Mitotic G1 phase and G1/S transition

Pathway network for the Mitotic G1 phase and G1/S transition SuperPath

Sources:

Reactome
WikiPathways

Pathways in the Mitotic G1 phase and G1/S transition SuperPath

#	Name	Source	Genes
1	Mitotic G1 phase and G1/S transition	Reactome	ABL1 ADRM1 AKT1 AKT2 AKT3 CABLES1 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CDC25A CDC45 CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CDT1 CKS1B CUL1 DBF4 DHFR DYRK1A E2F1 E2F2 E2F3 E2F4 E2F5 E2F6 FBXO5 GMNN HDAC1 JAK2 LIN37 LIN52 LIN54 LIN9 LYN MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYBL2 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLE POLE2 POLE3 POLE4 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R3B PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTK6 RB1 RBBP4 RBL1 RBL2 RPA1 RPA2 RPA3 RPA4 RPS27A RRM2 SEM1 SKP1 SKP2 SRC TFDP1 TFDP2 TK1 TOP2A TYMS UBA52 UBB UBC WEE1 (see all 139) (see less)
2	G1/S Transition	Reactome	ADRM1 AKT1 AKT2 AKT3 CABLES1 CCNA1 CCNA2 CCNB1 CCND1 CCNE1 CCNE2 CCNH CDC25A CDC45 CDC6 CDC7 CDK1 CDK2 CDK4 CDK7 CDKN1A CDKN1B CDT1 CKS1B CUL1 DBF4 DHFR E2F1 E2F4 E2F5 E2F6 FBXO5 GMNN HDAC1 LIN37 LIN52 LIN54 LIN9 MAX MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MCM8 MNAT1 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA1 POLA2 POLE POLE2 POLE3 POLE4 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R3B PRIM1 PRIM2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTK6 RB1 RBBP4 RBL1 RBL2 RPA1 RPA2 RPA3 RPA4 RPS27A RRM2 SEM1 SKP1 SKP2 TFDP1 TFDP2 TK1 TYMS UBA52 UBB UBC WEE1 (see all 121) (see less)
3	Cell cycle	WikiPathways	ABL1 ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ATM ATR BUB1 BUB3 CCNA1 CCNA2 CCNB1 CCNB2 CCNB3 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNH CDC14A CDC14B CDC16 CDC20 CDC23 CDC25A CDC25B CDC25C CDC27 CDC45 CDC6 CDC7 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CHEK1 CHEK2 CUL1 DBF4 E2F1 E2F2 E2F3 E2F4 E2F5 EP300 ESPL1 FZR1 GADD45A GADD45B GADD45G GSK3B HDAC1 HDAC2 MAD1L1 MAD2L2 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MDM2 MYC ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA PKMYT1 PLK1 PRKDC PTTG1 PTTG2 RAD21 RB1 RBL1 RBL2 RBX1 SFN SKP1 SKP2 SMAD2 SMAD3 SMAD4 SMC1A SMC1B SMC3 STAG1 STAG2 TFDP1 TFDP2 TGFB1 TGFB2 TGFB3 TP53 TTK WEE1 WEE2 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB17 (see all 120) (see less)
4	G1 to S cell cycle control	WikiPathways	ATF6B ATM CCNA1 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CCNG2 CCNH CDC25A CDC45 CDK1 CDK2 CDK4 CDK6 CDK7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CREB1 CREB3 CREB3L1 CREB3L3 CREB3L4 E2F1 E2F2 E2F3 GADD45A MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MDM2 MNAT1 MYC MYT1 ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PCNA POLA2 POLE POLE2 PRIM1 PRIM2 RB1 RPA1 RPA2 RPA3 TFDP1 TFDP2 TP53 WEE1 (see all 64) (see less)

Gene overlap in member pathways for Mitotic G1 phase and G1/S transition SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDK2	Cyclin Dependent Kinase 2	Protein Coding	4
2	CDK4	Cyclin Dependent Kinase 4	Protein Coding	4
3	CDK7	Cyclin Dependent Kinase 7	Protein Coding	4
4	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	4
5	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	4
6	E2F1	E2F Transcription Factor 1	Protein Coding	4
7	ORC6	Origin Recognition Complex Subunit 6	Protein Coding	4
8	ORC3	Origin Recognition Complex Subunit 3	Protein Coding	4
9	MCM2	Minichromosome Maintenance Complex Component 2	Protein Coding	4
10	MCM3	Minichromosome Maintenance Complex Component 3	Protein Coding	4
11	MCM4	Minichromosome Maintenance Complex Component 4	Protein Coding	4
12	MCM5	Minichromosome Maintenance Complex Component 5	Protein Coding	4
13	MCM6	Minichromosome Maintenance Complex Component 6	Protein Coding	4
14	MCM7	Minichromosome Maintenance Complex Component 7	Protein Coding	4
15	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	4
16	ORC1	Origin Recognition Complex Subunit 1	Protein Coding	4
17	ORC2	Origin Recognition Complex Subunit 2	Protein Coding	4
18	ORC4	Origin Recognition Complex Subunit 4	Protein Coding	4
19	ORC5	Origin Recognition Complex Subunit 5	Protein Coding	4
20	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	4
21	RB1	RB Transcriptional Corepressor 1	Protein Coding	4
22	CCND1	Cyclin D1	Protein Coding	4
23	TFDP1	Transcription Factor Dp-1	Protein Coding	4
24	TFDP2	Transcription Factor Dp-2	Protein Coding	4
25	WEE1	WEE1 G2 Checkpoint Kinase	Protein Coding	4
26	CDC45	Cell Division Cycle 45	Protein Coding	4
27	CCNA1	Cyclin A1	Protein Coding	4
28	CCNB1	Cyclin B1	Protein Coding	4
29	CCNE1	Cyclin E1	Protein Coding	4
30	CCNH	Cyclin H	Protein Coding	4
31	CCNE2	Cyclin E2	Protein Coding	4
32	CDK1	Cyclin Dependent Kinase 1	Protein Coding	4
33	CDC25A	Cell Division Cycle 25A	Protein Coding	4
34	CDK6	Cyclin Dependent Kinase 6	Protein Coding	3
35	CDKN1C	Cyclin Dependent Kinase Inhibitor 1C	Protein Coding	3
36	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3
37	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	3
38	CDKN2C	Cyclin Dependent Kinase Inhibitor 2C	Protein Coding	3
39	CDKN2D	Cyclin Dependent Kinase Inhibitor 2D	Protein Coding	3
40	DBF4	DBF4-CDC7 Kinase Regulatory Subunit	Protein Coding	3
41	E2F2	E2F Transcription Factor 2	Protein Coding	3
42	E2F3	E2F Transcription Factor 3	Protein Coding	3
43	E2F4	E2F Transcription Factor 4	Protein Coding	3
44	E2F5	E2F Transcription Factor 5	Protein Coding	3
45	POLA2	DNA Polymerase Alpha 2, Accessory Subunit	Protein Coding	3
46	HDAC1	Histone Deacetylase 1	Protein Coding	3
47	MNAT1	MNAT1 Component Of CDK Activating Kinase	Protein Coding	3
48	POLE	DNA Polymerase Epsilon, Catalytic Subunit	Protein Coding	3
49	POLE2	DNA Polymerase Epsilon 2, Accessory Subunit	Protein Coding	3
50	PRIM1	DNA Primase Subunit 1	Protein Coding	3
51	PRIM2	DNA Primase Subunit 2	Protein Coding	3
52	RBL1	RB Transcriptional Corepressor Like 1	Protein Coding	3
53	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	3
54	RPA1	Replication Protein A1	Protein Coding	3
55	RPA2	Replication Protein A2	Protein Coding	3
56	RPA3	Replication Protein A3	Protein Coding	3
57	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	3
58	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	3
59	CDC7	Cell Division Cycle 7	Protein Coding	3
60	CUL1	Cullin 1	Protein Coding	3
61	CCNA2	Cyclin A2	Protein Coding	3
62	CCND2	Cyclin D2	Protein Coding	3
63	CCND3	Cyclin D3	Protein Coding	3
64	CDC6	Cell Division Cycle 6	Protein Coding	3
65	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
66	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	2
67	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	2
68	CKS1B	CDC28 Protein Kinase Regulatory Subunit 1B	Protein Coding	2
69	LIN54	Lin-54 DREAM MuvB Core Complex Component	Protein Coding	2
70	DHFR	Dihydrofolate Reductase	Protein Coding	2
71	E2F6	E2F Transcription Factor 6	Protein Coding	2
72	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
73	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
74	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	2
75	FBXO5	F-Box Protein 5	Protein Coding	2
76	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	2
77	LIN9	Lin-9 DREAM MuvB Core Complex Component	Protein Coding	2
78	RPA4	Replication Protein A4	Protein Coding	2
79	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	2
80	GMNN	Geminin DNA Replication Inhibitor	Protein Coding	2
81	POLE3	DNA Polymerase Epsilon 3, Accessory Subunit	Protein Coding	2
82	POLA1	DNA Polymerase Alpha 1, Catalytic Subunit	Protein Coding	2
83	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
84	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
85	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
86	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
87	MCM10	Minichromosome Maintenance 10 Replication Initiation Factor	Protein Coding	2
88	LIN37	Lin-37 DREAM MuvB Core Complex Component	Protein Coding	2
89	POLE4	DNA Polymerase Epsilon 4, Accessory Subunit	Protein Coding	2
90	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	2
91	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	2
92	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	2
93	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	2
94	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	2
95	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	2
96	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	2
97	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	2
98	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	2
99	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	2
100	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	2
101	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	2
102	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	2
103	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	2
104	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	2
105	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	2
