Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids

No Pathway Network information available for Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids

#	Name	Source	Genes
1	Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids	WikiPathways	AKT1 ASAH2 CERK HIF1A NFKB1 S1PR3 TSC1 (see all 7) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ASAH2	N-Acylsphingosine Amidohydrolase 2	Protein Coding	1
2	CERK	Ceramide Kinase	Protein Coding	1
3	S1PR3	Sphingosine-1-Phosphate Receptor 3	Protein Coding	1
4	TSC1	TSC Complex Subunit 1	Protein Coding	1
5	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
6	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
7	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Proteus syndrome	Enrichment	AKT1	3.29
2	Cowden syndrome 6	Enrichment	AKT1	3.29
3	Lymphangioleiomyomatosis	Enrichment	TSC1	2.99
4	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.99
5	Common variable immunodeficiency 12	Enrichment	NFKB1	2.99
6	Tuberous sclerosis 1	Enrichment	TSC1	2.81
7	Hamartoma	Enrichment	TSC1	2.81
8	Enchondromatosis	Enrichment	HIF1A	2.81
9	Focal cortical dysplasia, type ii	Enrichment	TSC1	2.69
10	Tuberous sclerosis	Enrichment	TSC1	2.69
11	Isolated focal cortical dysplasia type ii	Enrichment	TSC1	2.69
12	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	2.59
13	Keratoconus	Enrichment	TSC1	2.51
14	Breast adenocarcinoma	Enrichment	AKT1	2.51
15	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	2.44
16	Common variable immunodeficiency	Enrichment	NFKB1	2.44
17	Adult hepatocellular carcinoma	Enrichment	TSC1	2.33
18	Cowden syndrome	Enrichment	AKT1	2.33
19	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.29
20	Meningioma	Enrichment	AKT1	2.21
21	Kidney disease	Enrichment	TSC1	2.11
22	Bladder cancer	Enrichment	TSC1	1.83
23	Hereditary breast carcinoma	Enrichment	AKT1	1.65
24	Breast cancer	Enrichment	AKT1	1.42
25	Colorectal cancer	Enrichment	AKT1	1.36
26	Ovarian cancer	Enrichment	AKT1	1.29
27	Inherited cancer-predisposing syndrome	Enrichment	TSC1	1.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids