mTOR signaling pathway

No Pathway Network information available for mTOR signaling pathway

Pathways in the mTOR signaling pathway SuperPath

#	Name	Source	Genes
1	mTOR signaling pathway	PubChem	AKT1 AKT1S1 ATG13 BNIP3 CCNE1 CDK2 CLIP1 CYCS DDIT4 DEPTOR EEF2 EEF2K EIF4A1 EIF4B EIF4E EIF4EBP1 IKBKB IRS1 MAP2K1 MAPK3 MAPKAP1 MLST8 MTOR PDCD4 PDPK1 PLD1 PML POLDIP3 PPARGC1A PRKCA PRR5 RAF1 RB1CC1 RHEB RICTOR RPS6KA1 RPS6KB1 RPTOR RRAGA RRAGC RRN3 SFN SGK1 SREBF1 TSC1 TSC2 ULK1 YY1 (see all 48) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	BNIP3	BCL2 Interacting Protein 3	Protein Coding	1
2	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	1
3	PLD1	Phospholipase D1	Protein Coding	1
4	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
5	PDCD4	Programmed Cell Death 4	Protein Coding	1
6	POLDIP3	DNA Polymerase Delta Interacting Protein 3	Protein Coding	1
7	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
8	RRN3	RNA Polymerase I Transcription Factor RRN3	Protein Coding	1
9	EEF2	Eukaryotic Translation Elongation Factor 2	Protein Coding	1
10	EIF4A1	Eukaryotic Translation Initiation Factor 4A1	Protein Coding	1
11	CCNE1	Cyclin E1	Protein Coding	1
12	ATG13	Autophagy Related 13	Protein Coding	1
13	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	1
14	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
15	RRAGC	Ras Related GTP Binding C	Protein Coding	1
16	RRAGA	Ras Related GTP Binding A	Protein Coding	1
17	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	1
18	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
19	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
20	EEF2K	Eukaryotic Elongation Factor 2 Kinase	Protein Coding	1
21	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
22	CLIP1	CAP-Gly Domain Containing Linker Protein 1	Protein Coding	1
23	AKT1S1	AKT1 Substrate 1	Protein Coding	1
24	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	1
25	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
26	PML	PML Nuclear Body Scaffold	Protein Coding	1
27	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
28	PRR5	Proline Rich 5	Protein Coding	1
29	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
30	RICTOR	RPTOR Independent Companion Of MTOR Complex 2	Protein Coding	1
31	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
32	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
33	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
34	YY1	YY1 Transcription Factor	Protein Coding	1
35	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
36	PRKCA	Protein Kinase C Alpha	Protein Coding	1
37	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
38	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
39	TSC1	TSC Complex Subunit 1	Protein Coding	1
40	TSC2	TSC Complex Subunit 2	Protein Coding	1
41	SFN	Stratifin	Protein Coding	1
42	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	1
43	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
44	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	1
45	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
46	CYCS	Cytochrome C, Somatic	Protein Coding	1
47	IRS1	Insulin Receptor Substrate 1	Protein Coding	1
48	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1