106	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	2
107	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	2
108	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	2
109	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	2
110	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	2
111	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	2
112	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	2
113	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	2
114	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	2
115	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	2
116	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	2
117	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	2
118	PTK6	Protein Tyrosine Kinase 6	Protein Coding	2
119	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
120	RPS27A	Ribosomal Protein S27a	Protein Coding	2
121	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	2
122	TK1	Thymidine Kinase 1	Protein Coding	2
123	TYMS	Thymidylate Synthetase	Protein Coding	2
124	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
125	UBB	Ubiquitin B	Protein Coding	2
126	UBC	Ubiquitin C	Protein Coding	2
127	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	2
128	CDT1	Chromatin Licensing And DNA Replication Factor 1	Protein Coding	2
129	MCM8	Minichromosome Maintenance 8 Homologous Recombination Repair Factor	Protein Coding	2
130	LIN52	Lin-52 DREAM MuvB Core Complex Component	Protein Coding	2
131	CABLES1	Cdk5 And Abl Enzyme Substrate 1	Protein Coding	2
132	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	2
133	TP53	Tumor Protein P53	Protein Coding	2
134	ATM	ATM Serine/Threonine Kinase	Protein Coding	2
135	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
136	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	2
137	DYRK1A	Dual Specificity Tyrosine Phosphorylation Regulated Kinase 1A	Protein Coding	1
138	JAK2	Janus Kinase 2	Protein Coding	1
139	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
140	MYBL2	MYB Proto-Oncogene Like 2	Protein Coding	1
141	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
142	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
143	TOP2A	DNA Topoisomerase II Alpha	Protein Coding	1
144	RBX1	Ring-Box 1	Protein Coding	1
145	CDC27	Cell Division Cycle 27	Protein Coding	1
146	CDC25C	Cell Division Cycle 25C	Protein Coding	1
147	CDC25B	Cell Division Cycle 25B	Protein Coding	1
148	CDC20	Cell Division Cycle 20	Protein Coding	1
149	ESPL1	Extra Spindle Pole Bodies Like 1, Separase	Protein Coding	1
150	PTTG1	PTTG1 Regulator Of Sister Chromatid Separation, Securin	Protein Coding	1
151	CCNB2	Cyclin B2	Protein Coding	1
152	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	1
153	PKMYT1	Protein Kinase, Membrane Associated Tyrosine/Threonine 1	Protein Coding	1
154	CDC14A	Cell Division Cycle 14A	Protein Coding	1
155	CCNB3	Cyclin B3	Protein Coding	1
156	MAD1L1	Mitotic Arrest Deficient 1 Like 1	Protein Coding	1
157	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
158	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
159	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
160	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
161	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
162	TTK	TTK Protein Kinase	Protein Coding	1
163	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
164	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
165	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
166	BUB1	BUB1 Mitotic Checkpoint Serine/Threonine Kinase	Protein Coding	1
167	RAD21	RAD21 Cohesin Complex Component	Protein Coding	1
168	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	1
169	ATR	ATR Checkpoint Kinase	Protein Coding	1
170	PLK1	Polo Like Kinase 1	Protein Coding	1
171	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	1
172	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	1
173	SMAD4	SMAD Family Member 4	Protein Coding	1
174	SMAD3	SMAD Family Member 3	Protein Coding	1
175	SMAD2	SMAD Family Member 2	Protein Coding	1
176	HDAC2	Histone Deacetylase 2	Protein Coding	1
177	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
178	SFN	Stratifin	Protein Coding	1
179	SMC1B	Structural Maintenance Of Chromosomes 1B	Protein Coding	1
180	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
181	CHEK2	Checkpoint Kinase 2	Protein Coding	1
182	CHEK1	Checkpoint Kinase 1	Protein Coding	1
183	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
184	STAG2	STAG2 Cohesin Complex Component	Protein Coding	1
185	MAD2L2	Mitotic Arrest Deficient 2 Like 2	Protein Coding	1
186	STAG1	STAG1 Cohesin Complex Component	Protein Coding	1
187	BUB3	BUB3 Mitotic Checkpoint Protein	Protein Coding	1
188	CDC16	Cell Division Cycle 16	Protein Coding	1
189	CDC23	Cell Division Cycle 23	Protein Coding	1
190	CDC14B	Cell Division Cycle 14B	Protein Coding	1
191	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	1
192	PTTG2	Pituitary Tumor-Transforming 2	Protein Coding	1
193	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	1
194	ZBTB17	Zinc Finger And BTB Domain Containing 17	Protein Coding	1
195	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
196	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	1
197	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	1
198	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	1
199	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	1
200	WEE2	WEE2 Oocyte Meiosis Inhibiting Kinase	Protein Coding	1
201	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	1
202	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	1
203	ANAPC13	Anaphase Promoting Complex Subunit 13	Protein Coding	1
204	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
205	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
206	CREB3L1	CAMP Responsive Element Binding Protein 3 Like 1	Protein Coding	1
207	CCNG2	Cyclin G2	Protein Coding	1
208	CREB3L3	CAMP Responsive Element Binding Protein 3 Like 3	Protein Coding	1
209	ATF6B	Activating Transcription Factor 6 Beta	Protein Coding	1
210	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
211	MYT1	Myelin Transcription Factor 1	Protein Coding	1

