mTOR Pathway

No Pathway Network information available for mTOR Pathway

Pathways in the mTOR Pathway SuperPath

#	Name	Source	Genes
1	mTOR Pathway	Tocris	AKT1 AKT2 AKT3 GSK3A GSK3B IGF1R IGF2R INSR MAPK10 MAPK3 MTOR PDPK1 PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PPARG PPP2CA PPP2CB PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 PRKCA RHEB RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA6 TP53 (see all 42) (see less)
2	TGF-beta Pathway	Tocris	ACVR1 ACVR1B AKT1 AKT2 AKT3 BMPR1A BMPR1B HRAS KRAS MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MTOR NRAS PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PPP2CA PPP2CB ROCK1 ROCK2 TGFBR1 TGFBR2 TGFBR3 (see all 37) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
3	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
4	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2
5	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	2
6	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	2
7	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	2
8	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	2
9	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
10	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
11	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	2
12	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
13	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
14	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
15	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
16	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	2
17	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
18	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
19	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
20	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
21	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
22	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
23	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
24	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
25	IGF2R	Insulin Like Growth Factor 2 Receptor	Protein Coding	1
26	INSR	Insulin Receptor	Protein Coding	1
27	TP53	Tumor Protein P53	Protein Coding	1
28	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
29	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
30	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	1
31	PRKCA	Protein Kinase C Alpha	Protein Coding	1
32	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
33	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
34	PRKAA1	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1	Protein Coding	1
35	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
36	PRKAB1	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 1	Protein Coding	1
37	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
38	PRKAG1	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1	Protein Coding	1
39	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
40	PRKAG3	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 3	Protein Coding	1
41	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
42	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
43	ACVR1	Activin A Receptor Type 1	Protein Coding	1
44	ACVR1B	Activin A Receptor Type 1B	Protein Coding	1
45	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	1
46	BMPR1B	Bone Morphogenetic Protein Receptor Type 1B	Protein Coding	1
47	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
48	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
49	TGFBR3	Transforming Growth Factor Beta Receptor 3	Protein Coding	1
50	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
51	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
52	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	1
53	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	1
54	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
55	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
56	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
57	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
58	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1

