Monoamine GPCRs

Pathway network for the Monoamine GPCRs SuperPath

Sources:

WikiPathways
Reactome

Pathways in the Monoamine GPCRs SuperPath

#	Name	Source	Genes
1	Monoamine GPCRs	WikiPathways	ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 DRD1 DRD2 DRD3 DRD4 DRD5 HRH1 HRH2 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR5BP HTR6 HTR7 (see all 34) (see less)
2	Amine ligand-binding receptors	Reactome	ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 CHRM1 CHRM2 CHRM3 CHRM4 CHRM5 DRD1 DRD2 DRD3 DRD4 DRD5 GPR143 HRH1 HRH2 HRH3 HRH4 HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 TAAR1 TAAR2 TAAR5 TAAR6 TAAR8 TAAR9 (see all 42) (see less)
3	Serotonin receptors	Reactome	HTR1A HTR1B HTR1D HTR1E HTR1F HTR2A HTR2B HTR2C HTR4 HTR5A HTR6 HTR7 (see all 12) (see less)
4	Adrenoceptors	Reactome	ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ADRB3 (see all 9) (see less)
5	Muscarinic acetylcholine receptors	Reactome	CHRM1 CHRM2 CHRM3 CHRM4 CHRM5
6	Histamine receptors	Reactome	HRH1 HRH2 HRH3 HRH4
7	Adrenaline signalling through Alpha-2 adrenergic receptor	Reactome	ADRA2A ADRA2B ADRA2C

Gene overlap in member pathways for Monoamine GPCRs SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADRA2C	Adrenoceptor Alpha 2C	Protein Coding	4
2	ADRA2B	Adrenoceptor Alpha 2B	Protein Coding	4
3	ADRA2A	Adrenoceptor Alpha 2A	Protein Coding	4
4	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	3
5	HTR6	5-Hydroxytryptamine Receptor 6	Protein Coding	3
6	HTR5A	5-Hydroxytryptamine Receptor 5A	Protein Coding	3
7	HTR4	5-Hydroxytryptamine Receptor 4	Protein Coding	3
8	HTR2C	5-Hydroxytryptamine Receptor 2C	Protein Coding	3
9	HTR2B	5-Hydroxytryptamine Receptor 2B	Protein Coding	3
10	HTR2A	5-Hydroxytryptamine Receptor 2A	Protein Coding	3
11	HTR1F	5-Hydroxytryptamine Receptor 1F	Protein Coding	3
12	HTR1D	5-Hydroxytryptamine Receptor 1D	Protein Coding	3
13	HTR1B	5-Hydroxytryptamine Receptor 1B	Protein Coding	3
14	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	3
15	HRH2	Histamine Receptor H2	Protein Coding	3
16	HRH1	Histamine Receptor H1	Protein Coding	3
17	ADRB3	Adrenoceptor Beta 3	Protein Coding	3
18	ADRB2	Adrenoceptor Beta 2	Protein Coding	3
19	ADRB1	Adrenoceptor Beta 1	Protein Coding	3
20	ADRA1A	Adrenoceptor Alpha 1A	Protein Coding	3
21	ADRA1B	Adrenoceptor Alpha 1B	Protein Coding	3
22	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	3
23	CHRM5	Cholinergic Receptor Muscarinic 5	Protein Coding	3
24	CHRM4	Cholinergic Receptor Muscarinic 4	Protein Coding	3
25	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	3
26	CHRM2	Cholinergic Receptor Muscarinic 2	Protein Coding	3
27	CHRM1	Cholinergic Receptor Muscarinic 1	Protein Coding	3
28	HTR1E	5-Hydroxytryptamine Receptor 1E	Protein Coding	3
29	DRD5	Dopamine Receptor D5	Protein Coding	2
30	DRD4	Dopamine Receptor D4	Protein Coding	2
31	DRD3	Dopamine Receptor D3	Protein Coding	2
32	DRD2	Dopamine Receptor D2	Protein Coding	2
33	DRD1	Dopamine Receptor D1	Protein Coding	2
34	HRH3	Histamine Receptor H3	Protein Coding	2
35	HRH4	Histamine Receptor H4	Protein Coding	2
36	HTR5BP	5-Hydroxytryptamine Receptor 5B, Pseudogene	Pseudogene	1
37	TAAR9	Trace Amine Associated Receptor 9	Protein Coding	1
38	TAAR1	Trace Amine Associated Receptor 1	Protein Coding	1
39	TAAR6	Trace Amine Associated Receptor 6	Protein Coding	1
40	GPR143	G Protein-Coupled Receptor 143	Protein Coding	1
41	TAAR8	Trace Amine Associated Receptor 8	Protein Coding	1
42	TAAR5	Trace Amine Associated Receptor 5	Protein Coding	1
43	TAAR2	Trace Amine Associated Receptor 2	Protein Coding	1

Disorders associated with Monoamine GPCRs SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lipodystrophy, familial partial, type 8	Enrichment	ADRA2A	3.66
2	Resting heart rate, variation in	Enrichment	ADRB1	3.18
3	Short sleep, familial natural, 2	Enrichment	ADRB1	3.18
4	Periodic fever, menstrual cycle-dependent	Enrichment	HTR1A	3.05
5	Prune belly syndrome	Enrichment	CHRM3	2.96
6	Familial adult myoclonic epilepsy	Enrichment	ADRA2B	2.88
7	Attention deficit-hyperactivity disorder	Enrichment	DRD4, DRD5	2.86
8	Obsessive-compulsive disorder	Enrichment	HTR2A	2.75
9	Blepharospasm, benign essential	Enrichment	DRD5	2.60
10	Tremor, hereditary essential, 1	Enrichment	DRD3	2.60
11	Autonomic nervous system disease	Enrichment	DRD4	2.60
12	Blepharospasm	Enrichment	DRD5	2.60
13	Nystagmus 6, congenital, x-linked	Enrichment	GPR143	2.51
14	Major depressive disorder	Enrichment	HTR2A	2.35
15	Schizophrenia	Enrichment	DRD3, HTR2A	2.02
16	Dystonia 11, myoclonic	Enrichment	DRD2	1.83
17	Albinism, ocular, type i	Enrichment	GPR143	1.73
18	Albinism	Enrichment	GPR143	1.73
19	Essential tremor	Enrichment	DRD3	1.70
20	Body mass index quantitative trait locus 11	Enrichment	ADRB3	1.49

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Monoamine GPCRs

Pathway network for the Monoamine GPCRs SuperPath

Member Pathways for Monoamine GPCRs

Pathways in the Monoamine GPCRs SuperPath

Gene overlap in member pathways for Monoamine GPCRs SuperPath

Associated Genes for Monoamine GPCRs

Associated Disorders for Monoamine GPCRs

Disorders associated with Monoamine GPCRs SuperPath

STRING Interaction Network for Monoamine GPCRs

Sources for Monoamine GPCRs