Disorders associated with Mitotic G1 phase and G1/S transition SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Meier-gorlin syndrome 1	Enrichment	CDC45, CDC6, CDT1, GMNN, MCM7, ORC1, ORC4, ORC6	16.00
2	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2B, CDKN2C	7.81
3	Li-fraumeni syndrome	Enrichment	CDKN2A, CHEK2, MDM2, TP53	7.06
4	Bladder cancer	Enrichment	ATM, CDKN1A, CDKN2A, RB1, TP53	6.66
5	Osteogenic sarcoma	Enrichment	CHEK2, RB1, TP53	6.17
6	Bone osteosarcoma	Enrichment	CHEK2, RB1, TP53	6.17
7	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3	6.15
8	Gastric cancer	Enrichment	ATM, CDK4, CDKN2A, CHEK2, SMAD4, TP53	5.71
9	Pancreatic cancer	Enrichment	ATM, CDKN2A, CHEK2, SMAD4, TP53	5.64
10	Lip and oral cavity carcinoma	Enrichment	ABL1, CDKN2A, RB1, TP53	5.56
11	Inherited cancer-predisposing syndrome	Enrichment	ATM, CDK4, CDKN1B, CDKN2A, POLE, RB1, TP53	5.56
12	Colorectal cancer	Enrichment	ATM, BUB1, CCND1, CHEK2, EP300, SMAD4, TP53	4.94
13	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	4.93
14	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	Enrichment	CDKN1C, POLE	4.66
15	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, CDKN2A, TP53	4.64
16	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1, BUB3, MAD1L1	4.44
17	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3	4.39
18	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC1A, SMC3	4.26
19	Cornelia de lange syndrome	Enrichment	RAD21, SMC1A, SMC3	4.26
20	Melanoma, cutaneous malignant 1	Enrichment	CDK4, CDKN2A, CDKN2B	4.19
21	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	4.18
22	Squamous cell carcinoma	Enrichment	RB1, TP53	4.18
23	Adenocarcinoma	Enrichment	ATM, TP53	4.18
24	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	4.18
25	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.11
26	Sarcoma	Enrichment	CHEK2, TP53	4.11
27	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.11
28	Ovarian cancer	Enrichment	ATM, CDKN1B, CDKN2A, RB1, TP53	3.95
29	Prostate cancer	Enrichment	ATM, CHEK2, MAD1L1, TP53	3.93
30	Small cell cancer of the lung	Enrichment	RB1, TP53	3.88
31	Mantle cell lymphoma	Enrichment	ATM, CCND1	3.88
32	Myeloma, multiple	Enrichment	ATM, CCND1, CDKN2C, TP53	3.86
33	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	3.49
34	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, CCND2	3.21
35	Enophthalmos	Enrichment	DYRK1A, MCM7	3.21
36	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, CDKN2A, MYC	2.98
37	Wiedemann-steiner syndrome	Enrichment	SMC1A, SMC3	2.94
38	Familial colorectal cancer type x	Enrichment	ATM, POLE	2.93
39	Gallbladder cancer	Enrichment	SMAD4, TP53	2.80
40	Hereditary hemorrhagic telangiectasia	Enrichment	CCNH, SMAD4	2.80
41	Lung cancer susceptibility 3	Enrichment	RB1, TP53	2.72
42	Myelofibrosis	Enrichment	JAK2, SRC	2.67
43	Gliosarcoma	Enrichment	ATM, TP53	2.60
44	Colonic benign neoplasm	Enrichment	ATM, CHEK2	2.57
45	Giant cell glioblastoma	Enrichment	ATM, TP53	2.55
46	Lynch syndrome 1	Enrichment	ATM, CHEK2	2.48
47	Melanoma	Enrichment	CDKN2A, CHEK2	2.48
48	Polymicrogyria	Enrichment	AKT3, PSMC3	2.47
49	Uterine corpus cancer	Enrichment	ATM, CHEK2	2.39
50	Breast cancer	Enrichment	ATM, CDKN2B, CHEK2, TP53	2.36
51	Microcephaly	Enrichment	ABL1, EP300, MCM7, SMC1A, YWHAG	2.33
52	Cystic fibrosis with helicobacter pylori gastritis, megaloblastic anemia, and impaired intellectual development	Enrichment	POLE	2.33
53	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.33
54	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.33
55	Lactose intolerance, adult type	Enrichment	MCM6	2.33
56	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.33
57	Meier-gorlin syndrome 3	Enrichment	ORC6	2.33
58	Osteogenesis imperfecta, type xvi	Enrichment	CREB3L1	2.33
59	Meier-gorlin syndrome 2	Enrichment	ORC4	2.33
60	Accelerated tumor formation	Enrichment	MDM2	2.33
61	Colorectal cancer 12	Enrichment	POLE	2.33
62	Hypertriglyceridemia 2	Enrichment	CREB3L3	2.33
63	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6	Enrichment	RPA1	2.33
64	Lessel-kubisch syndrome	Enrichment	MDM2	2.33
65	Bone marrow failure syndrome 5	Enrichment	TP53	2.33
66	Papilloma of choroid plexus	Enrichment	TP53	2.33
67	Anisometropia	Enrichment	MCM7	2.33