Disorders associated with mTOR Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, RHEB	9.37
2	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	8.78
3	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	7.82
4	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.13
5	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	7.13
6	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	6.43
7	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, PPARG, TP53	5.17
8	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.14
9	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.14
10	Lynch syndrome	Enrichment	KRAS, PIK3CA, TGFBR2	5.08
11	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	5.08
12	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.66
13	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.66
14	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.66
15	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	4.66
16	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.66
17	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	4.50
18	Hepatocellular carcinoma	Enrichment	IGF2R, PIK3CA, TP53	4.39
19	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	4.36
20	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.36
21	Rasopathy	Enrichment	HRAS, KRAS, NRAS	4.33
22	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB	4.25
23	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB	4.25
24	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	4.19
25	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.19
26	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.97
27	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	3.82
28	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	3.82
29	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	3.82
30	Noonan syndrome 3	Enrichment	HRAS, KRAS	3.82
31	Gallbladder cancer	Enrichment	KRAS, PIK3CA	3.82
32	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	3.82
33	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.82
34	Ovarian cancer	Enrichment	AKT1, BMPR1A, KRAS, PIK3CA	3.80
35	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	3.70
36	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	3.64
37	Loeys-dietz syndrome	Enrichment	TGFBR1, TGFBR2	3.59
38	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	3.59
39	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.59
40	Type 2 diabetes mellitus	Enrichment	AKT2, INSR, PPARG	3.54
41	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	3.49
42	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	3.49
43	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.49
44	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TP53	3.48
45	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.33
46	Meningioma	Enrichment	AKT1, PIK3CA	3.33
47	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.33
48	Nk-cell enteropathy	Enrichment	IGF1R, PIK3CB	3.15
49	Gliosarcoma	Enrichment	PPARG, TP53	2.96
50	Breast cancer	Enrichment	AKT1, KRAS, PIK3CA	2.96
51	Giant cell glioblastoma	Enrichment	PPARG, TP53	2.91
52	Pancreatic cancer	Enrichment	ACVR1B, KRAS	2.68
53	Macrodactyly	Enrichment	PIK3CA	2.56
54	Proteus syndrome	Enrichment	AKT1	2.56
55	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.56
56	Oculoectodermal syndrome	Enrichment	KRAS	2.56
57	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	2.56
58	Acromesomelic dysplasia 3	Enrichment	BMPR1B	2.56
59	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.56
60	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.56
61	Cowden syndrome 5	Enrichment	PIK3CA	2.56
62	Melanosis, neurocutaneous	Enrichment	NRAS	2.56
63	Noonan syndrome 6	Enrichment	NRAS	2.56
64	Brachydactyly, type a1, d	Enrichment	BMPR1B	2.56
65	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.56
66	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.56
67	Short syndrome	Enrichment	PIK3R1	2.56
68	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.56
69	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.56
70	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.56
71	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.56
72	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.56
73	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.56
74	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.56
75	Cowden syndrome 6	Enrichment	AKT1	2.56
76	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.56
77	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.56
78	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.56
79	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.56
80	Hypospadias	Enrichment	PIK3CA	2.56
81	Capillary hemangioma	Enrichment	AKT3	2.56
82	Congenital pulmonary airway malformation	Enrichment	KRAS	2.56
83	Rare venous malformation	Enrichment	PIK3CA	2.56
84	Diaphragmatic eventration	Enrichment	PIK3CA	2.56
85	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.56
86	Rare combined vascular malformation	Enrichment	PIK3CA	2.56
87	Cavernous lymphangioma	Enrichment	PIK3CA	2.56
88	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.56
89	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.56
90	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.56
91	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.56
92	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.56
93	Macrodactyly of toe	Enrichment	PIK3CA	2.56
94	Neurocutaneous melanocytosis	Enrichment	NRAS	2.56
95	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.56
96	Donohue syndrome	Enrichment	INSR	2.51
97	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.51
98	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.51
99	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.51
100	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.51
101	Bone marrow failure syndrome 5	Enrichment	TP53	2.51
102	Papilloma of choroid plexus	Enrichment	TP53	2.51
103	Basal cell carcinoma 7	Enrichment	TP53	2.51
104	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.51
105	Anaplastic thyroid carcinoma	Enrichment	TP53	2.51
106	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	2.51
107	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	2.51
108	Ductal carcinoma in situ	Enrichment	TP53	2.51
109	Skeletal muscle glycogen content and metabolism quantitative trait locus	Enrichment	PRKAG3	2.51
110	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.51
111	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.51
112	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.51
113	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.51
114	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.51
115	Choroid plexus cancer	Enrichment	TP53	2.51
116	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.51
117	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.49
118	Lung cancer	Enrichment	KRAS, PIK3CA	2.47
119	Prostate cancer	Enrichment	PIK3CA, TP53	2.44
120	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.28
121	Costello syndrome	Enrichment	HRAS	2.26
122	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.26
123	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.26
124	Keratosis, seborrheic	Enrichment	PIK3CA	2.26