Disorders associated with mTOR signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.85
2	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	9.85
3	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.91
4	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.44
5	Hamartoma	Enrichment	TSC1, TSC2	4.44
6	Tuberous sclerosis	Enrichment	TSC1, TSC2	4.14
7	Hemimegalencephaly	Enrichment	MTOR, RHEB	3.91
8	Breast adenocarcinoma	Enrichment	AKT1, RB1CC1	3.74
9	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	3.36
10	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, RAF1	2.90
11	Noonan syndrome 1	Enrichment	MAP2K1, RAF1	2.53
12	Proteus syndrome	Enrichment	AKT1	2.45
13	Noonan syndrome 5	Enrichment	RAF1	2.45
14	Melorheostosis, isolated	Enrichment	MAP2K1	2.45
15	Mucoepithelial dysplasia, hereditary	Enrichment	SREBF1	2.45
16	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.45
17	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.45
18	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.45
19	Immunodeficiency 15b	Enrichment	IKBKB	2.45
20	Immunodeficiency 15a	Enrichment	IKBKB	2.45
21	Autism 19	Enrichment	EIF4E	2.45
22	Ifap syndrome 2	Enrichment	SREBF1	2.45
23	Spinocerebellar ataxia 26	Enrichment	EEF2	2.45
24	Thrombocytopenia 4	Enrichment	CYCS	2.45
25	Melorheostosis	Enrichment	MAP2K1	2.45
26	Leopard syndrome 2	Enrichment	RAF1	2.45
27	Cowden syndrome 6	Enrichment	AKT1	2.45
28	Trigonitis	Enrichment	RAF1	2.45
29	Rasopathy	Enrichment	MAP2K1, RAF1	2.42
30	Gabriele-de vries syndrome	Enrichment	YY1	2.15
31	Cebalid syndrome	Enrichment	MTOR	2.15
32	Developmental and epileptic encephalopathy 78	Enrichment	YY1	2.15
33	Insulinoma	Enrichment	YY1	2.15
34	Smith-kingsmore syndrome	Enrichment	MTOR	2.15
35	Long-olsen-distelmaier syndrome	Enrichment	RRAGC	2.15
36	Hereditary breast carcinoma	Enrichment	AKT1, RB1CC1	1.98
37	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	SREBF1	1.98
38	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.98
39	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.98
40	Tuberous sclerosis 2	Enrichment	TSC2	1.98
41	Xanthinuria, type ii	Enrichment	TSC2	1.98
42	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	1.85
43	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	1.85
44	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.85
45	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.76
46	Keratoconus	Enrichment	TSC1	1.68
47	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.61
48	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.61
49	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.61
50	Noonan syndrome 3	Enrichment	RAF1	1.61
51	Polycystic kidney disease 1	Enrichment	TSC2	1.61
52	Pilomyxoid astrocytoma	Enrichment	RAF1	1.61
53	Overgrowth syndrome	Enrichment	MTOR	1.61
54	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.55
55	Breast cancer	Enrichment	AKT1, RB1CC1	1.54
56	Arteriovenous malformation	Enrichment	MAP2K1	1.50
57	Cowden syndrome	Enrichment	AKT1	1.50
58	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.46
59	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.42
60	Meningioma	Enrichment	AKT1	1.38
61	Acute promyelocytic leukemia	Enrichment	PML	1.35
62	Ovarian cancer	Enrichment	AKT1, TSC2	1.30
63	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.29
64	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.29
65	Kidney disease	Enrichment	TSC1	1.29
66	Rare genetic intellectual disability	Enrichment	MTOR	1.29
67	Autism spectrum disorder	Enrichment	MAP2K1, TSC2	1.25
68	Inherited cancer-predisposing syndrome	Enrichment	TSC1, TSC2	1.10
69	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.09
70	Bladder cancer	Enrichment	TSC1	1.01
71	Hirschsprung disease 1	Enrichment	SREBF1	1.01
72	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.96
73	Severe combined immunodeficiency	Enrichment	IKBKB	0.96
74	Left ventricular noncompaction	Enrichment	RAF1	0.93
75	Type 2 diabetes mellitus	Enrichment	IRS1	0.86
76	West syndrome	Enrichment	TSC2	0.84
77	Thrombocytopenia	Enrichment	CYCS	0.80
78	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.77
79	Myeloma, multiple	Enrichment	SGK1	0.74
80	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.73
81	Autosomal recessive non-syndromic intellectual disability	Enrichment	CLIP1	0.73
82	Primary ovarian insufficiency	Enrichment	RICTOR	0.72
83	Dilated cardiomyopathy	Enrichment	RAF1	0.61
84	Colorectal cancer	Enrichment	AKT1	0.57
85	Congenital nervous system abnormality	Enrichment	TSC2	0.50
86	Nervous system disease	Enrichment	TSC2	0.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

mTOR signaling pathway

Pathway Network for mTOR signaling pathway

Member Pathways for mTOR signaling pathway

Pathways in the mTOR signaling pathway SuperPath

Associated Genes for mTOR signaling pathway

Associated Disorders for mTOR signaling pathway

Disorders associated with mTOR signaling pathway SuperPath

STRING Interaction Network for mTOR signaling pathway

Sources for mTOR signaling pathway