68	Basal cell carcinoma 7	Enrichment	TP53	2.33
69	Anaplastic thyroid carcinoma	Enrichment	TP53	2.33
70	Immunodeficiency 54	Enrichment	MCM4	2.33
71	Deafness, autosomal dominant 70	Enrichment	MCM2	2.33
72	Meier-gorlin syndrome 8	Enrichment	MCM5	2.33
73	Neuroendocrine tumor	Enrichment	CDKN1B	2.33
74	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.33
75	Endometrial serous adenocarcinoma	Enrichment	ATM	2.33
76	Ductal carcinoma in situ	Enrichment	TP53	2.33
77	Meier-gorlin syndrome 7	Enrichment	CDC45	2.33
78	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.33
79	Trilateral retinoblastoma	Enrichment	RB1	2.33
80	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.33
81	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.33
82	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.33
83	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.33
84	Choroid plexus cancer	Enrichment	TP53	2.33
85	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.33
86	Intrauterine growth restriction-short stature-early adult-onset diabetes syndrome	Enrichment	CDKN1C	2.33
87	Lung oat cell carcinoma	Enrichment	RB1	2.33
88	Breast-ovarian cancer, familial 1	Enrichment	ATM, CHEK2	2.25
89	Hereditary breast carcinoma	Enrichment	ATM, CHEK2, TP53	2.16
90	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.05
91	Holoprosencephaly 13, x-linked	Enrichment	STAG2	2.05
92	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	2.05
93	Deafness, autosomal recessive 32, with or without immotile sperm	Enrichment	CDC14A	2.05
94	Seckel syndrome 1	Enrichment	ATR	2.05
95	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	2.05
96	Fanconi anemia, complementation group v	Enrichment	MAD2L2	2.05
97	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.05
98	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	2.05
99	Mullegama-klein-martinez syndrome	Enrichment	STAG2	2.05
100	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.05
101	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	2.05
102	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.05
103	Camurati-engelmann disease 2	Enrichment	TGFB2	2.05
104	Intellectual developmental disorder, autosomal dominant 47	Enrichment	STAG1	2.05
105	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.05
106	Mungan syndrome	Enrichment	RAD21	2.05
107	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.05
108	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.05
109	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.05
110	Meier-gorlin syndrome 5	Enrichment	CDC6	2.05
111	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.05
112	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.05
113	Xq25 microduplication syndrome	Enrichment	STAG2	2.05
114	Leiomyosarcoma	Enrichment	CHEK2	2.05
115	Autosomal recessive nonsyndromic deafness 32	Enrichment	CDC14A	2.05
116	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.05
117	Microcephaly 30, primary, autosomal recessive	Enrichment	BUB1	2.05
118	Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition	Enrichment	MAD1L1	2.05
119	Heritable thoracic aortic disease	Enrichment	SMAD4	2.05
120	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.05
121	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.05
122	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.05
123	Proteus syndrome	Enrichment	AKT1	2.05
124	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.05
125	Van esch-o'driscoll syndrome	Enrichment	POLA1	2.05
126	Immunodeficiency 80 with or without congenital cardiomyopathy	Enrichment	MCM10	2.05
127	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.05
128	Pigmentary disorder, reticulate, with systemic manifestations, x-linked	Enrichment	POLA1	2.05
129	Meier-gorlin syndrome 4	Enrichment	CDT1	2.05
130	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.05
131	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.05
132	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.05
133	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.05
134	Premature ovarian failure 10	Enrichment	MCM8	2.05
135	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.05
136	Cowden syndrome 6	Enrichment	AKT1	2.05
137	Megaloblastic anemia due to dihydrofolate reductase deficiency	Enrichment	DHFR	2.05