125	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.26
126	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.26
127	Fibrodysplasia ossificans progressiva	Enrichment	ACVR1	2.26
128	Noonan syndrome 8	Enrichment	PIK3CA	2.26
129	Spermatogenic failure 17	Enrichment	PIK3C2G	2.26
130	Cebalid syndrome	Enrichment	MTOR	2.26
131	Senior-loken syndrome 7	Enrichment	AKT3	2.26
132	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.26
133	Immune system disease	Enrichment	PIK3CD	2.26
134	Bardet-biedl syndrome 16	Enrichment	AKT3	2.26
135	Smith-kingsmore syndrome	Enrichment	MTOR	2.26
136	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A	2.26
137	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.26
138	Juvenile polyposis of infancy	Enrichment	BMPR1A	2.26
139	Wooly hair nevus	Enrichment	HRAS	2.26
140	Gastric cancer	Enrichment	KRAS, PIK3CA	2.22
141	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.21
142	Carotid intimal medial thickness 1	Enrichment	PPARG	2.21
143	Cervical cancer	Enrichment	TP53	2.21
144	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.21
145	Lymphoma, hodgkin, classic	Enrichment	TP53	2.21
146	Congenital fibrosarcoma	Enrichment	TP53	2.21
147	Li-fraumeni syndrome 1	Enrichment	TP53	2.21
148	Sarcoma	Enrichment	TP53	2.21
149	Cervix carcinoma	Enrichment	TP53	2.21
150	Hodgkin's lymphoma	Enrichment	TP53	2.21
151	Familial partial lipodystrophy	Enrichment	PPARG	2.21
152	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.21
153	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFBR1, TGFBR2	2.20
154	Brachydactyly, type a1	Enrichment	BMPR1B	2.09
155	Brachydactyly, type c	Enrichment	BMPR1B	2.09
156	Juvenile polyposis syndrome	Enrichment	BMPR1A	2.09
157	Acromesomelic dysplasia 2a	Enrichment	BMPR1B	2.09
158	Acromesomelic dysplasia 2c	Enrichment	BMPR1B	2.09
159	Acromesomelic dysplasia 2b	Enrichment	BMPR1B	2.09
160	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.09
161	Langerhans cell histiocytosis	Enrichment	NRAS	2.09
162	Transposition of the great arteries, dextro-looped	Enrichment	ACVR1B	2.09
163	Spermatocytoma	Enrichment	HRAS	2.09
164	Keratoacanthoma	Enrichment	PIK3CA	2.09
165	Osteogenic sarcoma	Enrichment	TP53	2.03
166	Nasopharyngeal carcinoma	Enrichment	TP53	2.03
167	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.03
168	Anaplastic astrocytoma	Enrichment	TP53	2.03
169	Squamous cell carcinoma	Enrichment	TP53	2.03
170	Adenocarcinoma	Enrichment	TP53	2.03
171	Bone osteosarcoma	Enrichment	TP53	2.03
172	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.03
173	Myeloma, multiple	Enrichment	KRAS, PIK3R2	1.99
174	Brachydactyly, type a2	Enrichment	BMPR1B	1.96
175	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.96
176	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.96
177	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.96
178	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.96
179	Cerebrovascular disease	Enrichment	PIK3CA	1.96
180	Aortic aneurysm	Enrichment	TGFBR1	1.96
181	Pilocytic astrocytoma	Enrichment	KRAS	1.96
182	Epidermolytic nevus	Enrichment	HRAS	1.96
183	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.96
184	Hypertelorism	Enrichment	PIK3CA, RPS6KA3	1.95
185	Small cell cancer of the lung	Enrichment	TP53	1.91
186	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.91
187	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.91
188	Leptin deficiency or dysfunction	Enrichment	PPARG	1.91
189	Congenital generalized lipodystrophy	Enrichment	PPARG	1.91
190	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.91
191	Capillary malformations, congenital	Enrichment	PIK3CA	1.87
192	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A	1.87
193	Familial cerebral saccular aneurysm	Enrichment	TGFBR3	1.87
194	Rhabdomyosarcoma 2	Enrichment	TP53	1.81
195	Insulin-like growth factor i	Enrichment	IGF1R	1.81
196	Lymphoma	Enrichment	TP53	1.81
197	Acute megakaryocytic leukemia	Enrichment	TP53	1.81
198	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.79
199	Cowden syndrome 1	Enrichment	PIK3CA	1.79
200	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.79
201	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.79
202	Li-fraumeni syndrome	Enrichment	TP53	1.73
203	Adrenocortical carcinoma	Enrichment	TP53	1.73
204	46,xy disorder of sex development	Enrichment	INSR	1.73
205	Esophageal cancer	Enrichment	TGFBR2	1.72
206	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.72
207	Pilomyxoid astrocytoma	Enrichment	KRAS	1.72
208	Megacolon	Enrichment	AKT3	1.72
209	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.67
210	Essential thrombocythemia	Enrichment	TP53	1.67
211	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.67
212	Lennox-gastaut syndrome	Enrichment	MAPK10	1.67
213	Glioma susceptibility 1	Enrichment	TP53	1.61
214	Gastroesophageal reflux	Enrichment	RPS6KA3	1.61
215	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.61
216	Orthostatic intolerance	Enrichment	RPS6KA3	1.61
217	Polymicrogyria	Enrichment	AKT3	1.57
218	Primary hyperaldosteronism	Enrichment	TP53	1.56
219	Ventricular septal defect	Enrichment	RPS6KA3	1.56
220	Pectus excavatum	Enrichment	TGFBR1	1.53
221	Familial colorectal cancer type x	Enrichment	BMPR1A	1.53
222	Leukemia, chronic lymphocytic	Enrichment	TP53	1.52
223	Familial colorectal cancer	Enrichment	TP53	1.52
224	Epicanthus	Enrichment	ACVR1	1.49
225	Myelodysplastic syndrome	Enrichment	TP53	1.47
226	Specific learning disability	Enrichment	RPS6KA3	1.47
227	Protein-deficiency anemia	Enrichment	NRAS	1.46
228	Lung cancer susceptibility 3	Enrichment	KRAS	1.43
229	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.40
230	Rare genetic intellectual disability	Enrichment	MTOR	1.40
231	Rhabdomyosarcoma	Enrichment	HRAS	1.37
232	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	1.31
233	Arteriovenous malformations of the brain	Enrichment	KRAS	1.30
234	Ehlers-danlos syndrome	Enrichment	TGFBR2	1.30
235	Endometrial cancer	Enrichment	PIK3CA	1.25
236	Diffuse large b-cell lymphoma	Enrichment	TP53	1.24
237	Hepatoblastoma	Enrichment	TP53	1.20
238	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.16
239	Diamond-blackfan anemia 1	Enrichment	TP53	1.16
240	Connective tissue disease	Enrichment	TGFBR2	1.08
241	Familial hypertrophic cardiomyopathy	Enrichment	PRKAG2	1.01
242	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.98
243	Diamond-blackfan anemia	Enrichment	TP53	0.98
244	Hypertrophic cardiomyopathy	Enrichment	PRKAG2	0.90
245	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.85
246	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.84
247	Primary ovarian insufficiency	Enrichment	IGF2R	0.78
248	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.54
249	Inherited cancer-predisposing syndrome	Enrichment	BMPR1A	0.52
250	Microcephaly	Enrichment	IGF1R	0.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

mTOR Pathway

Pathway Network for mTOR Pathway

Member Pathways for mTOR Pathway

Pathways in the mTOR Pathway SuperPath

Associated Genes for mTOR Pathway

Associated Disorders for mTOR Pathway

Disorders associated with mTOR Pathway SuperPath

STRING Interaction Network for mTOR Pathway

Sources for mTOR Pathway