2b	Enrichment	MFN2	2.63
23	Prognathism, mandibular	Enrichment	CSNK2B	2.61
24	Enophthalmos	Enrichment	CSNK2B	2.49
25	Syndactyly	Enrichment	CSNK2B	2.49
26	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B	2.47
27	Parkinson disease 12	Enrichment	PRKN	2.33
28	Lipomatosis, multiple symmetric, with or without axonal peripheral neuropathy	Enrichment	MFN2	2.33
29	Welander distal myopathy	Enrichment	SQSTM1	2.33
30	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.33
31	Frontotemporal dementia and/or amyotrophic lateral sclerosis 4	Enrichment	TBK1	2.33
32	Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia	Enrichment	OPTN	2.33
33	Axonal neuropathy	Enrichment	MFN2	2.33
34	Paget's disease of bone	Enrichment	SQSTM1	2.33
35	Amyotrophic lateral sclerosis type 12	Enrichment	OPTN	2.33
36	Submucosal cleft palate	Enrichment	UBB	2.33
37	Cleft hard palate	Enrichment	UBB	2.33
38	Multiple system atrophy, cerebellar type	Enrichment	MFN2	2.33
39	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.33
40	Myelofibrosis	Enrichment	SRC	2.25
41	Uvula, bifid	Enrichment	UBB	2.15
42	Neuropathy, hereditary motor and sensory, type via, with optic atrophy	Enrichment	MFN2	2.15
43	Cleft soft palate	Enrichment	UBB	2.15
44	Glaucoma, normal tension	Enrichment	OPTN	2.15
45	Hyperpigmentation of the skin	Enrichment	MFN2	2.15
46	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	2.03
47	Paget's disease of bone 2	Enrichment	SQSTM1	2.03
48	Complex hereditary spastic paraplegia	Enrichment	PRKN	2.03
49	Osteoporosis	Enrichment	SRC	1.95
50	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	1.93
51	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	OPTN	1.93
52	Parkin type of early-onset parkinson disease	Enrichment	PRKN	1.93
53	Herpes simplex virus encephalitis	Enrichment	TBK1	1.93
54	Genetic motor neuron disease	Enrichment	MFN2	1.93
55	Glaucoma, primary open angle	Enrichment	OPTN	1.85
56	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PINK1	1.85
57	Early-onset autosomal dominant alzheimer disease	Enrichment	TOMM40	1.79
58	Progressive non-fluent aphasia	Enrichment	TBK1	1.68
59	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.68
60	Lung cancer susceptibility 3	Enrichment	PRKN	1.49
61	Thrombocytopenia	Enrichment	SRC	1.42
62	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	1.40
63	Beckwith-wiedemann syndrome	Enrichment	MFN2	1.38
64	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	MFN2	1.36
65	Parkinson's disease	Enrichment	PRKN	1.36
66	Parkinson disease, late-onset	Enrichment	PRKN	1.26
67	Auditory neuropathy	Enrichment	MFN2	1.22
68	Colorectal cancer	Enrichment	SRC	1.17
69	Lung cancer	Enrichment	PRKN	1.14
70	Peripheral nervous system disease	Enrichment	MFN2	1.14
71	Neuropathy	Enrichment	MFN2	1.14
72	Systemic lupus erythematosus	Enrichment	UBE2L3	1.05
73	Cerebral palsy	Enrichment	MFN2	1.05
74	Charcot-marie-tooth disease	Enrichment	MFN2	1.03
75	Complex neurodevelopmental disorder	Enrichment	CSNK2A1	1.02
76	Schizophrenia	Enrichment	PRKN	0.88
77	Autism	Enrichment	PRKN	0.80
78	Ovarian cancer	Enrichment	PRKN	0.67
79	Microcephaly	Enrichment	MFN2	0.60

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Mitophagy

Pathway network for the Mitophagy SuperPath

Member Pathways for Mitophagy

Pathways in the Mitophagy SuperPath

Gene overlap in member pathways for Mitophagy SuperPath

Associated Genes for Mitophagy

Associated Disorders for Mitophagy

Disorders associated with Mitophagy SuperPath

STRING Interaction Network for Mitophagy

Sources for Mitophagy