138	Meier-gorlin syndrome 6	Enrichment	GMNN	2.05
139	Capillary hemangioma	Enrichment	AKT3	2.05
140	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.05
141	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.05
142	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.03
143	Burkitt lymphoma	Enrichment	MYC	2.03
144	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.03
145	Cervical cancer	Enrichment	TP53	2.03
146	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.03
147	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.03
148	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.03
149	Lymphoma, hodgkin, classic	Enrichment	TP53	2.03
150	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.03
151	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.03
152	Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency	Enrichment	POLE	2.03
153	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.03
154	Primordial dwarfism-immunodeficiency-lipodystrophy syndrome	Enrichment	PRIM1	2.03
155	Congenital fibrosarcoma	Enrichment	TP53	2.03
156	High grade glioma	Enrichment	ATM	2.03
157	Facial dysmorphism, immunodeficiency, livedo, and short stature	Enrichment	POLE	2.03
158	Cervix carcinoma	Enrichment	TP53	2.03
159	Hodgkin's lymphoma	Enrichment	TP53	2.03
160	T-cell prolymphocytic leukemia	Enrichment	ATM	2.03
161	Transient infantile hypertriglyceridemia and hepatosteatosis	Enrichment	CREB3L3	2.03
162	Familial retinoblastoma	Enrichment	RB1	2.03
163	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.03
164	Primary autosomal recessive microcephaly	Enrichment	CDK6, MCM7	2.00
165	Intellectual developmental disorder, autosomal dominant 7	Enrichment	DYRK1A	1.99
166	Thrombocytopenia 6	Enrichment	SRC	1.99
167	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	1.99
168	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	1.97
169	Diffuse large b-cell lymphoma	Enrichment	CHEK2, TP53	1.92
170	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2	1.92
171	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, CHEK2, TP53	1.90
172	Retinoblastoma	Enrichment	RB1	1.85
173	Ataxia-telangiectasia	Enrichment	ATM	1.85
174	Polycythemia vera	Enrichment	ATM	1.85
175	Nasopharyngeal carcinoma	Enrichment	TP53	1.85
176	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.85
177	Hypotrichosis 8	Enrichment	RB1	1.85
178	Koolen-de vries syndrome	Enrichment	ATM	1.85
179	Wieacker-wolff syndrome	Enrichment	CCNH	1.85
180	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.85
181	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.85
182	Anaplastic astrocytoma	Enrichment	TP53	1.85
183	Myxofibrosarcoma	Enrichment	CREB3L1	1.85
184	Melanoma of soft tissue	Enrichment	CREB1	1.85
185	Polymerase proofreading-related polyposis	Enrichment	POLE	1.85
186	Endometrial cancer	Enrichment	ATM, CHEK2	1.84
187	Myhre syndrome	Enrichment	SMAD4	1.75
188	Camurati-engelmann disease 1	Enrichment	TGFB1	1.75
189	Cornelia de lange syndrome 2	Enrichment	SMC1A	1.75
190	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.75
191	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.75
192	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	1.75
193	Oocyte/zygote/embryo maturation arrest 5	Enrichment	WEE2	1.75
194	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.75
195	Menke-hennekam syndrome 2	Enrichment	EP300	1.75
196	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.75
197	Camurati-engelmann disease	Enrichment	TGFB1	1.75
198	Birk-aharoni syndrome	Enrichment	PSMC1	1.75
199	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.75
200	Senior-loken syndrome 7	Enrichment	AKT3	1.75
201	Bardet-biedl syndrome 16	Enrichment	AKT3	1.75
202	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.75
203	Dyskeratosis congenita, digenic	Enrichment	TYMS	1.75
204	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.75
205	Submucosal cleft palate	Enrichment	UBB	1.75
206	Cleft hard palate	Enrichment	UBB	1.75
207	Hypertriglyceridemia 1	Enrichment	CREB3L3	1.73
208	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.73
209	Astigmatism	Enrichment	MCM7	1.73
210	Lynch syndrome 4	Enrichment	RB1	1.73
211	Lung sarcomatoid carcinoma	Enrichment	TP53	1.73
