mRNA Editing: C to U Conversion

Sources:

#	Name	Source	Genes
1	mRNA Editing: C to U Conversion	Reactome	A1CF APOBEC1 APOBEC2 APOBEC3A APOBEC3A_B APOBEC3B APOBEC3C APOBEC3H APOBEC4 (see all 9) (see less)
2	mRNA Editing	Reactome	A1CF ADAR ADARB1 APOBEC1 APOBEC2 APOBEC3A APOBEC3A_B APOBEC3B APOBEC3C APOBEC3H APOBEC4 (see all 11) (see less)
3	Formation of the Editosome	Reactome	A1CF APOBEC1 APOBEC2 APOBEC3A APOBEC3A_B APOBEC3B APOBEC3C APOBEC3H APOBEC4 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APOBEC3A_B	APOBEC3A And APOBEC3B Deletion Hybrid	Protein Coding	3
2	APOBEC2	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 2	Protein Coding	3
3	APOBEC3H	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3H	Protein Coding	3
4	APOBEC3A	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3A	Protein Coding	3
5	APOBEC3C	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3C	Protein Coding	3
6	A1CF	APOBEC1 Complementation Factor	Protein Coding	3
7	APOBEC1	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 1	Protein Coding	3
8	APOBEC4	Apolipoprotein B MRNA Editing Enzyme Catalytic Polypeptide Like 4	Protein Coding	3
9	APOBEC3B	Apolipoprotein B MRNA Editing Enzyme Catalytic Subunit 3B	Protein Coding	3
10	ADAR	Adenosine Deaminase RNA Specific	Protein Coding	1
11	ADARB1	Adenosine Deaminase RNA Specific B1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adar-related hereditary spastic paraplegia	Enrichment	ADAR	3.09
2	Dyschromatosis symmetrica hereditaria	Enrichment	ADAR	2.79
3	Aicardi-goutieres syndrome 6	Enrichment	ADAR	2.79
4	Neurodevelopmental disorder with hypotonia, microcephaly, and seizures	Enrichment	ADARB1	2.79
5	Symmetrical dyschromatosis of extremities	Enrichment	ADAR	2.79
6	Familial infantile bilateral striatal necrosis	Enrichment	ADAR	2.49
7	Aicardi-goutiares syndrome	Enrichment	ADAR	2.14
8	Aicardi-goutieres syndrome	Enrichment	ADAR	2.09
9	Colorectal cancer	Enrichment	ADAR	1.17

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for mRNA Editing: C to U Conversion