212	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.73
213	Silver-russell syndrome due to a point mutation	Enrichment	CDKN1C	1.73
214	Primary hyperparathyroidism	Enrichment	CDKN1B	1.73
215	Oculomotor apraxia	Enrichment	ATM	1.73
216	Thrombocythemia 3	Enrichment	JAK2	1.69
217	Polycythemia	Enrichment	JAK2	1.69
218	Hypereosinophilic syndrome	Enrichment	JAK2	1.69
219	Microphthalmia	Enrichment	DYRK1A, MCM7	1.68
220	Capillary malformations, congenital	Enrichment	CCNH	1.63
221	Von hippel-lindau syndrome	Enrichment	CCND1	1.63
222	Rhabdomyosarcoma 2	Enrichment	TP53	1.63
223	Lymphoma	Enrichment	TP53	1.63
224	Glioblastoma	Enrichment	ATM	1.63
225	2q23.1 microduplication syndrome	Enrichment	ORC4	1.63
226	Acute megakaryocytic leukemia	Enrichment	TP53	1.63
227	Farsightedness	Enrichment	MCM7	1.63
228	Juvenile polyposis syndrome	Enrichment	SMAD4	1.58
229	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.58
230	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.58
231	Loeys-dietz syndrome 1	Enrichment	SMAD2	1.58
232	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.58
233	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.58
234	Uvula, bifid	Enrichment	UBB	1.58
235	Partington syndrome	Enrichment	POLA1	1.58
236	Cleft soft palate	Enrichment	UBB	1.58
237	Familial adenomatous polyposis 4	Enrichment	DHFR	1.58
238	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.58
239	Thyroid hemiagenesis	Enrichment	PSMD3	1.58
240	Klippel-trenaunay-weber syndrome	Enrichment	CCNH	1.55
241	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	CCNH	1.55
242	Hemangioma, capillary infantile	Enrichment	CCNH	1.55
243	Basal cell carcinoma 1	Enrichment	CCNH	1.55
244	Clear cell renal cell carcinoma	Enrichment	ATM	1.55
245	Breast adenocarcinoma	Enrichment	TP53	1.55
246	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.55
247	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.52
248	Esophageal cancer	Enrichment	TP53	1.49
249	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.49
250	Capillary malformation-arteriovenous malformation 1	Enrichment	CCNH	1.49
251	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.49
252	Essential thrombocythemia	Enrichment	TP53	1.49
253	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	1.46
254	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	1.46
255	Aortic aneurysm	Enrichment	SMAD3	1.46
256	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.46
257	Pregnancy loss, recurrent 1	Enrichment	CCNB3	1.46
258	Hemoglobin c disease	Enrichment	CHEK2	1.46
259	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.46
260	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.45
261	Glioma susceptibility 1	Enrichment	TP53	1.43
262	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.43
263	Erythrocytosis, familial, 1	Enrichment	JAK2	1.39
264	Budd-chiari syndrome	Enrichment	JAK2	1.39
265	Arteriovenous malformation	Enrichment	CCNH	1.38
266	Adult hepatocellular carcinoma	Enrichment	TP53	1.38
267	Primary hyperaldosteronism	Enrichment	TP53	1.38
268	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.36
269	Mosaic variegated aneuploidy syndrome 1	Enrichment	MAD1L1	1.36
270	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.36
271	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.36
272	Female infertility due to oocyte meiotic arrest	Enrichment	WEE2	1.36
273	Endometrial stromal sarcoma	Enrichment	YWHAE	1.36
274	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.36
275	Ciliary dyskinesia, primary, 40	Enrichment	E2F6	1.36
276	Hemimegalencephaly	Enrichment	AKT3	1.36
277	Myopathy, x-linked, with excessive autophagy	Enrichment	CCNH	1.34
278	Familial colorectal cancer	Enrichment	TP53	1.34
279	Myeloproliferative neoplasm	Enrichment	JAK2	1.30
280	Immune deficiency disease	Enrichment	ATM	1.29
281	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.29
282	Myelodysplastic syndrome	Enrichment	TP53	1.29
283	Atrial septal defect 1	Enrichment	TGFB2	1.28
284	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.28
285	Wilms tumor 5	Enrichment	CHEK2	1.28
286	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.28
287	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.28
288	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.28
289	Kidney clear cell sarcoma	Enrichment	YWHAE	1.28
290	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.28
291	Patent ductus arteriosus	Enrichment	PSMC3	1.28
292	Leukemia, chronic myeloid	Enrichment	ABL1	1.22
293	Moyamoya angiopathy	Enrichment	ABL1	1.22
294	Megacolon	Enrichment	AKT3	1.22
295	Seckel syndrome	Enrichment	PRIM1	1.19
296	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.16
297	Osteogenesis imperfecta, type iii	Enrichment	CREB3L1	1.16
298	Rett syndrome, congenital variant	Enrichment	SMC1A	1.16
299	Isolated split hand-split foot malformation	Enrichment	SEM1	1.16
300	Rhabdomyosarcoma	Enrichment	TP53	1.14
301	Charge syndrome	Enrichment	EP300	1.11
302	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.11
303	Polycystic liver disease	Enrichment	CDC25A	1.11
304	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.11
305	Cowden syndrome	Enrichment	AKT1	1.11
306	Beckwith-wiedemann syndrome	Enrichment	CDKN1C	1.09
307	Marfan syndrome	Enrichment	TGFB2	1.07
308	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1, YWHAG	1.06
309	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.05
310	Williams-beuren syndrome	Enrichment	CDKN1C	1.04
311	Specific learning disability	Enrichment	YWHAG	1.03
312	Hepatoblastoma	Enrichment	TP53	1.02
313	Hepatocellular carcinoma	Enrichment	TP53	1.00
314	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	0.99
315	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	0.99
316	Meningioma	Enrichment	AKT1	0.99
317	Diamond-blackfan anemia 1	Enrichment	TP53	0.99
318	Brittle bone disorder	Enrichment	CREB3L1	0.99
319	Nk-cell enteropathy	Enrichment	CHEK2	0.96
320	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.93
321	Heart disease	Enrichment	ABL1	0.93
322	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.93
323	Pheochromocytoma	Enrichment	MAX	0.93
324	Polydactyly, postaxial, type a1	Enrichment	EP300	0.90
325	Wilms tumor 1	Enrichment	CHEK2	0.90
326	Lynch syndrome	Enrichment	CHEK2	0.90
327	Rare genetic intellectual disability	Enrichment	EP300	0.90
328	Osteoporosis	Enrichment	SRC	0.87
329	Complex neurodevelopmental disorder	Enrichment	DYRK1A, PPP2CA, PSMD12	0.87
330	Alobar holoprosencephaly	Enrichment	STAG2	0.85
331	Male infertility with spermatogenesis disorder	Enrichment	DYRK1A	0.84
332	Patent foramen ovale	Enrichment	PSMC3	0.83
333	Dyskeratosis congenita	Enrichment	TYMS	0.81
334	Diamond-blackfan anemia	Enrichment	TP53	0.80
335	Azoospermia	Enrichment	MCM8	0.78
336	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.77
337	Leukemia, acute myeloid	Enrichment	TP53	0.76
338	Myocardial infarction	Enrichment	PSMA6	0.75
339	Ear malformation	Enrichment	CDC14A	0.72
340	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MCM2	0.66
341	Lung cancer	Enrichment	CHEK2	0.61
342	Cystic fibrosis	Enrichment	TGFB1	0.61
343	Connective tissue disease	Enrichment	SMAD3	0.61
344	Fanconi anemia, complementation group a	Enrichment	MAD2L2	0.57
345	Type 2 diabetes mellitus	Enrichment	AKT2	0.50
346	Sensorineural hearing loss	Enrichment	CDC14A	0.46
347	Thrombocytopenia	Enrichment	SMAD4	0.46
348	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.44
349	Primary ovarian insufficiency	Enrichment	CHEK2	0.39
350	Rare genetic deafness	Enrichment	CDC14A	0.30
351	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CDC14A	0.26
352	Congenital nervous system abnormality	Enrichment	SMC1A	0.21
353	Nervous system disease	Enrichment	SMC1A	0.21
354	Autism spectrum disorder	Enrichment	SMC3	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Mitotic G1 phase and G1/S transition

Pathway Network for Mitotic G1 phase and G1/S transition

Pathway network for the Mitotic G1 phase and G1/S transition SuperPath

Member Pathways for Mitotic G1 phase and G1/S transition

Pathways in the Mitotic G1 phase and G1/S transition SuperPath

Gene overlap in member pathways for Mitotic G1 phase and G1/S transition SuperPath

Associated Genes for Mitotic G1 phase and G1/S transition

Associated Disorders for Mitotic G1 phase and G1/S transition

Disorders associated with Mitotic G1 phase and G1/S transition SuperPath

STRING Interaction Network for Mitotic G1 phase and G1/S transition

Sources for Mitotic G1 phase and G1/S transition